WO2016053003A1 - 비배당체가 세포내에 축적되어 있는 미생물 제제의 제조방법 및 이에 의해 제조된 미생물 제제 - Google Patents
비배당체가 세포내에 축적되어 있는 미생물 제제의 제조방법 및 이에 의해 제조된 미생물 제제 Download PDFInfo
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- WO2016053003A1 WO2016053003A1 PCT/KR2015/010325 KR2015010325W WO2016053003A1 WO 2016053003 A1 WO2016053003 A1 WO 2016053003A1 KR 2015010325 W KR2015010325 W KR 2015010325W WO 2016053003 A1 WO2016053003 A1 WO 2016053003A1
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- WO
- WIPO (PCT)
- Prior art keywords
- glycoside
- microorganism
- lactic acid
- glycosides
- microorganisms
- Prior art date
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- C12R2001/225—Lactobacillus
- C12R2001/25—Lactobacillus plantarum
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Abstract
Description
Claims (23)
- β-글루코시다아제를 발현하는 미생물을 배당체 함유 배지에서 배양하거나, 배당체 함유 반응물과 반응시켜, 상기 미생물 내에 배당체로부터 전환된 비배당체를 축적시키는 단계를 포함하는, 비배당체가 세포 내에 축적된 미생물을 제조하는 방법.
- 제1항에 있어서, 상기 배당체는 인삼, 산삼, 콩, 더덕, 메밀, 도라지, 미나리, 녹두, 마늘, 양파, 은행, 칡으로 구성된 군에서 선택되는 하나 또는 이들의 혼합물 유래인 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 배당체는 이소플라본 배당체, 사포닌 배당체, 페놀배당체, 청산 배당체, 안트라키논 배당체, 강심 배당체, 쓴맛 배당체, 쿠마린 배당체, 유황 배당체 또는 플라보노이드 배당체인 것을 특징으로 하는 방법.
- 제1항에 있어서, 다이드진 (daidzin), 제니스틴 (genistin), 글리시틴 (glycitin), 사포닌 (saponin), procyanidin, naringenin, quercetin, rutinose, hesparidin, baicalin, wogonoside, Mogroside V, amygdalin 및 3-Phenyl coumarin으로 구성된 군에서 선택된 하나 이상의 배당체를 제니스테인(genistein), 다이드제인(daidzein), 글리시테인(glycitein), 사포제닌 (sapogenin), 3,4-Hydroxyphenylactic acid, 4-HPA, m-coumaric acid, p-coumaric acid, O-beta-D-glucuroniodes, stilbenoids, rutin, quercetin, hesparetin, baicalein, wogonin, Mogroside IIIE, mendelonitrile, benzaldehyde, 및 coumarin-derivated compounds 로 구성된 군에서 선택된 하나 이상의 비배당체로 전환하는 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 β-글루코시다아제를 생산하는 미생물은 유산균, 비피더스, 효모, 코리네박테리움, 아스페르길루스 및 클로스트리디움으로 구성된 군에서 선택된 하나 이상인 것을 특징으로 하는 방법.
- 제5항에 있어서, 상기 유산균은 락토바실러스 플랜타럼 (L. plantarum), 락토바실러스 사케 (L. sakei), 락토바실러스 람노서스 GG (L. rhamnosus GG), 락토바실러스 델브루키 (L. delbrueckii), 락토바실러스 엑시도필러스 (L. acidophilus), 락토바실러스 존스니 (L. johnsonii), 락토바실러스 카제이 (L. casei) 및 락토바실러스 가세리 (L. gasseri)로 구성된 군에서 선택된 하나 이상인 것을 특징으로 하는 방법.
- 제5항에 있어서, 상기 유산균은 락토바실러스 플란타럼 K8 (L. plantarum K8) (기탁번호: KCTC 10887BP)인 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 β-글루코시다아제를 생산하는 미생물은 GRAS(Generally recognized as safe) 미생물, 비피더스, 효모, Bacillus licheniformis ZSP01, S. thermophilus, L. casei, Streptomyces sp., Bifidobacteria, Lactobacillus delbrueckii Rh2, Sporosarcina sp., Saccharomyces cerevisiae, Pyrococcus furiosus, Lactobacillus plantarum, Aspergillus ochraceus, Lactobacillus delbrueckii Rh2, Pseudomonas sp. Strain, Aspergillus niger, Pseudomonas fluorescens, Bifidobacterium adolescentis, Aspergillus sojae, Cunninghamella blakesleeana, Bifidobacteria and Lactobacillus, lactic acid bacteria, Bifidobacterium pseudocatenulatum, Penicillium melinii, Eubacterium ramulus, Clostridium orbiscindens, Aspergillus awamori, Lactobacillus brevis, Aspergillus parasiticus Speare BGB, Aspergillus aculeatus, Aspergillus niger로 구성된 군에서 선택된 하나 이상인 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 배양은 미생물 활성화를 위해 미생물을 정치 배양하는 단계, 진탕 배양하는 단계 및 피딩 배양하는 단계를 순서대로 포함하는 것을 특징으로 하는 방법.
- 제9항에 있어서, 상기 정치 배양은 37℃에서 12시간 동안 수행되는 것을 특징으로 하는 방법.
- 제9항에 있어서, 상기 진탕 배양은 37℃에서 12시간 동안 6rpm의 조건에서 수행되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 배양은 배지에 미생물 접종 후 배양한 다음, 배당체가 함유된 최소배지로 옮겨 1-36 시간 동안 추가 배양하는 것을 특징으로 하는 방법.
- 제1항에 있어서, 단백질 분해효소로 배당체 함유 식물체를 전처리하는 단계를 추가로 포함하는 것을 특징으로 하는 방법.
- 제13항에 있어서, 상기 단백질 분해효소는 프로모드 (promod), 알카라제 (alkalase), 뉴드라제 (neutrase) 및 파파인 (papain)으로 구성된 군으로부터 선택되는 하나 이상인 것을 특징으로 하는 방법.
- 제1항에 있어서, 상기 세포 내 축적된 비배당체의 농도는 미생물 배양 배지 중 비배당체의 농도 보다 1.5배 이상 높은 것을 특징으로 하는 방법.
- 제1항 내지 제15항 중 어느 한 항에 따른 방법에 의해 제조되고, 비배당체가 세포 내에 축적되어 있는 미생물 또는 이의 파쇄물.
- 제16항에 있어서, 상기 세포 내 축적된 비배당체의 농도는 미생물 배양 배지 중 비배당체의 농도 보다 2배 이상 높은 것을 특징으로 하는 미생물 또는 이의 파쇄물.
- 제16항에 있어서, 상기 파쇄물은 비드 밀(bead mills), 프레스 (Presses), 소니케이터(Sonicator) 또는 마이크로플루다이저 (Microfluidizer)로 처리하여 수득되는 것을 특징으로 하는 미생물 또는 이의 파쇄물.
- 제16항에 있어서, 건조된 분말 형태인 것을 특징으로 하는 미생물 또는 이의 파쇄물.
- 제16항에 따른 미생물 또는 이의 파쇄물을 함유하는 조성물.
- 제16항에 따른 미생물 또는 이의 파쇄물을 함유하는 식품.
- 제16항에 따른 미생물 또는 이의 파쇄물을 함유하는 피부 기능 개선용 조성물.
- 제22항에 있어서, 피부보습, 피부색, 피부탄력, 주름 또는 진피치밀도를 개선시키는 것을 특징으로 하는 조성물.
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CA2999821A CA2999821C (en) | 2014-09-30 | 2015-09-30 | Method for preparing microbial preparation and microbial preparation produced by the same |
US15/515,918 US10676708B2 (en) | 2014-09-30 | 2015-09-30 | Method for preparing microbial preparation and microbial preparation produced by the same |
JP2017518261A JP6737779B2 (ja) | 2014-09-30 | 2015-09-30 | 微生物製剤の製造方法およびこれにより製造された微生物製剤 |
EP15845575.8A EP3202910B1 (en) | 2014-09-30 | 2015-09-30 | Method for preparing microbial preparation in which aglycone accumulates in cells, and microbial preparation prepared thereby |
CN201580056931.6A CN107636145B (zh) | 2014-09-30 | 2015-09-30 | 制备其中苷元在细胞中积累的微生物制剂的方法和通过该方法生产的微生物制剂 |
AU2015324813A AU2015324813B2 (en) | 2014-09-30 | 2015-09-30 | Method for preparing microbial preparation and microbial preparation produced by the same |
US16/858,640 US20200255795A1 (en) | 2014-09-30 | 2020-04-26 | Method for preparing microbial preparation and microbial preparation produced by the same |
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- 2015-09-30 JP JP2017518261A patent/JP6737779B2/ja active Active
- 2015-09-30 KR KR1020150138083A patent/KR101825667B1/ko active IP Right Grant
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CN106011202A (zh) * | 2016-05-21 | 2016-10-12 | 济宁学院 | 利用微生物转化生产糖苷类化合物的方法 |
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JP2018104386A (ja) * | 2016-12-28 | 2018-07-05 | 高梨乳業株式会社 | 皮膚保湿剤 |
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EP3202910A1 (en) | 2017-08-09 |
CN107636145B (zh) | 2021-08-20 |
JP2017536093A (ja) | 2017-12-07 |
CA2999821A1 (en) | 2016-04-07 |
US20200255795A1 (en) | 2020-08-13 |
JP6737779B2 (ja) | 2020-08-12 |
EP3202910B1 (en) | 2022-07-06 |
KR20160038864A (ko) | 2016-04-07 |
AU2015324813B2 (en) | 2019-04-18 |
CN107636145A (zh) | 2018-01-26 |
CA2999821C (en) | 2021-03-23 |
US10676708B2 (en) | 2020-06-09 |
KR101825667B1 (ko) | 2018-02-06 |
US20170306289A1 (en) | 2017-10-26 |
EP3202910A4 (en) | 2018-03-28 |
AU2015324813A1 (en) | 2017-05-18 |
JP2020120657A (ja) | 2020-08-13 |
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