US20150258120A1 - Methods and devices for the treatment of ocular diseases in human subjects - Google Patents
Methods and devices for the treatment of ocular diseases in human subjects Download PDFInfo
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- US20150258120A1 US20150258120A1 US14/441,151 US201314441151A US2015258120A1 US 20150258120 A1 US20150258120 A1 US 20150258120A1 US 201314441151 A US201314441151 A US 201314441151A US 2015258120 A1 US2015258120 A1 US 2015258120A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
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- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Definitions
- FIG. 20B is a cross sectional image of a rabbit eye following suprachoroidal injection of 3.2 mg triamcinolone (left) or vehicle (right).
- Posterior segment of eyes injected with LPS IVT and low dose TA in SCS (Group 3). Scale bar: 200 ⁇ m.
- G Anterior segment of eyes injected with LPS IVT and high dose TA in SCS (Group 4). Scale bar: 1 mm.
- H Posterior segment of eyes injected with LPS IVT and high dose TA in SCS (Group 4). Arrows indicate presence of TA in SCS. Scale bar: 200 ⁇ m.
- I. Anterior segment of eyes injected with LPS IVT and low dose TA IVT (Group 5). Scale bar: 1 mm.
- J Posterior segment of eyes injected with LPS IVT and low dose TA IVT (Group 5). Scale bar: 200 ⁇ m.
- the microneedle device for non-surgically delivering drug to the suprachoroidal space of the eye of a human subject comprises a hollow microneedle.
- the device may include an elongated housing for holding the proximal end of the microneedle.
- the device may further include a means for conducting a drug formulation through the microneedle.
- the means may be a flexible or rigid conduit in fluid connection with the base or proximal end of the microneedle.
- the means may also include a pump or other devices for creating a pressure gradient for inducing fluid flow through the device.
- the conduit may in operable connection with a source of the drug formulation.
- the source may be any suitable container. In one embodiment, the source may be in the form of a conventional syringe.
- the source may be a disposable unit dose container.
- the posterior ocular disorders amenable for treatment by the methods, devices, and drug formulations described herein may be acute or chronic.
- the ocular disease may be acute or chronic uveitis.
- Uveitis can be caused by infection with viruses, fungi, or parasites; the presence of noninfectious foreign substances in the eye; autoimmune diseases; or surgical or traumatic injury.
- the suprachoroidal drug dose sufficient to achieve a therapeutic response in a human subject treated with the non-surgical SCS drug delivery method is less than the intravitreal, parenteral, intracameral, topical, or oral drug dose sufficient to elicit the identical or substantially identical therapeutic response.
- the suprachoroidal drug dose is at least 10 percent less than the oral, parenteral or intravitreal dose sufficient to achieve the identical or substantially identical therapeutic response.
- the suprachoroidal dose is about 10 percent to about 25 percent less, or about 10 percent to about 50 percent less than the oral, parenteral, intracameral, topical, or intravitreal dose sufficient to achieve the identical or substantially identical therapeutic response.
- This delivery method can be particularly advantageous with ocular tissues, where it is desirable for the insertion and withdrawal process to occur over as short a period as possible to minimize patient discomfort—in contrast to transdermal microneedle patch applications, where patches may more likely be worn (with microneedles inserted) over an extended period without patient discomfort.
- the efficacy of the drug for example infliximab (Remicade®)
- infliximab can be measured, for example, by observing changes in retinal thickness, inflammation, visual acuity, photophobia, typical time between flares, corneal ulceration, and/or edema.
- the efficacy of the drug for example nepafenac
- OCT optical coherence tomography
- a method for treating a patient for multi-focal choroiditis comprises non-surgically administering a drug formulation comprising an effective amount of a MFC treating drug to the SCS of one or both eyes of the patient in need of MFC treatment.
- the drug formulation is administered, in one embodiment, with one of the microneedles described herein.
- the intraocular elimination half life (tin) of the angiogenesis inhibitor administered to the SCS is greater than the intraocular t 1/2 of the angiogenesis inhibitor, when the identical dosage of the angiogenesis inhibitor is administered intravitreally, intracamerally, topically, parenterally or orally.
- the mean intraocular maximum concentration (C max ) of the angiogenesis inhibitor when the identical dosage of the angiogenesis inhibitor is administered to the SCS via the methods described herein, is greater than the intraocular C max of the angiogenesis inhibitor, when the identical dosage is administered intravitreally, intracamerally, topically, parenterally or orally.
- the mean intraocular area under the curve (AUC 0-t ) of the PDGF antagonist when administered to the SCS via the methods described herein, is greater than the intraocular AUC 0-t of the PDGF antagonist, when the identical dosage of the PDGF antagonist is administered intravitreally, intracamerally, topically, parenterally or orally.
- the drug is a steroid or a non-steroid anti-inflammatory drug (NSAID).
- the anti-inflammatory drug is an antibody or fragment thereof, an anti-inflammatory peptide(s) or an anti-inflammatory aptamer(s).
- the delivery of the anti-inflammatory drug to the suprachoroidal space results in benefits over administration of the same drug delivered via oral, intravitreal, intracameral, topical and/or a parenteral route of administration.
- the therapeutic effect of the drug delivered to the suprachoroidal space is greater than the therapeutic effect of the same drug, delivered at the same dosage, when the drug is delivered via oral, intravitreal, topical or parenteral route.
- Scanco ⁇ CT40 desktop conebeam system Scanco Medical AG, Brüttisellen, Switzerland
- TA triamcinolone acetonide
- FIG. 33 shows the mean TA concentration in plasma, ⁇ SD, as measured in 8 rabbits. Systemic exposure to TA following suprachoroidal administration was minimal with a mean C max of 12 ng/mL on Day 1.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/441,151 US20150258120A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261724144P | 2012-11-08 | 2012-11-08 | |
US201261734872P | 2012-12-07 | 2012-12-07 | |
US201261745237P | 2012-12-21 | 2012-12-21 | |
US201361773124P | 2013-03-05 | 2013-03-05 | |
US201361785229P | 2013-03-14 | 2013-03-14 | |
US201361819388P | 2013-05-03 | 2013-05-03 | |
US201361873660P | 2013-09-04 | 2013-09-04 | |
US201361898926P | 2013-11-01 | 2013-11-01 | |
US14/441,151 US20150258120A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
PCT/US2013/069156 WO2014074823A1 (fr) | 2012-11-08 | 2013-11-08 | Procédés et dispositifs pour le traitement de maladies oculaires chez des sujets humains |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/US2013/069156 A-371-Of-International WO2014074823A1 (fr) | 2012-11-08 | 2013-11-08 | Procédés et dispositifs pour le traitement de maladies oculaires chez des sujets humains |
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US15/001,610 Continuation US9636332B2 (en) | 2012-11-08 | 2016-01-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/454,636 Continuation US20180028516A1 (en) | 2012-11-08 | 2017-03-09 | Methods and devices for the treatment of ocular diseases in human subjects |
Publications (1)
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US20150258120A1 true US20150258120A1 (en) | 2015-09-17 |
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US14/441,151 Abandoned US20150258120A1 (en) | 2012-11-08 | 2013-11-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/001,610 Active US9636332B2 (en) | 2012-11-08 | 2016-01-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/086,485 Active US9572800B2 (en) | 2012-11-08 | 2016-03-31 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/454,636 Abandoned US20180028516A1 (en) | 2012-11-08 | 2017-03-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/673,073 Active US9931330B2 (en) | 2012-11-08 | 2017-08-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/830,727 Abandoned US20180092897A1 (en) | 2012-11-08 | 2017-12-04 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/041,067 Abandoned US20180325884A1 (en) | 2012-11-08 | 2018-07-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/124,407 Abandoned US20190240208A1 (en) | 2012-11-08 | 2018-09-07 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/737,010 Abandoned US20200383965A1 (en) | 2012-11-08 | 2020-01-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US17/314,272 Pending US20210260047A1 (en) | 2012-11-08 | 2021-05-07 | Methods and devices for the treatment of ocular diseases in human subjects |
Family Applications After (9)
Application Number | Title | Priority Date | Filing Date |
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US15/001,610 Active US9636332B2 (en) | 2012-11-08 | 2016-01-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/086,485 Active US9572800B2 (en) | 2012-11-08 | 2016-03-31 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/454,636 Abandoned US20180028516A1 (en) | 2012-11-08 | 2017-03-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/673,073 Active US9931330B2 (en) | 2012-11-08 | 2017-08-09 | Methods and devices for the treatment of ocular diseases in human subjects |
US15/830,727 Abandoned US20180092897A1 (en) | 2012-11-08 | 2017-12-04 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/041,067 Abandoned US20180325884A1 (en) | 2012-11-08 | 2018-07-20 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/124,407 Abandoned US20190240208A1 (en) | 2012-11-08 | 2018-09-07 | Methods and devices for the treatment of ocular diseases in human subjects |
US16/737,010 Abandoned US20200383965A1 (en) | 2012-11-08 | 2020-01-08 | Methods and devices for the treatment of ocular diseases in human subjects |
US17/314,272 Pending US20210260047A1 (en) | 2012-11-08 | 2021-05-07 | Methods and devices for the treatment of ocular diseases in human subjects |
Country Status (16)
Country | Link |
---|---|
US (10) | US20150258120A1 (fr) |
EP (2) | EP3721872A1 (fr) |
JP (4) | JP6487848B2 (fr) |
KR (3) | KR20210133321A (fr) |
CN (2) | CN110893188A (fr) |
AU (2) | AU2013342275B2 (fr) |
BR (1) | BR112015010566A2 (fr) |
CA (2) | CA3121763A1 (fr) |
EA (1) | EA034963B1 (fr) |
ES (1) | ES2813869T3 (fr) |
HK (1) | HK1213192A1 (fr) |
IL (1) | IL238432B (fr) |
MX (2) | MX2015005839A (fr) |
PH (1) | PH12015500986A1 (fr) |
SG (1) | SG11201503637SA (fr) |
WO (1) | WO2014074823A1 (fr) |
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USD756524S1 (en) * | 2013-08-05 | 2016-05-17 | Xialing Zhang | Protective cover for a subdermal needle electrode cable assembly |
US9353356B2 (en) | 2007-09-18 | 2016-05-31 | Acceleron Pharma Inc. | Activin-actriia antagonists for treating a follicle-stimulating horomone-secreting pituitary tumor |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US9399669B2 (en) | 2007-02-02 | 2016-07-26 | Acceleron Pharma Inc. | Variants derived from ActRIIB |
US9439945B2 (en) | 2008-08-14 | 2016-09-13 | Acceleron Pharma Inc. | Isolated nucleotide sequences encoding GDF traps |
US9480742B2 (en) | 2005-11-23 | 2016-11-01 | Acceleron Pharma Inc. | Method of promoting bone growth by an anti-actriia antibody |
US9493556B2 (en) | 2010-11-08 | 2016-11-15 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
US9505813B2 (en) | 2008-08-14 | 2016-11-29 | Acceleron Pharma Inc. | Use of GDF traps to treat anemia |
US9526759B2 (en) | 2007-02-01 | 2016-12-27 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
US9539139B2 (en) | 2013-05-03 | 2017-01-10 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US9572865B2 (en) | 2005-11-23 | 2017-02-21 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating multiple myeloma |
US9617319B2 (en) | 2009-11-17 | 2017-04-11 | Acceleron Pharma Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
WO2017120601A1 (fr) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Méthodes et dispositifs pour le traitement de troubles oculaires postérieurs avec l'aflibercept et d'autres substances biologiques |
WO2017120600A1 (fr) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions et méthodes de traitement de la dégénérescence maculaire humide liée à l'âge |
US9745559B2 (en) | 2009-06-12 | 2017-08-29 | Acceleron Pharma Inc. | Method for decreasing the body fat content in a subject by administering an ActRIIB protein |
US9795594B2 (en) | 2006-06-27 | 2017-10-24 | Aerpio Therapeutics, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
WO2017196881A1 (fr) * | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Polythérapie de troubles et de maladies inflammatoires oculaires |
WO2017210130A1 (fr) * | 2016-06-02 | 2017-12-07 | Cloudbreak Therapeutics, Llc | Compositions et procédés d'utilisation de nintedanib pour améliorer le taux de réussite de la chirurgie du glaucome |
US9850298B2 (en) | 2014-06-13 | 2017-12-26 | Acceleron Pharma Inc. | Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide |
WO2018022437A3 (fr) * | 2016-07-22 | 2018-03-08 | Aiviva Holding Limited | Inhibiteurs multikinases et leurs utilisations dans la fibrose oculaire |
US9926367B2 (en) | 2006-04-07 | 2018-03-27 | Aerpio Therapeutics, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
US9949956B2 (en) | 2009-07-06 | 2018-04-24 | Aerpio Therapeutics, Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
US9994560B2 (en) | 2014-03-14 | 2018-06-12 | Aerpio Therapeutics, Inc. | HPTP-β inhibitors |
US10071135B2 (en) | 2005-11-23 | 2018-09-11 | Acceleron Pharma Inc. | Method of identifying an agent that promotes bone growth or increases bone density |
US10093707B2 (en) | 2006-12-18 | 2018-10-09 | Acceleron Pharma Inc. | Antagonists of activin-ActRIIa and uses for increasing red blood cell levels |
US10150811B2 (en) | 2011-10-13 | 2018-12-11 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
US20180353694A1 (en) * | 2015-06-10 | 2018-12-13 | Sanofi-Aventis Deutschland Gmbh | Device for Attachment to a Drug Delivery Device |
US10188550B2 (en) | 2013-06-03 | 2019-01-29 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using multiple reservoirs |
US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
US10219936B2 (en) | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
US10220048B2 (en) | 2013-03-15 | 2019-03-05 | Aerpio Therapeutics, Inc. | Compositions and methods for treating ocular diseases |
US10226379B2 (en) | 2014-02-12 | 2019-03-12 | Orbit Biomedical Limited | Method and apparatus for subretinal administration of therapeutic agent |
US10253094B2 (en) | 2016-07-20 | 2019-04-09 | Aerpio Therapeutics, Inc. | Antibodies that target human protein tyrosine phosphatase-beta (HPTP-beta) and methods of use thereof to treat ocular conditions |
WO2019136133A1 (fr) * | 2018-01-03 | 2019-07-11 | The Trustees Of Columbia University In The City Of New York | Micro-aiguille pour l'administration locale d'un agent thérapeutique |
US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
US10426790B2 (en) | 2016-02-28 | 2019-10-01 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
WO2019217678A1 (fr) * | 2018-05-09 | 2019-11-14 | North Carolina State University | Applicateur pour agents thérapeutiques cornéens |
US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
WO2020028667A1 (fr) * | 2018-08-01 | 2020-02-06 | Nanoneuron Therapeutics, Inc. | Compositions neuroprotectrices et utilisation associée |
US10588913B2 (en) | 2015-05-08 | 2020-03-17 | Activus Pharma Co., Ltd. | Aqueous suspension agent containing glucocorticosteroid nanoparticles |
US10639193B2 (en) | 2014-06-06 | 2020-05-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with convergent lumen |
US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
WO2020123991A1 (fr) * | 2018-12-13 | 2020-06-18 | Arog Pharmaceuticals, Inc. | Traitement combiné à base de crénolanib |
US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
US10821021B2 (en) | 2014-06-06 | 2020-11-03 | Gyroscope Therapeutics Limited | Sub-retinal tangential needle catheter guide and introducer |
US10913722B2 (en) | 2005-05-26 | 2021-02-09 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US10952894B2 (en) | 2010-10-15 | 2021-03-23 | Clearside Biomedical, Inc. | Device for ocular access |
US10952992B2 (en) | 2015-09-23 | 2021-03-23 | Aerpio Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
US10973681B2 (en) | 2016-08-12 | 2021-04-13 | Clearside Biomedical, Inc. | Devices and methods for adjusting the insertion depth of a needle for medicament delivery |
US10980741B2 (en) | 2015-06-06 | 2021-04-20 | Cloudbreak Therapeutics, Llc | Compositions and methods for treating pterygium recurrence |
US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
US11197937B2 (en) | 2016-04-15 | 2021-12-14 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
US11253502B2 (en) | 2019-04-29 | 2022-02-22 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the Schlemm's canal |
US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
US11337852B2 (en) | 2014-09-18 | 2022-05-24 | Gyroscope Therapeutics Limited | Therapeutic agent delivery device |
US11596545B2 (en) | 2016-05-02 | 2023-03-07 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
US11724941B2 (en) | 2018-02-15 | 2023-08-15 | North Carolina State University | Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization |
US11752101B2 (en) | 2006-02-22 | 2023-09-12 | Clearside Biomedical, Inc. | Ocular injector and methods for accessing suprachoroidal space of the eye |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2600901B1 (fr) | 2010-08-06 | 2019-03-27 | ModernaTX, Inc. | Compositions pharmaceutiques a base d'acides nucléiques modifiés et leur utilisation medicale |
ES2737960T3 (es) | 2010-10-01 | 2020-01-17 | Modernatx Inc | Nucleósidos, nucleótidos y ácidos nucleicos modificados y sus usos |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
EP3682905B1 (fr) | 2011-10-03 | 2021-12-01 | ModernaTX, Inc. | Nucléosides, nucléotides et acides nucléiques modifiés et leurs utilisations |
EP2791160B1 (fr) | 2011-12-16 | 2022-03-02 | ModernaTX, Inc. | Compositions de mrna modifiés |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
AU2013243948A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins associated with human disease |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
EP4074834A1 (fr) | 2012-11-26 | 2022-10-19 | ModernaTX, Inc. | Arn à terminaison modifiée |
RU2015127211A (ru) * | 2013-01-18 | 2017-03-03 | Адвенчен Фармасьютикалс, Ллс | Способ получения противоопухолевого агента 6-(7-((1-аминоциклопропил) метокси)-6-метоксихинолин-4-илокси)-n-метил-1-нафтамида и его кристаллической структуры |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
EP3003480A1 (fr) * | 2013-05-24 | 2016-04-13 | Bayer Healthcare LLC | Traitement de la vasculopathie polypoïdale choroïdienne |
EP3010525A1 (fr) * | 2013-06-20 | 2016-04-27 | Novartis AG | Utilisation d'un antagoniste du vegf dans le traitement de la néovascularisation choroïdienne |
WO2015048744A2 (fr) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucléotides codant des polypeptides de modulation immunitaire |
CA2926218A1 (fr) | 2013-10-03 | 2015-04-09 | Moderna Therapeutics, Inc. | Polynucleotides codant pour un recepteur de lipoproteines de faible densite |
KR101660370B1 (ko) | 2013-12-12 | 2016-09-27 | 삼성메디슨 주식회사 | 초음파 영상 표시 방법 및 장치 |
US10010447B2 (en) | 2013-12-18 | 2018-07-03 | Novartis Ag | Systems and methods for subretinal delivery of therapeutic agents |
CA2936239A1 (fr) * | 2014-01-16 | 2015-07-23 | Ontogenesis, Llc | Compositions et methodes pour le traitement d'une neovascularisation et/ou d'une fuite intraoculaire |
US20170056469A1 (en) * | 2014-05-02 | 2017-03-02 | Mayo Foundation For Medical Education And Research | Individualized treatment of eye disease |
EP3157463A4 (fr) * | 2014-06-17 | 2018-02-21 | Clearside Biomedical, Inc. | Procédés et dispositifs de traitement de troubles oculaires postérieurs |
RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
ES2835499T3 (es) | 2014-07-30 | 2021-06-22 | Massachusetts Eye & Ear Infirmary | Metotrexato para la vitreorretinopatía proliferativa |
WO2016075036A1 (fr) | 2014-11-10 | 2016-05-19 | F. Hoffmann-La Roche Ag | Anticorps anti-pdgf-b et leurs méthodes d'utilisation |
RU2017120358A (ru) | 2014-11-10 | 2018-12-13 | Ф.Хоффманн-Ля Рош Аг | Анти-il-1-бета антитела и способы их применения |
KR20170082594A (ko) | 2014-11-10 | 2017-07-14 | 에프. 호프만-라 로슈 아게 | 항-ang2 항체 및 사용 방법 |
BR112017009764A2 (pt) | 2014-11-10 | 2018-02-20 | Hoffmann La Roche | anticorpos biespecíficos e métodos de uso em oftalmologia |
EP3231427A4 (fr) * | 2014-12-10 | 2018-07-11 | Senju Pharmaceutical Co., Ltd. | Agent liquide aqueux |
TWI597051B (zh) * | 2015-04-16 | 2017-09-01 | 林伯剛 | 高半胱胺酸用於偵測及診斷人類眼部之息肉狀脈絡膜血管病變的用途及方法 |
TWI664965B (zh) | 2015-06-22 | 2019-07-11 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法 |
KR101778004B1 (ko) * | 2015-06-22 | 2017-09-15 | (주) 에빅스젠 | 이마티닙을 유효성분으로 포함하는 안구 건조 질환 예방 및 치료용 약학 조성물 |
US20190004048A1 (en) * | 2015-06-26 | 2019-01-03 | Amgen Inc. | Biomarker of Survival in the Treatment of Renal Cell Carcinoma with a VEGFR Inhibitor and an Ang2 Inhibitor |
CA2993340C (fr) * | 2015-07-23 | 2024-04-30 | Aerie Pharmaceuticals, Inc. | Systemes d'administration de medicaments intravitreens pour le traitement d'etats oculaires |
MX2018000778A (es) * | 2015-07-31 | 2018-08-15 | Medimmune Ltd | Metodos para tratar trastornos mediados por hepcidinas. |
JP2018534930A (ja) * | 2015-10-30 | 2018-11-29 | ジェネンテック, インコーポレイテッド | 抗d因子抗体及びコンジュゲート |
CN108295072A (zh) * | 2015-12-09 | 2018-07-20 | 瑞阳(苏州)生物科技有限公司 | 尼达尼布防治眼部疾病的用途 |
US10761087B2 (en) * | 2015-12-17 | 2020-09-01 | Link Genomics, Inc. | Choroidal neovascularization suppressor or drusen formation suppressor, and method for assessing or screening for same |
CN105496957A (zh) * | 2015-12-22 | 2016-04-20 | 中山大学中山眼科中心 | 一种吡非尼酮缓释滴眼液 |
KR20180104635A (ko) | 2015-12-30 | 2018-09-21 | 코디악 사이언시스 인코포레이티드 | 항체 및 이의 접합체 |
EP3411399A4 (fr) * | 2016-02-04 | 2019-10-16 | Jinsong Ni | Technologie de synergie anticorps-médicament permettant le traitement de maladies |
RU2756109C2 (ru) * | 2016-03-10 | 2021-09-28 | Виела Байо, Инк. | Связывающие ilt7 молекулы и способы их применения |
WO2018054077A1 (fr) * | 2016-09-26 | 2018-03-29 | Reyoung (Suzhou) Biology Science & Technology Co., Ltd | Composition destinée au traitement de maladies oculaires, et méthodes d'utilisation et procédés de fabrication |
JP2020502149A (ja) * | 2016-12-15 | 2020-01-23 | プロゲン・ピージー500・シリーズ・プロプライエタリー・リミテッドProgen Pg500 Series Pty Ltd | 組成物およびその使用 |
WO2018112305A1 (fr) | 2016-12-16 | 2018-06-21 | The Brigham And Women's Hospital, Inc. | Système et procédé de pénétration médicale autorégulée, dépendant de la résistance |
AU2018214554C1 (en) | 2017-02-01 | 2022-12-15 | Novo Nordisk A/S | Treatment of diuretic resistance |
WO2018162271A1 (fr) * | 2017-03-05 | 2018-09-13 | Rita Dobmeyer | Nanoparticules pour le traitement de la dégénérescence maculaire |
RU2643955C1 (ru) * | 2017-04-19 | 2018-02-06 | Галина Мэлсовна Чернакова | Способ отбора и подготовки пробы клеток конъюнктивы для проведения бактериологического, вирусологического и иммунологического исследований |
US20200061357A1 (en) * | 2017-05-02 | 2020-02-27 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
US20200172974A1 (en) * | 2017-05-08 | 2020-06-04 | Hadasit Medical Research Services & Development Ltd. | Biomarker for anti-tnf therapy in retinal diseases |
CA3065474A1 (fr) * | 2017-05-30 | 2018-12-06 | Eximore Ltd. | Compositions et procedes de traitement du syndrome de la keratoconjonctivite seche par administration d'un antibiotique macrolide |
US11786607B2 (en) | 2017-06-15 | 2023-10-17 | Modernatx, Inc. | RNA formulations |
CN112996486A (zh) * | 2017-07-17 | 2021-06-18 | K·罗伊兹曼 | 包含细胞穿透肽的治疗剂的局部递送用于治疗年龄相关性黄斑变性及其它眼病 |
WO2019046809A1 (fr) | 2017-08-31 | 2019-03-07 | Modernatx, Inc. | Procédés de fabrication de nanoparticules lipidiques |
WO2019055594A1 (fr) | 2017-09-13 | 2019-03-21 | North Carolina State University | Brunissement de tissu adipeux induit localement par timbre à micro-aiguilles pour le traitement de l'obésité |
WO2019070727A2 (fr) | 2017-10-02 | 2019-04-11 | The Johns Hopkins University | Transfert de gène non viral vers l'espace suprachoroïdien |
CN107815453B (zh) * | 2017-10-23 | 2020-08-07 | 中山大学中山眼科中心 | 一种核酸适配子及其用途 |
CA3083743C (fr) | 2017-11-29 | 2023-09-26 | Copernicus Therapeutics, Inc. | Therapie genique pour l'amelioration des fonctions oculaires |
AU2018390167A1 (en) * | 2017-12-21 | 2020-06-11 | F. Hoffmann-La Roche Ag | Companion diagnostic for HTRA1 RNA antagonists |
CA3087699A1 (fr) | 2018-01-05 | 2019-07-11 | Corvidia Therapeutics, Inc. | Methodes de traitement d'une inflammation mediee par il-6 sans immunosuppression |
US20200345637A1 (en) * | 2018-01-19 | 2020-11-05 | Aiviva Biopharma, Inc. | Suspension compositions of multi-target inhibitors |
US11524053B2 (en) | 2018-01-26 | 2022-12-13 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents |
CN108452309B (zh) * | 2018-03-05 | 2019-08-23 | 佳木斯大学附属第一医院 | 一种用于预防或治疗视神经炎的药物组合物及其制备方法 |
WO2019203310A1 (fr) * | 2018-04-18 | 2019-10-24 | 株式会社ニコン | Procédé de traitement d'images, programme et dispositif de traitement d'images |
JP2021533154A (ja) | 2018-08-06 | 2021-12-02 | アルデイラ セラピューティクス, インコーポレイテッド | 多形化合物およびその使用 |
CN109187987B (zh) * | 2018-08-23 | 2021-05-11 | 中国人民解放军第三0九医院 | Ms4a3蛋白作为标志物在诊断活动性结核病中的应用 |
CN115869258A (zh) | 2018-09-25 | 2023-03-31 | 奥尔德拉医疗公司 | 用于治疗干眼病的调配物 |
CN109172128A (zh) * | 2018-09-28 | 2019-01-11 | 宜邻医疗科技(上海)有限公司 | 一种用于细胞和基因药物注入治疗的精准注射系统 |
EP3902525A4 (fr) * | 2018-12-27 | 2022-09-28 | Surface Ophthalmics, Inc. | Compositions pharmaceutiques ophtalmiques et procédés de traitement d'une maladie de surface oculaire |
CN109799216B (zh) * | 2018-12-29 | 2021-11-12 | 佛山科学技术学院 | 一种基于吲哚箐绿纳米的荧光oct双模成像方法和装置 |
EP3920950A1 (fr) | 2019-02-08 | 2021-12-15 | CureVac AG | Arn codant administré dans l'espace suprachoroïdien pour le traitement de maladies ophtalmiques |
WO2020198064A1 (fr) | 2019-03-26 | 2020-10-01 | Aldeyra Therapeutics, Inc. | Formulations ophtalmiques et leurs utilisations |
EP3953395A4 (fr) * | 2019-04-08 | 2023-01-18 | Biocryst Pharmaceuticals, Inc. | Inhibiteurs de la kallicréine plasmatique et leurs procédés d'utilisation dans des troubles oculaires |
CA3136814A1 (fr) * | 2019-04-16 | 2020-10-22 | Clearside Biomedical, Inc. | Formulations injectables de triamcinolone |
CN109999032A (zh) * | 2019-04-30 | 2019-07-12 | 南昌大学 | 雷帕霉素在制备降眼内压的局部滴眼给药药物中的应用 |
WO2020227341A1 (fr) * | 2019-05-06 | 2020-11-12 | 9 Meters Biopharma, Inc. | Compositions et procédés de traitement du syndrome de sjögren |
WO2020243608A1 (fr) * | 2019-05-31 | 2020-12-03 | Dose Medical Corporation | Implants vertébraux en polyester bioérodable et procédés d'utilisation associés |
CN114786731A (zh) | 2019-10-10 | 2022-07-22 | 科达制药股份有限公司 | 治疗眼部病症的方法 |
CA3168512A1 (fr) | 2019-11-25 | 2021-06-03 | Napoleone Ferrara | Inhibiteurs de vegf a action prolongee pour neovascularisation intraoculaire |
BR112022009192A2 (pt) * | 2019-12-19 | 2022-07-26 | Active Biotech Ab | Composição, método para tratar uma doença ocular ou distúrbio ocular, e, uso de um composto |
WO2021140424A1 (fr) * | 2020-01-06 | 2021-07-15 | Shilpa Medicare Limited | Suspension injectable à libération prolongée de fingolimod |
JP7451732B2 (ja) | 2020-02-06 | 2024-03-18 | オキュラ セラピューティクス,インコーポレイテッド | 眼疾患を治療するための組成物及び方法 |
US20230089914A1 (en) * | 2020-02-19 | 2023-03-23 | Clearside Biomedical, Inc. | Compositions comprising axitinib and methods of treating ocular disorders |
WO2021195163A1 (fr) | 2020-03-25 | 2021-09-30 | Ocular Therapeutix, Inc. | Implant oculaire contenant un inhibiteur de tyrosine kinase |
CN113797164B (zh) * | 2020-06-17 | 2023-07-14 | 成都瑞沐生物医药科技有限公司 | 一种眼用制剂的载体或辅料及其制备方法和应用 |
EP4282401A1 (fr) * | 2021-01-22 | 2023-11-29 | Chengdu Ruimu Biopharmaceuticals Co., Ltd. | Préparation ophtalmique administrée par collyre et utilisée pour la prévention et le traitement de la dégénérescence maculaire sèche et de la détérioration de la lumière rétinienne |
WO2022226347A1 (fr) * | 2021-04-23 | 2022-10-27 | AmMax Bio, Inc. | Traitement de maladies ophtalmiques |
WO2023004072A1 (fr) * | 2021-07-21 | 2023-01-26 | Slbst Pharma, Inc. | Formulations d'hydroxychloroquine, formes posologiques et procédés d'utilisation |
WO2023039168A1 (fr) * | 2021-09-09 | 2023-03-16 | The Board Of Trustees Of The Leland Stanford Junior University | Utilisation de la vertéporfine pour moduler la cicatrisation de plaies après une intervention chirurgicale oculaire ou une lésion oculaire |
EP4147709A1 (fr) * | 2021-09-14 | 2023-03-15 | The Provost, Fellows, Foundation Scholars, and The Other Members of Board, of The College of The Holy and Undivided Trinity of Queen Elizabeth | Composition comprenant de l'il-36 et/ou de l'il-18 pour une utilisation dans le traitement de troubles oculaires |
CN114134195A (zh) * | 2021-11-03 | 2022-03-04 | 南方科技大学 | 预防前列腺癌的药剂的筛选方法、硝唑尼特在制药中的应用 |
CN114099515A (zh) * | 2021-12-27 | 2022-03-01 | 中山大学中山眼科中心 | 氨甲蝶呤在制备治疗视网膜色素变性的药物方面的应用 |
WO2023141251A1 (fr) * | 2022-01-24 | 2023-07-27 | Celanese Eva Performance Polymers Llc | Procédé pour prévenir et/ou traiter une affection oculaire |
WO2023220136A1 (fr) * | 2022-05-10 | 2023-11-16 | The Regents Of The University Of California | Acide zolédronique à dosage ultra faible pour le traitement d'une maladie rétinienne |
US11911385B1 (en) | 2022-12-14 | 2024-02-27 | Aldeyra Therapeutics, Inc. | Methotrexate treatment methods |
CN117224314B (zh) * | 2023-08-28 | 2024-04-26 | 叶绿体(北京)生物医药有限公司 | 一种可降解式自密封眼球给药微针及其制备方法与应用 |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143329A (en) * | 1996-07-03 | 2000-11-07 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
US20050065137A1 (en) * | 2003-09-23 | 2005-03-24 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US20050245906A1 (en) * | 2004-04-21 | 2005-11-03 | Exploramed Nc1, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20100256597A1 (en) * | 2006-05-02 | 2010-10-07 | Emory University | Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
Family Cites Families (372)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2008700A (en) | 1930-05-12 | 1935-07-23 | Jr John Hays Hammond | Reediting of talking films |
US2187259A (en) | 1936-07-11 | 1940-01-16 | George E Barnhart | Hypodermic needle |
US2841145A (en) | 1956-05-07 | 1958-07-01 | John A Epps | Syringe |
US2939459A (en) | 1957-01-11 | 1960-06-07 | Jorge A Lazarte | Tandem syringe |
US3477432A (en) | 1964-07-21 | 1969-11-11 | Joseph Denman Shaw | Combination mixing and injecting medical syringe |
US3376999A (en) | 1967-05-31 | 1968-04-09 | Gen Dynamics Corp | Packaging, mixing and dispensing apparatus |
US3892311A (en) | 1969-01-31 | 1975-07-01 | Vincent R Sneider | Disposable syringe kit |
AT318132B (de) | 1969-08-01 | 1974-09-25 | Dentaire Ivoclar Ets | Mischbehälter für die Aufnahme von miteinander reagierenden Substanzen für die Herstellung von gebrauchsfertigen pastenförmigen Dentalpräparaten |
US3762540A (en) | 1970-05-19 | 1973-10-02 | Dentaire Ivoclar Ets | Receptacle having at least three chambers |
US3964482A (en) | 1971-05-17 | 1976-06-22 | Alza Corporation | Drug delivery device |
US3788320A (en) | 1972-02-25 | 1974-01-29 | Kendall & Co | Spinal needle |
US4226328A (en) | 1979-04-09 | 1980-10-07 | Baxter Travenol Laboratories, Inc. | Catheterization package |
US4383530A (en) | 1981-06-05 | 1983-05-17 | John Bruno | Hypodermic needle and method of making needles |
US4377897A (en) | 1981-08-04 | 1983-03-29 | Ocular Associates | Ophthalmic needle and method for manufacturing the same |
US4525346A (en) * | 1981-09-28 | 1985-06-25 | Alcon Laboratories, Inc. | Aqueous antimicrobial ophthalmic solutions |
JPS5875563A (ja) | 1981-10-30 | 1983-05-07 | テルモ株式会社 | 留置カテ−テル用接続具 |
US4564016A (en) | 1982-05-24 | 1986-01-14 | The Board Of Trustees Of The Leland Stanford Junior University | Apparatus for introducing ionized drugs into the posterior segment of the eye and method |
WO1985000097A1 (fr) | 1983-06-28 | 1985-01-17 | Sterimed Gesellschaft Für Medizinischen Bedarf Mbh | Appareils medicaux avec dispositif d'aide d'introduction |
US4501363A (en) | 1983-10-25 | 1985-02-26 | Isbey Jr Edward K | Surgical kit |
NZ212899A (en) | 1984-07-31 | 1987-10-30 | Phillips Pty Ltd N J | Piston operated adjustable volume dose injector for animals |
US4708147A (en) | 1985-02-25 | 1987-11-24 | Haaga John R | Universal biopsy needle |
US4826871A (en) | 1985-03-13 | 1989-05-02 | Gressel Philip D | Topical ophthalmic compositions containing one or more retinoids |
US4689040A (en) | 1985-04-29 | 1987-08-25 | Thompson Robert J | Tip for a phacoemulsification needle |
US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
US4826490A (en) | 1985-07-29 | 1989-05-02 | National Research Development Corporation | Safety device for hypodermic needle or the like |
US4601708A (en) | 1985-09-09 | 1986-07-22 | Pavel Jordan | Automatic injection for syringe needle, and assembly |
US4736850A (en) | 1986-10-17 | 1988-04-12 | W. L. Gore & Associates, Inc. | Endothelial cell harvesting kit |
US4966773A (en) | 1986-11-25 | 1990-10-30 | Alcon Laboratories, Inc. | Topical ophthalmic compositions containing microfine retinoid particles |
US4795432A (en) | 1987-02-19 | 1989-01-03 | Karczmer Claude M | Shield assembly for hypodermic injection devices |
US4804371A (en) | 1987-05-06 | 1989-02-14 | Vaillancourt Vincent L | Post-injection needle sheath |
DE3886779D1 (de) | 1987-07-10 | 1994-02-10 | Braun Melsungen Ag | Kanüle. |
DE3802158A1 (de) | 1987-08-11 | 1989-02-23 | Hoechst Ag | Vorrichtung zur applikation von implantaten |
US5547467A (en) | 1988-01-21 | 1996-08-20 | Massachusettes Institute Of Technology | Method for rapid temporal control of molecular transport across tissue |
US5066276A (en) | 1988-06-21 | 1991-11-19 | Alcon Laboratories, Inc. | Method and apparatus for injecting viscous fluid into the eye to lift pre-retinal and post-retinal membrane with linear pressure control |
WO1990003162A1 (fr) | 1988-09-23 | 1990-04-05 | Frank Hunter | Ameliorations de l'hygiene buccale |
US5817075A (en) | 1989-08-14 | 1998-10-06 | Photogenesis, Inc. | Method for preparation and transplantation of planar implants and surgical instrument therefor |
US5164188A (en) | 1989-11-22 | 1992-11-17 | Visionex, Inc. | Biodegradable ocular implants |
US5015240A (en) | 1990-05-01 | 1991-05-14 | Ian Campbell Cree | Hypodermic needle shield |
US5098389A (en) | 1990-06-28 | 1992-03-24 | Becton, Dickinson And Company | Hypodermic needle assembly |
ES2023597A6 (es) | 1990-11-05 | 1992-01-16 | Rodiera Olive Jose Javier | Aguja para uso medico, en especial para funcion lumbar y anestesia regional. |
US5273530A (en) | 1990-11-14 | 1993-12-28 | The University Of Rochester | Intraretinal delivery and withdrawal instruments |
EP0501034A1 (fr) | 1991-01-30 | 1992-09-02 | CeramOptec GmbH | Dispositif de guidage illuminé |
US5206267A (en) * | 1991-05-09 | 1993-04-27 | Morton Shulman | Pain controlling composition and method of preparation |
US5181909A (en) | 1991-05-15 | 1993-01-26 | Mcfarlane Richard H | Ampule-container medical syringe and methods |
DE4120173A1 (de) | 1991-06-19 | 1992-12-24 | Hoechst Ag | Positiv arbeitendes strahlungsempfindliches gemisch und damit hergestelltes strahlungsempfindliches aufzeichnungsmaterial |
US5312361A (en) | 1991-09-13 | 1994-05-17 | Zadini Filiberto P | Automatic cannulation device |
US5172807A (en) | 1991-09-30 | 1992-12-22 | Centrix, Inc. | Cement mixing capsule |
AU4282793A (en) | 1992-04-10 | 1993-11-18 | State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | A microneedle for injection of ocular blood vessels |
JPH08502033A (ja) | 1992-07-08 | 1996-03-05 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | TGF−βを用いる眼疾患の治療方法 |
US5767079A (en) | 1992-07-08 | 1998-06-16 | Celtrix Pharmaceuticals, Inc. | Method of treating ophthalmic disorders using TGF -β |
US5295972A (en) | 1992-08-04 | 1994-03-22 | Metatech Corporation | Hypodermic syringe with protective cap |
US5279564A (en) | 1992-09-11 | 1994-01-18 | Edward Weck Incorporated | Cannula retention device |
US5300084A (en) | 1992-11-23 | 1994-04-05 | United States Surgical Corporation | Pneumoperitoneum needle |
AU672862B2 (en) | 1992-12-02 | 1996-10-17 | Insite Vision Incorporated | Cyclodextrin and polymer based drug delivery system |
US5681825A (en) | 1993-03-15 | 1997-10-28 | Lindqvist; Bengt | Surgical method |
US5399159A (en) | 1993-03-30 | 1995-03-21 | Origin Medsystems, Inc. | Apparatus and method for hand-held insufflation |
US5407070A (en) | 1993-08-18 | 1995-04-18 | Bascos; Christine M. | One-time resealable package for needled medical devices |
US5415629A (en) | 1993-09-15 | 1995-05-16 | Henley; Julian L. | Programmable apparatus for the transdermal delivery of drugs and method |
US5443505A (en) | 1993-11-15 | 1995-08-22 | Oculex Pharmaceuticals, Inc. | Biocompatible ocular implants |
US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
US5397313A (en) | 1994-01-27 | 1995-03-14 | The Kendall Company | Low friction syringe |
US5658256A (en) | 1994-08-22 | 1997-08-19 | Shields; Jack W. | Universal sharps shield |
SE9402816D0 (sv) | 1994-08-24 | 1994-08-24 | Pharmacia Ab | Method and meams for drug administration |
AU3584895A (en) | 1994-09-28 | 1996-04-19 | Celtrix Pharmaceuticals, Inc. | Method of treating macular degeneration using tgf-beta |
US5792099A (en) | 1995-02-14 | 1998-08-11 | Decamp; Dennis | Syringe and cannula for insertion of viscoelastic material into an eye and method of using same |
US5779668A (en) | 1995-03-29 | 1998-07-14 | Abbott Laboratories | Syringe barrel for lyophilization, reconstitution and administration |
US5968022A (en) | 1995-04-28 | 1999-10-19 | Saito; Yoshikuni | Medical hollow needle and method of production |
USD383049S (en) | 1995-06-30 | 1997-09-02 | Fiskars Inc. | Tool handle grip |
US6280470B1 (en) | 1995-10-20 | 2001-08-28 | Gholam A. Peyman | Intrastromal corneal modification |
US5788679A (en) | 1996-06-26 | 1998-08-04 | Gravlee, Jr.; Joseph F. | Phacoemulsification needle |
US5911223A (en) | 1996-08-09 | 1999-06-15 | Massachusetts Institute Of Technology | Introduction of modifying agents into skin by electroporation |
EA199901013A1 (ru) | 1997-05-16 | 2000-06-26 | Амген Инк. | Гели пролонгированного действия |
AUPO940697A0 (en) | 1997-09-23 | 1997-10-16 | Kaal, Joseph Hermes | Retractable syringe |
WO1999034858A1 (fr) | 1998-01-12 | 1999-07-15 | Georgia Tech Research Corporation | Estimation et regulation des effet de l'energie acoustique sur des tissus |
AU2895899A (en) | 1998-03-04 | 1999-09-20 | Medtronic, Inc. | Medical device packaging system |
US6309347B1 (en) | 1998-03-17 | 2001-10-30 | Fuji Photo Optical Co., Ltd. | Air and water supply system for endoscopes |
US6391005B1 (en) | 1998-03-30 | 2002-05-21 | Agilent Technologies, Inc. | Apparatus and method for penetration with shaft having a sensor for sensing penetration depth |
US6540725B1 (en) | 1998-06-04 | 2003-04-01 | Biosense Webster, Inc. | Injection catheter with controllably extendable injection needle |
US6503231B1 (en) | 1998-06-10 | 2003-01-07 | Georgia Tech Research Corporation | Microneedle device for transport of molecules across tissue |
US6936053B1 (en) | 1998-07-02 | 2005-08-30 | Jeffrey N. Weiss | Ocular implant needle |
US6378526B1 (en) | 1998-08-03 | 2002-04-30 | Insite Vision, Incorporated | Methods of ophthalmic administration |
US6309374B1 (en) | 1998-08-03 | 2001-10-30 | Insite Vision Incorporated | Injection apparatus and method of using same |
FR2784034B1 (fr) | 1998-10-01 | 2000-12-15 | Marc Brunel | Dispositif d'injection a usage unique destine a etre pre-rempli |
US6219575B1 (en) | 1998-10-23 | 2001-04-17 | Babak Nemati | Method and apparatus to enhance optical transparency of biological tissues |
US20040141925A1 (en) * | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
US6670321B1 (en) | 1998-12-30 | 2003-12-30 | The Children's Medical Center Corporation | Prevention and treatment for retinal ischemia and edema |
WO2000040262A1 (fr) | 1999-01-05 | 2000-07-13 | The Flinders University Of South Australia | Nouveaux agents et methodes pour le traitement et le diagnostic de troubles oculaires |
US6699210B2 (en) | 1999-04-27 | 2004-03-02 | The Arizona Board Of Regents | Glaucoma shunt and a method of making and surgically implanting the same |
US6319240B1 (en) | 1999-05-25 | 2001-11-20 | Iomed, Inc. | Methods and apparatus for ocular iontophoresis |
US6743211B1 (en) | 1999-11-23 | 2004-06-01 | Georgia Tech Research Corporation | Devices and methods for enhanced microneedle penetration of biological barriers |
US6611707B1 (en) | 1999-06-04 | 2003-08-26 | Georgia Tech Research Corporation | Microneedle drug delivery device |
US6256533B1 (en) | 1999-06-09 | 2001-07-03 | The Procter & Gamble Company | Apparatus and method for using an intracutaneous microneedle array |
FR2794650B1 (fr) | 1999-06-10 | 2001-09-14 | Marc Brunel | Dispositif d'injection a usage unique |
FR2801795B1 (fr) | 1999-12-07 | 2002-07-05 | Plastef Investissements | Dispositif de support de securite pour une seringue et ensemble d'un tel dispositif et d'une seringue |
KR100771150B1 (ko) | 1999-12-10 | 2007-10-29 | 아이싸이언스 인터벤셔날 코포레이션 | 안 질환의 치료방법 |
US20010051798A1 (en) | 1999-12-28 | 2001-12-13 | Hochman Mark N. | Method of performing an injection using a bi-directional rotational insertion technique |
US6726676B2 (en) | 2000-01-05 | 2004-04-27 | Grieshaber & Co. Ag Schaffhausen | Method of and device for improving the flow of aqueous humor within the eye |
JP4372310B2 (ja) | 2000-04-10 | 2009-11-25 | ニプロ株式会社 | 混注用アダプター |
US6622864B1 (en) | 2000-06-01 | 2003-09-23 | Osteotech, Inc. | Moisture resistant package for storing sterile items |
JP4187922B2 (ja) | 2000-09-14 | 2008-11-26 | テルモ株式会社 | 液体注入針および液体注入装置 |
US20020112981A1 (en) | 2000-10-31 | 2002-08-22 | Cooper Michael B. | Package and delivery system for bone graft particles |
US20030060447A1 (en) | 2002-04-24 | 2003-03-27 | Mutlu Karakelle | Non-aspirating transitional viscoelastics for use in surgery |
US6915901B2 (en) | 2000-12-11 | 2005-07-12 | Marc Feinberg | Packaging assembly for surgical use |
WO2002064193A2 (fr) | 2000-12-14 | 2002-08-22 | Georgia Tech Research Corporation | Appareils a microaiguilles et fabrication |
US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
US20030171722A1 (en) | 2001-01-04 | 2003-09-11 | Michel Paques | Microsurgical injection and/or distending instruments and surgical method and apparatus utilizing same |
AU2002243612A1 (en) | 2001-01-18 | 2002-07-30 | The Regents Of The University Of California | Minimally invasive glaucoma surgical instrument and method |
US6378849B1 (en) * | 2001-04-13 | 2002-04-30 | General Electric Company | Methods and apparatus for mounting motors |
US20090088721A1 (en) | 2001-04-17 | 2009-04-02 | Eyegate Pharma S.A.S. | Enhanced retinal delivery of a nucleic acid through iontophoresis |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
US8337419B2 (en) | 2002-04-19 | 2012-12-25 | Sanofi-Aventis Deutschland Gmbh | Tissue penetration device |
US20030073609A1 (en) | 2001-06-29 | 2003-04-17 | Pinkerton Thomas C. | Enhanced pharmacokinetic profile of intradermally delivered substances |
US6749792B2 (en) | 2001-07-09 | 2004-06-15 | Lifescan, Inc. | Micro-needles and methods of manufacture and use thereof |
WO2003009884A2 (fr) | 2001-07-24 | 2003-02-06 | Artes Medical Usa, Inc. | Seringue allongee |
JP2003052819A (ja) | 2001-08-10 | 2003-02-25 | Seikagaku Kogyo Co Ltd | 薬剤充填注射器包装物およびその滅菌または殺菌方法 |
WO2003024507A2 (fr) | 2001-09-19 | 2003-03-27 | Biovalve Technologies, Inc. | Microaiguilles, jeux de microaiguilles, et systemes et procedes associes |
AU2002330083A1 (en) | 2001-09-21 | 2003-04-01 | Biovalve Technologies, Inc. | Gas pressure actuated microneedle arrays, and systems and methods relating to same |
US7429258B2 (en) | 2001-10-26 | 2008-09-30 | Massachusetts Institute Of Technology | Microneedle transport device |
US7569035B1 (en) | 2001-11-02 | 2009-08-04 | Meridian Medical Technologies, Inc. | Automatic injector with anti-coring needle |
EP1446079B1 (fr) | 2001-11-22 | 2007-07-25 | Eduard Anton Haefliger | Dispositif permettant d'effectuer des interventions ophtalmologiques |
US7204823B2 (en) | 2001-12-19 | 2007-04-17 | Medtronic Minimed, Inc. | Medication delivery system and monitor |
US6821286B1 (en) | 2002-01-23 | 2004-11-23 | Cardica, Inc. | System for preparing a graft vessel for anastomosis |
US20050033230A1 (en) | 2002-02-15 | 2005-02-10 | Alchas Paul G. | Prefillable intradermal delivery device with hidden needle and passive shielding |
KR20100102749A (ko) | 2002-02-22 | 2010-09-24 | 산텐 세이야꾸 가부시키가이샤 | 미립자 결막하 투여를 위한 약물 수송 시스템 |
US7226461B2 (en) | 2002-04-19 | 2007-06-05 | Pelikan Technologies, Inc. | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release |
EP1511528A4 (fr) | 2002-05-16 | 2008-07-02 | Scott Lab Inc | Mecanismes de penetration dans un contenant a medicaments, et procede associe |
US6945952B2 (en) | 2002-06-25 | 2005-09-20 | Theraject, Inc. | Solid solution perforator for drug delivery and other applications |
US7316676B2 (en) | 2002-08-20 | 2008-01-08 | Gholam A. Peyman | Treatment of retinal detachment |
DE10242984B4 (de) | 2002-09-17 | 2010-09-23 | Sanatis Gmbh | Vorrichtung zum Herstellen von Gemischen aus zwei Komponenten |
CN1301692C (zh) | 2002-09-18 | 2007-02-28 | 阿勒根公司 | 眼植入物导入的器械 |
AU2003277306A1 (en) | 2002-10-07 | 2004-05-04 | Biovalve Technologies, Inc. | Microneedle array patch |
US6883222B2 (en) | 2002-10-16 | 2005-04-26 | Bioject Inc. | Drug cartridge assembly and method of manufacture |
JP2004196787A (ja) | 2002-12-04 | 2004-07-15 | Santen Pharmaceut Co Ltd | 結膜下デポによるドラッグデリバリーシステム |
CN100453066C (zh) | 2002-12-04 | 2009-01-21 | 参天制药株式会社 | 利用结膜下储存库的药物释放系统 |
EP1589901A4 (fr) | 2002-12-20 | 2006-08-09 | Generipharm Inc | Injection intracutanee |
WO2004064903A1 (fr) | 2003-01-21 | 2004-08-05 | Carmel Pharma Ab | Aiguille de penetration d'une membrane |
GB0301934D0 (en) | 2003-01-28 | 2003-02-26 | Sundar Satish | Delivery apparatus and location method |
AU2003227802A1 (en) | 2003-02-24 | 2004-10-11 | Becton Dickinson France | Plate for holding a group of syringe body objects |
US20040199130A1 (en) | 2003-04-03 | 2004-10-07 | Chornenky Victor I. | Apparatus and method for treatment of macular degeneration |
US7533514B2 (en) | 2003-04-25 | 2009-05-19 | Boston Scientific Scimed, Inc. | Method and apparatus for automated handling of medical devices during manufacture |
US8403941B2 (en) | 2003-06-02 | 2013-03-26 | Abbott Medical Optics Inc. | Intraocular lens and cartridge packaging with lens-loading function |
US7435237B2 (en) | 2003-06-02 | 2008-10-14 | Boston Scientific Scimed, Inc. | Mixing syringes with breakable septums |
EP1633250A2 (fr) | 2003-06-04 | 2006-03-15 | Georgia Tech Research Corporation | Dispositif a micro-aiguille de forage |
DE10327119A1 (de) | 2003-06-13 | 2004-12-30 | Aventis Pharma Deutschland Gmbh | Kappe für Injektionsvorrichtungen |
US7914803B2 (en) | 2003-06-13 | 2011-03-29 | Alcon, Inc. | Ophthalmic compositions containing a synergistic combination of three polymers |
JP2007526013A (ja) | 2003-06-16 | 2007-09-13 | ソルクス インコーポレイテッド | 緑内障を治療するためのシャント装置 |
DK1638468T3 (da) | 2003-06-30 | 2007-12-17 | Alza Corp | Fremgangsmåde til coating af hudpiercingmikrofremspring |
USD499153S1 (en) | 2003-07-08 | 2004-11-30 | Test Rite International Company, Ltd | Handle for jump rope |
US20050009910A1 (en) | 2003-07-10 | 2005-01-13 | Allergan, Inc. | Delivery of an active drug to the posterior part of the eye via subconjunctival or periocular delivery of a prodrug |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
US20050101882A1 (en) | 2003-11-12 | 2005-05-12 | Leira Enrique C. | Safety pressure device for body fluid extraction |
US20090148527A1 (en) | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
KR20060130648A (ko) | 2004-01-12 | 2006-12-19 | 아이싸이언스 인터벤셔날 코포레이션 | 점성 물질용 인젝터 |
CA2553381C (fr) | 2004-01-20 | 2011-03-22 | Allergan, Inc. | Compositions pour traitement local de l'oeil, comprenant de preference de l'acetonide de triamcinolone et de l'acide hyaluronique |
ES2424797T3 (es) | 2004-01-23 | 2013-10-08 | Iscience Interventional Corporation | Microcánula oftálmica compuesta |
US7678077B2 (en) | 2004-02-20 | 2010-03-16 | Boston Scientific Scimed, Inc. | Variable depth injection device and method |
US20100173866A1 (en) | 2004-04-29 | 2010-07-08 | Iscience Interventional Corporation | Apparatus and method for ocular treatment |
US20080058704A1 (en) | 2004-04-29 | 2008-03-06 | Michael Hee | Apparatus and Method for Ocular Treatment |
MXPA06012461A (es) | 2004-04-29 | 2007-08-07 | Iscience Surgical Corp | Metodo y aparato para tratamiento ocular. |
EP1758598B1 (fr) | 2004-04-30 | 2016-04-13 | Eyegate Pharma SAS | Dispositif d'iontophorèse oculaire diminuant les irritations |
US20050244463A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Sustained release intraocular implants and methods for treating ocular vasculopathies |
US8685435B2 (en) | 2004-04-30 | 2014-04-01 | Allergan, Inc. | Extended release biodegradable ocular implants |
US20050244462A1 (en) | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Devices and methods for treating a mammalian eye |
US8690865B2 (en) | 2004-05-28 | 2014-04-08 | Georgia Tech Research Corporation | Methods and devices for thermal treatment |
US8323227B2 (en) | 2004-07-02 | 2012-12-04 | C. R. Bard, Inc. | Tip configurations for a multi-lumen catheter |
EP2216026B1 (fr) | 2004-07-12 | 2016-04-20 | Allergan, Inc. | Compositions ophthalmologiques et leur utilisation pour le traitement des maladies oculaires. |
US7615041B2 (en) | 2004-07-29 | 2009-11-10 | Boston Scientific Scimed, Inc. | Vial adaptor |
US7503920B2 (en) | 2004-08-11 | 2009-03-17 | Tzony Siegal | Spinal surgery system and method |
US7722669B2 (en) | 2004-08-13 | 2010-05-25 | Richard Foulkes | Method and insert for modifying eye color |
US8114110B2 (en) | 2004-09-22 | 2012-02-14 | St. Jude Medical, Atrial Fibrillation Division, Inc. | Transseptal puncture needle and needle assemblies |
US7947267B2 (en) | 2004-10-08 | 2011-05-24 | Potentia Pharmaceuticals, Inc. | Viral complement control proteins for eye disorders |
US7627938B2 (en) | 2004-10-15 | 2009-12-08 | Board Of Regents, The Univeristy Of Texas System | Tapered hollow metallic microneedle array assembly and method of making and using the same |
US7097776B2 (en) | 2004-10-22 | 2006-08-29 | Hewlett-Packard Development Company, L.P. | Method of fabricating microneedles |
US8262715B2 (en) | 2004-11-23 | 2012-09-11 | Eye Delivery System, Llc | Medical device and method for temperature control and treatment of the eye and surrounding tissues via magnetic drug therapy |
DE602005026978D1 (de) | 2004-11-23 | 2011-04-28 | Timothy L Lee | Medizinische vorrichtung zur temperaturregelung und behandlung des auges sowie des umgebenden gewebes |
US20060173418A1 (en) | 2004-12-13 | 2006-08-03 | Arrow International, Inc. | Loss of resistance syringe |
US20060169664A1 (en) | 2004-12-28 | 2006-08-03 | Holopack International Corp. | Vial for filling a syringe |
US7803142B2 (en) | 2005-02-02 | 2010-09-28 | Summit Access Llc | Microtaper needle and method of use |
WO2007059187A1 (fr) | 2005-11-14 | 2007-05-24 | Pactiv Corporation | Recipient muni d'un reservoir interne |
TW200640443A (en) | 2005-02-23 | 2006-12-01 | Alcon Inc | Methods for treating ocular angiogenesis, retinal edema, retinal ischemia, and diabetic retinopathy using selective RTK inhibitors |
US20060233858A1 (en) | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
BRPI0609206A2 (pt) | 2005-03-11 | 2010-03-02 | Alcon Inc | inibiÇço mediada por rnai de proteÍna relacionada frizzled-1 para tratamento de glaucoma |
CA2601864A1 (fr) | 2005-04-08 | 2006-10-19 | Surmodics, Inc. | Implants a liberation prolongee et methodes d'administration sous-retinienne d'agents bioactifs pour traiter ou prevenir les maladies de la retine |
US7722581B2 (en) | 2005-04-11 | 2010-05-25 | Gholam A. Peyman | Crystalline lens drug delivery |
US7645264B2 (en) | 2005-04-11 | 2010-01-12 | Becton, Dickinson And Company | Injection device with secondary reservoir |
US7665467B2 (en) | 2005-04-26 | 2010-02-23 | Biolase Technology, Inc. | Methods for treating eye conditions |
US20060259008A1 (en) | 2005-04-27 | 2006-11-16 | Allergan, Inc. | Apparatus and methods useful for intravitreal injection of drugs |
CN100463668C (zh) | 2005-05-09 | 2009-02-25 | 凌沛学 | 可逆性热凝胶化水性药物组合物 |
US20080269666A1 (en) | 2005-05-25 | 2008-10-30 | Georgia Tech Research Corporation | Microneedles and Methods for Microinfusion |
CA2612005C (fr) | 2005-06-17 | 2013-10-29 | Georgia Tech Research Corporation | Microstructures revetues et procede de fabrication de celles-ci |
CN100430069C (zh) | 2005-07-28 | 2008-11-05 | 凌沛学 | 一种中药及其复方的可逆性热凝胶化水性药物组合物 |
US20070082841A1 (en) | 2005-09-27 | 2007-04-12 | Aciont, Inc. | Ocular administration of immunosuppressive agents |
US20070093877A1 (en) | 2005-10-26 | 2007-04-26 | Beecham Michael C | System for maintaining normal health of retinal cells and promoting regeneration of retinal cells |
US20070123947A1 (en) | 2005-11-30 | 2007-05-31 | Wenger William K | Medical device packaging system |
JP4886789B2 (ja) | 2005-12-23 | 2012-02-29 | キャスリックス リミテッド | 洗浄カテーテル |
WO2007084582A2 (fr) | 2006-01-17 | 2007-07-26 | Forsight Labs, Llc | Dispositif de traitement d’administration de medicament |
US20070185495A1 (en) | 2006-01-30 | 2007-08-09 | Howmedica International S. De R. L. | Plug-in syringe stand |
US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
US7918814B2 (en) | 2006-05-02 | 2011-04-05 | Georgia Tech Research Corporation | Method for drug delivery to ocular tissue using microneedle |
US20070270768A1 (en) | 2006-05-17 | 2007-11-22 | Bruno Dacquay | Mechanical Linkage Mechanism For Ophthalmic Injection Device |
US20070270745A1 (en) | 2006-05-18 | 2007-11-22 | Camran Nezhat | Vacuum actuated tissue lifting device |
USD598543S1 (en) | 2006-06-13 | 2009-08-18 | Angiomed Gmbh & Co. Medizintechnik Kg | Handle for a medical delivery device |
US8668676B2 (en) | 2006-06-19 | 2014-03-11 | Allergan, Inc. | Apparatus and methods for implanting particulate ocular implants |
US8802128B2 (en) | 2006-06-23 | 2014-08-12 | Allergan, Inc. | Steroid-containing sustained release intraocular implants and related methods |
US8852137B2 (en) | 2010-11-15 | 2014-10-07 | Aquesys, Inc. | Methods for implanting a soft gel shunt in the suprachoroidal space |
US8974511B2 (en) | 2010-11-15 | 2015-03-10 | Aquesys, Inc. | Methods for treating closed angle glaucoma |
US8663303B2 (en) | 2010-11-15 | 2014-03-04 | Aquesys, Inc. | Methods for deploying an intraocular shunt from a deployment device and into an eye |
US20080152694A1 (en) | 2006-07-20 | 2008-06-26 | Neurosystec Corporation | Devices, Systems and Methods for Ophthalmic Drug Delivery |
US20080097335A1 (en) | 2006-08-04 | 2008-04-24 | Allergan, Inc. | Ocular implant delivery assemblies |
US20080058717A1 (en) | 2006-09-04 | 2008-03-06 | Spector David M | Oral cavity liquid delivery system including pre-angled needle guidance assembly and method for using the same |
US8944069B2 (en) | 2006-09-12 | 2015-02-03 | Vidacare Corporation | Assemblies for coupling intraosseous (IO) devices to powered drivers |
US7998108B2 (en) | 2006-09-12 | 2011-08-16 | Psivida Us, Inc. | Injector apparatus and method of use |
US20080097346A1 (en) | 2006-09-19 | 2008-04-24 | Alcon, Inc. | Trocar cannula |
US20080097390A1 (en) | 2006-09-27 | 2008-04-24 | Alcon Manufacturing, Ltd. | Spring actuated delivery system |
EP2088976B1 (fr) | 2006-11-10 | 2019-07-03 | Glaukos Corporation | Dérivation uvéosclérale |
US8969415B2 (en) | 2006-12-01 | 2015-03-03 | Allergan, Inc. | Intraocular drug delivery systems |
WO2008070479A2 (fr) | 2006-12-01 | 2008-06-12 | Allergan, Inc. | Procédé pour déterminer des emplacements oculaires optimaux pour des systèmes d'administration de médicament |
RU2344767C2 (ru) | 2006-12-18 | 2009-01-27 | Наталья Александровна Уракова | Способ внутриартериальной инъекции по а.л. уракову |
TWI457336B (zh) * | 2006-12-28 | 2014-10-21 | Kinex Pharmaceuticals Llc | 調節激酶級聯之組成物及方法 |
US9308125B2 (en) | 2007-01-09 | 2016-04-12 | Fovea Pharmaceuticals | Apparatus for intra-ocular injection |
US20080177239A1 (en) | 2007-01-18 | 2008-07-24 | Yong Li | Trocar cannula system |
DE102007018696A1 (de) | 2007-04-18 | 2008-10-23 | Sanofi-Aventis Deutschland Gmbh | Injektionsvorrichtung zur Abgabe eines Medikaments |
USD590690S1 (en) | 2007-05-24 | 2009-04-21 | Domino S.P.A. | Handlebar hand grip |
US20090030381A1 (en) | 2007-07-23 | 2009-01-29 | Lind Casey J | Arced Hypodermic Needle |
US20110202012A1 (en) | 2007-08-16 | 2011-08-18 | Bartlett Edwin C | Smart Injection Syring Systems Providing Real-Time User Feedback of Correct Needle Position |
AU2008300018A1 (en) | 2007-09-07 | 2009-03-19 | Qlt Inc. | Insertion and extraction tools for lacrimal implants |
CA2639322C (fr) | 2007-09-07 | 2016-11-08 | Becton, Dickinson And Company | Collet d'aiguille pour stylo injecteur presentant une surface de contact accrue |
US20090076463A1 (en) | 2007-09-17 | 2009-03-19 | Jurg Attinger | Trocar Cannula |
US20090081277A1 (en) | 2007-09-21 | 2009-03-26 | Allergan, Inc. | Pharmaceutical formulations and methods for treating ocular conditions |
US8631935B2 (en) | 2009-06-03 | 2014-01-21 | Medline Industries, Inc. | Catheter tray, packaging system, and associated methods |
US8448786B2 (en) | 2009-06-30 | 2013-05-28 | Medline Industries, Inc. | Catheter tray, packaging system, instruction insert, and associated methods |
US8602959B1 (en) | 2010-05-21 | 2013-12-10 | Robert Park | Methods and devices for delivery of radiation to the posterior portion of the eye |
JP2009183441A (ja) | 2008-02-06 | 2009-08-20 | Ken Kondo | 静脈留置針組立体 |
BRPI0908502A2 (pt) | 2008-02-21 | 2017-05-23 | Ista Pharmaceuticals | aines oftálmicos como adjuvantes |
US20100152646A1 (en) | 2008-02-29 | 2010-06-17 | Reshma Girijavallabhan | Intravitreal injection device and method |
MX2010009974A (es) * | 2008-03-11 | 2010-09-30 | Alcon Res Ltd | Suspensiones de acetonida de triamcinolona de baja viscosidad, altamente floculadas para inyeccion intravitrea. |
US20090259180A1 (en) | 2008-04-11 | 2009-10-15 | Jong Soo Choi | Injection method using injector with length-adjustable needle and injection apparatus using the same |
US20090287161A1 (en) | 2008-05-15 | 2009-11-19 | Allergan, Inc | Metered, multiple dose/aliquot syringe |
US20090312782A1 (en) | 2008-06-13 | 2009-12-17 | Maxwell Choongwon Park | Method and apparatus for repairing tendons |
US8821870B2 (en) | 2008-07-18 | 2014-09-02 | Allergan, Inc. | Method for treating atrophic age related macular degeneration |
US9022940B2 (en) | 2008-07-18 | 2015-05-05 | Joseph H. Meier | Handheld imaging devices and related methods |
JP5635984B2 (ja) | 2008-07-21 | 2014-12-03 | スミスズ メディカル エイエスディー インコーポレイテッド | トレイ組立品 |
DK2346551T3 (da) | 2008-08-30 | 2021-03-01 | Sanofi Aventis Deutschland | Cylinderampul og kanylesystem til denne |
US8221353B2 (en) | 2008-10-21 | 2012-07-17 | KMG Pharma, Inc | Intravitreal injection device and system |
US7678078B1 (en) | 2008-10-21 | 2010-03-16 | KMG Pharma LLC | Intravitreal injection device, system and method |
WO2010054660A1 (fr) | 2008-11-11 | 2010-05-20 | Herlev Hospital | Système à double canule pour une aiguille d'anesthésie |
WO2010065970A1 (fr) | 2008-12-05 | 2010-06-10 | Ivantis, Inc. | Procédés et appareils de placement d'implants oculaires dans l'oeil |
WO2010067319A2 (fr) | 2008-12-09 | 2010-06-17 | Nanopass Technologies Ltd. | Dispositif pour injecter un fluide à partir d'un raccord de micro-aiguille comportant un élément d'insertion réduisant l'espace mort |
US8545554B2 (en) | 2009-01-16 | 2013-10-01 | Allergan, Inc. | Intraocular injector |
US8425473B2 (en) | 2009-01-23 | 2013-04-23 | Iscience Interventional Corporation | Subretinal access device |
ES2378012B1 (es) | 2009-01-29 | 2013-02-12 | Innova Salud Desarrollos Sanitarios S.L. | Dispositivo para la administración de productos inyectables con caudal controlado. |
JP5969212B2 (ja) | 2009-02-10 | 2016-08-17 | シヴィダ・ユーエス・インコーポレイテッドPsivida Us,Inc. | 眼用トロカール組立体 |
US8057483B2 (en) | 2009-02-14 | 2011-11-15 | Ocular Transplantation Llc | Subretinal implantation instrument |
CN201356711Y (zh) | 2009-02-23 | 2009-12-09 | 徐学农 | 玻璃体腔冲洗针头 |
CA2753724C (fr) | 2009-03-02 | 2018-01-16 | Sanofi-Aventis Deutschland Gmbh | Dispositif d'administration de medicament avec support de doigt pliable |
EP2403567B1 (fr) | 2009-03-05 | 2014-12-10 | Sanofi-Aventis Deutschland GmbH | Ensemble d'aiguille |
AU2010220257B2 (en) | 2009-03-05 | 2015-01-15 | Sanofi-Aventis Deutschland Gmbh | Needle unit |
CA2753939A1 (fr) | 2009-03-05 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Dispositif d'administration de medicament au moyen d'une aiguille retractable |
EP2403570B1 (fr) | 2009-03-05 | 2015-07-15 | Sanofi-Aventis Deutschland GmbH | Dispositif d'administration de médicaments |
EP2403571A1 (fr) | 2009-03-06 | 2012-01-11 | Sanofi-Aventis Deutschland GmbH | Dispositif de distribution de médicament muni d'une aiguille rétractable |
US8287494B2 (en) | 2009-03-23 | 2012-10-16 | Colin Ma | Intravitreal injection devices and methods of injecting a substance into the vitreous chamber of the eye |
SE0900371A1 (sv) | 2009-03-24 | 2010-09-25 | Istvan Bartha | Anordning för distribution av flytande läkemedel |
EP2419005B1 (fr) | 2009-04-15 | 2014-11-19 | Koninklijke Philips N.V. | Aiguille avec des fibres intégrées dans les facettes coupantes du biseau |
US20120130207A1 (en) | 2009-04-29 | 2012-05-24 | Janisys Limited | micro-needle device and apparatus and a method for applying a micro-needle element to a site on the skin of a subject |
US20120191064A1 (en) | 2009-05-15 | 2012-07-26 | Iscience Interventional Corporation | Methods and apparatus for sub-retinal catheterization |
WO2010149734A1 (fr) | 2009-06-25 | 2010-12-29 | Sanofi-Aventis Deutschland Gmbh | Ensemble de canule pour co-administration de médicaments |
RU2428956C2 (ru) | 2009-07-13 | 2011-09-20 | Александр Дмитриевич Ромащенко | Способ лечения атрофии зрительного нерва посредством трансплантации аутологичных стволовых клеток |
US8535333B2 (en) | 2009-07-29 | 2013-09-17 | Transcend Medical, Inc. | Ocular implant applier and methods of use |
JP5865835B2 (ja) | 2009-08-12 | 2016-02-17 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 携帯用医薬品送達デバイス用キャップ及びそのような医薬品送達デバイス |
US8221753B2 (en) * | 2009-09-30 | 2012-07-17 | Tracon Pharmaceuticals, Inc. | Endoglin antibodies |
WO2011023738A1 (fr) | 2009-08-28 | 2011-03-03 | Sanofi-Aventis Deutschland Gmbh | Kit de montage pour la préparation dune seringue pré-remplie |
US20130041265A1 (en) | 2009-09-21 | 2013-02-14 | Ron Sostek | Methods and apparatus for introducing cells at a tissue site |
WO2011057065A1 (fr) | 2009-11-06 | 2011-05-12 | The Uab Research Foundation | Appareils et procédés pour administrer des substances dans l'oeil interne |
US9254365B2 (en) | 2009-11-11 | 2016-02-09 | Unitract Syringe Pty Ltd | Clinical syringe with replaceable retractable needle |
AU2010336003B2 (en) | 2009-12-22 | 2014-07-03 | Unitract Syringe Pty Ltd | Retractable syringe with improved delivery efficiency and locking system |
US8529492B2 (en) | 2009-12-23 | 2013-09-10 | Trascend Medical, Inc. | Drug delivery devices and methods |
CA2786366A1 (fr) | 2010-01-05 | 2011-07-14 | Allergan, Inc. | Seringue comprenant deux plongeurs pourvus de moyens de verrouillage |
WO2011109388A2 (fr) | 2010-03-01 | 2011-09-09 | Medical Instrument Development Laboratories, Inc. | Canule pour chirurgie intraoculaire |
EP2364740A1 (fr) | 2010-03-09 | 2011-09-14 | Sanofi-Aventis Deutschland GmbH | Agencement pour transférer une translation de moyen de commande à un piston |
GB201004102D0 (en) | 2010-03-12 | 2010-04-28 | Liversidge Barry P | Syringe barrels and handling systems |
US9408746B2 (en) | 2010-03-31 | 2016-08-09 | Ocuject, Llc | Device and method for intraocular drug delivery |
US9320647B2 (en) | 2010-03-31 | 2016-04-26 | Ocuject, Llc | Device and method for intraocular drug delivery |
US8430862B2 (en) | 2010-04-08 | 2013-04-30 | KMG Pharma LLC | Subconjunctival agent delivery apparatus, system and method |
US8652118B2 (en) | 2010-04-08 | 2014-02-18 | Kmg Pharma, Llc | Sub-mucosal agent delivery, apparatus, system and method |
US8574217B2 (en) | 2010-04-08 | 2013-11-05 | Kmg Pharma, Llc | Sub-mucosal agent delivery method for the eye |
WO2011137488A1 (fr) | 2010-05-04 | 2011-11-10 | Unitract Syringe Pty Ltd | Adaptateur de cylindre de seringue et ensemble aiguille |
US8632589B2 (en) | 2010-05-04 | 2014-01-21 | Abbott Medical Optics Inc. | IOL insertion system with semi-automatic trailing haptic configuration management |
US8932258B2 (en) | 2010-05-14 | 2015-01-13 | C. R. Bard, Inc. | Catheter placement device and method |
US8545430B2 (en) | 2010-06-09 | 2013-10-01 | Transcend Medical, Inc. | Expandable ocular devices |
US9987435B2 (en) | 2010-06-10 | 2018-06-05 | Anthony J. Colantonio | Apparatus and method for safely inserting an introducer needle into epidural space |
WO2012003141A1 (fr) | 2010-07-02 | 2012-01-05 | Alcon Research, Ltd. | Composés pour le traitement de troubles et maladies de segment postérieur |
KR101180032B1 (ko) | 2010-07-12 | 2012-09-05 | 인싸이토(주) | 외형 조절이 가능한 중공형 마이크로니들의 제조방법 |
TW201216948A (en) | 2010-07-19 | 2012-05-01 | Sanofi Aventis Deutschland | Medicament cartridges with non-standard dimensions |
AU2011308629A1 (en) | 2010-09-30 | 2013-05-23 | Evonik Corporation | Drug delivery blade and methods for delivering a drug depot to a target site |
EP2621563A1 (fr) | 2010-10-01 | 2013-08-07 | Sanofi-Aventis Deutschland GmbH | Ensemble aiguille comprenant un mécanisme de libération |
EP2438939A1 (fr) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Agencement pour coupler un piston avec une seringue ou un butoir |
EP3520749A1 (fr) | 2010-10-15 | 2019-08-07 | Clearside Biomedical, Inc. | Dispositif d'accès oculaire |
US20120101475A1 (en) | 2010-10-21 | 2012-04-26 | Meridian Medical Technologies, Inc. | High Efficiency Auto-Injector |
JP2013540028A (ja) | 2010-10-25 | 2013-10-31 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 注射針の刺入深さを制御するためのデバイス |
EP2446866A1 (fr) | 2010-11-02 | 2012-05-02 | Fovea Pharmaceuticals | Appareil pour injection dans un oeil |
CN103313744B (zh) | 2010-11-03 | 2015-06-10 | 赛诺菲-安万特德国有限公司 | 容纳药物的针插管 |
US9241701B2 (en) | 2010-11-11 | 2016-01-26 | Depuy Mitek, Inc. | Cannula system and method for partial thickness rotator cuff repair |
JP5704389B2 (ja) | 2010-11-29 | 2015-04-22 | ニプロ株式会社 | 医療用中空針および医療用中空針の製造方法 |
US8608710B2 (en) | 2010-12-09 | 2013-12-17 | Becton Dickinson & Company | Pen needle assembly with different gauge needle cannulas |
US9968337B2 (en) | 2010-12-20 | 2018-05-15 | Cook Medical Technologies Llc | Coring tissue biopsy needle and method of use |
CA2828831C (fr) * | 2011-03-02 | 2019-05-07 | Aquilus Pharmaceuticals, Inc. | Composes et methodes de traitement de la douleur et d'autres troubles |
US20140303013A1 (en) * | 2011-03-15 | 2014-10-09 | University Of Utah Research Foundation | Methods of diagnosing and treating vascular associated maculopathy and symptoms thereof |
EP2500002A1 (fr) | 2011-03-17 | 2012-09-19 | Sanofi-Aventis Deutschland GmbH | Appareil pour injection intraoculaire |
USD667111S1 (en) | 2011-03-17 | 2012-09-11 | Surgical Innovations Limited | Handle for surgical instrument |
EP2510911A1 (fr) | 2011-04-13 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Appareil pour injection intraoculaire |
EP2510902A1 (fr) | 2011-04-15 | 2012-10-17 | Sanofi-Aventis Deutschland GmbH | Dispositif d'injection intraoculaire |
EP2514684A1 (fr) | 2011-04-20 | 2012-10-24 | Becton Dickinson France | Conditionnement pour récipients médicaux |
EP2514461A1 (fr) | 2011-04-20 | 2012-10-24 | Sanofi-Aventis Deutschland GmbH | Ensemble d'aiguille pour dispositif médical |
EP2522318A1 (fr) | 2011-05-12 | 2012-11-14 | Sanofi-Aventis Deutschland GmbH | Guide device for intraocular injection |
WO2012162459A1 (fr) | 2011-05-26 | 2012-11-29 | Pepose Jay | Dispositif et procédé pour administrer des médications oculaires |
EP2540261A1 (fr) | 2011-06-30 | 2013-01-02 | Sanofi-Aventis Deutschland GmbH | Dispositif d'administration intra-oculaire de médicaments |
EP2739333A1 (fr) | 2011-08-05 | 2014-06-11 | Unitract Syringe Pty Ltd | Canule présentant une profondeur d'introduction régulée |
JP5933719B2 (ja) | 2011-09-13 | 2016-06-15 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 注射デバイス |
EP2574355A1 (fr) | 2011-09-27 | 2013-04-03 | Sanofi-Aventis Deutschland GmbH | Conditionnement pour dispositif d'administration de médicaments |
EP2578190A1 (fr) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Dispositif d'injection intraoculaire |
EP2578189A1 (fr) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Appareil pour injection intraoculaire |
EP2578191A1 (fr) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Appareil pour injection intraoculaire |
EP2578260A1 (fr) | 2011-10-07 | 2013-04-10 | Sanofi-Aventis Deutschland GmbH | Appareil pour injection intraoculaire |
EP2586407A1 (fr) | 2011-10-31 | 2013-05-01 | Sanofi-Aventis Deutschland GmbH | Dispositif d'aide pour injection intraoculaire |
EP2596826A1 (fr) | 2011-11-24 | 2013-05-29 | Sanofi-Aventis Deutschland GmbH | Seringue de sécurité |
EP2601990A1 (fr) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Support de seringue |
EP2601992A1 (fr) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Support de seringue |
MX351572B (es) | 2011-12-08 | 2017-10-18 | Unitract Syringe Pty Ltd | Mecanismos de control de dosis exacta y jeringas de administración de fármacos. |
EP2601988A1 (fr) | 2011-12-08 | 2013-06-12 | Sanofi-Aventis Deutschland GmbH | Support de seringue |
AU2012351522A1 (en) | 2011-12-15 | 2014-07-24 | Sanofi-Aventis Deutschland Gmbh | Reservoir or medicated module for a drug delivery system and method of and assembly for filling the same |
EP2609952B1 (fr) | 2011-12-30 | 2015-01-14 | Q-Med AB | Canule sans pinçon |
AU344164S (en) | 2012-02-02 | 2012-09-04 | Terumo Corp | Safety device for indwelling needle |
EP2626096A1 (fr) | 2012-02-10 | 2013-08-14 | Sanofi-Aventis Deutschland GmbH | Dispositif d'administration de médicaments doté d'un mécanisme de retrait de l'ensemble formant aiguille |
IN2014DN07800A (fr) | 2012-02-20 | 2015-05-15 | Terumo Corp | |
US9474594B2 (en) | 2012-02-22 | 2016-10-25 | Ira H. Schachar | Device and method for treatment of retinal detachment and other maladies of the eye |
JP6109203B2 (ja) | 2012-02-23 | 2017-04-12 | ユニトラクト シリンジ プロプライエタリイ リミテッドUnitract Syringe Pty Ltd | 治療用インプラントの標的送達の為の器具 |
USD672506S1 (en) | 2012-02-28 | 2012-12-11 | Idea Village Products, Inc. | Exfoliating device |
US20150013835A1 (en) | 2012-02-29 | 2015-01-15 | Sanofi-Aventis Deutschland Gmbh | Extraction device for a single extraction of a medicament from a container |
WO2013138392A1 (fr) | 2012-03-12 | 2013-09-19 | Unitract Syringe Pty Ltd | Cartouches de remplissage-finition pour ensembles parcours stériles de fluide et dispositifs de distribution de médicaments incorporant des cartouches de remplissage-finition |
EP2641629A1 (fr) | 2012-03-22 | 2013-09-25 | Sanofi-Aventis Deutschland GmbH | Dispositif d'injection avec dispositif de réduction de la douleur au site d'injection |
US9421129B2 (en) | 2012-04-02 | 2016-08-23 | Ocuject, Llc | Intraocular delivery devices and methods therefor |
US9833523B2 (en) | 2012-04-24 | 2017-12-05 | The Ohio State University | Pharmacokinetic determination of intravitreal agents |
US9889248B2 (en) | 2012-05-21 | 2018-02-13 | Baxalta GmbH | Syringe storage tray |
US9956341B2 (en) | 2012-07-03 | 2018-05-01 | Milestone Scientific, Inc. | Drug infusion with pressure sensing and non-continuous flow for identification of and injection into fluid-filled anatomic spaces |
US8727117B2 (en) | 2012-07-16 | 2014-05-20 | Becton, Dickinson And Company | Package for syringe |
WO2014028285A1 (fr) | 2012-08-13 | 2014-02-20 | The Brigham And Women's Hospital, Inc. | Procédés et dispositifs d'introduction d'une aiguille |
CA2882184C (fr) | 2012-08-27 | 2021-09-07 | Clearside Biomedical, Inc. | Appareil et procedes d'administration de medicaments a l'aide de micro-aiguilles |
USD715125S1 (en) | 2012-10-08 | 2014-10-14 | The Ames Companies, Inc. | Grip |
US9022968B2 (en) | 2013-01-08 | 2015-05-05 | University Of South Florida | Auto-regulation system for intraocular pressure |
EP2968113B8 (fr) | 2013-03-14 | 2020-10-28 | Forsight Vision4, Inc. | Systèmes pour l'administration intra-oculaire entretenue de composés à faible solubilité provenant d'un implant de système de pose d'orifice |
USD740098S1 (en) | 2013-03-19 | 2015-10-06 | Tong Yah Electronic Technology Co., Ltd. | Vehicular handle |
US9987163B2 (en) | 2013-04-16 | 2018-06-05 | Novartis Ag | Device for dispensing intraocular substances |
WO2014179698A2 (fr) | 2013-05-03 | 2014-11-06 | Clearside Biomedical, Inc. | Appareil et procédés pour une injection oculaire |
US10188550B2 (en) | 2013-06-03 | 2019-01-29 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using multiple reservoirs |
WO2015015467A1 (fr) | 2013-08-02 | 2015-02-05 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Dispositif pour l'administration de compositions à l'œil |
WO2015021261A1 (fr) | 2013-08-07 | 2015-02-12 | Unitract Syringe Pty Ltd | Adaptateurs de raccord luer pour seringues à aiguille rétractable |
WO2015021169A1 (fr) | 2013-08-07 | 2015-02-12 | Unitract Syringe Pty Ltd | Adaptateurs de raccord luer pour seringues |
USD718602S1 (en) | 2013-09-09 | 2014-12-02 | Midwest Tool And Cutlery Company | Hand grip for hand tools |
USD713958S1 (en) | 2013-12-05 | 2014-09-23 | Becton, Dickinson And Company | Pen needle outer cover |
WO2015095772A2 (fr) | 2013-12-20 | 2015-06-25 | Emory University | Préparations et procédés servant à introduire de manière ciblée des agents thérapeutiques dans l'œil |
USD726908S1 (en) | 2014-02-06 | 2015-04-14 | St. Jude Medical, Cardiology Division, Inc. | Catheter handle |
EP3157463A4 (fr) | 2014-06-17 | 2018-02-21 | Clearside Biomedical, Inc. | Procédés et dispositifs de traitement de troubles oculaires postérieurs |
RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
WO2016042163A2 (fr) | 2014-09-19 | 2016-03-24 | Medterials, Inc. | Compositions médicamenteuses ophtalmiques |
US11096822B2 (en) | 2014-09-19 | 2021-08-24 | Oxular Limited | Ophthalmic delivery device |
USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
WO2017120601A1 (fr) | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Méthodes et dispositifs pour le traitement de troubles oculaires postérieurs avec l'aflibercept et d'autres substances biologiques |
WO2017120600A1 (fr) | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions et méthodes de traitement de la dégénérescence maculaire humide liée à l'âge |
US10390901B2 (en) | 2016-02-10 | 2019-08-27 | Clearside Biomedical, Inc. | Ocular injection kit, packaging, and methods of use |
WO2017190142A1 (fr) | 2016-04-29 | 2017-11-02 | Clearside Biomedical, Inc. | Formulations et méthodes de réduction de la pression intraoculaire |
WO2017192565A1 (fr) | 2016-05-02 | 2017-11-09 | Clearside Biomedical, Inc. | Systèmes et méthodes pour l'administration de médicaments par voie ophtalmique |
-
2013
- 2013-11-08 BR BR112015010566A patent/BR112015010566A2/pt not_active Application Discontinuation
- 2013-11-08 JP JP2015540925A patent/JP6487848B2/ja active Active
- 2013-11-08 CA CA3121763A patent/CA3121763A1/fr active Pending
- 2013-11-08 CN CN201911001650.7A patent/CN110893188A/zh active Pending
- 2013-11-08 CA CA2890471A patent/CA2890471C/fr active Active
- 2013-11-08 CN CN201380069089.0A patent/CN104884049A/zh active Pending
- 2013-11-08 EP EP20178612.6A patent/EP3721872A1/fr active Pending
- 2013-11-08 ES ES13853777T patent/ES2813869T3/es active Active
- 2013-11-08 EP EP13853777.4A patent/EP2916827B1/fr active Active
- 2013-11-08 KR KR1020217034816A patent/KR20210133321A/ko not_active Application Discontinuation
- 2013-11-08 KR KR1020217008160A patent/KR102467714B1/ko active IP Right Grant
- 2013-11-08 US US14/441,151 patent/US20150258120A1/en not_active Abandoned
- 2013-11-08 KR KR1020157015062A patent/KR20150083117A/ko active Application Filing
- 2013-11-08 WO PCT/US2013/069156 patent/WO2014074823A1/fr active Application Filing
- 2013-11-08 EA EA201590902A patent/EA034963B1/ru unknown
- 2013-11-08 MX MX2015005839A patent/MX2015005839A/es active IP Right Grant
- 2013-11-08 SG SG11201503637SA patent/SG11201503637SA/en unknown
- 2013-11-08 MX MX2020005126A patent/MX2020005126A/es unknown
- 2013-11-08 AU AU2013342275A patent/AU2013342275B2/en active Active
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- 2015-04-22 IL IL238432A patent/IL238432B/en active IP Right Grant
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- 2016-02-02 HK HK16101221.1A patent/HK1213192A1/zh unknown
- 2016-03-31 US US15/086,485 patent/US9572800B2/en active Active
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- 2017-03-09 US US15/454,636 patent/US20180028516A1/en not_active Abandoned
- 2017-08-09 US US15/673,073 patent/US9931330B2/en active Active
- 2017-12-04 US US15/830,727 patent/US20180092897A1/en not_active Abandoned
- 2017-12-05 AU AU2017272182A patent/AU2017272182A1/en not_active Abandoned
-
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- 2018-03-13 JP JP2018045358A patent/JP2018090632A/ja not_active Withdrawn
- 2018-07-20 US US16/041,067 patent/US20180325884A1/en not_active Abandoned
- 2018-09-07 US US16/124,407 patent/US20190240208A1/en not_active Abandoned
-
2019
- 2019-11-29 JP JP2019216125A patent/JP7082599B2/ja active Active
-
2020
- 2020-01-08 US US16/737,010 patent/US20200383965A1/en not_active Abandoned
-
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- 2021-05-07 US US17/314,272 patent/US20210260047A1/en active Pending
-
2022
- 2022-05-27 JP JP2022086839A patent/JP2022119912A/ja active Pending
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6143329A (en) * | 1996-07-03 | 2000-11-07 | Rorer Pharmaceutical Products Inc. | Aqueous-based pharmaceutical composition |
US20050065137A1 (en) * | 2003-09-23 | 2005-03-24 | Alcon, Inc. | Triamcinolone acetonide and anecortave acetate formulations for injection |
US20060141049A1 (en) * | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20050245906A1 (en) * | 2004-04-21 | 2005-11-03 | Exploramed Nc1, Inc. | Implantable device and methods for delivering drugs and other substances to treat sinusitis and other disorders |
US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
US20100256597A1 (en) * | 2006-05-02 | 2010-10-07 | Emory University | Methods and Devices for Drug Delivery to Ocular Tissue Using Microneedle |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
Non-Patent Citations (1)
Title |
---|
Ãzkiris, Abdullah ("Intravitreal Triamcinolone Acetonide Injection for the Treatment of Posterior Uveitis," Ocular Immunology and Inflammation, Volume 14, 2006 - Issue 4, Pages 233-238 - Abstract attached) * |
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US10913722B2 (en) | 2005-05-26 | 2021-02-09 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US11724987B2 (en) | 2005-05-26 | 2023-08-15 | Aldeyra Therapeutics, Inc. | Compositions and methods of treating retinal disease |
US10071135B2 (en) | 2005-11-23 | 2018-09-11 | Acceleron Pharma Inc. | Method of identifying an agent that promotes bone growth or increases bone density |
US11129873B2 (en) | 2005-11-23 | 2021-09-28 | Acceleron Pharma Inc. | Method for promoting bone growth using activin-actriia antagonists |
US9572865B2 (en) | 2005-11-23 | 2017-02-21 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating multiple myeloma |
US9480742B2 (en) | 2005-11-23 | 2016-11-01 | Acceleron Pharma Inc. | Method of promoting bone growth by an anti-actriia antibody |
US10239940B2 (en) | 2005-11-23 | 2019-03-26 | Acceleron Pharma Inc. | Method of promoting bone growth by an anti-actriia antibody |
US11752101B2 (en) | 2006-02-22 | 2023-09-12 | Clearside Biomedical, Inc. | Ocular injector and methods for accessing suprachoroidal space of the eye |
US11944703B2 (en) | 2006-02-22 | 2024-04-02 | Clearside Biomedical, Inc. | Ocular injector and methods for accessing suprachoroidal space of the eye |
US9926367B2 (en) | 2006-04-07 | 2018-03-27 | Aerpio Therapeutics, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
US11814425B2 (en) | 2006-04-07 | 2023-11-14 | Eye Point Pharmaceuticals, Inc. | Antibodies that bind human protein tyrosine phosphatase beta (HPTPbeta) and uses thereof |
US10463650B2 (en) | 2006-06-27 | 2019-11-05 | Aerpio Pharmaceuticals, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
US9795594B2 (en) | 2006-06-27 | 2017-10-24 | Aerpio Therapeutics, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
USRE46592E1 (en) | 2006-06-27 | 2017-10-31 | Aerpio Therapeutics, Inc. | Human protein tyrosine phosphatase inhibitors and methods of use |
US10093707B2 (en) | 2006-12-18 | 2018-10-09 | Acceleron Pharma Inc. | Antagonists of activin-ActRIIa and uses for increasing red blood cell levels |
US9526759B2 (en) | 2007-02-01 | 2016-12-27 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for treating or preventing breast cancer |
US10259861B2 (en) | 2007-02-02 | 2019-04-16 | Acceleron Pharma Inc. | Variants derived from ActRIIB and uses therefor |
US9399669B2 (en) | 2007-02-02 | 2016-07-26 | Acceleron Pharma Inc. | Variants derived from ActRIIB |
US9353356B2 (en) | 2007-09-18 | 2016-05-31 | Acceleron Pharma Inc. | Activin-actriia antagonists for treating a follicle-stimulating horomone-secreting pituitary tumor |
US11155791B2 (en) | 2008-08-14 | 2021-10-26 | Acceleron Pharma Inc. | Methods for treating anemia in a subject in need thereof |
US10689427B2 (en) | 2008-08-14 | 2020-06-23 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
US11168311B2 (en) | 2008-08-14 | 2021-11-09 | Acceleron Pharma Inc. | Methods for treating anemia in a subject in need thereof |
US10377996B2 (en) | 2008-08-14 | 2019-08-13 | Acceleron Pharma Inc. | Methods of identifying ActRIIB variants |
US11162085B2 (en) | 2008-08-14 | 2021-11-02 | Acceleron Pharma Inc. | Methods for treating anemia in a subject in need thereof |
US10829532B2 (en) | 2008-08-14 | 2020-11-10 | Acceleron Pharma Inc. | Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels |
US9439945B2 (en) | 2008-08-14 | 2016-09-13 | Acceleron Pharma Inc. | Isolated nucleotide sequences encoding GDF traps |
US10829533B2 (en) | 2008-08-14 | 2020-11-10 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
US9932379B2 (en) | 2008-08-14 | 2018-04-03 | Acceleron Pharma Inc. | Isolated nucleotide sequences encoding GDF traps |
US10889626B2 (en) | 2008-08-14 | 2021-01-12 | Acceleron Pharma Inc. | Combined use of GDF traps and erythropoietin receptor activators to increase red blood cell levels |
US9505813B2 (en) | 2008-08-14 | 2016-11-29 | Acceleron Pharma Inc. | Use of GDF traps to treat anemia |
US9745559B2 (en) | 2009-06-12 | 2017-08-29 | Acceleron Pharma Inc. | Method for decreasing the body fat content in a subject by administering an ActRIIB protein |
US11066654B2 (en) | 2009-06-12 | 2021-07-20 | Acceleron Pharma Inc. | Methods and compositions for reducing serum lipids |
US10358633B2 (en) | 2009-06-12 | 2019-07-23 | Acceleron Pharma Inc. | Method for producing an ActRIIB-Fc fusion polypeptide |
US9949956B2 (en) | 2009-07-06 | 2018-04-24 | Aerpio Therapeutics, Inc. | Compounds, compositions, and methods for preventing metastasis of cancer cells |
US9617319B2 (en) | 2009-11-17 | 2017-04-11 | Acceleron Pharma Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
US10968262B2 (en) | 2009-11-17 | 2021-04-06 | Acceleron Pharma Inc. | Methods of increasing sarcolemmal utrophin |
US10952894B2 (en) | 2010-10-15 | 2021-03-23 | Clearside Biomedical, Inc. | Device for ocular access |
US9493556B2 (en) | 2010-11-08 | 2016-11-15 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
US10150811B2 (en) | 2011-10-13 | 2018-12-11 | Aerpio Therapeutics, Inc. | Methods for treating vascular leak syndrome and cancer |
US10815300B2 (en) | 2011-10-13 | 2020-10-27 | Aerpio Pharmaceuticals, Inc. | Methods for treating vascular leak syndrome and cancer |
US10195249B2 (en) | 2012-11-02 | 2019-02-05 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
US9636332B2 (en) * | 2012-11-08 | 2017-05-02 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US9931330B2 (en) | 2012-11-08 | 2018-04-03 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US9572800B2 (en) | 2012-11-08 | 2017-02-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US20160206628A1 (en) * | 2012-11-08 | 2016-07-21 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
US10220048B2 (en) | 2013-03-15 | 2019-03-05 | Aerpio Therapeutics, Inc. | Compositions and methods for treating ocular diseases |
US9937075B2 (en) | 2013-05-03 | 2018-04-10 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US9539139B2 (en) | 2013-05-03 | 2017-01-10 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US9636253B1 (en) | 2013-05-03 | 2017-05-02 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US11559428B2 (en) | 2013-05-03 | 2023-01-24 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US10722396B2 (en) | 2013-05-03 | 2020-07-28 | Clearside Biomedical., Inc. | Apparatus and methods for ocular injection |
US9770361B2 (en) | 2013-05-03 | 2017-09-26 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US10555833B2 (en) | 2013-05-03 | 2020-02-11 | Clearside Biomedical, Inc. | Apparatus and methods for ocular injection |
US10517756B2 (en) | 2013-05-03 | 2019-12-31 | Clearside Biomedical, Inc | Apparatus and methods for ocular injection |
US10188550B2 (en) | 2013-06-03 | 2019-01-29 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using multiple reservoirs |
USD756524S1 (en) * | 2013-08-05 | 2016-05-17 | Xialing Zhang | Protective cover for a subdermal needle electrode cable assembly |
US10226379B2 (en) | 2014-02-12 | 2019-03-12 | Orbit Biomedical Limited | Method and apparatus for subretinal administration of therapeutic agent |
US11058576B2 (en) | 2014-02-12 | 2021-07-13 | Gyroscope Therapeutics Limited | Method and apparatus for subretinal administration of therapeutic agent |
US11554042B2 (en) | 2014-02-12 | 2023-01-17 | Gyroscope Therapeutics Limited | Method and apparatus for subretinal administration of therapeutic agent |
US9994560B2 (en) | 2014-03-14 | 2018-06-12 | Aerpio Therapeutics, Inc. | HPTP-β inhibitors |
US10858354B2 (en) | 2014-03-14 | 2020-12-08 | Aerpio Pharmaceuticals, Inc. | HPTP-Beta inhibitors |
US10639193B2 (en) | 2014-06-06 | 2020-05-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with convergent lumen |
US10821021B2 (en) | 2014-06-06 | 2020-11-03 | Gyroscope Therapeutics Limited | Sub-retinal tangential needle catheter guide and introducer |
US11723798B2 (en) | 2014-06-06 | 2023-08-15 | Gyroscope Therapeutics Limited | Sub-retinal tangential needle catheter guide and introducer |
US11672696B2 (en) | 2014-06-06 | 2023-06-13 | Gyroscope Therapeutics Limited | Therapeutic agent delivery device with convergent lumen |
US9850298B2 (en) | 2014-06-13 | 2017-12-26 | Acceleron Pharma Inc. | Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide |
US11260107B2 (en) | 2014-06-13 | 2022-03-01 | Acceleron Pharma Inc. | Methods and compositions for treating ulcers |
US10487144B2 (en) | 2014-06-13 | 2019-11-26 | Acceleron Pharma Inc. | Methods for treating ulcers in a hemoglobinopathy anemia with a soluble actRIIB polypeptide |
US10219936B2 (en) | 2014-09-11 | 2019-03-05 | Orbit Biomedical Limited | Therapeutic agent delivery device with advanceable cannula and needle |
US11337852B2 (en) | 2014-09-18 | 2022-05-24 | Gyroscope Therapeutics Limited | Therapeutic agent delivery device |
US10588913B2 (en) | 2015-05-08 | 2020-03-17 | Activus Pharma Co., Ltd. | Aqueous suspension agent containing glucocorticosteroid nanoparticles |
US11376262B2 (en) | 2015-05-08 | 2022-07-05 | Activus Pharma Co., Ltd. | Method of treating an inflammatory or infectious disease |
US10980741B2 (en) | 2015-06-06 | 2021-04-20 | Cloudbreak Therapeutics, Llc | Compositions and methods for treating pterygium recurrence |
US10786627B2 (en) * | 2015-06-10 | 2020-09-29 | Sanofi-Aventis Deutschland Gmbh | Device for attachment to a drug delivery device |
US20180353694A1 (en) * | 2015-06-10 | 2018-12-13 | Sanofi-Aventis Deutschland Gmbh | Device for Attachment to a Drug Delivery Device |
US11046650B2 (en) | 2015-08-21 | 2021-06-29 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
US10550085B2 (en) | 2015-08-21 | 2020-02-04 | Aldeyra Therapeutics, Inc. | Deuterated compounds and uses thereof |
US11666558B2 (en) | 2015-09-23 | 2023-06-06 | EyePoint Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
US10952992B2 (en) | 2015-09-23 | 2021-03-23 | Aerpio Pharmaceuticals, Inc. | Methods of treating intraocular pressure with activators of Tie-2 |
WO2017120601A1 (fr) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Méthodes et dispositifs pour le traitement de troubles oculaires postérieurs avec l'aflibercept et d'autres substances biologiques |
WO2017120600A1 (fr) * | 2016-01-08 | 2017-07-13 | Clearside Biomedical, Inc. | Compositions et méthodes de traitement de la dégénérescence maculaire humide liée à l'âge |
US10426790B2 (en) | 2016-02-28 | 2019-10-01 | Aldeyra Therapeutics, Inc. | Treatment of allergic eye conditions with cyclodextrins |
US11338084B2 (en) | 2016-03-09 | 2022-05-24 | Gyroscope Therapeutics Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
US10478553B2 (en) | 2016-03-09 | 2019-11-19 | Orbit Biomedical Limited | Apparatus for subretinal administration of therapeutic agent via a curved needle |
US11197937B2 (en) | 2016-04-15 | 2021-12-14 | The Trustees Of The University Of Pennsylvania | Compositions for treatment of wet age-related macular degeneration |
US11596545B2 (en) | 2016-05-02 | 2023-03-07 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
US11129823B2 (en) | 2016-05-09 | 2021-09-28 | Aldeyra Therapeutics, Inc. | Combination treatment of ocular inflammatory disorders and diseases |
WO2017196881A1 (fr) * | 2016-05-09 | 2017-11-16 | Aldeyra Therapeutics, Inc. | Polythérapie de troubles et de maladies inflammatoires oculaires |
US11246864B2 (en) | 2016-06-02 | 2022-02-15 | Ads Therapeutics Llc | Compositions and methods of using nintedanib for treating ocular diseases with abnormal neovascularization |
US11911379B2 (en) | 2016-06-02 | 2024-02-27 | Ads Therapeutics Llc | Compositions and methods of using nintedanib for treating ocular diseases with abnormal neovascularization |
WO2017210130A1 (fr) * | 2016-06-02 | 2017-12-07 | Cloudbreak Therapeutics, Llc | Compositions et procédés d'utilisation de nintedanib pour améliorer le taux de réussite de la chirurgie du glaucome |
US10335408B2 (en) | 2016-06-02 | 2019-07-02 | Cloudbreak Therapeutics, Llc | Compositions and methods of using nintedanib for improving glaucoma surgery success |
US10688092B2 (en) | 2016-06-02 | 2020-06-23 | Cloudbreak Therapeutics, Llc | Compositions and methods of using nintedanib for improving glaucoma surgery success |
US10646374B2 (en) | 2016-06-17 | 2020-05-12 | Orbit Biomedical Limited | Apparatus and method to form entry bleb for subretinal delivery of therapeutic agent |
US10806630B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
US11000410B2 (en) | 2016-06-17 | 2021-05-11 | Gyroscope Therapeutics Limited | Guide apparatus for tangential entry into suprachoroidal space |
US10806629B2 (en) | 2016-06-17 | 2020-10-20 | Gyroscope Therapeutics Limited | Injection device for subretinal delivery of therapeutic agent |
US10604569B2 (en) | 2016-07-20 | 2020-03-31 | Aerpio Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target protein tyrosine phosphatase-beta (HPTP-β/VE-PTP) |
US11180551B2 (en) | 2016-07-20 | 2021-11-23 | EyePoint Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target VE-PTP (HPTP-beta) |
US11136389B2 (en) | 2016-07-20 | 2021-10-05 | Aerpio Pharmaceuticals, Inc. | Humanized monoclonal antibodies that target VE-PTP (HPTP-β) |
US10597452B2 (en) | 2016-07-20 | 2020-03-24 | Aerpio Pharmaceuticals, Inc. | Methods of treating ocular conditions by administering humanized monoclonal antibodies that target VE-PTP (HPTP-beta) |
US10253094B2 (en) | 2016-07-20 | 2019-04-09 | Aerpio Therapeutics, Inc. | Antibodies that target human protein tyrosine phosphatase-beta (HPTP-beta) and methods of use thereof to treat ocular conditions |
US11278546B2 (en) | 2016-07-22 | 2022-03-22 | Aiviva Biopharma, Inc. | Multikinase inhibitors and uses in ocular fibrosis |
WO2018022437A3 (fr) * | 2016-07-22 | 2018-03-08 | Aiviva Holding Limited | Inhibiteurs multikinases et leurs utilisations dans la fibrose oculaire |
US10973681B2 (en) | 2016-08-12 | 2021-04-13 | Clearside Biomedical, Inc. | Devices and methods for adjusting the insertion depth of a needle for medicament delivery |
US11273072B2 (en) | 2017-01-13 | 2022-03-15 | Gyroscope Therapeutics Limited | Suprachoroidal injection device |
US11076984B2 (en) | 2017-03-13 | 2021-08-03 | Gyroscope Therapeutics Limited | Method of performing subretinal drainage and agent delivery |
US10414732B2 (en) | 2017-03-16 | 2019-09-17 | Aldeyra Therapeutics, Inc. | Polymorphic compounds and uses thereof |
US11040039B2 (en) | 2017-10-10 | 2021-06-22 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
US11583529B2 (en) | 2017-10-10 | 2023-02-21 | Aldeyra Therapeutics, Inc. | Treatment of inflammatory disorders |
WO2019136133A1 (fr) * | 2018-01-03 | 2019-07-11 | The Trustees Of Columbia University In The City Of New York | Micro-aiguille pour l'administration locale d'un agent thérapeutique |
US11844919B2 (en) | 2018-01-03 | 2023-12-19 | The Trustees Of Columbia University In The City Of New York | Microneedle for local delivery of therapeutic agent |
US11724941B2 (en) | 2018-02-15 | 2023-08-15 | North Carolina State University | Synthesis of micron and nanoscale carbon spheres and structures using hydrothemal carbonization |
WO2019217678A1 (fr) * | 2018-05-09 | 2019-11-14 | North Carolina State University | Applicateur pour agents thérapeutiques cornéens |
WO2020028667A1 (fr) * | 2018-08-01 | 2020-02-06 | Nanoneuron Therapeutics, Inc. | Compositions neuroprotectrices et utilisation associée |
US11602533B2 (en) | 2018-12-13 | 2023-03-14 | Arog Pharmaceuticals, Inc. | Crenolanib combination therapy |
WO2020123991A1 (fr) * | 2018-12-13 | 2020-06-18 | Arog Pharmaceuticals, Inc. | Traitement combiné à base de crénolanib |
US11253502B2 (en) | 2019-04-29 | 2022-02-22 | EyePoint Pharmaceuticals, Inc. | Tie-2 activators targeting the Schlemm's canal |
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