WO2003014064A1 - Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists - Google Patents

Naphthylurea and naphthylacetamide derivatives as vanilloid receptor 1 (vr1) antagonists Download PDF

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WO2003014064A1
WO2003014064A1 PCT/EP2002/008493 EP0208493W WO03014064A1 WO 2003014064 A1 WO2003014064 A1 WO 2003014064A1 EP 0208493 W EP0208493 W EP 0208493W WO 03014064 A1 WO03014064 A1 WO 03014064A1
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Prior art keywords
straight
branched
chain
represents hydrogen
hydroxy
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PCT/EP2002/008493
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English (en)
French (fr)
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WO2003014064A8 (en
Inventor
Takeshi Yura
Muneto Mogi
Yuka Ikegami
Tsutomu Masuda
Toshio Kokubo
Klaus Urbahns
Timothy B. Lowinger
Nagahiro Yoshida
Joachim Freitag
Heinrich Meier
Reilinde Nopper
Makiko Marumo
Masahiro Shiroo
Masaomi Tajimi
Keisuke Takeshita
Toshiya Moriwaki
Yasuhiro Tsukimi
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Bayer Healthcare Ag
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Priority claimed from JP2001232503A external-priority patent/JP2003055209A/ja
Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag
Priority to CA002455754A priority Critical patent/CA2455754A1/en
Priority to EP02758413A priority patent/EP1414788A1/en
Priority to JP2003524319A priority patent/JP2005501873A/ja
Priority to US10/485,481 priority patent/US20040259875A1/en
Priority to AU2002325381A priority patent/AU2002325381A1/en
Publication of WO2003014064A1 publication Critical patent/WO2003014064A1/en
Publication of WO2003014064A8 publication Critical patent/WO2003014064A8/en

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    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
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    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
    • C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
    • C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
    • C07C2603/18—Fluorenes; Hydrogenated fluorenes
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JP2005501873A (ja) 2005-01-20
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US20040259875A1 (en) 2004-12-23
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