WO2011069475A2 - A method of preparation of an oxidized derivative of hyaluronic acid and a method of modification thereof - Google Patents
A method of preparation of an oxidized derivative of hyaluronic acid and a method of modification thereof Download PDFInfo
- Publication number
- WO2011069475A2 WO2011069475A2 PCT/CZ2010/000129 CZ2010000129W WO2011069475A2 WO 2011069475 A2 WO2011069475 A2 WO 2011069475A2 CZ 2010000129 W CZ2010000129 W CZ 2010000129W WO 2011069475 A2 WO2011069475 A2 WO 2011069475A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hyaluronic acid
- water
- hyaluronan
- oxidized
- tempo
- Prior art date
Links
- 0 C[*+]N(CC(C(C)C)C1OC(CO)C2O)C1C2OC(C(C1OC*(C)*C11)O)OC1C(O)=O Chemical compound C[*+]N(CC(C(C)C)C1OC(CO)C2O)C1C2OC(C(C1OC*(C)*C11)O)OC1C(O)=O 0.000 description 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
Definitions
- R is hydrogen or any substitute and the co-oxidant is sodium hypochlorite (NaClO) or trichloroisocyanuric acid (TCC).
- NaClO sodium hypochlorite
- TCC trichloroisocyanuric acid
- the hyaluronic acid is an important polysaccharide, composed of two repeating units of P-(l,3)-D-glucuronic acid and -(l,4)-N-acetyl-D-glucosamine.
- the molecular weight depending on the method of isolation and on the source material, is within the range from 5.10 4 to 5.10 6 g.mol '1 .
- the hyaluronic acid or its sodium salt hyaluronan is an essential component of connective tissues, synovial fluid of joints, and plays an important role in biological processes, such as hydratation, organization of proteoglycans, cell differentiation, proliferation and angiogenesis.
- the hyaluronic acid is a considerably hydrophilic polysaccharide and is soluble in water in the form of a salt in the whole range of pH.
- TEMPO is a relatively stable radical which can exist in reaction in three redox forms. Only the oxidized form of TEMPO is effective for alcohols or geminal diols oxidation.
- a catalytic amount of TEMPO is added to the reaction and therefore, it is necessary to use a co-oxidant which restores the presence of the TEMPO oxidized form.
- Oxidation of hyaluronan by use of TEMPO/NaClO system was described in the patent application WO 02/18448 A2. The authors also dealt with interactions of percarboxylated polysaccharides, while forming biological complexes.
- the physico-chemical properties of the resulting hydrogels have been elucidated by instrumental analyses FT-IR, SEM (scanning electron microscopy) and rheometry. Increasing the oxidation degree of the hyaluronan lead to a corresponding increase of hydrogels compatibility and decrease of water absorption capacity. Dermal fibroblasts were used to study the cell-hydrogel interactions. Both the hydrogels and their degradation products are biocompatible, as proved by the long-term cell viability assay. When cultured with cells, the hydrogel underwent a degradation within 4 weeks, with an obvious loss of cohesiveness. The good biocompatibility and biodegradability was further demonstrated in mice subdermal implantations. Lastly, in vitro and in vivo depositions of extracellular matrix in hydrogels were demonstrated by SEM analysis.
- the present invention relates to an improvement of a method of selective oxidation of the primary hydroxyl group of the hyaluronic acid in the position 6 of the polysaccharide glucosamine part to aldehyde.
- the new reaction is performed using a system of 2,2,6,6- -tetramethyl-l-piperidinyloxyl radical TEMPO / co-oxidant.
- Approaches published up to date have introduced either an aldehydic group to the position 2 and 3 of the hyaluronan glucuronic part, while opening the saccharide ring (scheme 6, structure 2), or a carboxyl group to the position 6 of the hyaluronan glucosamine part (scheme 6, structure 1).
- the method according to the invention is more advantageous in that the respective oxidation product (structure 3, scheme 6) maintains the structure of conjugated saccharide rings. Ring opening in the product oxidized to dialdehyde (structure 2, scheme 6) gives rise to the chain linearity subreakage" and, therefore, a significant change of the polysaccharide 3- dimensional structure compared to the non-modified hyaluronan. Although in the product oxidized to a carboxylic acid (structure 1, scheme 6) the chain linearity impartbreakage" does not occur, the carboxyl group does not enable such various modification (binding) possibilities like the aldehydic group.
- the prepared oxidized hyaluronan can be used for binding compounds containing for example an amino group.
- the binding can be realized either in an imine form or after the reduction in an amine form (reductive amination) (scheme 7):
- the modification of the hyaluronic acid derivative can be performed by a reaction of the oxidized derivative with an amine of the general formula H 2 N-R or with a hyaluronan substituted by an -R-NH 2 group, wherein R is an alkyl, linear or branched chain CI- C30, optionally containing aromatic or heteroaromatic groups.
- This amine can be an alkylamine, e.g. butylamine or hexanediamine, amino acid, peptide or polysaccharide containing a free amino group.
- cross-linked hyaluronan derivatives can be prepared.
- the cross-linked derivatives can be prepared also by the reaction of an aldehyde with a hyaluronan substituted by an aminoalkyl group HA-alkyl-NH 2 .
- Example 8 Oxidation of the hyaluronic acid by the TEMPO/TCC system
- TEMPO (0.01 eq) and TCC (0.2 eq) were added to a hyaluronic acid solution (1%) (O.lg, 20 kDa) in the mixture of DMF/water 70/30. The mixture was stirred for 100 hours at the temperature of -5°C. The solution was then diluted to 0.1 % and dialyzed against the mixture (0.1% NaCl, 0.1% NaHC0 3 ) 3 x 5 liters (once per day) and against distilled water 7 x 5 liters (twice per day). The resulting solution was evaporated and analyzed.
- the solution was then mixed with NaBH 3 CN (3 eq) in 0.5 ml of water. The mixture was stirred for 24 hours at the temperature of 20°C. The solution was then diluted to 0.1% and dialyzed against the mixture (0.1% NaCl, 0.1% NaHC0 3 ) 3 x 5 liters (once per day) and against distilled water 7 x 5 liters (twice per day). The resulting solution was evaporated and analyzed.
- the resulting solution was diluted to 0.1% and dialyzed against the mixture (0.1% NaCI, 0.1% NaHC0 3 ) 3 x 5 liters (once per day) and against distilled water 7 x 5 liters (twice per day). The resulting solution was then evaporated and analyzed.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020127017887A KR101766693B1 (ko) | 2009-12-11 | 2010-12-10 | 히알루론산의 산화된 유도체의 제조 방법 및 이의 변형 방법 |
EP10812840.6A EP2510016B1 (en) | 2009-12-11 | 2010-12-10 | A method of preparation of an oxidized derivative of hyaluronic acid and a method of modification thereof |
US13/512,484 US9434791B2 (en) | 2009-12-11 | 2010-12-10 | Method of preparation of an oxidized derivative of hyaluronic acid and a method of modification thereof |
JP2012542356A JP5886754B2 (ja) | 2009-12-11 | 2010-12-10 | ヒアルロン酸の酸化誘導体の調製方法及びその修飾方法 |
RU2012125154/05A RU2559447C2 (ru) | 2009-12-11 | 2010-12-10 | Способ получения окисленного производного гиалуроновой кислоты и способ его модификации |
BR112012013955A BR112012013955B1 (pt) | 2009-12-11 | 2010-12-10 | método de preparação do derivado de ácido hialurônico seletivamente oxidado na posição (6) da parte glucosamina do polissacarídeo ao aldeído e método de modificação do derivado de ácido hialurônico |
DK10812840.6T DK2510016T3 (en) | 2009-12-11 | 2010-12-10 | A process for preparing an oxidized derivative of hyaluronic acid and a process for modifying it |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CZ20090835A CZ2009835A3 (cs) | 2009-12-11 | 2009-12-11 | Zpusob prípravy derivátu kyseliny hyaluronové oxidovaného v poloze 6 glukosaminové cásti polysacharidu selektivne na aldehyd a zpusob jeho modifikace |
CZPV2009-835 | 2009-12-11 |
Publications (2)
Publication Number | Publication Date |
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WO2011069475A2 true WO2011069475A2 (en) | 2011-06-16 |
WO2011069475A3 WO2011069475A3 (en) | 2011-08-11 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/CZ2010/000129 WO2011069475A2 (en) | 2009-12-11 | 2010-12-10 | A method of preparation of an oxidized derivative of hyaluronic acid and a method of modification thereof |
Country Status (11)
Country | Link |
---|---|
US (1) | US9434791B2 (pt) |
EP (1) | EP2510016B1 (pt) |
JP (1) | JP5886754B2 (pt) |
KR (1) | KR101766693B1 (pt) |
BR (1) | BR112012013955B1 (pt) |
CZ (1) | CZ2009835A3 (pt) |
DK (1) | DK2510016T3 (pt) |
HU (1) | HUE031497T2 (pt) |
PL (1) | PL2510016T3 (pt) |
RU (1) | RU2559447C2 (pt) |
WO (1) | WO2011069475A2 (pt) |
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US9999678B2 (en) | 2012-11-27 | 2018-06-19 | Contipro A.S. | C6-C18-acylated derivative of hyaluronic acid and method of preparation thereof |
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CZ302503B6 (cs) | 2011-06-22 |
DK2510016T3 (en) | 2016-10-10 |
KR20120095463A (ko) | 2012-08-28 |
US9434791B2 (en) | 2016-09-06 |
PL2510016T3 (pl) | 2017-02-28 |
CZ2009835A3 (cs) | 2011-06-22 |
HUE031497T2 (en) | 2017-07-28 |
BR112012013955A2 (pt) | 2016-06-07 |
KR101766693B1 (ko) | 2017-08-09 |
US20120264913A1 (en) | 2012-10-18 |
BR112012013955B1 (pt) | 2020-01-14 |
RU2559447C2 (ru) | 2015-08-10 |
EP2510016A2 (en) | 2012-10-17 |
JP2013513672A (ja) | 2013-04-22 |
JP5886754B2 (ja) | 2016-03-16 |
EP2510016B1 (en) | 2016-08-24 |
RU2012125154A (ru) | 2014-01-20 |
WO2011069475A3 (en) | 2011-08-11 |
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