WO2011071343A3 - 라만 활성분자가 나노입자 이합체의 접합부에 위치한 이합체 코어쉘 나노 입자, 이의 용도 및 이의 제조방법 - Google Patents

라만 활성분자가 나노입자 이합체의 접합부에 위치한 이합체 코어쉘 나노 입자, 이의 용도 및 이의 제조방법 Download PDF

Info

Publication number
WO2011071343A3
WO2011071343A3 PCT/KR2010/008862 KR2010008862W WO2011071343A3 WO 2011071343 A3 WO2011071343 A3 WO 2011071343A3 KR 2010008862 W KR2010008862 W KR 2010008862W WO 2011071343 A3 WO2011071343 A3 WO 2011071343A3
Authority
WO
WIPO (PCT)
Prior art keywords
heterodimer
nanoparticle
core
raman
binding portion
Prior art date
Application number
PCT/KR2010/008862
Other languages
English (en)
French (fr)
Other versions
WO2011071343A2 (ko
Inventor
서영덕
남좌민
임동권
전기석
Original Assignee
한국화학연구원
서울대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CN201080060485.3A priority Critical patent/CN102811943B/zh
Application filed by 한국화학연구원, 서울대학교 산학협력단 filed Critical 한국화학연구원
Priority to RU2012129158/10A priority patent/RU2542386C2/ru
Priority to EP10836238.5A priority patent/EP2511231B1/en
Priority to CA2783788A priority patent/CA2783788C/en
Priority to US13/514,920 priority patent/US20130029360A1/en
Priority to BR112012013999-1A priority patent/BR112012013999B1/pt
Priority to AU2010328768A priority patent/AU2010328768B2/en
Priority to JP2012543027A priority patent/JP5701896B2/ja
Publication of WO2011071343A2 publication Critical patent/WO2011071343A2/ko
Publication of WO2011071343A3 publication Critical patent/WO2011071343A3/ko
Priority to IL220294A priority patent/IL220294A/en
Priority to US15/069,063 priority patent/US20160266104A1/en
Priority to US16/906,093 priority patent/US20200385790A1/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/155—Particles of a defined size, e.g. nanoparticles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/628—Detection means characterised by use of a special device being a surface plasmon resonance spectrometer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/632—Detection means characterised by use of a special device being a surface enhanced, e.g. resonance, Raman spectrometer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Nanotechnology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Powder Metallurgy (AREA)
  • Manufacture Of Metal Powder And Suspensions Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 라만 활성분자가 나노입자 이합체의 접합부에 위치한 구조의 나노입자 이합체에 관한 것으로, 보다 구체적으로는 표면에 올리고뉴클레오티드로 결합된 금 또는 은 코어(core) 및 상기 코어를 둘러싼 금 또는 은 쉘(shell)로 이루어진 코어-쉘 나노 입자로 이루어진 나노입자 이합체에 관한 것이다. 또한, 본 발명은 상기 코어-쉘 나노입자 이합체와 이의 제조방법, 및 용도에 관한 것이다.
PCT/KR2010/008862 2008-05-07 2010-12-10 라만 활성분자가 나노입자 이합체의 접합부에 위치한 이합체 코어쉘 나노 입자, 이의 용도 및 이의 제조방법 WO2011071343A2 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
BR112012013999-1A BR112012013999B1 (pt) 2009-12-11 2010-12-10 nanoestrutura dimérica de casca-núcleo marcada com molécula raman ativa localizada na junção de interpartículas e método para preparação do mesmo e para a detecção de um analito
RU2012129158/10A RU2542386C2 (ru) 2009-12-11 2010-12-10 Димерная окклюдантная наноструктура, меченная молекулой, активной в отношении рамановского рассеяния, локализованной в межчастичном соединении, ее использование и способ ее получения
EP10836238.5A EP2511231B1 (en) 2009-12-11 2010-12-10 Heterodimer core-shell nanoparticle in which raman-active molecules are located at a binding portion of a nanoparticle heterodimer, use thereof, and method for preparing same
CA2783788A CA2783788C (en) 2009-12-11 2010-12-10 Dimeric core-shell nanostructure labeled with raman active molecule localized at interparticle junction, use thereof, and method for preparing the same
US13/514,920 US20130029360A1 (en) 2009-12-11 2010-12-10 Dimeric core-shell nanostructure labeled with raman active molecule localized at interparticle junction, use thereof, and method for preparing the same
CN201080060485.3A CN102811943B (zh) 2009-12-11 2010-12-10 以位于粒子间的结合部的拉曼活性分子标记的二聚体核壳纳米结构、其用途及制备方法
AU2010328768A AU2010328768B2 (en) 2009-12-11 2010-12-10 A dimeric core-shell nanostructure labeled with a raman active molecule localized at an interparticle junction, use thereof, and method for preparing the same
JP2012543027A JP5701896B2 (ja) 2009-12-11 2010-12-10 ラマン活性分子がナノ粒子二量体の接合部に位置する二量体コア−シェルナノ粒子、その用途およびその製造方法
IL220294A IL220294A (en) 2009-12-11 2012-06-10 Nano structure with a dimeric nucleus shell labeled with a raman active molecule is located at the intersection of particles, its use and method for making it
US15/069,063 US20160266104A1 (en) 2008-05-07 2016-03-14 Heterodimeric core-shell nanoparticle in which raman-active molecules are located at a binding portion of a nanoparticle heterodimer, use thereof, and method for preparing same
US16/906,093 US20200385790A1 (en) 2008-05-07 2020-06-19 Heterodimeric core-shell nanoparticle in which raman-active molecules are located at a binding portion of a nanoparticle heterodimer, use thereof, and method for preparing same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20090123017 2009-12-11
KR10-2009-0123017 2009-12-11

Related Child Applications (4)

Application Number Title Priority Date Filing Date
PCT/KR2009/002399 Continuation-In-Part WO2009136741A1 (en) 2008-05-07 2009-05-07 Novel au / ag core-shell composite useful for biosensor
US12/991,537 Continuation-In-Part US20110124008A1 (en) 2008-05-07 2009-05-07 NOVEL Au/Ag CORE-SHELL COMPOSITE USEFUL FOR BIOSENSOR
US13/514,920 A-371-Of-International US20130029360A1 (en) 2009-12-11 2010-12-10 Dimeric core-shell nanostructure labeled with raman active molecule localized at interparticle junction, use thereof, and method for preparing the same
US15/069,063 Continuation-In-Part US20160266104A1 (en) 2008-05-07 2016-03-14 Heterodimeric core-shell nanoparticle in which raman-active molecules are located at a binding portion of a nanoparticle heterodimer, use thereof, and method for preparing same

Publications (2)

Publication Number Publication Date
WO2011071343A2 WO2011071343A2 (ko) 2011-06-16
WO2011071343A3 true WO2011071343A3 (ko) 2011-10-13

Family

ID=44146071

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/008862 WO2011071343A2 (ko) 2008-05-07 2010-12-10 라만 활성분자가 나노입자 이합체의 접합부에 위치한 이합체 코어쉘 나노 입자, 이의 용도 및 이의 제조방법

Country Status (11)

Country Link
US (1) US20130029360A1 (ko)
EP (1) EP2511231B1 (ko)
JP (1) JP5701896B2 (ko)
KR (1) KR101247610B1 (ko)
CN (1) CN102811943B (ko)
AU (1) AU2010328768B2 (ko)
BR (1) BR112012013999B1 (ko)
CA (1) CA2783788C (ko)
IL (1) IL220294A (ko)
RU (1) RU2542386C2 (ko)
WO (1) WO2011071343A2 (ko)

Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011158829A1 (ja) * 2010-06-15 2011-12-22 日産化学工業株式会社 表面増強ラマン散乱用金属粒子及び分子センシング
KR101352342B1 (ko) * 2010-11-24 2014-02-17 서울대학교산학협력단 코어 물질과 쉘 물질 사이에 나노갭이 형성된 단일 나노입자 및 이의 제조방법
JP5762225B2 (ja) * 2011-09-08 2015-08-12 新留　康郎 銀シェル金ナノロッドを用いる分析方法
CN102442638A (zh) * 2011-09-15 2012-05-09 王利兵 一种具有手性信号的不对称金纳米粒子二聚体的制备方法
EP2773958B1 (en) * 2011-11-02 2017-11-29 University of Cape Town A method of identifying an analyte in a biological sample
CN102556959B (zh) * 2011-12-30 2014-04-16 中国科学院苏州纳米技术与纳米仿生研究所 一种金属纳米颗粒二聚体的制备方法
CN102590174A (zh) * 2012-02-14 2012-07-18 厦门大学 用Fe3O4@Au核壳纳米探针检测生物分子的方法
KR101467667B1 (ko) * 2012-05-04 2014-12-11 서울대학교산학협력단 헤드부 및 바디부로 이루어진 나노스노우맨 형태의 나노입자, 이의 제조방법 및 이를 이용한 검출 방법
KR101387357B1 (ko) * 2012-07-09 2014-04-21 인텔렉추얼디스커버리 주식회사 양자점 및 양자점 나노 복합체의 형성 방법 및 이를 포함하는 백색 발광 소자
WO2014022330A2 (en) * 2012-07-31 2014-02-06 Northwestern University Dispersible surface-enhanced raman scattering nanosheets
KR101538218B1 (ko) * 2012-08-24 2015-07-22 한양대학교 에리카산학협력단 표면―증강 라만 산란에 기초한 고속 및 고감도 미량 분석용 유무기 나노섬유 복합체 기판 및 이의 제조방법
GB2505401A (en) * 2012-08-31 2014-03-05 Uni Heidelberg Transferring nanoparticles into eukaryotic cells
CA2882388C (en) 2012-08-31 2020-10-20 Sloan-Kettering Institute For Cancer Research Particles, methods and uses thereof
JP6147860B2 (ja) 2012-09-27 2017-06-14 ロディア オペレーションズＲｈｏｄｉａ Ｏｐｅｒａｔｉｏｎｓ 銀ナノ構造を作製するための方法及び同方法に有用なコポリマー
CN102914646B (zh) * 2012-11-16 2014-08-20 湖南大学 基于表面等离子体耦合效应的均相多组分免疫分析方法
AU2013361366B2 (en) 2012-12-19 2018-10-18 Sloan-Kettering Institute For Cancer Research Multimodal particles, methods and uses thereof
CN103074327B (zh) * 2013-01-11 2015-05-06 东南大学 三角银纳米片在分离单链dna中的应用
JP6635791B2 (ja) 2013-02-20 2020-01-29 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ 広視野ラマン撮像装置および関連方法
WO2014134338A1 (en) * 2013-03-01 2014-09-04 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Oligonucleotide functionalized quantum dots
CN103212705B (zh) * 2013-03-13 2015-06-10 江南大学 基于聚合酶链反应的金-金核壳结构二聚体的手性研究的方法
CN103192089B (zh) * 2013-03-13 2015-04-22 江南大学 基于聚合酶链反应的大小金二聚体-金核壳结构组装产物手性研究的方法
CN103212704B (zh) * 2013-03-13 2015-02-11 江南大学 基于聚合酶链反应的金-银核壳结构二聚体的手性研究的方法
CN103212707B (zh) * 2013-03-13 2016-03-23 江南大学 基于聚合酶链反应的大小金链状可控组装产物拉曼性质研究的方法
KR101484743B1 (ko) * 2013-08-13 2015-01-26 고려대학교 산학협력단 생체분자를 기반으로 하는 금속 나노구조물의 제조방법
CN104698171B (zh) * 2013-12-04 2017-02-01 内蒙古农业大学 一种基于胶体金与发光量子点二聚体的二级可选灵敏度侧向层析快速检测方法
US10912947B2 (en) 2014-03-04 2021-02-09 Memorial Sloan Kettering Cancer Center Systems and methods for treatment of disease via application of mechanical force by controlled rotation of nanoparticles inside cells
KR101597894B1 (ko) * 2014-05-20 2016-02-26 서울대학교산학협력단 금속증강형광용 코어-쉘 나노 복합체
US10688202B2 (en) 2014-07-28 2020-06-23 Memorial Sloan-Kettering Cancer Center Metal(loid) chalcogen nanoparticles as universal binders for medical isotopes
CN104280542B (zh) * 2014-10-21 2016-06-08 基蛋生物科技股份有限公司 基于金属增强发光及纳米粒子标记放大的双增强化学发光免疫分析法
CA2976963A1 (en) * 2015-02-19 2016-08-25 Ionica Sciences Reagents and methods for detecting infectious diseases
CN104923777A (zh) * 2015-03-18 2015-09-23 华南理工大学 一种高耐盐性金属纳米粒子组装体及其制备方法
CN104914087B (zh) * 2015-05-18 2018-05-04 上海交通大学 一种多层核壳结构的表面增强拉曼探针及制备方法
WO2016187588A1 (en) * 2015-05-21 2016-11-24 Lamdagen Corporation Plasmonic nanoparticles and lspr-based assays
CN104897645B (zh) * 2015-06-08 2018-01-09 江南大学 一种基于金银纳米粒子二聚体拉曼信号检测叶酸的方法
CN105158125B (zh) * 2015-06-11 2018-01-05 东南大学 一种端粒长度测量方法
WO2017004301A1 (en) 2015-07-01 2017-01-05 Memorial Sloan Kettering Cancer Center Anisotropic particles, methods and uses thereof
WO2017007291A1 (ko) * 2015-07-09 2017-01-12 서울대학교산학협력단 표면 증강 라만 산란 입자를 이용한 핵산 분자 검출 방법
CN104940956B (zh) * 2015-07-09 2017-12-29 中国科学院宁波材料技术与工程研究所 一种核壳结构的复合纳米材料及其制法和应用
KR101802386B1 (ko) 2015-12-11 2017-11-30 재단법인 대구경북첨단의료산업진흥재단 표면증강라만산란(sers) 나노입자, 이의 제조 방법 및 이의 응용
CN105566903B (zh) * 2015-12-16 2018-07-31 苏州大学 一种金属纳米多聚体-导电聚合物及其制备方法
CN105928923A (zh) * 2016-04-22 2016-09-07 上海应用技术学院 一种青色素类染料纳米金sers探针及其制备方法
CN106111974B (zh) * 2016-07-26 2017-11-28 江南大学 一种金银核壳粒子‑金纳米棒自组装结构的制备方法及应用
WO2019004804A2 (ko) * 2017-06-30 2019-01-03 한국화학연구원 패혈증 진단용 키트 및 이를 이용한 진단방법
CN107741415B (zh) * 2017-08-30 2020-12-22 艾柏森(江苏)生物科技有限公司 一种基于磁性纳米组装体双重检测小分子和蛋白质的方法
EP3753652A4 (en) * 2018-01-10 2021-12-15 Seoul National University R & DB Foundation DISCHARGE-BASED PLASMONIC NANOPARTICLES WITH INTERNAL NANOGAPS, METHOD FOR THEIR PRODUCTION AND USE
WO2020036438A1 (ko) * 2018-08-14 2020-02-20 고려대학교 산학협력단 단일 금속 나노 브릿지 구조의 합성 방법 및 이를 이용한 dna 점돌연변이 검출 센서 제작 방법
KR102300360B1 (ko) * 2018-08-14 2021-09-09 고려대학교 산학협력단 단일 금속 나노 브릿지 구조의 합성 방법 및 이를 이용한 dna 점돌연변이 검출 센서 제작 방법
CN108872194B (zh) * 2018-08-22 2020-09-04 暨南大学 一种三明治夹心结构sers检测病原菌的方法
KR102190796B1 (ko) 2019-02-12 2020-12-14 건국대학교 산학협력단 Sers 신호를 내부표준 신호로 포함하는 다층 코어-쉘 입자 및 이를 이용한 표적 분석물의 검출방법
KR102202505B1 (ko) * 2019-06-10 2021-01-14 서울대학교 산학협력단 Dna 혼성화에 의해 형성된 계층적 구조의 금속나노큐브 조립체를 이용하는 표면증강라만산란에 의한 표적 물질 검출방법
KR102246333B1 (ko) * 2019-09-05 2021-04-29 한국표준과학연구원 표면 증강 라만 산란용 라만 활성 입자 및 이의 제조방법
KR102246335B1 (ko) * 2019-09-05 2021-04-29 한국표준과학연구원 표면 증강 라만 산란을 이용한 검출 대상 물질 검출 장치 및 방법
CN112229828B (zh) * 2020-08-11 2021-04-06 嘉兴学院 高选择性捕捉苏丹染料的sers活性基底及其制备方法
WO2022182126A1 (ko) * 2021-02-23 2022-09-01 모던밸류 주식회사 타겟 핵산의 라만 검출을 위한 핵산 기반 자가조립 복합체 및 이의 용도
CN113249698B (zh) * 2021-04-23 2023-04-28 杭州电子科技大学 一种多层纳米帽-星耦合周期性阵列及其制备方法
CN113267628A (zh) * 2021-04-25 2021-08-17 南通大学 一种精子sp10蛋白检测试纸条及定量检测方法
US20230061881A1 (en) * 2021-08-25 2023-03-02 The United States Of America, As Represented By The Secretary Of The Navy Measurement Device with Tunable Two-Dimensional Material for Environment Characterization
CN114438215A (zh) * 2022-04-02 2022-05-06 山东中医药大学 一种基于dna超支化自组装检测肺癌标志物的sers探针和试剂盒
CN114624225B (zh) * 2022-05-16 2022-07-29 南京邮电大学 膜蛋白二聚态原位检测试剂盒及其应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524602A (ja) * 2004-12-17 2008-07-10 インテル・コーポレーション 表面増強ラマン分光法（ｓｅｒｓ）による増強された多重信号の検出
KR20090116653A (ko) * 2008-05-07 2009-11-11 재단법인서울대학교산학협력재단 바이오센서로 유용한 새로운 형태의 금／은 코어쉘 복합체

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60027578T2 (de) * 1999-07-16 2007-01-25 WM. Marsh Rice University, Houston Verfahren zum Nachweis von Bioanalyten unter Verwendung metallischer Nanohüllen
CA2402955C (en) * 2000-03-28 2010-03-09 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
WO2002096262A2 (en) * 2001-05-25 2002-12-05 Northwestern University Non-alloying core shell nanoparticles
US20030211488A1 (en) * 2002-05-07 2003-11-13 Northwestern University Nanoparticle probs with Raman spectrocopic fingerprints for analyte detection
GB0216197D0 (en) * 2002-07-12 2002-08-21 Univ Strathclyde Serrs active particles
US7361821B2 (en) * 2002-09-20 2008-04-22 Intel Corporation Controlled alignment of nanobarcodes encoding specific information for scanning probe microscopy (SPM) reading
US20080076119A9 (en) 2003-12-29 2008-03-27 Lei Sun Composite organic inorganic nanoclusters
US7361410B2 (en) 2003-12-29 2008-04-22 Intel Corporation External modification of composite organic inorganic nanoclusters comprising raman active organic compound
US7381529B2 (en) * 2003-12-31 2008-06-03 Intel Corporation Methods and compositions for detecting nucleic acids using scanning probe microscopy and nanocodes
AU2005246415B8 (en) * 2004-05-19 2011-09-01 Vp Holding, Llc Optical sensor with layered plasmon structure for enhanced detection of chemical groups by SERS
CN1285737C (zh) * 2004-08-03 2006-11-22 湖南大学 硅壳纳米颗粒检测sars病毒基因组片断的方法
JP2007225576A (ja) * 2006-02-27 2007-09-06 Canon Inc 検出試薬、検出素子、および検出方法
JP2009535060A (ja) * 2006-05-03 2009-10-01 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 単一ナノクレセントｓｅｒｓプローブを使用したプロテアーゼおよびプロテアーゼ活性の検出
WO2008097328A2 (en) * 2006-06-23 2008-08-14 Northwestern University Asymmetric functionalized nanoparticles and methods of use
EP1992938A1 (en) * 2007-05-14 2008-11-19 Koninklijke Philips Electronics N.V. Improved methods of SE(R)RS detection using multiple labels
WO2009113674A1 (ja) * 2008-03-14 2009-09-17 学校法人北里研究所 膀胱癌の診断

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008524602A (ja) * 2004-12-17 2008-07-10 インテル・コーポレーション 表面増強ラマン分光法（ｓｅｒｓ）による増強された多重信号の検出
KR20090116653A (ko) * 2008-05-07 2009-11-11 재단법인서울대학교산학협력재단 바이오센서로 유용한 새로운 형태의 금／은 코어쉘 복합체

Also Published As

Publication number Publication date
RU2542386C2 (ru) 2015-02-20
BR112012013999B1 (pt) 2020-12-01
BR112012013999A2 (pt) 2016-04-12
CA2783788C (en) 2015-02-10
IL220294A0 (en) 2012-07-31
WO2011071343A2 (ko) 2011-06-16
JP2013513796A (ja) 2013-04-22
AU2010328768B2 (en) 2014-01-16
CN102811943A (zh) 2012-12-05
JP5701896B2 (ja) 2015-04-15
KR20110066881A (ko) 2011-06-17
EP2511231A2 (en) 2012-10-17
US20130029360A1 (en) 2013-01-31
EP2511231A4 (en) 2013-05-22
CN102811943B (zh) 2015-08-19
IL220294A (en) 2017-01-31
RU2012129158A (ru) 2014-01-20
CA2783788A1 (en) 2011-06-16
AU2010328768A1 (en) 2012-08-02
EP2511231B1 (en) 2015-03-11
KR101247610B1 (ko) 2013-03-26

Similar Documents

Publication Publication Date Title
WO2011071343A3 (ko) 라만 활성분자가 나노입자 이합체의 접합부에 위치한 이합체 코어쉘 나노 입자, 이의 용도 및 이의 제조방법
IL209457A0 (en) Metal-containing transaction card and method of making the same
WO2007099377A3 (en) Cancer treatments
EP1936378A4 (en) BIODETECTION NANOPARTICLE, PRODUCTION METHOD AND APPLICATIONS
EP2298471A4 (en) COMPOSITE SILVER NANOPARTICLES, COMPOSITE SILVER NANOPATHES, AND METHOD FOR PRODUCING THE SAME, PRODUCTION APPARATUS, CONJUGATION METHOD, AND METHOD OF MANUFACTURING
EP1903119A4 (en) EXTREMELY HIGH PURITY COPPER AND METHOD OF MANUFACTURING THE SAME, AND BONDING YARN COMPRISING EXTREMELY HIGH PURITY COPPER
EP2253410A4 (en) Method of bonding different metals and bonded structure
HK1158309A1 (zh) 用於生物傳感器的新型 核-殼複合材料
WO2010010329A3 (en) Method for producing aqueous compatible nanoparticles
IL218024A0 (en) Metal-containing transaction card and method of making the same
WO2009052431A3 (en) Cd19 binding agents and uses thereof
WO2010023327A3 (en) Method for obtaining oligonucleotide aptamers and uses thereof
PL2009122T3 (pl) Stop miedź-cynk, sposób jego wytwarzania i zastosowanie
EP2455179A4 (en) Bonding material and bonding method each using metal nanoparticles
EP2156253A4 (en) SYSTEM AND METHOD FOR PROVIDING EXPORT SERVICES TO MERCHANTS
EP2135972A4 (en) GOLD ALLOY COATING, GOLD ALLOY COATING SHEATH LAMINATE AND GOLD ALLOY COATING SHEATH ELEMENT.
HK1150731A1 (en) The extract, tea drink and method of producing the same
TWI347643B (en) Under bump metallurgy structure and die structure using the same and method of manufacturing die structure
WO2009012871A3 (de) Uv-filter-kapsel
GB201015040D0 (en) Novel antigen binding dimer complexes, methods of making and uses thereof
EP2113517A4 (en) COMPLEXES COMPRISING ANGIOSTATIN AND ITS FRAGMENTS, PROCESSES FOR THEIR PREPARATION AND USES THEREOF
WO2009001019A3 (fr) Nanocapsules a coeur lipidique liquide chargees en actifs(s) hydrosoluble(s) ou hydrodispersible(s)
EP2251445A4 (en) TIAL-BASED ALLOY AND METHOD FOR MANUFACTURING SAME, AND ROTOR BLADE COMPRISING SAME
EP2323757A4 (en) STABLE SILVER-BASED STABLE COLLOIDS AND SILVER-COATED SILVER-BASED COLLOIDS, AND PROCESSES FOR PREPARING THE SAME
IL188998A0 (en) Supported gold catalyst and methods for the production thereof

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 201080060485.3

Country of ref document: CN

121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10836238

Country of ref document: EP

Kind code of ref document: A1

ENP Entry into the national phase

Ref document number: 2783788

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 220294

Country of ref document: IL

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2012543027

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 1619/MUMNP/2012

Country of ref document: IN

WWE Wipo information: entry into national phase

Ref document number: 2010328768

Country of ref document: AU

Ref document number: 2010836238

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2012129158

Country of ref document: RU

ENP Entry into the national phase

Ref document number: 2010328768

Country of ref document: AU

Date of ref document: 20101210

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 13514920

Country of ref document: US

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112012013999

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112012013999

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20120611