WO2010033240A3 - Polymères à base de glucide pour administration de médicaments et leurs conjugués - Google Patents

Polymères à base de glucide pour administration de médicaments et leurs conjugués Download PDF

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Publication number
WO2010033240A3
WO2010033240A3 PCT/US2009/005233 US2009005233W WO2010033240A3 WO 2010033240 A3 WO2010033240 A3 WO 2010033240A3 US 2009005233 W US2009005233 W US 2009005233W WO 2010033240 A3 WO2010033240 A3 WO 2010033240A3
Authority
WO
WIPO (PCT)
Prior art keywords
carbohydrate
conjugates
drug delivery
based drug
delivery polymers
Prior art date
Application number
PCT/US2009/005233
Other languages
English (en)
Other versions
WO2010033240A2 (fr
Inventor
Antoni Kozlowski
Samuel P. Mcmanus
Xiaoming Shen
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Priority to EP09789344.0A priority Critical patent/EP2350118B1/fr
Priority to US13/119,276 priority patent/US8680263B2/en
Publication of WO2010033240A2 publication Critical patent/WO2010033240A2/fr
Publication of WO2010033240A3 publication Critical patent/WO2010033240A3/fr
Priority to US14/167,271 priority patent/US9173951B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne des polymères glucidiques hydrosolubles qui sont monodérivés à leur extrémité réductrice, de telle sorte que les polymères glucidiques puissent être sélectivement conjugués en un seul site. Elle concerne également des procédés de préparation et de conjugaison des polymères glucidiques monodérivés.
PCT/US2009/005233 2008-09-19 2009-09-17 Polymères à base de glucide pour administration de médicaments et leurs conjugués WO2010033240A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP09789344.0A EP2350118B1 (fr) 2008-09-19 2009-09-17 Polymères à base de glucide pour administration de médicaments et leurs conjugués
US13/119,276 US8680263B2 (en) 2008-09-19 2009-09-17 Carbohydrate-based drug delivery polymers and conjugates thereof
US14/167,271 US9173951B2 (en) 2008-09-19 2014-01-29 Carbohydrate-based drug delivery polymers and conjugates thereof

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US19267208P 2008-09-19 2008-09-19
US61/192,672 2008-09-19
US20808909P 2009-02-18 2009-02-18
US61/208,089 2009-02-18
US15396609P 2009-02-19 2009-02-19
US61/153,966 2009-02-19

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/119,276 A-371-Of-International US8680263B2 (en) 2008-09-19 2009-09-17 Carbohydrate-based drug delivery polymers and conjugates thereof
US14/167,271 Continuation US9173951B2 (en) 2008-09-19 2014-01-29 Carbohydrate-based drug delivery polymers and conjugates thereof

Publications (2)

Publication Number Publication Date
WO2010033240A2 WO2010033240A2 (fr) 2010-03-25
WO2010033240A3 true WO2010033240A3 (fr) 2010-06-17

Family

ID=41226622

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2009/005233 WO2010033240A2 (fr) 2008-09-19 2009-09-17 Polymères à base de glucide pour administration de médicaments et leurs conjugués
PCT/US2009/005192 WO2010033207A1 (fr) 2008-09-19 2009-09-17 Conjugués polymères de peptides thérapeutiques

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2009/005192 WO2010033207A1 (fr) 2008-09-19 2009-09-17 Conjugués polymères de peptides thérapeutiques

Country Status (7)

Country Link
US (5) US8680263B2 (fr)
EP (3) EP2341942A1 (fr)
JP (2) JP5765813B2 (fr)
AU (1) AU2009292643B2 (fr)
CA (1) CA2737040C (fr)
MX (1) MX2011003117A (fr)
WO (2) WO2010033240A2 (fr)

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