WO2000044772A2 - Human serum albumin - Google Patents

Human serum albumin Download PDF

Info

Publication number
WO2000044772A2
WO2000044772A2 PCT/GB2000/000257 GB0000257W WO0044772A2 WO 2000044772 A2 WO2000044772 A2 WO 2000044772A2 GB 0000257 W GB0000257 W GB 0000257W WO 0044772 A2 WO0044772 A2 WO 0044772A2
Authority
WO
WIPO (PCT)
Prior art keywords
albumin
process according
anion exchange
cation exchange
exchange chromatography
Prior art date
Application number
PCT/GB2000/000257
Other languages
English (en)
French (fr)
Other versions
WO2000044772A3 (en
Inventor
Hendrik Van Urk
David John Mead
Philip Harvey Morton
Andrew John Cartwright
Jason Cameron
David James Ballance
Michel Gaston Joseph Grandgeorge
Stephen Berezenko
John Rodney Woodrow
Darrell Sleep
Jean-Luc Bernard Veron
Original Assignee
Delta Biotechnology Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU21207/00A priority Critical patent/AU763899B2/en
Priority to JP2000596028A priority patent/JP4586150B2/ja
Priority to DE60040967T priority patent/DE60040967D1/de
Priority to EP00901252A priority patent/EP1149163B1/en
Priority to KR1020057009776A priority patent/KR100886554B1/ko
Priority to CA2359705A priority patent/CA2359705C/en
Priority to MXPA01007719A priority patent/MXPA01007719A/es
Application filed by Delta Biotechnology Limited filed Critical Delta Biotechnology Limited
Publication of WO2000044772A2 publication Critical patent/WO2000044772A2/en
Publication of WO2000044772A3 publication Critical patent/WO2000044772A3/en
Priority to HK02104220.2A priority patent/HK1042521B/zh
Priority to AU2003248302A priority patent/AU2003248302B2/en
Priority to US12/207,325 priority patent/US7993877B2/en
Priority to US13/175,155 priority patent/US9029102B2/en
Priority to US14/330,703 priority patent/US9555344B2/en

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804Affinity chromatography
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/363Anion-exchange
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76Albumins
    • C07K14/765Serum albumin, e.g. HSA

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
PCT/GB2000/000257 1999-01-30 2000-01-31 Human serum albumin WO2000044772A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
CA2359705A CA2359705C (en) 1999-01-30 2000-01-31 Chromatographic process for purification of albumin
JP2000596028A JP4586150B2 (ja) 1999-01-30 2000-01-31 方法
DE60040967T DE60040967D1 (de) 1999-01-30 2000-01-31 Chromatographisches verfahren zur reinigung von albumin
EP00901252A EP1149163B1 (en) 1999-01-30 2000-01-31 Chromatographic method for purification of albumin
KR1020057009776A KR100886554B1 (ko) 1999-01-30 2000-01-31 알부민 용액의 정제방법
AU21207/00A AU763899B2 (en) 1999-01-30 2000-01-31 Process
MXPA01007719A MXPA01007719A (es) 1999-01-30 2000-01-31 Procedimiento.
HK02104220.2A HK1042521B (zh) 1999-01-30 2002-06-04 生產重組白蛋白的方法
AU2003248302A AU2003248302B2 (en) 1999-01-30 2003-09-23 Process
US12/207,325 US7993877B2 (en) 1999-01-30 2008-09-09 Process for the purification of recombinant albumin
US13/175,155 US9029102B2 (en) 1999-01-30 2011-07-01 Process for the purification of recombinant albumin
US14/330,703 US9555344B2 (en) 1999-01-30 2014-07-14 Process for the purification of recombinant albumin

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9902000A GB9902000D0 (en) 1999-01-30 1999-01-30 Process
GB9902000.0 1999-01-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09890297 A-371-Of-International 2000-01-31
US12/207,325 Continuation US7993877B2 (en) 1999-01-30 2008-09-09 Process for the purification of recombinant albumin

Publications (2)

Publication Number Publication Date
WO2000044772A2 true WO2000044772A2 (en) 2000-08-03
WO2000044772A3 WO2000044772A3 (en) 2000-11-30

Family

ID=10846743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2000/000257 WO2000044772A2 (en) 1999-01-30 2000-01-31 Human serum albumin

Country Status (16)

Country Link
US (3) US7993877B2 (US07993877-20110809-P00003.png)
EP (3) EP2272961A1 (US07993877-20110809-P00003.png)
JP (3) JP4586150B2 (US07993877-20110809-P00003.png)
KR (2) KR100577493B1 (US07993877-20110809-P00003.png)
CN (4) CN1810834B (US07993877-20110809-P00003.png)
AT (1) ATE416254T1 (US07993877-20110809-P00003.png)
AU (2) AU763899B2 (US07993877-20110809-P00003.png)
CA (1) CA2359705C (US07993877-20110809-P00003.png)
DE (1) DE60040967D1 (US07993877-20110809-P00003.png)
DK (1) DK2048234T3 (US07993877-20110809-P00003.png)
ES (1) ES2317827T3 (US07993877-20110809-P00003.png)
GB (1) GB9902000D0 (US07993877-20110809-P00003.png)
HK (2) HK1096691A1 (US07993877-20110809-P00003.png)
MX (1) MXPA01007719A (US07993877-20110809-P00003.png)
SG (2) SG174629A1 (US07993877-20110809-P00003.png)
WO (1) WO2000044772A2 (US07993877-20110809-P00003.png)

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EP1273592A2 (en) 2001-07-06 2003-01-08 ALFA WASSERMANN S.p.A. Process for the purification of pharmacologically active proteins through cationic exchange chromatography
WO2003066681A1 (en) * 2002-02-05 2003-08-14 Delta Biotechnology Limited Stabilization of protein preparations
WO2004020405A2 (en) 2002-08-30 2004-03-11 Biorexis Pharmaceutical Corporation Modified transferrin fusion proteins
WO2005054286A2 (en) 2003-12-03 2005-06-16 Delta Biotechnology Limited Interleukin-11 fusion proteins
WO2005061719A1 (en) * 2003-12-23 2005-07-07 Delta Biotechnology Limited 2-micron family plasmid and use thereof
JP2006512283A (ja) * 2002-05-15 2006-04-13 アメルシャム・バイオサイエンシーズ・アクチボラグ 液体中の夾雑物からアルブミンを分離する方法、使用及びキット
WO2006067511A1 (en) 2004-12-23 2006-06-29 Novozymes Delta Limited Gene expression technique
WO2006066595A2 (en) * 2004-12-22 2006-06-29 Novozymes A/S Recombinant production of serum albumin
WO2007063129A2 (en) * 2005-12-02 2007-06-07 Novozymes A/S Insolation of peptides , polypeptides and proteins
WO2008012629A2 (en) 2006-07-24 2008-01-31 Biorexis Pharmaceutical Corporation Exendin fusion proteins
EP1997829A1 (en) 2001-12-21 2008-12-03 Human Genome Sciences, Inc. Albumin fusion proteins
WO2009019314A1 (en) 2007-08-08 2009-02-12 Novozymes A/S Transferrin variants and conjugates
EP2048236A1 (en) 2003-12-23 2009-04-15 Novozymes Biopharma DK A/S Gene expression technique
EP2090589A1 (en) 2002-02-07 2009-08-19 Dyax Corp. Albumin-fused Kunitz domain peptides
WO2010066090A1 (zh) 2008-12-10 2010-06-17 浙江日升昌药业有限公司 凋亡素-ec-sod羧基末端蛋白转导域融合蛋白
EP2206720A1 (en) 2000-04-12 2010-07-14 Human Genome Sciences, Inc. Albumin fusion proteins
WO2010092135A2 (en) 2009-02-11 2010-08-19 Novozymes Biopharma Uk Ltd. Albumin variants and conjugates
WO2010115634A1 (en) 2009-04-09 2010-10-14 Cellca Gmbh Method for improved single cell cloning
WO2010128142A1 (en) * 2009-05-07 2010-11-11 Novozymes Biopharma Dk A/S Method for purifying albumin
US7847071B2 (en) 2003-02-28 2010-12-07 Lonza Biologics Plc. Antibody purification by protein a and ion exchange chromatography
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WO2011124718A1 (en) 2010-04-09 2011-10-13 Novozymes A/S Albumin derivatives and variants
EP2390333A1 (en) 2002-07-23 2011-11-30 Novozymes Biopharma DK A/S Polypeptides comprising a modified human serum albumin secretion pre-sequence with improved secretion yield
CN101684459B (zh) * 2008-09-22 2012-01-25 上海普天欣生物技术有限公司 CehA突变体蛋白、基因、重组载体及其用途和制备方法
WO2012059486A1 (en) 2010-11-01 2012-05-10 Novozymes Biopharma Dk A/S Albumin variants
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WO2013006675A1 (en) 2011-07-05 2013-01-10 Novozymes Biopharma Uk Limited Albumin formulation and use
CN103025757A (zh) * 2010-04-29 2013-04-03 巴克斯特国际有限公司 二价阳离子结合蛋白在阴离子交换树脂上的纯化方法
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WO2014094406A1 (zh) 2012-12-21 2014-06-26 武汉禾元生物科技有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
US8822417B2 (en) 2011-05-05 2014-09-02 Novozymes Biopharma DIC A/S Albumin variants
KR20140109925A (ko) * 2011-12-05 2014-09-16 팩터 바이오사이언스 인크. 세포를 형질감염시키는 방법들 및 생성물들
WO2015063611A2 (en) 2013-11-01 2015-05-07 University Of Oslo Albumin variants and uses thereof
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KR102111078B1 (ko) 2013-07-04 2020-05-18 노파르티스 아게 O-만노실트랜스퍼라제 결핍 사상균 세포 및 이의 이용 방법
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CN112858682B (zh) * 2019-11-27 2023-06-02 广东唯实生物技术有限公司 用于尿微量白蛋白的检测试纸条及其制备方法、检测试剂盒和检测方法
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
CN112062833A (zh) * 2020-10-09 2020-12-11 国药集团武汉血液制品有限公司 一种从血浆组分ⅳ沉淀中提取人血白蛋白的方法
CN114885608A (zh) 2020-12-08 2022-08-09 通化安睿特生物制药股份有限公司 纯化重组蛋白的方法
CN112646045A (zh) * 2021-01-06 2021-04-13 海默斯(重庆)医学生物技术有限公司 一种重组角蛋白分离纯化方法
CN114907469A (zh) * 2021-02-08 2022-08-16 首都医科大学附属北京朝阳医院 一种人血清中白蛋白分离纯化方法
CN113735963A (zh) * 2021-09-10 2021-12-03 山东健通生物科技有限公司 一种重组人血清白蛋白纯化过程去除色素的方法

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