US20150258120A1 - Methods and devices for the treatment of ocular diseases in human subjects - Google Patents
Methods and devices for the treatment of ocular diseases in human subjects Download PDFInfo
- Publication number
- US20150258120A1 US20150258120A1 US14/441,151 US201314441151A US2015258120A1 US 20150258120 A1 US20150258120 A1 US 20150258120A1 US 201314441151 A US201314441151 A US 201314441151A US 2015258120 A1 US2015258120 A1 US 2015258120A1
- Authority
- US
- United States
- Prior art keywords
- drug
- microneedle
- eye
- scs
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Definitions
- FIG. 20B is a cross sectional image of a rabbit eye following suprachoroidal injection of 3.2 mg triamcinolone (left) or vehicle (right).
- Posterior segment of eyes injected with LPS IVT and low dose TA in SCS (Group 3). Scale bar: 200 ⁇ m.
- G Anterior segment of eyes injected with LPS IVT and high dose TA in SCS (Group 4). Scale bar: 1 mm.
- H Posterior segment of eyes injected with LPS IVT and high dose TA in SCS (Group 4). Arrows indicate presence of TA in SCS. Scale bar: 200 ⁇ m.
- I. Anterior segment of eyes injected with LPS IVT and low dose TA IVT (Group 5). Scale bar: 1 mm.
- J Posterior segment of eyes injected with LPS IVT and low dose TA IVT (Group 5). Scale bar: 200 ⁇ m.
- the microneedle device for non-surgically delivering drug to the suprachoroidal space of the eye of a human subject comprises a hollow microneedle.
- the device may include an elongated housing for holding the proximal end of the microneedle.
- the device may further include a means for conducting a drug formulation through the microneedle.
- the means may be a flexible or rigid conduit in fluid connection with the base or proximal end of the microneedle.
- the means may also include a pump or other devices for creating a pressure gradient for inducing fluid flow through the device.
- the conduit may in operable connection with a source of the drug formulation.
- the source may be any suitable container. In one embodiment, the source may be in the form of a conventional syringe.
- the source may be a disposable unit dose container.
- the posterior ocular disorders amenable for treatment by the methods, devices, and drug formulations described herein may be acute or chronic.
- the ocular disease may be acute or chronic uveitis.
- Uveitis can be caused by infection with viruses, fungi, or parasites; the presence of noninfectious foreign substances in the eye; autoimmune diseases; or surgical or traumatic injury.
- the suprachoroidal drug dose sufficient to achieve a therapeutic response in a human subject treated with the non-surgical SCS drug delivery method is less than the intravitreal, parenteral, intracameral, topical, or oral drug dose sufficient to elicit the identical or substantially identical therapeutic response.
- the suprachoroidal drug dose is at least 10 percent less than the oral, parenteral or intravitreal dose sufficient to achieve the identical or substantially identical therapeutic response.
- the suprachoroidal dose is about 10 percent to about 25 percent less, or about 10 percent to about 50 percent less than the oral, parenteral, intracameral, topical, or intravitreal dose sufficient to achieve the identical or substantially identical therapeutic response.
- This delivery method can be particularly advantageous with ocular tissues, where it is desirable for the insertion and withdrawal process to occur over as short a period as possible to minimize patient discomfort—in contrast to transdermal microneedle patch applications, where patches may more likely be worn (with microneedles inserted) over an extended period without patient discomfort.
- the efficacy of the drug for example infliximab (Remicade®)
- infliximab can be measured, for example, by observing changes in retinal thickness, inflammation, visual acuity, photophobia, typical time between flares, corneal ulceration, and/or edema.
- the efficacy of the drug for example nepafenac
- OCT optical coherence tomography
- a method for treating a patient for multi-focal choroiditis comprises non-surgically administering a drug formulation comprising an effective amount of a MFC treating drug to the SCS of one or both eyes of the patient in need of MFC treatment.
- the drug formulation is administered, in one embodiment, with one of the microneedles described herein.
- the intraocular elimination half life (tin) of the angiogenesis inhibitor administered to the SCS is greater than the intraocular t 1/2 of the angiogenesis inhibitor, when the identical dosage of the angiogenesis inhibitor is administered intravitreally, intracamerally, topically, parenterally or orally.
- the mean intraocular maximum concentration (C max ) of the angiogenesis inhibitor when the identical dosage of the angiogenesis inhibitor is administered to the SCS via the methods described herein, is greater than the intraocular C max of the angiogenesis inhibitor, when the identical dosage is administered intravitreally, intracamerally, topically, parenterally or orally.
- the mean intraocular area under the curve (AUC 0-t ) of the PDGF antagonist when administered to the SCS via the methods described herein, is greater than the intraocular AUC 0-t of the PDGF antagonist, when the identical dosage of the PDGF antagonist is administered intravitreally, intracamerally, topically, parenterally or orally.
- the drug is a steroid or a non-steroid anti-inflammatory drug (NSAID).
- the anti-inflammatory drug is an antibody or fragment thereof, an anti-inflammatory peptide(s) or an anti-inflammatory aptamer(s).
- the delivery of the anti-inflammatory drug to the suprachoroidal space results in benefits over administration of the same drug delivered via oral, intravitreal, intracameral, topical and/or a parenteral route of administration.
- the therapeutic effect of the drug delivered to the suprachoroidal space is greater than the therapeutic effect of the same drug, delivered at the same dosage, when the drug is delivered via oral, intravitreal, topical or parenteral route.
- Scanco ⁇ CT40 desktop conebeam system Scanco Medical AG, Brüttisellen, Switzerland
- TA triamcinolone acetonide
- FIG. 33 shows the mean TA concentration in plasma, ⁇ SD, as measured in 8 rabbits. Systemic exposure to TA following suprachoroidal administration was minimal with a mean C max of 12 ng/mL on Day 1.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/441,151 US20150258120A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261724144P | 2012-11-08 | 2012-11-08 | |
US201261734872P | 2012-12-07 | 2012-12-07 | |
US201261745237P | 2012-12-21 | 2012-12-21 | |
US201361773124P | 2013-03-05 | 2013-03-05 | |
US201361785229P | 2013-03-14 | 2013-03-14 | |
US201361819388P | 2013-05-03 | 2013-05-03 | |
US201361873660P | 2013-09-04 | 2013-09-04 | |
US201361898926P | 2013-11-01 | 2013-11-01 | |
PCT/US2013/069156 WO2014074823A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US14/441,151 US20150258120A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2013/069156 A-371-Of-International WO2014074823A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/001,610 Continuation US9636332B2 (en) | 2012-11-08 | 2016-01-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/454,636 Continuation US20180028516A1 (en) | 2012-11-08 | 2017-03-09 | Methods and devices for the treatment of ocular diseases in human subjects |
Publications (1)
Publication Number | Publication Date |
---|---|
US20150258120A1 true US20150258120A1 (en) | 2015-09-17 |
Family
ID=50685178
Family Applications (10)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US14/441,151 Abandoned US20150258120A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/001,610 Active US9636332B2 (en) | 2012-11-08 | 2016-01-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/086,485 Active US9572800B2 (en) | 2012-11-08 | 2016-03-31 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/454,636 Abandoned US20180028516A1 (en) | 2012-11-08 | 2017-03-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/673,073 Active US9931330B2 (en) | 2012-11-08 | 2017-08-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/830,727 Abandoned US20180092897A1 (en) | 2012-11-08 | 2017-12-04 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/041,067 Abandoned US20180325884A1 (en) | 2012-11-08 | 2018-07-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/124,407 Abandoned US20190240208A1 (en) | 2012-11-08 | 2018-09-07 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/737,010 Abandoned US20200383965A1 (en) | 2012-11-08 | 2020-01-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US17/314,272 Pending US20210260047A1 (en) | 2012-11-08 | 2021-05-07 | Methods and devices for the treatment of ocular diseases in human subjects |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US15/001,610 Active US9636332B2 (en) | 2012-11-08 | 2016-01-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/086,485 Active US9572800B2 (en) | 2012-11-08 | 2016-03-31 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/454,636 Abandoned US20180028516A1 (en) | 2012-11-08 | 2017-03-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/673,073 Active US9931330B2 (en) | 2012-11-08 | 2017-08-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/830,727 Abandoned US20180092897A1 (en) | 2012-11-08 | 2017-12-04 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/041,067 Abandoned US20180325884A1 (en) | 2012-11-08 | 2018-07-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/124,407 Abandoned US20190240208A1 (en) | 2012-11-08 | 2018-09-07 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/737,010 Abandoned US20200383965A1 (en) | 2012-11-08 | 2020-01-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US17/314,272 Pending US20210260047A1 (en) | 2012-11-08 | 2021-05-07 | Methods and devices for the treatment of ocular diseases in human subjects |
Country Status (16)
Country | Link |
---|---|
US (10) | US20150258120A1 (ko) |
EP (2) | EP2916827B1 (ko) |
JP (4) | JP6487848B2 (ko) |
KR (3) | KR20150083117A (ko) |
CN (2) | CN104884049A (ko) |
AU (2) | AU2013342275B2 (ko) |
BR (1) | BR112015010566A2 (ko) |
CA (2) | CA2890471C (ko) |
EA (1) | EA034963B1 (ko) |
ES (1) | ES2813869T3 (ko) |
HK (1) | HK1213192A1 (ko) |
IL (1) | IL238432B (ko) |
MX (2) | MX2015005839A (ko) |
PH (1) | PH12015500986A1 (ko) |
SG (1) | SG11201503637SA (ko) |
WO (1) | WO2014074823A1 (ko) |
Cited By (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USD756524S1 (en) * | 2013-08-05 | 2016-05-17 | Xialing Zhang | Protective cover for a subdermal needle electrode cable assembly |
US9353356B2 (en) | 2007-09-18 | 2016-05-31 | Acceleron Pharma Inc. | Activin-actriia antagonists for treating a follicle-stimulating horomone-secreting pituitary tumor |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US9399669B2 (en) | 2007-02-02 | 2016-07-26 | Acceleron Pharma Inc. | Variants derived from ActRIIB |
US9439945B2 (en) | 2008-08-14 | 2016-09-13 | Acceleron Pharma Inc. | Isolated nucleotide sequences encoding GDF traps |
US9480742B2 (en) | 2005-11-23 | 2016-11-01 | Acceleron Pharma Inc. | Method of promoting bone growth by an anti-actriia antibody |
US9493556B2 (en) | 2010-11-08 | 2016-11-15 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
US9505813B2 (en) | 2008-08-14 | 2016-11-29 | Acceleron Pharma Inc. | Use of GDF traps to treat anemia |
US9526759B2 (en) | 2007-02-01 | 2016-12-27 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
US9539139B2 (en) | 2013-05-03 | 2017-01-10 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US9572865B2 (en) | 2005-11-23 | 2017-02-21 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating multiple myeloma |
US9617319B2 (en) | 2009-11-17 | 2017-04-11 | Acceleron Pharma Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
WO2017120600A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
WO2017120601A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
US9745559B2 (en) | 2009-06-12 | 2017-08-29 | Acceleron Pharma Inc. | Method for decreasing the body fat content in a subject by administering an ActRIIB protein |
US9795594B2 (en) | 2006-06-27 | 2017-10-24 | Aerpio Therapeutics, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
WO2017196881A1 (en) * | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
WO2017210130A1 (en) * | 2016-06-02 | 2017-12-07 | Cloudbreak Therapeutics, Llc | Compositions and methods of using nintedanib for improving glaucoma surgery success |
US9850298B2 (en) | 2014-06-13 | 2017-12-26 | Acceleron Pharma Inc. | Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide |
WO2018022437A3 (en) * | 2016-07-22 | 2018-03-08 | Aiviva Holding Limited | Multikinase inhibitors and uses in ocular fibrosis |
US9926367B2 (en) | 2006-04-07 | 2018-03-27 | Aerpio Therapeutics, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
US9949956B2 (en) | 2009-07-06 | 2018-04-24 | Aerpio Therapeutics, Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
US9994560B2 (en) | 2014-03-14 | 2018-06-12 | Aerpio Therapeutics, Inc. | HPTP-β inhibitors |
US10071135B2 (en) | 2005-11-23 | 2018-09-11 | Acceleron Pharma Inc. | Method of identifying an agent that promotes bone growth or increases bone density |
US10093707B2 (en) | 2006-12-18 | 2018-10-09 | Acceleron Pharma Inc. | Antagonists of activin-ActRIIa and uses for increasing red blood cell levels |
US10150811B2 (en) | 2011-10-13 | 2018-12-11 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
US20180353694A1 (en) * | 2015-06-10 | 2018-12-13 | Sanofi-Aventis Deutschland Gmbh | Device for Attachment to a Drug Delivery Device |
US10188550B2 (en) | 2013-06-03 | 2019-01-29 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using multiple reservoirs |
US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
US10220048B2 (en) | 2013-03-15 | 2019-03-05 | Aerpio Therapeutics, Inc. | Compositions and methods for treating ocular diseases |
US10219936B2 (en) | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
US10226379B2 (en) | 2014-02-12 | 2019-03-12 | Orbit Biomedical Limited | Method and apparatus for subretinal administration of therapeutic agent |
US10253094B2 (en) | 2016-07-20 | 2019-04-09 | Aerpio Therapeutics, Inc. | Antibodies that target human protein tyrosine phosphatase-beta (HPTP-beta) and methods of use thereof to treat ocular conditions |
WO2019136133A1 (en) * | 2018-01-03 | 2019-07-11 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
US10426790B2 (en) | 2016-02-28 | 2019-10-01 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
WO2019217678A1 (en) * | 2018-05-09 | 2019-11-14 | North Carolina State University | Applicator for corneal therapeutics |
US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
WO2020028667A1 (en) * | 2018-08-01 | 2020-02-06 | Nanoneuron Therapeutics, Inc. | Neuroprotective compositions and use thereof |
US10588913B2 (en) | 2015-05-08 | 2020-03-17 | Activus Pharma Co., Ltd. | Aqueous suspension agent containing glucocorticosteroid nanoparticles |
US10639193B2 (en) | 2014-06-06 | 2020-05-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with convergent lumen |
US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
WO2020123991A1 (en) * | 2018-12-13 | 2020-06-18 | Arog Pharmaceuticals, Inc. | Crenolanib combination therapy |
US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
US10821021B2 (en) | 2014-06-06 | 2020-11-03 | Gyroscope Therapeutics Limited | Sub-retinal tangential needle catheter guide and introducer |
US10913722B2 (en) | 2005-05-26 | 2021-02-09 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US10952992B2 (en) | 2015-09-23 | 2021-03-23 | Aerpio Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
US10952894B2 (en) | 2010-10-15 | 2021-03-23 | Clearside Biomedical, Inc. | Device for ocular access |
US10973681B2 (en) | 2016-08-12 | 2021-04-13 | Clearside Biomedical, Inc. | Devices and methods for adjusting the insertion depth of a needle for medicament delivery |
US10980741B2 (en) | 2015-06-06 | 2021-04-20 | Cloudbreak Therapeutics, Llc | Compositions and methods for treating pterygium recurrence |
US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
US11197937B2 (en) | 2016-04-15 | 2021-12-14 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
US11253502B2 (en) | 2019-04-29 | 2022-02-22 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the Schlemm's canal |
US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
US11337852B2 (en) | 2014-09-18 | 2022-05-24 | Gyroscope Therapeutics Limited | Therapeutic agent delivery device |
US11596545B2 (en) | 2016-05-02 | 2023-03-07 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
US11724941B2 (en) | 2018-02-15 | 2023-08-15 | North Carolina State University | Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization |
US11752101B2 (en) | 2006-02-22 | 2023-09-12 | Clearside Biomedical, Inc. | Ocular injector and methods for accessing suprachoroidal space of the eye |
Families Citing this family (96)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
US20120237975A1 (en) | 2010-10-01 | 2012-09-20 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP3682905B1 (en) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
RS63244B1 (sr) | 2011-12-16 | 2022-06-30 | Modernatx Inc | Kompozicije modifikovane mrna |
US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
EP2833892A4 (en) | 2012-04-02 | 2016-07-20 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF PROTEINS AND PEPTIDES ASSOCIATED WITH ONCOLOGY |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
ES2921623T3 (es) | 2012-11-26 | 2022-08-30 | Modernatx Inc | ARN modificado terminalmente |
KR102275034B1 (ko) * | 2013-01-18 | 2021-07-12 | 어드밴첸 파마수티컬스, 엘엘씨 | 항-종양제 6-(7-((1-아미노시클로프로필)메톡시)-6-메톡시퀴놀린-4-일옥시)-n-메틸-1-나프타미드 및 그의 결정형을 제조하는 공정 |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
RU2015155331A (ru) * | 2013-05-24 | 2017-06-27 | Байер Хелскеа Ллк | Лечение полипоидной хороидальной васкулопатии |
US20160137717A1 (en) * | 2013-06-20 | 2016-05-19 | Gabriela Burian | Use of a vegf antagonist in treating choroidal neovascularisation |
WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
AU2014329452B2 (en) | 2013-10-03 | 2019-06-20 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
KR101660370B1 (ko) | 2013-12-12 | 2016-09-27 | 삼성메디슨 주식회사 | 초음파 영상 표시 방법 및 장치 |
US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
MX2016009312A (es) * | 2014-01-16 | 2017-01-06 | Ontogenesis Llc | Composiciones y metodos para el tratamiento de la neovascularizacion y/o fuga intraocular. |
WO2015168619A1 (en) * | 2014-05-02 | 2015-11-05 | Mayo Foundation For Medical Education And Research | Individualized treatment of eye disease |
AU2015277133A1 (en) * | 2014-06-17 | 2017-02-02 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorders |
CA2952958A1 (en) | 2014-06-20 | 2015-12-23 | Clearside Biomedical, Inc. | Variable diameter cannula and methods for controlling insertion depth for medicament delivery |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
CA3200870A1 (en) * | 2014-07-30 | 2016-02-04 | Massachusetts Eye And Ear Infirmary | Methotrexate for proliferative vitreoretinopathy |
SG11201703428SA (en) | 2014-11-10 | 2017-05-30 | Hoffmann La Roche | Bispecific antibodies and methods of use in ophthalmology |
KR20170082594A (ko) | 2014-11-10 | 2017-07-14 | 에프. 호프만-라 로슈 아게 | 항-ang2 항체 및 사용 방법 |
WO2016075036A1 (en) * | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | Anti-pdgf-b antibodies and methods of use |
CN107074942A (zh) | 2014-11-10 | 2017-08-18 | 豪夫迈·罗氏有限公司 | 抗‑IL‑1β抗体和使用方法 |
EP3231427A4 (en) * | 2014-12-10 | 2018-07-11 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid agent |
TWI597051B (zh) * | 2015-04-16 | 2017-09-01 | 林伯剛 | 高半胱胺酸用於偵測及診斷人類眼部之息肉狀脈絡膜血管病變的用途及方法 |
KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
TWI700085B (zh) * | 2015-06-22 | 2020-08-01 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物的用途 |
WO2016209972A1 (en) * | 2015-06-26 | 2016-12-29 | Amgen Inc. | Biomarker of survival in the treatment of renal cell carcinoma with a vegfr inhibitor and an ang2 inhibitor |
CA2993340A1 (en) * | 2015-07-23 | 2017-01-26 | Aerie Pharmaceuticals, Inc. | Intravitreal drug delivery systems for the treatment of ocular conditions |
EA201890185A1 (ru) * | 2015-07-31 | 2018-07-31 | Медиммун Лимитед | Способы лечения опосредованных гепсидином нарушений |
TW201730211A (zh) * | 2015-10-30 | 2017-09-01 | 建南德克公司 | 抗因子d抗體及結合物 |
CN108295072A (zh) * | 2015-12-09 | 2018-07-20 | 瑞阳(苏州)生物科技有限公司 | 尼达尼布防治眼部疾病的用途 |
EP3750540B1 (en) * | 2015-12-17 | 2023-12-13 | Link Genomics, Inc. | Choroidal neovascularization suppressor or drusen formation suppressor |
CN105496957A (zh) * | 2015-12-22 | 2016-04-20 | 中山大学中山眼科中心 | 一种吡非尼酮缓释滴眼液 |
WO2017117464A1 (en) | 2015-12-30 | 2017-07-06 | Kodiak Sciences Inc. | Antibodies and conjugates thereof |
BR112018014467A2 (pt) * | 2016-02-04 | 2018-12-11 | Ni Jinsong | tecnologia de sinergismo fármaco-anticorpo para o tratamento de doenças |
SG11201807523PA (en) | 2016-03-10 | 2018-09-27 | Viela Bio Inc | Ilt7 binding molecules and methods of using the same |
WO2018054077A1 (en) * | 2016-09-26 | 2018-03-29 | Reyoung (Suzhou) Biology Science & Technology Co., Ltd | Composition for treating ocular diseases and methods of usage and making |
AU2017376836A1 (en) * | 2016-12-15 | 2019-07-18 | Progen Pg500 Series Pty Ltd | Composition and uses thereof |
EP3554582A4 (en) | 2016-12-16 | 2020-06-24 | The Brigham and Women's Hospital, Inc. | SYSTEM AND METHOD FOR RESISTANCE-DEPENDENT SELF-CONTROLLED MEDICAL PENETRATION |
US11203636B2 (en) | 2017-02-01 | 2021-12-21 | Yale University | Treatment of existing left ventricular heart failure |
WO2018162271A1 (en) * | 2017-03-05 | 2018-09-13 | Rita Dobmeyer | Nanoparticles for the treatment of macular degeneration |
RU2643955C1 (ru) * | 2017-04-19 | 2018-02-06 | Галина Мэлсовна Чернакова | Способ отбора и подготовки пробы клеток конъюнктивы для проведения бактериологического, вирусологического и иммунологического исследований |
US20200061357A1 (en) * | 2017-05-02 | 2020-02-27 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
WO2018207182A1 (en) * | 2017-05-08 | 2018-11-15 | Hadasit Medical Research Services & Development Ltd. | Biomarker for anti-tnf therapy in retinal diseases |
US20200147055A1 (en) * | 2017-05-30 | 2020-05-14 | Eximore Ltd. | Compositions and methods for treating dry eye syndrome delivering antibiotic macrolide |
EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
EP3654941A1 (en) * | 2017-07-17 | 2020-05-27 | Keith Roizman | Topical delivery of therapeutic agents comprising cell-penetrating peptides for use for the treatment of age-related macular degeneration and other eye diseases |
MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
US11826358B2 (en) | 2017-09-13 | 2023-11-28 | North Carolina State University | Locally-induced adipose tissue browning by microneedle patch for obesity treatment |
WO2019070727A2 (en) | 2017-10-02 | 2019-04-11 | The Johns Hopkins University | NON-VIRAL GENE TRANSFER TO THE SUPRACHOROIDIAN SPACE |
CN107815453B (zh) * | 2017-10-23 | 2020-08-07 | 中山大学中山眼科中心 | 一种核酸适配子及其用途 |
CA3083743C (en) * | 2017-11-29 | 2023-09-26 | Copernicus Therapeutics, Inc. | Gene therapy for ocular improvement |
BR112020012523A2 (pt) * | 2017-12-21 | 2020-11-24 | F. Hoffmann-La Roche Ag | diagnóstico complementar para antagonistas de rna htra1 |
CA3087699A1 (en) | 2018-01-05 | 2019-07-11 | Corvidia Therapeutics, Inc. | Methods for treating il-6 mediated inflammation without immunosuppression |
US20200345637A1 (en) * | 2018-01-19 | 2020-11-05 | Aiviva Biopharma, Inc. | Suspension compositions of multi-target inhibitors |
EA202091786A1 (ru) | 2018-01-26 | 2020-10-20 | Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния | Способы и композиции для лечения ангиогенных расстройств с применением агентов против фрэс |
CN108452309B (zh) * | 2018-03-05 | 2019-08-23 | 佳木斯大学附属第一医院 | 一种用于预防或治疗视神经炎的药物组合物及其制备方法 |
DE112019001996T5 (de) * | 2018-04-18 | 2020-12-31 | Nikon Corporation | Bildverarbeitungsverfahren, Programm und Bildverarbeitungsvorrichtung |
EP3833660A4 (en) | 2018-08-06 | 2022-05-11 | Aldeyra Therapeutics, Inc. | POLYMORPHIC COMPOUNDS AND THEIR USES |
CN109187987B (zh) * | 2018-08-23 | 2021-05-11 | 中国人民解放军第三0九医院 | Ms4a3蛋白作为标志物在诊断活动性结核病中的应用 |
CN115869258A (zh) | 2018-09-25 | 2023-03-31 | 奥尔德拉医疗公司 | 用于治疗干眼病的调配物 |
CN109172128A (zh) * | 2018-09-28 | 2019-01-11 | 宜邻医疗科技(上海)有限公司 | 一种用于细胞和基因药物注入治疗的精准注射系统 |
AU2019417161B2 (en) * | 2018-12-27 | 2023-06-15 | Surface Ophthalmics, Inc. | Ophthalmic pharmaceutical compositions and methods for treating ocular surface disease |
CN109799216B (zh) * | 2018-12-29 | 2021-11-12 | 佛山科学技术学院 | 一种基于吲哚箐绿纳米的荧光oct双模成像方法和装置 |
CA3125511A1 (en) | 2019-02-08 | 2020-08-13 | Curevac Ag | Coding rna administered into the suprachoroidal space in the treatment of ophthalmic diseases |
US11786518B2 (en) | 2019-03-26 | 2023-10-17 | Aldeyra Therapeutics, Inc. | Ophthalmic formulations and uses thereof |
EP3953395A4 (en) * | 2019-04-08 | 2023-01-18 | Biocryst Pharmaceuticals, Inc. | PLASMACALLICREIN INHIBITORS AND METHODS OF USE THEM IN EYE DISEASES |
CA3136814A1 (en) * | 2019-04-16 | 2020-10-22 | Clearside Biomedical, Inc. | Injectable triamcinolone formulations |
CN109999032A (zh) * | 2019-04-30 | 2019-07-12 | 南昌大学 | 雷帕霉素在制备降眼内压的局部滴眼给药药物中的应用 |
WO2020227341A1 (en) * | 2019-05-06 | 2020-11-12 | 9 Meters Biopharma, Inc. | Compositions and methods for treating sjogren's syndrome |
AU2020283135A1 (en) * | 2019-05-31 | 2022-01-06 | Dose Medical Corporation | Bioerodible polyester polymer implants and related methods of use |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
EP4065150A4 (en) | 2019-11-25 | 2023-12-06 | The Regents of the University of California | LONG-ACTING VEGF INHIBITORS FOR INTRAOCULAR NEOVASCULARIZATION |
IL293469B2 (en) * | 2019-12-19 | 2024-04-01 | Active Biotech Ab | Compounds for the treatment of eye diseases are associated with increased blood vessel formation |
US20230049974A1 (en) * | 2020-01-06 | 2023-02-16 | Shilpa Medicare Ltd | Fingolimod extended release injectable suspension |
EP3861985B1 (en) | 2020-02-06 | 2023-06-14 | Ocular Therapeutix, Inc. | Compositions and methods for treating ocular diseases |
CA3171479A1 (en) * | 2020-02-19 | 2021-08-26 | Clearside Biomedical, Inc. | Compositions comprising axitinib and methods of treating ocular disorders |
FI3884929T3 (fi) | 2020-03-25 | 2023-08-07 | Ocular Therapeutix Inc | Tyrosiinikinaasi-inhibiittoria sisältävä silmäimplantti |
CN113797164B (zh) * | 2020-06-17 | 2023-07-14 | 成都瑞沐生物医药科技有限公司 | 一种眼用制剂的载体或辅料及其制备方法和应用 |
WO2022156373A1 (zh) * | 2021-01-22 | 2022-07-28 | 成都瑞沐生物医药科技有限公司 | 一种滴眼给药治疗黄斑水肿、视神经炎和非感染性眼内炎的眼用制剂 |
WO2022226347A1 (en) * | 2021-04-23 | 2022-10-27 | AmMax Bio, Inc. | Treatment of ophthalmic diseases |
WO2023004072A1 (en) * | 2021-07-21 | 2023-01-26 | Slbst Pharma, Inc. | Hydroxychloroquine formulations, dosage forms, and methods of use |
WO2023039168A1 (en) * | 2021-09-09 | 2023-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Use of verteporfin to modulate wound healing after an ocular surgical procedure or ocular injury |
EP4147709A1 (en) * | 2021-09-14 | 2023-03-15 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | A composition comprising il-36 and/or il-18 for use in treating ocular disorders |
CN114134195A (zh) * | 2021-11-03 | 2022-03-04 | 南方科技大学 | 预防前列腺癌的药剂的筛选方法、硝唑尼特在制药中的应用 |
CN114099515A (zh) * | 2021-12-27 | 2022-03-01 | 中山大学中山眼科中心 | 氨甲蝶呤在制备治疗视网膜色素变性的药物方面的应用 |
US20230233455A1 (en) * | 2022-01-24 | 2023-07-27 | Celanese Eva Performance Polymers Llc | Method for Prohibiting and/or Treating an Eye Condition |
WO2023220136A1 (en) * | 2022-05-10 | 2023-11-16 | The Regents Of The University Of California | Ultra low dosage zoledronic acid for treatment of retinal disease |
US11911385B1 (en) | 2022-12-14 | 2024-02-27 | Aldeyra Therapeutics, Inc. | Methotrexate treatment methods |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143329A (en) * | 1996-07-03 | 2000-11-07 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
US20050065137A1 (en) * | 2003-09-23 | 2005-03-24 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
US20050245906A1 (en) * | 2004-04-21 | 2005-11-03 | Exploramed Nc1, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20100256597A1 (en) * | 2006-05-02 | 2010-10-07 | Emory University | Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
Family Cites Families (372)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2008700A (en) | 1930-05-12 | 1935-07-23 | Jr John Hays Hammond | Reediting of talking films |
US2187259A (en) | 1936-07-11 | 1940-01-16 | George E Barnhart | Hypodermic needle |
US2841145A (en) | 1956-05-07 | 1958-07-01 | John A Epps | Syringe |
US2939459A (en) | 1957-01-11 | 1960-06-07 | Jorge A Lazarte | Tandem syringe |
US3477432A (en) | 1964-07-21 | 1969-11-11 | Joseph Denman Shaw | Combination mixing and injecting medical syringe |
US3376999A (en) | 1967-05-31 | 1968-04-09 | Gen Dynamics Corp | Packaging, mixing and dispensing apparatus |
US3892311A (en) | 1969-01-31 | 1975-07-01 | Vincent R Sneider | Disposable syringe kit |
AT318132B (de) | 1969-08-01 | 1974-09-25 | Dentaire Ivoclar Ets | Mischbehälter für die Aufnahme von miteinander reagierenden Substanzen für die Herstellung von gebrauchsfertigen pastenförmigen Dentalpräparaten |
US3762540A (en) | 1970-05-19 | 1973-10-02 | Dentaire Ivoclar Ets | Receptacle having at least three chambers |
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3788320A (en) | 1972-02-25 | 1974-01-29 | Kendall & Co | Spinal needle |
US4226328A (en) | 1979-04-09 | 1980-10-07 | Baxter Travenol Laboratories, Inc. | Catheterization package |
US4383530A (en) | 1981-06-05 | 1983-05-17 | John Bruno | Hypodermic needle and method of making needles |
US4377897A (en) | 1981-08-04 | 1983-03-29 | Ocular Associates | Ophthalmic needle and method for manufacturing the same |
US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
JPS5875563A (ja) | 1981-10-30 | 1983-05-07 | テルモ株式会社 | 留置カテ−テル用接続具 |
US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
JPS60501696A (ja) | 1983-06-28 | 1985-10-11 | シユテリメ−ト ゲゼルシヤフト フユ−ル メデイツイ−ニツシエンベダルフ ミツト ベシユレンクテル ハフツング | 導入補助装置を有する医療装置 |
US4501363A (en) | 1983-10-25 | 1985-02-26 | Isbey Jr Edward K | Surgical kit |
NZ212899A (en) | 1984-07-31 | 1987-10-30 | Phillips Pty Ltd N J | Piston operated adjustable volume dose injector for animals |
US4708147A (en) | 1985-02-25 | 1987-11-24 | Haaga John R | Universal biopsy needle |
US4826871A (en) | 1985-03-13 | 1989-05-02 | Gressel Philip D | Topical ophthalmic compositions containing one or more retinoids |
US4689040A (en) | 1985-04-29 | 1987-08-25 | Thompson Robert J | Tip for a phacoemulsification needle |
US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
US4826490A (en) | 1985-07-29 | 1989-05-02 | National Research Development Corporation | Safety device for hypodermic needle or the like |
US4601708A (en) | 1985-09-09 | 1986-07-22 | Pavel Jordan | Automatic injection for syringe needle, and assembly |
US4736850A (en) | 1986-10-17 | 1988-04-12 | W. L. Gore & Associates, Inc. | Endothelial cell harvesting kit |
US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
US4795432A (en) | 1987-02-19 | 1989-01-03 | Karczmer Claude M | Shield assembly for hypodermic injection devices |
US4804371A (en) | 1987-05-06 | 1989-02-14 | Vaillancourt Vincent L | Post-injection needle sheath |
DE3868298D1 (de) | 1987-07-10 | 1992-03-19 | Braun Melsungen Ag | Kanuele. |
DE3802158A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Vorrichtung zur applikation von implantaten |
US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
US5066276A (en) | 1988-06-21 | 1991-11-19 | Alcon Laboratories, Inc. | Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control |
ATE122227T1 (de) | 1988-09-23 | 1995-05-15 | Frank Hunter | Klinische messsonde. |
US5817075A (en) | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
US5015240A (en) | 1990-05-01 | 1991-05-14 | Ian Campbell Cree | Hypodermic needle shield |
US5098389A (en) | 1990-06-28 | 1992-03-24 | Becton, Dickinson And Company | Hypodermic needle assembly |
ES2023597A6 (es) | 1990-11-05 | 1992-01-16 | Rodiera Olive Jose Javier | Aguja para uso medico, en especial para funcion lumbar y anestesia regional. |
US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
EP0501034A1 (en) | 1991-01-30 | 1992-09-02 | CeramOptec GmbH | Illuminated leading probe device |
US5206267A (en) * | 1991-05-09 | 1993-04-27 | Morton Shulman | Pain controlling composition and method of preparation |
US5181909A (en) | 1991-05-15 | 1993-01-26 | Mcfarlane Richard H | Ampule-container medical syringe and methods |
DE4120173A1 (de) | 1991-06-19 | 1992-12-24 | Hoechst Ag | Positiv arbeitendes strahlungsempfindliches gemisch und damit hergestelltes strahlungsempfindliches aufzeichnungsmaterial |
US5312361A (en) | 1991-09-13 | 1994-05-17 | Zadini Filiberto P | Automatic cannulation device |
US5172807A (en) | 1991-09-30 | 1992-12-22 | Centrix, Inc. | Cement mixing capsule |
WO1993020784A1 (en) | 1992-04-10 | 1993-10-28 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
US5767079A (en) | 1992-07-08 | 1998-06-16 | Celtrix Pharmaceuticals, Inc. | Method of treating ophthalmic disorders using TGF -β |
JPH08502033A (ja) | 1992-07-08 | 1996-03-05 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | TGF−βを用いる眼疾患の治療方法 |
US5295972A (en) | 1992-08-04 | 1994-03-22 | Metatech Corporation | Hypodermic syringe with protective cap |
US5279564A (en) | 1992-09-11 | 1994-01-18 | Edward Weck Incorporated | Cannula retention device |
US5300084A (en) | 1992-11-23 | 1994-04-05 | United States Surgical Corporation | Pneumoperitoneum needle |
JPH08503951A (ja) | 1992-12-02 | 1996-04-30 | インサイト・ビジョン・インコーポレイテッド | シクロデキストリンとポリマーを用いた薬剤供給系 |
US5681825A (en) | 1993-03-15 | 1997-10-28 | Lindqvist; Bengt | Surgical method |
US5399159A (en) | 1993-03-30 | 1995-03-21 | Origin Medsystems, Inc. | Apparatus and method for hand-held insufflation |
US5407070A (en) | 1993-08-18 | 1995-04-18 | Bascos; Christine M. | One-time resealable package for needled medical devices |
US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
US5397313A (en) | 1994-01-27 | 1995-03-14 | The Kendall Company | Low friction syringe |
US5658256A (en) | 1994-08-22 | 1997-08-19 | Shields; Jack W. | Universal sharps shield |
SE9402816D0 (sv) | 1994-08-24 | 1994-08-24 | Pharmacia Ab | Method and meams for drug administration |
AU3584895A (en) | 1994-09-28 | 1996-04-19 | Celtrix Pharmaceuticals, Inc. | Method of treating macular degeneration using tgf-beta |
US5792099A (en) | 1995-02-14 | 1998-08-11 | Decamp; Dennis | Syringe and cannula for insertion of viscoelastic material into an eye and method of using same |
US5779668A (en) | 1995-03-29 | 1998-07-14 | Abbott Laboratories | Syringe barrel for lyophilization, reconstitution and administration |
US5968022A (en) | 1995-04-28 | 1999-10-19 | Saito; Yoshikuni | Medical hollow needle and method of production |
USD383049S (en) | 1995-06-30 | 1997-09-02 | Fiskars Inc. | Tool handle grip |
US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
US5788679A (en) | 1996-06-26 | 1998-08-04 | Gravlee, Jr.; Joseph F. | Phacoemulsification needle |
US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
DE69838750T2 (de) | 1997-05-16 | 2008-10-30 | Amgen Inc., Thousand Oaks | Zeitverzögerte gelzusammensetzungen mit verlängerter wirkstoffverabreichung |
AUPO940697A0 (en) | 1997-09-23 | 1997-10-16 | Kaal, Joseph Hermes | Retractable syringe |
WO1999034858A1 (en) | 1998-01-12 | 1999-07-15 | Georgia Tech Research Corporation | Assessment and control of acoustic tissue effects |
AU2895899A (en) | 1998-03-04 | 1999-09-20 | Medtronic, Inc. | Medical device packaging system |
US6309347B1 (en) | 1998-03-17 | 2001-10-30 | Fuji Photo Optical Co., Ltd. | Air and water supply system for endoscopes |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6540725B1 (en) | 1998-06-04 | 2003-04-01 | Biosense Webster, Inc. | Injection catheter with controllably extendable injection needle |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6936053B1 (en) | 1998-07-02 | 2005-08-30 | Jeffrey N. Weiss | Ocular implant needle |
US6309374B1 (en) | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
FR2784034B1 (fr) | 1998-10-01 | 2000-12-15 | Marc Brunel | Dispositif d'injection a usage unique destine a etre pre-rempli |
US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
US20040141925A1 (en) * | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
US6670321B1 (en) | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
CA2348488C (en) | 1999-01-05 | 2011-03-01 | The Flinders University Of South Australia | Novel agents and methods for treatment and diagnosis of ocular disorders |
US6699210B2 (en) | 1999-04-27 | 2004-03-02 | The Arizona Board Of Regents | Glaucoma shunt and a method of making and surgically implanting the same |
US6319240B1 (en) | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
FR2794650B1 (fr) | 1999-06-10 | 2001-09-14 | Marc Brunel | Dispositif d'injection a usage unique |
FR2801795B1 (fr) | 1999-12-07 | 2002-07-05 | Plastef Investissements | Dispositif de support de securite pour une seringue et ensemble d'un tel dispositif et d'une seringue |
DK1239774T3 (da) | 1999-12-10 | 2006-01-16 | Iscience Corp | Apparat til behandling af öjensygdomme |
US20010051798A1 (en) | 1999-12-28 | 2001-12-13 | Hochman Mark N. | Method of performing an injection using a bi-directional rotational insertion technique |
US6726676B2 (en) | 2000-01-05 | 2004-04-27 | Grieshaber & Co. Ag Schaffhausen | Method of and device for improving the flow of aqueous humor within the eye |
JP4372310B2 (ja) | 2000-04-10 | 2009-11-25 | ニプロ株式会社 | 混注用アダプター |
US6622864B1 (en) | 2000-06-01 | 2003-09-23 | Osteotech, Inc. | Moisture resistant package for storing sterile items |
JP4187922B2 (ja) | 2000-09-14 | 2008-11-26 | テルモ株式会社 | 液体注入針および液体注入装置 |
AU2002234184A1 (en) | 2000-10-31 | 2002-05-27 | Smith & Nephew, Inc. | Packaging and delivery system for bone graft particles |
US20030060447A1 (en) | 2002-04-24 | 2003-03-27 | Mutlu Karakelle | Non-aspirating transitional viscoelastics for use in surgery |
US6915901B2 (en) | 2000-12-11 | 2005-07-12 | Marc Feinberg | Packaging assembly for surgical use |
WO2002064193A2 (en) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Microneedle devices and production thereof |
US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
US20030171722A1 (en) | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
MXPA03006394A (es) | 2001-01-18 | 2003-10-15 | Univ California | Instrumento quirurgico paraglaucoma minimamente invasivo y metodo. |
US6378849B1 (en) * | 2001-04-13 | 2002-04-30 | General Electric Company | Methods and apparatus for mounting motors |
US20090088721A1 (en) | 2001-04-17 | 2009-04-02 | Eyegate Pharma S.A.S. | Enhanced retinal delivery of a nucleic acid through iontophoresis |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US20030073609A1 (en) | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
US6749792B2 (en) | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
WO2003009884A2 (en) | 2001-07-24 | 2003-02-06 | Artes Medical Usa, Inc. | Elongated syringe |
JP2003052819A (ja) | 2001-08-10 | 2003-02-25 | Seikagaku Kogyo Co Ltd | 薬剤充填注射器包装物およびその滅菌または殺菌方法 |
US8361037B2 (en) | 2001-09-19 | 2013-01-29 | Valeritas, Inc. | Microneedles, microneedle arrays, and systems and methods relating to same |
WO2003024508A2 (en) | 2001-09-21 | 2003-03-27 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US7569035B1 (en) | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
ATE475388T1 (de) | 2001-11-22 | 2010-08-15 | Eduard Anton Haefliger | Vorrichtung und verfahren zur durchführung opthalmologischer eingriffe |
US7204823B2 (en) | 2001-12-19 | 2007-04-17 | Medtronic Minimed, Inc. | Medication delivery system and monitor |
US6821286B1 (en) | 2002-01-23 | 2004-11-23 | Cardica, Inc. | System for preparing a graft vessel for anastomosis |
US20050033230A1 (en) | 2002-02-15 | 2005-02-10 | Alchas Paul G. | Prefillable intradermal delivery device with hidden needle and passive shielding |
SI1484054T1 (sl) | 2002-02-22 | 2012-12-31 | Santen Pharmaceutical Co. Ltd. | Sistem razdeljevanja zdravil za subkonjuktivalno dajane finih zrn |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
MXPA04011395A (es) | 2002-05-16 | 2005-02-17 | Scott Lab Inc | Mecanismos de introduccion a recipiente de farmaco y metodo. |
US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
US7316676B2 (en) | 2002-08-20 | 2008-01-08 | Gholam A. Peyman | Treatment of retinal detachment |
DE10242984B4 (de) | 2002-09-17 | 2010-09-23 | Sanatis Gmbh | Vorrichtung zum Herstellen von Gemischen aus zwei Komponenten |
TWI282271B (en) | 2002-09-18 | 2007-06-11 | Allergan Inc | Apparatus for delivery of ocular implants |
US20040106904A1 (en) | 2002-10-07 | 2004-06-03 | Gonnelli Robert R. | Microneedle array patch |
US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
JP2004196787A (ja) | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
AU2003289127A1 (en) | 2002-12-04 | 2004-06-23 | Santen Pharmaceutical Co., Ltd. | Drug delivery system using subconjunctival depot |
EP3597262B1 (en) | 2002-12-20 | 2023-12-27 | Xeris Pharmaceuticals, Inc. | Formulation for intracutaneous injection |
EP1590024B1 (en) | 2003-01-21 | 2016-04-27 | Carmel Pharma AB | A needle for penetrating a membrane |
GB0301934D0 (en) | 2003-01-28 | 2003-02-26 | Sundar Satish | Delivery apparatus and location method |
CN1764484B (zh) | 2003-02-24 | 2011-04-06 | 贝克顿迪金森法国公司 | 用于注射器主体集装的台架 |
US20040199130A1 (en) | 2003-04-03 | 2004-10-07 | Chornenky Victor I. | Apparatus and method for treatment of macular degeneration |
US7533514B2 (en) | 2003-04-25 | 2009-05-19 | Boston Scientific Scimed, Inc. | Method and apparatus for automated handling of medical devices during manufacture |
US7435237B2 (en) | 2003-06-02 | 2008-10-14 | Boston Scientific Scimed, Inc. | Mixing syringes with breakable septums |
US8403941B2 (en) | 2003-06-02 | 2013-03-26 | Abbott Medical Optics Inc. | Intraocular lens and cartridge packaging with lens-loading function |
US20050137525A1 (en) | 2003-06-04 | 2005-06-23 | Georgia Tech Research Corporation | Drilling microneedle device |
US7914803B2 (en) | 2003-06-13 | 2011-03-29 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
DE10327119A1 (de) | 2003-06-13 | 2004-12-30 | Aventis Pharma Deutschland Gmbh | Kappe für Injektionsvorrichtungen |
JP2007526013A (ja) | 2003-06-16 | 2007-09-13 | ソルクス インコーポレイテッド | 緑内障を治療するためのシャント装置 |
JP5174347B2 (ja) | 2003-06-30 | 2013-04-03 | アルザ・コーポレーシヨン | 皮膚を貫通する微小突起の被覆方法 |
USD499153S1 (en) | 2003-07-08 | 2004-11-30 | Test Rite International Company, Ltd | Handle for jump rope |
US20050009910A1 (en) | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
US20050101882A1 (en) | 2003-11-12 | 2005-05-12 | Leira Enrique C. | Safety pressure device for body fluid extraction |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
US20090148527A1 (en) | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
CN1950124B (zh) | 2004-01-12 | 2010-11-10 | Ⅰ科学外科公司 | 一种输送粘性材料的注射器 |
ES2318453T3 (es) | 2004-01-20 | 2009-05-01 | Allergan, Inc. | Composiciones para terapia localizada del ojo, que comprenden, de preferencia,triamcinolona acetonida y acido hialuronico. |
CN1909859B (zh) | 2004-01-23 | 2010-05-12 | 伊萨恩斯外科手术股份有限公司 | 眼部复合微型插管 |
US7678077B2 (en) | 2004-02-20 | 2010-03-16 | Boston Scientific Scimed, Inc. | Variable depth injection device and method |
US20100173866A1 (en) | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
US20080058704A1 (en) | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
AU2005240073A1 (en) | 2004-04-29 | 2005-11-17 | Iscience Surgical Corporation | Apparatus and method for ocular treatment |
BRPI0509334A (pt) | 2004-04-30 | 2007-10-16 | Eyegate Pharma S A | dispositivo de iontoforese ocular, que diminui as irritações |
US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
US20050244462A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
EP1755733A4 (en) | 2004-05-28 | 2010-04-21 | Georgia Tech Res Inst | METHOD AND DEVICES FOR THERMAL TREATMENT |
US8323227B2 (en) | 2004-07-02 | 2012-12-04 | C. R. Bard, Inc. | Tip configurations for a multi-lumen catheter |
BRPI0513243B8 (pt) | 2004-07-12 | 2021-05-25 | Allergan Inc | composições oftálmicas e respectivos usos |
US7615041B2 (en) | 2004-07-29 | 2009-11-10 | Boston Scientific Scimed, Inc. | Vial adaptor |
US7503920B2 (en) | 2004-08-11 | 2009-03-17 | Tzony Siegal | Spinal surgery system and method |
US7722669B2 (en) | 2004-08-13 | 2010-05-25 | Richard Foulkes | Method and insert for modifying eye color |
US8114110B2 (en) | 2004-09-22 | 2012-02-14 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Transseptal puncture needle and needle assemblies |
WO2006042252A2 (en) | 2004-10-08 | 2006-04-20 | Potentia Pharmeceuticals, Inc. | Viral complement control proteins for eye disorders |
US7627938B2 (en) | 2004-10-15 | 2009-12-08 | Board Of Regents, The Univeristy Of Texas System | Tapered hollow metallic microneedle array assembly and method of making and using the same |
US7097776B2 (en) | 2004-10-22 | 2006-08-29 | Hewlett-Packard Development Company, L.P. | Method of fabricating microneedles |
ATE501684T1 (de) | 2004-11-23 | 2011-04-15 | Edward Wong | Medizinische vorrichtung zur temperaturregelung und behandlung des auges sowie des umgebenden gewebes |
US8262715B2 (en) | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
US20060173418A1 (en) | 2004-12-13 | 2006-08-03 | Arrow International, Inc. | Loss of resistance syringe |
US20060169664A1 (en) | 2004-12-28 | 2006-08-03 | Holopack International Corp. | Vial for filling a syringe |
US7803142B2 (en) | 2005-02-02 | 2010-09-28 | Summit Access Llc | Microtaper needle and method of use |
WO2007059187A1 (en) | 2005-11-14 | 2007-05-24 | Pactiv Corporation | Container having internal reservoir |
TW200640443A (en) | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
US20060233858A1 (en) | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
US7947660B2 (en) | 2005-03-11 | 2011-05-24 | Alcon, Inc. | RNAi-mediated inhibition of frizzled related protein-1 for treatment of glaucoma |
JP2008535847A (ja) | 2005-04-08 | 2008-09-04 | サーモディクス,インコーポレイティド | 網膜下に送達するための持続放出インプラント |
US7722581B2 (en) | 2005-04-11 | 2010-05-25 | Gholam A. Peyman | Crystalline lens drug delivery |
US7645264B2 (en) | 2005-04-11 | 2010-01-12 | Becton, Dickinson And Company | Injection device with secondary reservoir |
AU2006239308C1 (en) | 2005-04-26 | 2010-06-03 | Biolase, Inc. | Methods for treating eye conditions |
US20060259008A1 (en) | 2005-04-27 | 2006-11-16 | Allergan, Inc. | Apparatus and methods useful for intravitreal injection of drugs |
CN100463668C (zh) | 2005-05-09 | 2009-02-25 | 凌沛学 | 可逆性热凝胶化水性药物组合物 |
US20080269666A1 (en) | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
CA2612005C (en) | 2005-06-17 | 2013-10-29 | Georgia Tech Research Corporation | Coated microstructures and method of manufacture thereof |
CN100430069C (zh) | 2005-07-28 | 2008-11-05 | 凌沛学 | 一种中药及其复方的可逆性热凝胶化水性药物组合物 |
WO2007038687A2 (en) | 2005-09-27 | 2007-04-05 | Aciont, Inc. | Ocular administration of immunosuppressive agents |
US20070093877A1 (en) | 2005-10-26 | 2007-04-26 | Beecham Michael C | System for maintaining normal health of retinal cells and promoting regeneration of retinal cells |
US20070123947A1 (en) | 2005-11-30 | 2007-05-31 | Wenger William K | Medical device packaging system |
EP1971386B1 (en) | 2005-12-23 | 2013-11-13 | Cathrx Ltd | Irrigation catheter |
ES2653845T3 (es) | 2006-01-17 | 2018-02-09 | Novartis Ag | Dispositivo de tratamiento de administración de fármaco |
US20070185495A1 (en) | 2006-01-30 | 2007-08-09 | Howmedica International S. De R. L. | Plug-in syringe stand |
US20070202186A1 (en) * | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
WO2007131050A2 (en) | 2006-05-02 | 2007-11-15 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
US20070270768A1 (en) | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Mechanical Linkage Mechanism For Ophthalmic Injection Device |
US20070270745A1 (en) | 2006-05-18 | 2007-11-22 | Camran Nezhat | Vacuum actuated tissue lifting device |
USD598543S1 (en) | 2006-06-13 | 2009-08-18 | Angiomed Gmbh & Co. Medizintechnik Kg | Handle for a medical delivery device |
US8668676B2 (en) | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8974511B2 (en) | 2010-11-15 | 2015-03-10 | Aquesys, Inc. | Methods for treating closed angle glaucoma |
US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
US8852137B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for implanting a soft gel shunt in the suprachoroidal space |
WO2008011125A2 (en) | 2006-07-20 | 2008-01-24 | Neurosystec Corporation | Devices, systems and methods for ophthalmic drug delivery |
US20080097335A1 (en) | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
US20080058717A1 (en) | 2006-09-04 | 2008-03-06 | Spector David M | Oral cavity liquid delivery system including pre-angled needle guidance assembly and method for using the same |
US7998108B2 (en) | 2006-09-12 | 2011-08-16 | Psivida Us, Inc. | Injector apparatus and method of use |
US8944069B2 (en) | 2006-09-12 | 2015-02-03 | Vidacare Corporation | Assemblies for coupling intraosseous (IO) devices to powered drivers |
US20080097346A1 (en) | 2006-09-19 | 2008-04-24 | Alcon, Inc. | Trocar cannula |
US20080097390A1 (en) | 2006-09-27 | 2008-04-24 | Alcon Manufacturing, Ltd. | Spring actuated delivery system |
EP2088976B1 (en) | 2006-11-10 | 2019-07-03 | Glaukos Corporation | Uveoscleral shunt |
CA2670990A1 (en) | 2006-12-01 | 2008-06-12 | Allergan, Inc. | Method for determining optimum intraocular locations for drug delivery systems |
US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
RU2344767C2 (ru) | 2006-12-18 | 2009-01-27 | Наталья Александровна Уракова | Способ внутриартериальной инъекции по а.л. уракову |
TWI457336B (zh) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
JP5201744B2 (ja) | 2007-01-09 | 2013-06-05 | フォヴェア ファルマシューティカル | 眼内注射装置 |
US20080177239A1 (en) | 2007-01-18 | 2008-07-24 | Yong Li | Trocar cannula system |
DE102007018696A1 (de) | 2007-04-18 | 2008-10-23 | Sanofi-Aventis Deutschland Gmbh | Injektionsvorrichtung zur Abgabe eines Medikaments |
USD590690S1 (en) | 2007-05-24 | 2009-04-21 | Domino S.P.A. | Handlebar hand grip |
US20090030381A1 (en) | 2007-07-23 | 2009-01-29 | Lind Casey J | Arced Hypodermic Needle |
US20110202012A1 (en) | 2007-08-16 | 2011-08-18 | Bartlett Edwin C | Smart Injection Syring Systems Providing Real-Time User Feedback of Correct Needle Position |
CA2639322C (en) | 2007-09-07 | 2016-11-08 | Becton, Dickinson And Company | Pen needle hub having increased contact area |
CN102670352A (zh) | 2007-09-07 | 2012-09-19 | Qlt股份有限公司 | 用于泪腺植入物的插入和抽出工具 |
US20090076463A1 (en) | 2007-09-17 | 2009-03-19 | Jurg Attinger | Trocar Cannula |
US20090081277A1 (en) | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
US8337509B2 (en) | 2007-11-20 | 2012-12-25 | Ivantis, Inc. | Methods and apparatus for delivering ocular implants into the eye |
US8448786B2 (en) | 2009-06-30 | 2013-05-28 | Medline Industries, Inc. | Catheter tray, packaging system, instruction insert, and associated methods |
US8631935B2 (en) | 2009-06-03 | 2014-01-21 | Medline Industries, Inc. | Catheter tray, packaging system, and associated methods |
US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
JP2009183441A (ja) | 2008-02-06 | 2009-08-20 | Ken Kondo | 静脈留置針組立体 |
WO2009105534A2 (en) | 2008-02-21 | 2009-08-27 | Ista Pharmaceuticals | Ophthalmic nsaids as adjuvants |
US20100152646A1 (en) | 2008-02-29 | 2010-06-17 | Reshma Girijavallabhan | Intravitreal injection device and method |
JP5581227B2 (ja) * | 2008-03-11 | 2014-08-27 | アルコン リサーチ, リミテッド | 硝子体内注射のための低粘度、高凝集トリアムシノロンアセトニド懸濁剤 |
US20090259180A1 (en) | 2008-04-11 | 2009-10-15 | Jong Soo Choi | Injection method using injector with length-adjustable needle and injection apparatus using the same |
US20090287161A1 (en) | 2008-05-15 | 2009-11-19 | Allergan, Inc | Metered, multiple dose/aliquot syringe |
US20090312782A1 (en) | 2008-06-13 | 2009-12-17 | Maxwell Choongwon Park | Method and apparatus for repairing tendons |
US8821870B2 (en) | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
US9022940B2 (en) | 2008-07-18 | 2015-05-05 | Joseph H. Meier | Handheld imaging devices and related methods |
JP5635984B2 (ja) | 2008-07-21 | 2014-12-03 | スミスズ メディカル エイエスディー インコーポレイテッド | トレイ組立品 |
JP5854836B2 (ja) | 2008-08-30 | 2016-02-09 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | カートリッジ及びそのための針システム |
US7678078B1 (en) | 2008-10-21 | 2010-03-16 | KMG Pharma LLC | Intravitreal injection device, system and method |
US8221353B2 (en) | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
WO2010054660A1 (en) | 2008-11-11 | 2010-05-20 | Herlev Hospital | Double cannula system for anaesthetic needle |
US20110282298A1 (en) | 2008-12-09 | 2011-11-17 | Nadav Agian | Device for injecting fluid isolated from microneedle hub with dead-space-reducing insert |
US8545554B2 (en) | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
US8425473B2 (en) | 2009-01-23 | 2013-04-23 | Iscience Interventional Corporation | Subretinal access device |
ES2378012B1 (es) | 2009-01-29 | 2013-02-12 | Innova Salud Desarrollos Sanitarios S.L. | Dispositivo para la administración de productos inyectables con caudal controlado. |
AU2010213840B2 (en) | 2009-02-10 | 2014-03-20 | Eyepoint Pharmaceuticals Us, Inc. | Ocular trocar assembly |
US8057483B2 (en) | 2009-02-14 | 2011-11-15 | Ocular Transplantation Llc | Subretinal implantation instrument |
CN201356711Y (zh) | 2009-02-23 | 2009-12-09 | 徐学农 | 玻璃体腔冲洗针头 |
AU2010220388B2 (en) | 2009-03-02 | 2015-04-02 | Sanofi-Aventis Deutschland Gmbh | Medication delivery device with foldable finger pad |
WO2010100243A1 (en) | 2009-03-05 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Needle unit |
AU2010220254B2 (en) | 2009-03-05 | 2014-12-04 | Sanofi-Aventis Deutschland Gmbh | Needle assembly |
EP2403570B1 (en) | 2009-03-05 | 2015-07-15 | Sanofi-Aventis Deutschland GmbH | Drug delivery device |
JP5608686B2 (ja) | 2009-03-05 | 2014-10-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 後退可能な針を備えた薬物送達デバイス |
AU2010220259A1 (en) | 2009-03-06 | 2011-09-22 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with retractable needle |
US8287494B2 (en) | 2009-03-23 | 2012-10-16 | Colin Ma | Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye |
SE0900371A1 (sv) | 2009-03-24 | 2010-09-25 | Istvan Bartha | Anordning för distribution av flytande läkemedel |
CN102395312B (zh) | 2009-04-15 | 2015-02-04 | 皇家飞利浦电子股份有限公司 | 具有在斜面的切割作用面中的集成光纤的探针 |
EP2424610A2 (en) | 2009-04-29 | 2012-03-07 | Janisys Limited | A micro-needle device and apparatus and a method for applying a micro-needle element to a site on the skin of a subject |
CA2762071A1 (en) | 2009-05-15 | 2010-11-18 | Iscience Interventional Corporation | Methods and apparatus for sub-retinal catheterization |
US8795226B2 (en) | 2009-06-25 | 2014-08-05 | Sanofi-Aventis Deutschland Gmbh | Cannula assembly for co-delivery of medicaments |
RU2428956C2 (ru) | 2009-07-13 | 2011-09-20 | Александр Дмитриевич Ромащенко | Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток |
US8535333B2 (en) | 2009-07-29 | 2013-09-17 | Transcend Medical, Inc. | Ocular implant applier and methods of use |
WO2011018408A1 (en) | 2009-08-12 | 2011-02-17 | Sanofi-Aventis Deutschland Gmbh | Cap for a portable medical delivery device and such a medical delivery device |
US8221753B2 (en) * | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
US20120259288A1 (en) | 2009-08-28 | 2012-10-11 | Sanofi-Aventis Deutschland Gmbh | Assembly kit for preparing of a pre-filled syringe |
US20130041265A1 (en) | 2009-09-21 | 2013-02-14 | Ron Sostek | Methods and apparatus for introducing cells at a tissue site |
WO2011057065A1 (en) | 2009-11-06 | 2011-05-12 | The Uab Research Foundation | Apparatuses and methods for delivering substances to the inner eye |
AU2010317659B2 (en) | 2009-11-11 | 2014-01-23 | Unitract Syringe Pty Ltd | Clinical syringe |
EP2918302B1 (en) | 2009-12-22 | 2018-11-14 | UNL Holdings LLC | Retractable syringe with improved delivery efficiency and locking system |
US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
US8961474B2 (en) | 2010-01-05 | 2015-02-24 | Allergan, Inc. | Syringe |
US20110213317A1 (en) | 2010-03-01 | 2011-09-01 | Chen David E-Bin | Cannula for intraocular surgery |
EP2364740A1 (en) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Arrangement for transferring a translation of a drive means to a plunger |
GB201004102D0 (en) | 2010-03-12 | 2010-04-28 | Liversidge Barry P | Syringe barrels and handling systems |
US9320647B2 (en) | 2010-03-31 | 2016-04-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
US8574217B2 (en) | 2010-04-08 | 2013-11-05 | Kmg Pharma, Llc | Sub-mucosal agent delivery method for the eye |
US8430862B2 (en) | 2010-04-08 | 2013-04-30 | KMG Pharma LLC | Subconjunctival agent delivery apparatus, system and method |
US8652118B2 (en) | 2010-04-08 | 2014-02-18 | Kmg Pharma, Llc | Sub-mucosal agent delivery, apparatus, system and method |
US8632589B2 (en) | 2010-05-04 | 2014-01-21 | Abbott Medical Optics Inc. | IOL insertion system with semi-automatic trailing haptic configuration management |
BR112012028038A2 (pt) | 2010-05-04 | 2018-05-15 | Unitract Syringe Pty Ltd | conjunto de agulhas e adaptador de tubo de seringa |
US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
US8545430B2 (en) | 2010-06-09 | 2013-10-01 | Transcend Medical, Inc. | Expandable ocular devices |
WO2011155988A1 (en) | 2010-06-10 | 2011-12-15 | Colantonio Anthony J | Apparatus and method for safely inserting an introducer needle into epidural space |
AU2011271518A1 (en) | 2010-07-02 | 2012-12-13 | Alcon Research, Ltd. | Compounds for the treatment of posterior segment disorders and diseases |
KR101180032B1 (ko) | 2010-07-12 | 2012-09-05 | 인싸이토(주) | 외형 조절이 가능한 중공형 마이크로니들의 제조방법 |
TW201216948A (en) | 2010-07-19 | 2012-05-01 | Sanofi Aventis Deutschland | Medicament cartridges with non-standard dimensions |
AU2011308629A1 (en) | 2010-09-30 | 2013-05-23 | Evonik Corporation | Drug delivery blade and methods for delivering a drug depot to a target site |
US8864740B2 (en) | 2010-10-01 | 2014-10-21 | Sanofi-Aventis Deutschland Gmbh | Needle assembly with release mechanism |
EP2438939A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Arrangement for coupling a plunger to either a syringe or a stopper |
EP3520749A1 (en) | 2010-10-15 | 2019-08-07 | Clearside Biomedical, Inc. | Device for ocular access |
US20120101475A1 (en) | 2010-10-21 | 2012-04-26 | Meridian Medical Technologies, Inc. | High Efficiency Auto-Injector |
US20130331786A1 (en) | 2010-10-25 | 2013-12-12 | Sanofi-Aventis Deutschland Gmbh | Device for Controlling a Penetration Depth of Injection Needle |
EP2446866A1 (en) | 2010-11-02 | 2012-05-02 | Fovea Pharmaceuticals | Apparatus for injection into an eye |
WO2012059456A1 (en) | 2010-11-03 | 2012-05-10 | Sanofi-Aventis Deutschland Gmbh | Needle cannula containing medicament |
US9241701B2 (en) | 2010-11-11 | 2016-01-26 | Depuy Mitek, Inc. | Cannula system and method for partial thickness rotator cuff repair |
JP5704389B2 (ja) | 2010-11-29 | 2015-04-22 | ニプロ株式会社 | 医療用中空針および医療用中空針の製造方法 |
US8608710B2 (en) | 2010-12-09 | 2013-12-17 | Becton Dickinson & Company | Pen needle assembly with different gauge needle cannulas |
US9968337B2 (en) | 2010-12-20 | 2018-05-15 | Cook Medical Technologies Llc | Coring tissue biopsy needle and method of use |
JP2014514259A (ja) * | 2011-03-02 | 2014-06-19 | アクイラス ファーマシューティカルズ, インコーポレイテッド | 疼痛および他の障害の処置のための化合物および方法 |
JP2014510526A (ja) * | 2011-03-15 | 2014-05-01 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | 血管関連黄斑症およびその症状の診断および治療方法 |
USD667111S1 (en) | 2011-03-17 | 2012-09-11 | Surgical Innovations Limited | Handle for surgical instrument |
EP2500002A1 (en) | 2011-03-17 | 2012-09-19 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
EP2510911A1 (en) | 2011-04-13 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
EP2510902A1 (en) | 2011-04-15 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Intraocular injection device |
EP2514461A1 (en) | 2011-04-20 | 2012-10-24 | Sanofi-Aventis Deutschland GmbH | Needle assembly for a medical device |
EP2514684A1 (en) | 2011-04-20 | 2012-10-24 | Becton Dickinson France | Packaging for medical containers |
EP2522318A1 (en) | 2011-05-12 | 2012-11-14 | Sanofi-Aventis Deutschland GmbH | Guide device for intraocular injection |
WO2012162459A1 (en) | 2011-05-26 | 2012-11-29 | Pepose Jay | Device and method for administering eye medications |
EP2540261A1 (en) | 2011-06-30 | 2013-01-02 | Sanofi-Aventis Deutschland GmbH | Intraocular medicament delivery device |
CA2843904A1 (en) | 2011-08-05 | 2013-02-14 | Unitract Syringe Pty Ltd | Cannula with controlled depth of insertion |
EP2755705B1 (en) | 2011-09-13 | 2015-11-25 | Sanofi-Aventis Deutschland GmbH | Injection device |
EP2574355A1 (en) | 2011-09-27 | 2013-04-03 | Sanofi-Aventis Deutschland GmbH | Package for a medicament delivery device |
EP2578189A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
EP2578190A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Intraocular injection device |
EP2578191A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
EP2578260A1 (en) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Apparatus for intraocular injection |
EP2586407A1 (en) | 2011-10-31 | 2013-05-01 | Sanofi-Aventis Deutschland GmbH | Aid device for intraocular injection |
EP2596826A1 (en) | 2011-11-24 | 2013-05-29 | Sanofi-Aventis Deutschland GmbH | Safety syringe |
EP2601992A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
EP2601988A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
JP6298946B2 (ja) | 2011-12-08 | 2018-03-28 | ユーエヌエル ホールディングス エルエルシーUNL Holdings LLC | 正確な投与制御機構及び薬物送達用注射器 |
EP2601990A1 (en) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Syringe carrier |
AU2012351522A1 (en) | 2011-12-15 | 2014-07-24 | Sanofi-Aventis Deutschland Gmbh | Reservoir or medicated module for a drug delivery system and method of and assembly for filling the same |
EP2609952B1 (en) | 2011-12-30 | 2015-01-14 | Q-Med AB | Bruiseless cannula |
AU344164S (en) | 2012-02-02 | 2012-09-04 | Terumo Corp | Safety device for indwelling needle |
EP2626096A1 (en) | 2012-02-10 | 2013-08-14 | Sanofi-Aventis Deutschland GmbH | Medicament delivery device with needle assembly removal mechanism |
CN110251766A (zh) | 2012-02-20 | 2019-09-20 | 泰尔茂株式会社 | 医疗用具包装体 |
US9474594B2 (en) | 2012-02-22 | 2016-10-25 | Ira H. Schachar | Device and method for treatment of retinal detachment and other maladies of the eye |
WO2013126853A2 (en) | 2012-02-23 | 2013-08-29 | Unitract Syringe Pty Ltd | Devices for targeted delivery of therapeutic implants |
USD672506S1 (en) | 2012-02-28 | 2012-12-11 | Idea Village Products, Inc. | Exfoliating device |
JP2015508690A (ja) | 2012-02-29 | 2015-03-23 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 容器から薬剤を1回だけ引き出すための引出しデバイス |
US11033679B2 (en) | 2012-03-12 | 2021-06-15 | Unl Holdings Llc | Fill-finish cartridges for sterile fluid pathway assemblies and drug delivery devices incorporating fill-finish cartridges |
EP2641629A1 (en) | 2012-03-22 | 2013-09-25 | Sanofi-Aventis Deutschland GmbH | Medical injection device with injection site pain reduction device |
US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
US9833523B2 (en) | 2012-04-24 | 2017-12-05 | The Ohio State University | Pharmacokinetic determination of intravitreal agents |
US9889248B2 (en) | 2012-05-21 | 2018-02-13 | Baxalta GmbH | Syringe storage tray |
US9956341B2 (en) | 2012-07-03 | 2018-05-01 | Milestone Scientific, Inc. | Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces |
US8727117B2 (en) | 2012-07-16 | 2014-05-20 | Becton, Dickinson And Company | Package for syringe |
WO2014028285A1 (en) | 2012-08-13 | 2014-02-20 | The Brigham And Women's Hospital, Inc. | Methods and devices for inserting a needle |
CA2882184C (en) | 2012-08-27 | 2021-09-07 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using microneedles |
USD715125S1 (en) | 2012-10-08 | 2014-10-14 | The Ames Companies, Inc. | Grip |
US9022968B2 (en) | 2013-01-08 | 2015-05-05 | University Of South Florida | Auto-regulation system for intraocular pressure |
EP2968113B8 (en) | 2013-03-14 | 2020-10-28 | Forsight Vision4, Inc. | Systems for sustained intraocular delivery of low solubility compounds from a port delivery system implant |
USD740098S1 (en) | 2013-03-19 | 2015-10-06 | Tong Yah Electronic Technology Co., Ltd. | Vehicular handle |
US9987163B2 (en) | 2013-04-16 | 2018-06-05 | Novartis Ag | Device for dispensing intraocular substances |
SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
US20160143776A1 (en) | 2013-08-02 | 2016-05-26 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | A device for delivery of compositions to the eye |
CN105492054A (zh) | 2013-08-07 | 2016-04-13 | 尤尼特拉克特注射器公司 | 用于注射器的鲁尔连接适配器 |
WO2015021261A1 (en) | 2013-08-07 | 2015-02-12 | Unitract Syringe Pty Ltd | Luer connection adapters for retractable needle syringes |
USD718602S1 (en) | 2013-09-09 | 2014-12-02 | Midwest Tool And Cutlery Company | Hand grip for hand tools |
USD713958S1 (en) | 2013-12-05 | 2014-09-23 | Becton, Dickinson And Company | Pen needle outer cover |
CA2933900A1 (en) | 2013-12-20 | 2015-06-25 | Georgia Tech Research Corporation | Formulations and methods for targeted ocular delivery of therapeutic agents |
USD726908S1 (en) | 2014-02-06 | 2015-04-14 | St. Jude Medical, Cardiology Division, Inc. | Catheter handle |
AU2015277133A1 (en) | 2014-06-17 | 2017-02-02 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorders |
CA2952958A1 (en) | 2014-06-20 | 2015-12-23 | Clearside Biomedical, Inc. | Variable diameter cannula and methods for controlling insertion depth for medicament delivery |
CN107405306A (zh) | 2014-09-19 | 2017-11-28 | 奥叙拉尔有限公司 | 眼部药物组合物 |
CN107249522B (zh) | 2014-09-19 | 2021-04-20 | 奥叙拉尔有限公司 | 眼科递送装置 |
USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
WO2017120600A1 (en) | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
WO2017120601A1 (en) | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
WO2017139375A1 (en) | 2016-02-10 | 2017-08-17 | Clearside Biomedical, Inc. | Ocular injection kit, packaging, and methods of use |
WO2017190142A1 (en) | 2016-04-29 | 2017-11-02 | Clearside Biomedical, Inc. | Formulations and methods for reduction of intraocular pressure |
JP2019514581A (ja) | 2016-05-02 | 2019-06-06 | クリアサイド バイオメディカル,インコーポレイテッド | 眼の薬物送達のためのシステムおよび方法 |
-
2013
- 2013-11-08 CA CA2890471A patent/CA2890471C/en active Active
- 2013-11-08 US US14/441,151 patent/US20150258120A1/en not_active Abandoned
- 2013-11-08 KR KR1020157015062A patent/KR20150083117A/ko active Application Filing
- 2013-11-08 EP EP13853777.4A patent/EP2916827B1/en active Active
- 2013-11-08 KR KR1020217034816A patent/KR20210133321A/ko not_active Application Discontinuation
- 2013-11-08 CN CN201380069089.0A patent/CN104884049A/zh active Pending
- 2013-11-08 EP EP20178612.6A patent/EP3721872A1/en active Pending
- 2013-11-08 EA EA201590902A patent/EA034963B1/ru unknown
- 2013-11-08 MX MX2015005839A patent/MX2015005839A/es active IP Right Grant
- 2013-11-08 CN CN201911001650.7A patent/CN110893188A/zh active Pending
- 2013-11-08 CA CA3121763A patent/CA3121763A1/en active Pending
- 2013-11-08 MX MX2020005126A patent/MX2020005126A/es unknown
- 2013-11-08 BR BR112015010566A patent/BR112015010566A2/pt not_active Application Discontinuation
- 2013-11-08 WO PCT/US2013/069156 patent/WO2014074823A1/en active Application Filing
- 2013-11-08 JP JP2015540925A patent/JP6487848B2/ja active Active
- 2013-11-08 ES ES13853777T patent/ES2813869T3/es active Active
- 2013-11-08 AU AU2013342275A patent/AU2013342275B2/en active Active
- 2013-11-08 KR KR1020217008160A patent/KR102467714B1/ko active IP Right Grant
- 2013-11-08 SG SG11201503637SA patent/SG11201503637SA/en unknown
-
2015
- 2015-04-22 IL IL238432A patent/IL238432B/en active IP Right Grant
- 2015-05-04 PH PH12015500986A patent/PH12015500986A1/en unknown
-
2016
- 2016-01-20 US US15/001,610 patent/US9636332B2/en active Active
- 2016-02-02 HK HK16101221.1A patent/HK1213192A1/zh unknown
- 2016-03-31 US US15/086,485 patent/US9572800B2/en active Active
-
2017
- 2017-03-09 US US15/454,636 patent/US20180028516A1/en not_active Abandoned
- 2017-08-09 US US15/673,073 patent/US9931330B2/en active Active
- 2017-12-04 US US15/830,727 patent/US20180092897A1/en not_active Abandoned
- 2017-12-05 AU AU2017272182A patent/AU2017272182A1/en not_active Abandoned
-
2018
- 2018-03-13 JP JP2018045358A patent/JP2018090632A/ja not_active Withdrawn
- 2018-07-20 US US16/041,067 patent/US20180325884A1/en not_active Abandoned
- 2018-09-07 US US16/124,407 patent/US20190240208A1/en not_active Abandoned
-
2019
- 2019-11-29 JP JP2019216125A patent/JP7082599B2/ja active Active
-
2020
- 2020-01-08 US US16/737,010 patent/US20200383965A1/en not_active Abandoned
-
2021
- 2021-05-07 US US17/314,272 patent/US20210260047A1/en active Pending
-
2022
- 2022-05-27 JP JP2022086839A patent/JP2022119912A/ja active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143329A (en) * | 1996-07-03 | 2000-11-07 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
US20050065137A1 (en) * | 2003-09-23 | 2005-03-24 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20050245906A1 (en) * | 2004-04-21 | 2005-11-03 | Exploramed Nc1, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US20100256597A1 (en) * | 2006-05-02 | 2010-10-07 | Emory University | Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
Non-Patent Citations (1)
Title |
---|
Ãzkiris, Abdullah ("Intravitreal Triamcinolone Acetonide Injection for the Treatment of Posterior Uveitis," Ocular Immunology and Inflammation, Volume 14, 2006 - Issue 4, Pages 233-238 - Abstract attached) * |
Cited By (118)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10913722B2 (en) | 2005-05-26 | 2021-02-09 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US11724987B2 (en) | 2005-05-26 | 2023-08-15 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US10071135B2 (en) | 2005-11-23 | 2018-09-11 | Acceleron Pharma Inc. | Method of identifying an agent that promotes bone growth or increases bone density |
US9572865B2 (en) | 2005-11-23 | 2017-02-21 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating multiple myeloma |
US11129873B2 (en) | 2005-11-23 | 2021-09-28 | Acceleron Pharma Inc. | Method for promoting bone growth using activin-actriia antagonists |
US9480742B2 (en) | 2005-11-23 | 2016-11-01 | Acceleron Pharma Inc. | Method of promoting bone growth by an anti-actriia antibody |
US10239940B2 (en) | 2005-11-23 | 2019-03-26 | Acceleron Pharma Inc. | Method of promoting bone growth by an anti-actriia antibody |
US11752101B2 (en) | 2006-02-22 | 2023-09-12 | Clearside Biomedical, Inc. | Ocular injector and methods for accessing suprachoroidal space of the eye |
US11944703B2 (en) | 2006-02-22 | 2024-04-02 | Clearside Biomedical, Inc. | Ocular injector and methods for accessing suprachoroidal space of the eye |
US9926367B2 (en) | 2006-04-07 | 2018-03-27 | Aerpio Therapeutics, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
US11814425B2 (en) | 2006-04-07 | 2023-11-14 | Eye Point Pharmaceuticals, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
US10463650B2 (en) | 2006-06-27 | 2019-11-05 | Aerpio Pharmaceuticals, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
US9795594B2 (en) | 2006-06-27 | 2017-10-24 | Aerpio Therapeutics, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
USRE46592E1 (en) | 2006-06-27 | 2017-10-31 | Aerpio Therapeutics, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
US10093707B2 (en) | 2006-12-18 | 2018-10-09 | Acceleron Pharma Inc. | Antagonists of activin-ActRIIa and uses for increasing red blood cell levels |
US9526759B2 (en) | 2007-02-01 | 2016-12-27 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
US10259861B2 (en) | 2007-02-02 | 2019-04-16 | Acceleron Pharma Inc. | Variants derived from ActRIIB and uses therefor |
US9399669B2 (en) | 2007-02-02 | 2016-07-26 | Acceleron Pharma Inc. | Variants derived from ActRIIB |
US9353356B2 (en) | 2007-09-18 | 2016-05-31 | Acceleron Pharma Inc. | Activin-actriia antagonists for treating a follicle-stimulating horomone-secreting pituitary tumor |
US10829532B2 (en) | 2008-08-14 | 2020-11-10 | Acceleron Pharma Inc. | Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels |
US9505813B2 (en) | 2008-08-14 | 2016-11-29 | Acceleron Pharma Inc. | Use of GDF traps to treat anemia |
US10829533B2 (en) | 2008-08-14 | 2020-11-10 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
US11168311B2 (en) | 2008-08-14 | 2021-11-09 | Acceleron Pharma Inc. | Methods for treating anemia in a subject in need thereof |
US11162085B2 (en) | 2008-08-14 | 2021-11-02 | Acceleron Pharma Inc. | Methods for treating anemia in a subject in need thereof |
US9439945B2 (en) | 2008-08-14 | 2016-09-13 | Acceleron Pharma Inc. | Isolated nucleotide sequences encoding GDF traps |
US10889626B2 (en) | 2008-08-14 | 2021-01-12 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
US9932379B2 (en) | 2008-08-14 | 2018-04-03 | Acceleron Pharma Inc. | Isolated nucleotide sequences encoding GDF traps |
US10377996B2 (en) | 2008-08-14 | 2019-08-13 | Acceleron Pharma Inc. | Methods of identifying ActRIIB variants |
US11155791B2 (en) | 2008-08-14 | 2021-10-26 | Acceleron Pharma Inc. | Methods for treating anemia in a subject in need thereof |
US10689427B2 (en) | 2008-08-14 | 2020-06-23 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
US10358633B2 (en) | 2009-06-12 | 2019-07-23 | Acceleron Pharma Inc. | Method for producing an ActRIIB-Fc fusion polypeptide |
US9745559B2 (en) | 2009-06-12 | 2017-08-29 | Acceleron Pharma Inc. | Method for decreasing the body fat content in a subject by administering an ActRIIB protein |
US11066654B2 (en) | 2009-06-12 | 2021-07-20 | Acceleron Pharma Inc. | Methods and compositions for reducing serum lipids |
US9949956B2 (en) | 2009-07-06 | 2018-04-24 | Aerpio Therapeutics, Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
US9617319B2 (en) | 2009-11-17 | 2017-04-11 | Acceleron Pharma Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
US10968262B2 (en) | 2009-11-17 | 2021-04-06 | Acceleron Pharma Inc. | Methods of increasing sarcolemmal utrophin |
US10952894B2 (en) | 2010-10-15 | 2021-03-23 | Clearside Biomedical, Inc. | Device for ocular access |
US9493556B2 (en) | 2010-11-08 | 2016-11-15 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
US10150811B2 (en) | 2011-10-13 | 2018-12-11 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
US10815300B2 (en) | 2011-10-13 | 2020-10-27 | Aerpio Pharmaceuticals, Inc. | Methods for treating vascular leak syndrome and cancer |
US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
US9636332B2 (en) * | 2012-11-08 | 2017-05-02 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US9572800B2 (en) | 2012-11-08 | 2017-02-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US9931330B2 (en) | 2012-11-08 | 2018-04-03 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US10220048B2 (en) | 2013-03-15 | 2019-03-05 | Aerpio Therapeutics, Inc. | Compositions and methods for treating ocular diseases |
US9937075B2 (en) | 2013-05-03 | 2018-04-10 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US11559428B2 (en) | 2013-05-03 | 2023-01-24 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US9770361B2 (en) | 2013-05-03 | 2017-09-26 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US10555833B2 (en) | 2013-05-03 | 2020-02-11 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US10722396B2 (en) | 2013-05-03 | 2020-07-28 | Clearside Biomedical., Inc. | Apparatus and methods for ocular injection |
US9539139B2 (en) | 2013-05-03 | 2017-01-10 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US9636253B1 (en) | 2013-05-03 | 2017-05-02 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US10517756B2 (en) | 2013-05-03 | 2019-12-31 | Clearside Biomedical, Inc | Apparatus and methods for ocular injection |
US10188550B2 (en) | 2013-06-03 | 2019-01-29 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using multiple reservoirs |
USD756524S1 (en) * | 2013-08-05 | 2016-05-17 | Xialing Zhang | Protective cover for a subdermal needle electrode cable assembly |
US11058576B2 (en) | 2014-02-12 | 2021-07-13 | Gyroscope Therapeutics Limited | Method and apparatus for subretinal administration of therapeutic agent |
US10226379B2 (en) | 2014-02-12 | 2019-03-12 | Orbit Biomedical Limited | Method and apparatus for subretinal administration of therapeutic agent |
US11554042B2 (en) | 2014-02-12 | 2023-01-17 | Gyroscope Therapeutics Limited | Method and apparatus for subretinal administration of therapeutic agent |
US10858354B2 (en) | 2014-03-14 | 2020-12-08 | Aerpio Pharmaceuticals, Inc. | HPTP-Beta inhibitors |
US9994560B2 (en) | 2014-03-14 | 2018-06-12 | Aerpio Therapeutics, Inc. | HPTP-β inhibitors |
US10639193B2 (en) | 2014-06-06 | 2020-05-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with convergent lumen |
US10821021B2 (en) | 2014-06-06 | 2020-11-03 | Gyroscope Therapeutics Limited | Sub-retinal tangential needle catheter guide and introducer |
US11723798B2 (en) | 2014-06-06 | 2023-08-15 | Gyroscope Therapeutics Limited | Sub-retinal tangential needle catheter guide and introducer |
US11672696B2 (en) | 2014-06-06 | 2023-06-13 | Gyroscope Therapeutics Limited | Therapeutic agent delivery device with convergent lumen |
US9850298B2 (en) | 2014-06-13 | 2017-12-26 | Acceleron Pharma Inc. | Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide |
US11260107B2 (en) | 2014-06-13 | 2022-03-01 | Acceleron Pharma Inc. | Methods and compositions for treating ulcers |
US10487144B2 (en) | 2014-06-13 | 2019-11-26 | Acceleron Pharma Inc. | Methods for treating ulcers in a hemoglobinopathy anemia with a soluble actRIIB polypeptide |
US10219936B2 (en) | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
US11337852B2 (en) | 2014-09-18 | 2022-05-24 | Gyroscope Therapeutics Limited | Therapeutic agent delivery device |
US11376262B2 (en) | 2015-05-08 | 2022-07-05 | Activus Pharma Co., Ltd. | Method of treating an inflammatory or infectious disease |
US10588913B2 (en) | 2015-05-08 | 2020-03-17 | Activus Pharma Co., Ltd. | Aqueous suspension agent containing glucocorticosteroid nanoparticles |
US10980741B2 (en) | 2015-06-06 | 2021-04-20 | Cloudbreak Therapeutics, Llc | Compositions and methods for treating pterygium recurrence |
US10786627B2 (en) * | 2015-06-10 | 2020-09-29 | Sanofi-Aventis Deutschland Gmbh | Device for attachment to a drug delivery device |
US20180353694A1 (en) * | 2015-06-10 | 2018-12-13 | Sanofi-Aventis Deutschland Gmbh | Device for Attachment to a Drug Delivery Device |
US11046650B2 (en) | 2015-08-21 | 2021-06-29 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
US10952992B2 (en) | 2015-09-23 | 2021-03-23 | Aerpio Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
US11666558B2 (en) | 2015-09-23 | 2023-06-06 | EyePoint Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
WO2017120600A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions and methods of treating wet age-related macular degeneration |
WO2017120601A1 (en) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
US10426790B2 (en) | 2016-02-28 | 2019-10-01 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
US11338084B2 (en) | 2016-03-09 | 2022-05-24 | Gyroscope Therapeutics Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
US11197937B2 (en) | 2016-04-15 | 2021-12-14 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
US11596545B2 (en) | 2016-05-02 | 2023-03-07 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
US11129823B2 (en) | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
WO2017196881A1 (en) * | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
US11246864B2 (en) | 2016-06-02 | 2022-02-15 | Ads Therapeutics Llc | Compositions and methods of using nintedanib for treating ocular diseases with abnormal neovascularization |
US11911379B2 (en) | 2016-06-02 | 2024-02-27 | Ads Therapeutics Llc | Compositions and methods of using nintedanib for treating ocular diseases with abnormal neovascularization |
WO2017210130A1 (en) * | 2016-06-02 | 2017-12-07 | Cloudbreak Therapeutics, Llc | Compositions and methods of using nintedanib for improving glaucoma surgery success |
US10335408B2 (en) | 2016-06-02 | 2019-07-02 | Cloudbreak Therapeutics, Llc | Compositions and methods of using nintedanib for improving glaucoma surgery success |
US10688092B2 (en) | 2016-06-02 | 2020-06-23 | Cloudbreak Therapeutics, Llc | Compositions and methods of using nintedanib for improving glaucoma surgery success |
US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
US10806630B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
US10604569B2 (en) | 2016-07-20 | 2020-03-31 | Aerpio Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target protein tyrosine phosphatase-beta (HPTP-β/VE-PTP) |
US11180551B2 (en) | 2016-07-20 | 2021-11-23 | EyePoint Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target VE-PTP (HPTP-beta) |
US11136389B2 (en) | 2016-07-20 | 2021-10-05 | Aerpio Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target VE-PTP (HPTP-β) |
US10597452B2 (en) | 2016-07-20 | 2020-03-24 | Aerpio Pharmaceuticals, Inc. | Methods of treating ocular conditions by administering humanized monoclonal antibodies that target VE-PTP (HPTP-beta) |
US10253094B2 (en) | 2016-07-20 | 2019-04-09 | Aerpio Therapeutics, Inc. | Antibodies that target human protein tyrosine phosphatase-beta (HPTP-beta) and methods of use thereof to treat ocular conditions |
US11278546B2 (en) | 2016-07-22 | 2022-03-22 | Aiviva Biopharma, Inc. | Multikinase inhibitors and uses in ocular fibrosis |
WO2018022437A3 (en) * | 2016-07-22 | 2018-03-08 | Aiviva Holding Limited | Multikinase inhibitors and uses in ocular fibrosis |
US10973681B2 (en) | 2016-08-12 | 2021-04-13 | Clearside Biomedical, Inc. | Devices and methods for adjusting the insertion depth of a needle for medicament delivery |
US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
US11583529B2 (en) | 2017-10-10 | 2023-02-21 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
WO2019136133A1 (en) * | 2018-01-03 | 2019-07-11 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
US11844919B2 (en) | 2018-01-03 | 2023-12-19 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
US11724941B2 (en) | 2018-02-15 | 2023-08-15 | North Carolina State University | Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization |
WO2019217678A1 (en) * | 2018-05-09 | 2019-11-14 | North Carolina State University | Applicator for corneal therapeutics |
WO2020028667A1 (en) * | 2018-08-01 | 2020-02-06 | Nanoneuron Therapeutics, Inc. | Neuroprotective compositions and use thereof |
US11602533B2 (en) | 2018-12-13 | 2023-03-14 | Arog Pharmaceuticals, Inc. | Crenolanib combination therapy |
WO2020123991A1 (en) * | 2018-12-13 | 2020-06-18 | Arog Pharmaceuticals, Inc. | Crenolanib combination therapy |
US11253502B2 (en) | 2019-04-29 | 2022-02-22 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the Schlemm's canal |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20210260047A1 (en) | Methods and devices for the treatment of ocular diseases in human subjects | |
US20220280341A1 (en) | Apparatus and methods for drug delivery using microneedles | |
US20160310417A1 (en) | Formulations and Methods For Targeted Ocular Delivery of Therapeutic Agents | |
US20180042765A1 (en) | Methods and devices for treating posterior ocular disorders | |
AU2017206114A1 (en) | Methods and devices for treating posterior ocular disorderswith aflibercept and other biologics |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AS | Assignment |
Owner name: CLEARSIDE BIOMEDICAL, INC., GEORGIA Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:ZARNITSYN, VLADIMIR;PATEL, SAMIRKUMAR;WHITE, DANIEL;AND OTHERS;SIGNING DATES FROM 20140210 TO 20140218;REEL/FRAME:032297/0969 |
|
STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |
|
AS | Assignment |
Owner name: SILICON VALLEY BANK, CALIFORNIA Free format text: SECURITY INTEREST;ASSIGNOR:CLEARSIDE BIOMEDICAL, INC.;REEL/FRAME:050217/0270 Effective date: 20190829 |
|
AS | Assignment |
Owner name: CLEARSIDE BIOMEDICAL, INC., GEORGIA Free format text: RELEASE BY SECURED PARTY;ASSIGNOR:SILICON VALLEY BANK;REEL/FRAME:053139/0929 Effective date: 20200706 |