US20100135949A1 - Antimicrobial compositions - Google Patents

Antimicrobial compositions Download PDF

Info

Publication number
US20100135949A1
US20100135949A1 US12/397,760 US39776009A US2010135949A1 US 20100135949 A1 US20100135949 A1 US 20100135949A1 US 39776009 A US39776009 A US 39776009A US 2010135949 A1 US2010135949 A1 US 2010135949A1
Authority
US
United States
Prior art keywords
antimicrobial
parts
coating
weight
curable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US12/397,760
Other languages
English (en)
Inventor
David Tien-Tung Ou-Yang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Becton Dickinson and Co
Original Assignee
Becton Dickinson and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Becton Dickinson and Co filed Critical Becton Dickinson and Co
Priority to US12/397,760 priority Critical patent/US20100135949A1/en
Assigned to BECTON, DICKINSON AND COMPANY reassignment BECTON, DICKINSON AND COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OU-YANG, DAVID TIEN-TUNG
Priority to BRPI0922357A priority patent/BRPI0922357A2/pt
Priority to PCT/US2009/065941 priority patent/WO2010065421A1/en
Priority to EP09764419.9A priority patent/EP2370525B1/en
Priority to JP2011539604A priority patent/JP5615289B2/ja
Priority to CN2009801542921A priority patent/CN102272245A/zh
Priority to CA2745191A priority patent/CA2745191C/en
Priority to ES09764419.9T priority patent/ES2618803T3/es
Priority to MX2011005729A priority patent/MX336185B/es
Priority to KR1020117015127A priority patent/KR101691679B1/ko
Priority to AU2009322693A priority patent/AU2009322693B2/en
Publication of US20100135949A1 publication Critical patent/US20100135949A1/en
Priority to ZA2011/04198A priority patent/ZA201104198B/en
Assigned to BECTON, DICKINSON AND COMPANY reassignment BECTON, DICKINSON AND COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: OU-YANG, DAVID TIEN-TUNG
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
    • A61L29/085—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
    • A61L29/16—Biologically active materials, e.g. therapeutic substances
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/02—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by baking
    • B05D3/0254—After-treatment
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/06—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation
    • B05D3/061—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to radiation using U.V.
    • B05D3/065—After-treatment
    • B05D3/067—Curing or cross-linking the coating
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/02—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber
    • B05D7/04—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials to macromolecular substances, e.g. rubber to surfaces of films or sheets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D7/00—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials
    • B05D7/24—Processes, other than flocking, specially adapted for applying liquids or other fluent materials to particular surfaces or for applying particular liquids or other fluent materials for applying particular liquids or other fluent materials
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1811—C10or C11-(Meth)acrylate, e.g. isodecyl (meth)acrylate, isobornyl (meth)acrylate or 2-naphthyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/103—Esters of polyhydric alcohols or polyhydric phenols of trialcohols, e.g. trimethylolpropane tri(meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/104—Esters of polyhydric alcohols or polyhydric phenols of tetraalcohols, e.g. pentaerythritol tetra(meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D4/00—Coating compositions, e.g. paints, varnishes or lacquers, based on organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond ; Coating compositions, based on monomers of macromolecular compounds of groups C09D183/00 - C09D183/16
    • C09D4/06—Organic non-macromolecular compounds having at least one polymerisable carbon-to-carbon unsaturated bond in combination with a macromolecular compound other than an unsaturated polymer of groups C09D159/00 - C09D187/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/14—Paints containing biocides, e.g. fungicides, insecticides or pesticides
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D5/00—Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced; Filling pastes
    • C09D5/16—Antifouling paints; Underwater paints
    • C09D5/1656—Antifouling paints; Underwater paints characterised by the film-forming substance
    • C09D5/1662—Synthetic film-forming substance
    • C09D5/1668—Vinyl-type polymers
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M105/00—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound
    • C10M105/08—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound containing oxygen
    • C10M105/20—Aldehydes; Ketones
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M105/00—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound
    • C10M105/08—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound containing oxygen
    • C10M105/32—Esters
    • C10M105/40—Esters containing free hydroxy or carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M105/00—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound
    • C10M105/56—Lubricating compositions characterised by the base-material being a non-macromolecular organic compound containing nitrogen
    • C10M105/58—Amines, e.g. polyalkylene polyamines, quaternary amines
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
    • C10M125/04—Metals; Alloys
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
    • C10M125/06—Sulfur
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
    • C10M125/16—Hydrogen peroxide; Oxygenated water
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
    • C10M125/20—Compounds containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M125/00—Lubricating compositions characterised by the additive being an inorganic material
    • C10M125/26—Compounds containing silicon or boron, e.g. silica, sand
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M129/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen
    • C10M129/02—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing oxygen having a carbon chain of less than 30 atoms
    • C10M129/24—Aldehydes; Ketones
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M133/00—Lubricating compositions characterised by the additive being an organic non-macromolecular compound containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M169/00—Lubricating compositions characterised by containing as components a mixture of at least two types of ingredient selected from base-materials, thickeners or additives, covered by the preceding groups, each of these compounds being essential
    • C10M169/04—Mixtures of base-materials and additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/206—Biguanides, e.g. chlorohexidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/204—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials with nitrogen-containing functional groups, e.g. aminoxides, nitriles, guanidines
    • A61L2300/208—Quaternary ammonium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/10—Esters
    • C08F220/12—Esters of monohydric alcohols or phenols
    • C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
    • C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
    • C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F222/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides, or nitriles thereof
    • C08F222/10—Esters
    • C08F222/1006—Esters of polyhydric alcohols or polyhydric phenols
    • C08F222/102—Esters of polyhydric alcohols or polyhydric phenols of dialcohols, e.g. ethylene glycol di(meth)acrylate or 1,4-butanediol dimethacrylate
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2201/00—Inorganic compounds or elements as ingredients in lubricant compositions
    • C10M2201/10—Compounds containing silicon
    • C10M2201/105—Silica
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2205/00—Organic macromolecular hydrocarbon compounds or fractions, whether or not modified by oxidation as ingredients in lubricant compositions
    • C10M2205/14—Synthetic waxes, e.g. polythene waxes
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
    • C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
    • C10M2215/04—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to acyclic or cycloaliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2215/00—Organic non-macromolecular compounds containing nitrogen as ingredients in lubricant compositions
    • C10M2215/02—Amines, e.g. polyalkylene polyamines; Quaternary amines
    • C10M2215/06—Amines, e.g. polyalkylene polyamines; Quaternary amines having amino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10M—LUBRICATING COMPOSITIONS; USE OF CHEMICAL SUBSTANCES EITHER ALONE OR AS LUBRICATING INGREDIENTS IN A LUBRICATING COMPOSITION
    • C10M2229/00—Organic macromolecular compounds containing atoms of elements not provided for in groups C10M2205/00, C10M2209/00, C10M2213/00, C10M2217/00, C10M2221/00 or C10M2225/00 as ingredients in lubricant compositions
    • C10M2229/04—Siloxanes with specific structure
    • C10M2229/05—Siloxanes with specific structure containing atoms other than silicon, hydrogen, oxygen or carbon
    • C10M2229/051—Siloxanes with specific structure containing atoms other than silicon, hydrogen, oxygen or carbon containing halogen
    • C10M2229/0515—Siloxanes with specific structure containing atoms other than silicon, hydrogen, oxygen or carbon containing halogen used as base material
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2020/00—Specified physical or chemical properties or characteristics, i.e. function, of component of lubricating compositions
    • C10N2020/01—Physico-chemical properties
    • C10N2020/055—Particles related characteristics
    • C10N2020/06—Particles of special shape or size
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2030/00—Specified physical or chemical properties which is improved by the additive characterising the lubricating composition, e.g. multifunctional additives
    • C10N2030/16—Antiseptic; (micro) biocidal or bactericidal
    • C—CHEMISTRY; METALLURGY
    • C10—PETROLEUM, GAS OR COKE INDUSTRIES; TECHNICAL GASES CONTAINING CARBON MONOXIDE; FUELS; LUBRICANTS; PEAT
    • C10N—INDEXING SCHEME ASSOCIATED WITH SUBCLASS C10M RELATING TO LUBRICATING COMPOSITIONS
    • C10N2040/00—Specified use or application for which the lubricating composition is intended
    • C10N2040/50—Medical uses

Definitions

  • the present invention relates to antimicrobial compositions and methods for use of those compositions in various medical applications.
  • One of the major challenges of modern medical treatment is control of infection and the spread of microbial organisms.
  • Infusion therapy is one of the most common health care procedures. Hospitalized, home care, and other patients receive fluids, pharmaceuticals, and blood products via a vascular access device inserted into the vascular system. Infusion therapy may be used to treat an infection, provide anesthesia or analgesia, provide nutritional support, treat cancerous growths, maintain blood pressure and heart rhythm, or many other clinically significant uses.
  • vascular access device may access a patient's peripheral or central vasculature.
  • the vascular access device may be indwelling for short term (days), moderate term (weeks), or long term (months to years).
  • the vascular access device may be used for continuous infusion therapy or for intermittent therapy.
  • a common vascular access device is a plastic catheter that is inserted into a patient's vein.
  • the catheter length may vary from a few centimeters for peripheral access, to many centimeters for central access and may included devices such as peripherally inserted central catheters (PICC).
  • PICC peripherally inserted central catheters
  • the catheter may be inserted transcutaneously or may be surgically implanted beneath the patient's skin.
  • the catheter, or any other vascular access device attached thereto, may have a single lumen or multiple lumens for infusion of many fluids simultaneously.
  • the vascular access device commonly includes a Luer adapter to which other medical devices may be attached.
  • an administration set may be attached to a vascular access device at one end and an intravenous (IV) bag at the other.
  • the administration set is a fluid conduit for the continuous infusion of fluids and pharmaceuticals.
  • an IV access device is a vascular access device that may be attached to another vascular access device, closes the vascular access device, and allows for intermittent infusion or injection of fluids and pharmaceuticals.
  • An IV access device may include a housing and a septum for closing the system. The septum may be opened with a blunt cannula or a male Luer of a medical device.
  • CBSI catheter related blood stream infection
  • CVC central venous catheter
  • a vascular access device may serve as a nidus of infection, resulting in a disseminated BSI (blood stream infection). This may be caused by failure to regularly flush the device, a non-sterile insertion technique, or by pathogens that enter the fluid flow path through either end of the path subsequent to catheter insertion.
  • BSI blood stream infection
  • pathogens adhere to the vascular access device, colonize, and form a biofilm.
  • the biofilm is resistant to most biocidal agents and provides a replenishing source for pathogens to enter a patient's bloodstream and cause a BSI.
  • devices with antimicrobial properties are needed.
  • One approach to preventing biofilm formation and patient infection is to provide an antimicrobial coating on various medical devices and components.
  • Many medical devices are made with either metallic or polymeric materials. These materials usually have a high coefficient of friction.
  • a low molecular weight material or liquid with a low coefficient of friction is usually compounded into the bulk of the materials or coated onto the surface of the substrates to help the functionality of the devices.
  • thermoplastic polyurethane solution As the carrier for antimicrobial coatings.
  • the solvent is usually tetrahydrofuran (THF), dimethylformamide (DMF), or a blend of both. Because THF can be oxidized very quickly and tends to be very explosive, an expensive explosion-proof coating facility is necessary.
  • THF tetrahydrofuran
  • DMF dimethylformamide
  • SBR styrene-butadiene rubber
  • One of the most commonly used antimicrobial agents used in coating medical device is silver.
  • Silver salts and silver element are well known antimicrobial agents in both the medical surgical industry and general industries. They are usually incorporated into the polymeric bulk material or coated onto the surface of the medical devices by plasma, heat evaporation, electroplating, or by conventional solvent coating technologies. These technologies are tedious, expensive, and not environmentally friendly.
  • the performance of silver coated medical devices is mediocre at best. For example, it can take up to eight (8) hours before the silver ion, ionized from the silver salts or silver element, to reach efficacy as an antimicrobial agent. As a result, substantial microbial activity can occur prior to the silver coating even becoming effective. Furthermore, the silver compound or silver element has an unpleasant color, from dark amber to black.
  • compositions for providing antimicrobial capability to medical devices of various types, and particularly devices related to infusion therapy there is a need in the art for improved compositions for providing antimicrobial capability to medical devices of various types, and particularly devices related to infusion therapy.
  • an effective antimicrobial coating that can be easily applied to medical devices constructed of polymeric materials and metals.
  • improved methods of applying such antimicrobial coatings to medical devices are also a need for improved methods of applying such antimicrobial coatings to medical devices.
  • the present invention has been developed in response to problems and needs in the art that have not yet been fully resolved by currently available antimicrobial compositions and methods.
  • these compositions and methods are developed to reduce complications, such as the risk and occurrence of CRBSIs, by providing improved antimicrobial compositions and methods for use in conjunction with medical devices.
  • the present invention relates to ultraviolet (UV) (wavelength of approximately 200 nm to 600 nm)-curable coatings that have antimicrobial properties.
  • the coatings may be cured by light in the range set forth above, namely from about 200 nm to about 600 nm. In some embodiments, it may be preferable to cure the composition with light in the range of from about 300 nm to about 450 nm.
  • These coatings are particularly adaptable for use on medical devices, particularly intravascular access devices like needleless valves.
  • the medical devices are often comprised of polymeric substrates, especially polycarbonate (PC), polyurethane (PU), polyvinyl chloride (PVC), styrene-butadiene rubber (SBR), and acrylics.
  • the surfaces of such devices are coated with a UV-curable coating (sometimes hereinafter referred to as “UV coating”) which comprises a UV curable composition and addition components incorporated therein such as antimicrobial agents uniformly distributed throughout its matrix.
  • UV coating which comprises a UV curable composition and addition components incorporated therein such as antimicrobial agents uniformly distributed throughout its matrix.
  • the antimicrobial agents are able to diffuse through the matrix and kill microscopic organisms that come in contact with the coating surface.
  • the antimicrobial agents which are uniformly distributed in the UV coating matrix, gradually diffuse out of the matrix when the matrix is softened by IV fluids. The antimicrobial agents are then available to kill the microbes that come in contact with the coating surface.
  • the formulations of this invention are generally comprised of a combination of urethane or polyester-type oligomer with acrylate-type functional groups, acrylate-type monomers, photoinitiators, rheological modifiers, and antimicrobial agents.
  • the nano- or micro-sized particles of the antimicrobial agents are uniformly and permanently distributed throughout the whole coating matrix.
  • the coatings are solventless and can be sprayed, wiped, dipped or distributed by using other conventional coating methods to coat a substrate's surface. They can then be rapidly cured with ultraviolet light. Curing may be completed in seconds or minutes depending on the formulation and curing conditions.
  • the coatings of the present invention are generally efficacious within minutes instead of hours as with conventional coatings.
  • the coatings also generally have a pleasant light color or an even clear color.
  • oligomers can be used within the scope of the present invention. It is only necessary that the oligomer be capable of UV curing and of carrying antimicrobial agents of the type described herein.
  • the oligomers can be acrylated aliphatic urethanes, acrylated aromatic urethanes, acrylated polyesters, unsaturated polyesters, acrylated polyethers, acrylated acrylics, and the like, or combinations of the above.
  • the acrylated functional group can be mono-functional, di-functional, tri-functional, tetra-functional, penta-functional, or hexa-functional.
  • the monomers can be 2-ethyl hexyl acrylate, isooctyl acrylate, isobornylacrylate, 1,6-hexanediol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, pentaerythritol tetra acrylate, penta erythritol tri acrylate, dimethoxy phenyl acetophenone hexyl methyl acrylate, 1,6 hexanidiol methacrylate, and the like, or combinations of these compounds.
  • the composition should be provided with an adequate and compatible photoinitiator.
  • the photoinitiators can be: 1) single molecule cleavage type, such as benzoin ethers, acetophenones, benzoyl oximes, and acyl phosphine oxide, and 2) hydrogen abstraction type, such as Michler's ketone, thioxanthone, anthroguionone, benzophenone, methyl diethanol amine, 2-N-butoxyethyl-4-(dimethylamino) benzoate, and the like, or combinations of these materials.
  • a rheological modifier can preferrably be added to the composition.
  • the rheological modifier allows the flow characteristics of the composition to be controlled and modified as desired.
  • the rheological modifier can also aid in the uniform distribution of antimicrobial agent and other materials within the composition.
  • Suitable rheological modifiers may include organic clay, castor wax, polyamide wax, polyurethane, and fumed silica or combinations of these materials.
  • antimicrobial agents may be used in the compositions of the present invention. It is only necessary that the antimicrobial agent be compatible with the other components of the compositions and that it be effective in controlling microbial agents. Specifically, it is preferred that that antimicrobial agent not chemically react with the other components of the composition. As discussed above, in certain embodiments it is preferred that the antimicrobial agent be capable of moving within the matrix of the composition such that it can be delivered to the site of the microbial agent. Examples of suitable antimicrobial agents within the scope of the present invention include be aldehydes, anilides, biguanides, silver element or its compounds, bis-phenols, and quaternary ammonium compounds and the like or combinations of the above.
  • the invention may be solventless.
  • many conventional coatings employ harsh solvents such as THF and DMF.
  • the present invention is operable without the use of solvents and, therefore, avoids the difficulties presented by the use of conventional solvents.
  • the formulations demonstrate good adhesion to numerous plastic surfaces (such as PC, PU, PVC, acrylics, and SBR).
  • the formulation can be cured with adequate ultraviolet light (wavelength of approximately 200 nm to 600 nm, and in certain embodiments in the range of from about 300 nm to about 450 nm).
  • the present invention provides antimicrobial coating compositions which overcome many of the limitations of existing technology.
  • the present invention employs known components which have achieved acceptance for medical use. These components are combined and used easily and efficiently.
  • the compositions of the present invention generally including oligomers, monomers, photoinitiators, rheological modifiers, and suitable antimicrobial agents. The resulting compositions are easily applied to the surfaces of medical devices and quickly cured by UV light.
  • an antimicrobial ultra violet (UV)-curable coating comprising a UV curable composition comprising an oligomer, a monomer, and a photoinitiator which are together capable of forming a UV curable polymer composition.
  • the composition may also include a rheology modifier in order to improve the flow characteristics of the composition and uniform distribution of components within the compositions.
  • an effective antimicrobial agent incorporated within the UV curable coating compositions is an effective antimicrobial agent.
  • the UV curable coating compositions are comprised primarily of one or more oligomers and one or more monomers, combined with one or more suitable photoinitiators.
  • the UV curable coating composition will comprise 100 parts by weight.
  • Materials added to the UV curable coating composition may include rheological modifiers, antimicrobial agents, and other additives. These materials will be defined in parts by weight added to 100 parts by weight of the UV curable coating composition.
  • the oligomer is generally selected from the group consisting of acrylated aliphatic urethanes, acrylated aromatic urethanes, acrylated polyesters, unsaturated polyesters, acrylated polyethers, acrylated acrylics, and the like, or combinations thereof.
  • the acrylated functional group is selected from the group consisting of mono-functional, di-functional, tri-functional, tetra-functional, penta-functional, and hexa-functional acrylates. Any oligomer which is compatible with the other components of the composition is usable within the scope of the present invention.
  • the oligomer will typically comprise from about 10% to about 90% of the UV curable composition. In some embodiments the oligomer will comprise from about 20% to about 80% of the UV curable composition. In certain embodiments of the invention the oligomer will comprise from about 30% to about 70% of the UV curable composition.
  • the monomer is selected from the group consisting of 2-ethyl hexyl acrylate, isooctyl acrylate, isobornylacrylate, 1,6-hexanediol diacrylate, diethylene glycol diacrylate, triethylene glycol diacrylate, pentaerythritol tetra acrylate, penta erythritol tri acrylate, dimethoxy phenyl acetophenone hexyl methyl acrylate, 1,6 hexanidiol methacrylate and the like, or combinations of these compounds.
  • any monomer which is compatible with the other components of the composition is usable within the scope of the present invention.
  • the monomer will typically comprise from about 5% to about 90% of the UV curable composition. In some embodiments the monomer will comprise from about 10% to about 75% of the UV curable composition. In certain embodiments of the invention the monomer will comprise from about 20% to about 60% of the UV curable composition.
  • the photoinitiator is selected from the group consisting of single molecule cleavage type, such as benzoin ethers, acetophenones, benzoyl oximes, and acyl phosphine oxide, and hydrogen abstraction types consisting of Michler's ketone, thioxanthone, anthroguionone, benzophenone, methyl diethanol amine, and 2-N-butoxyethyl-4-(dimethylamino) benzoate.
  • the photoinitiaor will also be selected such that it is compatible with the other components of the composition is usable within the scope of the present invention.
  • the photoinitiator will typically comprise from about 0.5% to about 10% of the UV curable composition. In some embodiments the photoinitiator will comprise from about 1% to about 8.5% of the UV curable composition. In certain embodiments of the invention the photoinitiator will comprise from about 2% to about 7% of the UV curable composition.
  • UV curable composition As mentioned above, certain additional components are added to the UV curable composition. Prominent among these are suitable rheological modifiers and antimicrobial agents. As mentioned above, the amounts of these additional components will be expressed in parts by weight added to 100 parts by weight of UV-curable composition.
  • the rheological modifier is selected from the group consisting of organic clay, castor wax, polyamide wax, polyurethane, and fumed silica.
  • the Theological modifier generally comprises from about 0.1 to about 30 parts by weight added to 100 parts by weight of UV curable composition, i.e. the UV curable composition is 100 weight units, while the rheological modifier comprises from about 0.1 to about 30 parts of additional weight.
  • the rheological modifier comprises from 0.1 to about 20 parts by weight compared to 100 parts by weight of the UV curable composition.
  • the Theological modifier comprises from about 0.2 to about 10 parts by weight compared to 100 parts by weight of the UV curable composition.
  • the antimicrobial agent is generally selected from the group consisting of aldehydes, anilides, biguanides, silver, silver compound, bis-phenols, and quaternary ammonium compounds.
  • the antimicrobial agent is generally present in the amount of from about 0.5 to about 50 parts by weight in compared to 100 parts by weight of the UV curable composition. In other embodiments, the antimicrobial agent may be present in the amount of from about 0.5 to about 30 parts by weight of the composition. In certain further embodiments, the antimicrobial agent is present in the amount of from about 0.5 to about 20 parts by weight.
  • the antimicrobial agent may either dissolve in the UV curable composition or may be uniformly distributed therein. In this manner it is found that sufficient antimicrobial agent can migrate within the composition to contact the location of microbial activity. In any event, it is preferred that the antimicrobial agent not react chemically with the other components of the compositions.
  • the UV coating formulations can be urethane or polyester type arylate such as 7104, 7101, 7124-K, 7105-5K from Electronic Materials Inc. (EMI) (EM Breckenridge, Co.), 1168-M, I-20781 from Dymax Corporation (Torrington, Conn.), UV 630 from Permabond Engineering Adhesives (Somerset, N.J.).
  • the viscosity of the coating should be less than 10,000 cps, preferable below 5,000 cps, and most preferably between 20 to 1,000 cps.
  • UV-curable compositions within the scope of the present invention were formulated and their microbial kill rate and zone of inhibition were tested as set forth in Table 1 below. Each of the compositions was essentially identical except for the antimicrobial agent which was varied as set forth below.
  • the composition was comprised of a UV curable composition designated EMI 7104.
  • the UV curable composition was comprised of 30-70% oligomer, 20-60% monomer; 2-7% photoinitiator. Added to 100 parts of the UV curable composition was 2.6 parts fumed silica obtained from Cabot and designated Cabot's MS-55. Also added was 7.2 parts antimicrobial agent.
  • the specific antimicrobial agent was used in the formulation were as follows:
  • composition was tested on three (3) microbial agents, namely: Staphylococcus epidermidis (gram positive bacteria), Pseudomonas aeruginosa (gram negative bacteria), and Candida albicans (yeast or fungi). The results are summarized in Table 1.
  • compositions were generally effective in killing the bacterial agents. All of the compositions, except that containing silver element, were effective in killing Candida albicans with one (1) hour. As set forth in Table 1 is appears that cetyl pyridium chloride and cetrimide were generally more effective than the other antimicrobial agents.
  • UV curable coating compositions within the scope of the present invention.
  • Each of the formulations included 100 parts of 7104 UV coating, 2.6 parts of fumed silica [designed M-5], and 5.0 parts of antimicrobial agent.
  • Silver and chlorhexidine were included in the test because they are commonly used antimicrobial agents being used in medical technologies. The results of these tests are set forth in Table 2.
  • formulation #1 cetyl pyridium chloride
  • formulation #4 chlorhexidine diacetate
  • both conventional compositions had 100% contact kill for selected microbes only after about 8 hours (both are using silver compound or silver element as the agent).
  • Table 5 shows that the four agents identified above can have 100% contact kill within 1 hour and last up to almost 4 days when using S. epidermidis as the microbe. However, conventional silver agent formulations have no 1 hour contact kill at all starting from day 1.
  • UV-curable composition was varied using various proprietary formulations manufactured by EMI.
  • Antimicrobial activity was measured and compared to elongation at break. The data is as follows:

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Inorganic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Plant Pathology (AREA)
  • Emergency Medicine (AREA)
  • Metallurgy (AREA)
  • Materials For Medical Uses (AREA)
  • Paints Or Removers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Lubricants (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
US12/397,760 2008-12-01 2009-03-04 Antimicrobial compositions Abandoned US20100135949A1 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
US12/397,760 US20100135949A1 (en) 2008-12-01 2009-03-04 Antimicrobial compositions
AU2009322693A AU2009322693B2 (en) 2008-12-01 2009-11-25 Antimicrobial UV curable coating compositions
CA2745191A CA2745191C (en) 2008-12-01 2009-11-25 Antimicrobial uv curable coating compositions
MX2011005729A MX336185B (es) 2008-12-01 2009-11-25 Composiciones antimicrobianas con revestimiento curable por uv.
EP09764419.9A EP2370525B1 (en) 2008-12-01 2009-11-25 A solventless antimicrobial uv curable coating compositions
JP2011539604A JP5615289B2 (ja) 2008-12-01 2009-11-25 抗菌性ｕｖ硬化性コーティング組成物
CN2009801542921A CN102272245A (zh) 2008-12-01 2009-11-25 抗微生物的uv可固化涂料组合物
BRPI0922357A BRPI0922357A2 (pt) 2008-12-01 2009-11-25 composições de revestimento curáveis uv antimicrobianas
ES09764419.9T ES2618803T3 (es) 2008-12-01 2009-11-25 Composiciones de recubrimiento curables por UV antimicrobianas sin disolvente
PCT/US2009/065941 WO2010065421A1 (en) 2008-12-01 2009-11-25 Antimicrobial uv curable coating compositions
KR1020117015127A KR101691679B1 (ko) 2008-12-01 2009-11-25 항미생물성 자외선 경화성 코팅 조성물
ZA2011/04198A ZA201104198B (en) 2008-12-01 2011-06-06 Antimicrobial uv curable coating compositions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11898808P 2008-12-01 2008-12-01
US12/397,760 US20100135949A1 (en) 2008-12-01 2009-03-04 Antimicrobial compositions

Publications (1)

Publication Number Publication Date
US20100135949A1 true US20100135949A1 (en) 2010-06-03

Family

ID=42223012

Family Applications (5)

Application Number Title Priority Date Filing Date
US12/397,760 Abandoned US20100135949A1 (en) 2008-12-01 2009-03-04 Antimicrobial compositions
US12/436,404 Active 2030-03-23 US8426348B2 (en) 2008-12-01 2009-05-06 Antimicrobial lubricant compositions
US12/476,997 Active 2029-07-06 US8691887B2 (en) 2008-12-01 2009-06-02 Antimicrobial coating compositions
US12/490,235 Abandoned US20100136209A1 (en) 2008-12-01 2009-06-23 Systems and methods for applying an antimicrobial coating to a medical device
US13/867,901 Active US8754020B2 (en) 2008-12-01 2013-04-22 Antimicrobial lubricant compositions

Family Applications After (4)

Application Number Title Priority Date Filing Date
US12/436,404 Active 2030-03-23 US8426348B2 (en) 2008-12-01 2009-05-06 Antimicrobial lubricant compositions
US12/476,997 Active 2029-07-06 US8691887B2 (en) 2008-12-01 2009-06-02 Antimicrobial coating compositions
US12/490,235 Abandoned US20100136209A1 (en) 2008-12-01 2009-06-23 Systems and methods for applying an antimicrobial coating to a medical device
US13/867,901 Active US8754020B2 (en) 2008-12-01 2013-04-22 Antimicrobial lubricant compositions

Country Status (12)

Country Link
US (5) US20100135949A1 (ko)
EP (4) EP2370559B1 (ko)
JP (4) JP6022771B2 (ko)
KR (4) KR20110099293A (ko)
CN (4) CN102272274B (ko)
AU (4) AU2009322693B2 (ko)
BR (4) BRPI0922357A2 (ko)
CA (4) CA2745191C (ko)
ES (3) ES2618803T3 (ko)
MX (4) MX336185B (ko)
WO (4) WO2010065422A1 (ko)
ZA (3) ZA201104198B (ko)

Cited By (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100137472A1 (en) * 2008-12-01 2010-06-03 Becton, Dickinson And Company Antimicrobial coating compositions
US20130310764A1 (en) * 2012-05-15 2013-11-21 Becton, Dickinson And Company Blood control iv catheter with antimicrobial properties
US20140228466A1 (en) * 2013-02-13 2014-08-14 Becton, Dickinson And Company Uv curable solventless antimicrobial compositions
US8821455B2 (en) 2009-07-09 2014-09-02 Becton, Dickinson And Company Antimicrobial coating for dermally invasive devices
WO2015164129A2 (en) 2014-04-23 2015-10-29 Becton, Dickinson And Company Antimicrobial caps for medical connectors
WO2015164130A2 (en) 2014-04-23 2015-10-29 Becton, Dickinson And Company Antimicrobial stopcock medical connector
WO2015164132A2 (en) 2014-04-23 2015-10-29 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
US20160008569A1 (en) * 2014-07-08 2016-01-14 Becton, Dickinson And Company Antimicrobial actuator for opening the side port of a ported catheter
WO2016007439A1 (en) * 2014-07-08 2016-01-14 Becton, Dickinson And Company Antimicrobial coating forming kink resistant feature on a vascular access device
US9327095B2 (en) 2013-03-11 2016-05-03 Becton, Dickinson And Company Blood control catheter with antimicrobial needle lube
US9579486B2 (en) 2012-08-22 2017-02-28 Becton, Dickinson And Company Blood control IV catheter with antimicrobial properties
US9750927B2 (en) 2013-03-11 2017-09-05 Becton, Dickinson And Company Blood control catheter with antimicrobial needle lube
US9750928B2 (en) 2013-02-13 2017-09-05 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
US9789279B2 (en) 2014-04-23 2017-10-17 Becton, Dickinson And Company Antimicrobial obturator for use with vascular access devices
US10004890B2 (en) 2015-01-27 2018-06-26 Becton, Dickinson And Company Antimicrobial inserts for stopcock medical connectors
US20180213789A1 (en) * 2015-07-24 2018-08-02 Teleflex Medical Incorporated Antimicrobial compositions for surgical applications
US10266705B2 (en) * 2013-02-01 2019-04-23 Croda International Plc Self-disinfecting surfaces
US10493244B2 (en) 2015-10-28 2019-12-03 Becton, Dickinson And Company Extension tubing strain relief
US10543354B2 (en) 2017-09-27 2020-01-28 Becton, Dickinson And Company Peripheral intravenous catheters having flow diverting features
CN111282777A (zh) * 2020-03-26 2020-06-16 苏州微比特自动化有限公司 一种涂覆固化产线
US10792399B2 (en) 2014-02-20 2020-10-06 Becton, Dickinson And Company Antimicrobial inserts for medical devices
US10792398B2 (en) 2014-02-20 2020-10-06 Becton, Dickinson And Company Antimicrobial inserts for medical devices
US10882085B2 (en) 2012-11-19 2021-01-05 Massachusetts Institute Of Technology Apparatus and methods employing liquid-impregnated surfaces
US10968035B2 (en) 2012-03-23 2021-04-06 Massachusetts Institute Of Technology Self-lubricating surfaces for food packaging and food processing equipment
US11058803B2 (en) 2012-05-24 2021-07-13 Massachusetts Institute Of Technology Medical devices and implements with liquid-impregnated surfaces
US11492500B2 (en) 2012-11-19 2022-11-08 Massachusetts Institute Of Technology Apparatus and methods employing liquid-impregnated surfaces
US11850331B2 (en) 2013-03-11 2023-12-26 Teleflex Medical Incorporated Devices with anti-thrombogenic and anti-microbial treatment
US11933551B2 (en) 2011-08-05 2024-03-19 Massachusetts Institute Of Technology Liquid-impregnated surfaces, methods of making, and devices incorporating the same

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11229746B2 (en) 2006-06-22 2022-01-25 Excelsior Medical Corporation Antiseptic cap
US9078992B2 (en) 2008-10-27 2015-07-14 Pursuit Vascular, Inc. Medical device for applying antimicrobial to proximal end of catheter
US11219706B2 (en) 2009-03-11 2022-01-11 Arrow International Llc Enhanced formulations for coating medical devices
US20140314818A1 (en) * 2009-03-11 2014-10-23 Arrow International, Inc. Novel Enhanced Formulations for Coating Medical Devices
NZ602911A (en) 2010-04-28 2015-01-30 Univ Georgia Photochemical cross-linkable polymers, methods of marking photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
US20110301553A1 (en) * 2010-06-04 2011-12-08 Smiths Medical Asd, Inc. Antimicrobial lubricant
KR101420581B1 (ko) 2010-09-10 2014-07-16 헨켈 코포레이션 단열 특성이 있는 개선된 접착제
WO2014089680A1 (en) 2012-12-11 2014-06-19 Nano Safe Coatings Incorporated (A Florida Corporation 3 P14000024914) Uv cured benzophenone terminated quaternary ammonium antimicrobials for surfaces
US8257827B1 (en) 2011-06-02 2012-09-04 The Regents Of The University Of California Silicone composition and devices incorporating same
CN106902405B (zh) 2011-07-12 2020-12-11 Icu医学有限公司 用于将抗微生物剂递送到经皮导管中的装置
WO2013019917A2 (en) * 2011-08-04 2013-02-07 The University Of Georgia Research Foundation, Inc. Permanent attachment of ammonium and guanidine-based antimicrobials to surfaces containing c-h functionality
CA2852999A1 (en) 2011-10-14 2013-04-18 University Of Georgia Research Foundation, Inc. Photochemical cross-linkable polymers, methods of making photochemical cross-linkable polymers, methods of using photochemical cross-linkable polymers, and methods of making articles containing photochemical cross-linkable polymers
JP5935133B2 (ja) * 2012-03-29 2016-06-15 フジコピアン株式会社 ハードコートフィルム
US20130255061A1 (en) * 2012-04-03 2013-10-03 Becton, Dickinson And Company Systems and methods for applying a novel antimicrobial coating material to a medical device
CA2874096C (en) * 2012-05-24 2021-11-09 Massachusetts Institute Of Technology Apparatus with a liquid-impregnated surface
WO2014028203A1 (en) * 2012-08-14 2014-02-20 Henkel US IP LLC Moisture and vapor barrier coating compositions
KR101398301B1 (ko) * 2012-09-25 2014-05-27 주식회사 신바람 좁은 공간을 활용할 수 있는 다용도 수납형 문
US20150027920A1 (en) * 2013-07-25 2015-01-29 Dennis Christopher Riordan Medicine cup with infection control tab
US8877882B1 (en) 2013-10-04 2014-11-04 Rochal Industries Llp Non-self-adherent coating materials
GB201322453D0 (en) * 2013-12-18 2014-02-05 Dow Corning Antifriction coating
SG10202006371TA (en) 2014-04-18 2020-08-28 Becton Dickinson Co Needle capture safety interlock for catheter
US20160073937A1 (en) * 2014-09-11 2016-03-17 Becton, Dickinson And Company Blood sampling system for improving draw success and reducing hemolysis
KR101641857B1 (ko) * 2014-11-26 2016-07-22 삼화페인트공업주식회사 자외선 경화형 항균 도료 조성물
MX2017013301A (es) 2015-04-17 2018-03-01 Becton Dickinson Co Enclavamiento de seguridad de captura de aguja para cateter.
EP3294404A4 (en) 2015-05-08 2018-11-14 ICU Medical, Inc. Medical connectors configured to receive emitters of therapeutic agents
BR112018003786B1 (pt) 2015-08-27 2022-05-17 Nano Safe Coatings Incorporated (A Florida Corporation 3 P 14000024914) Preparação de antimicrobianos contendo sulfonamida e composições de tratamento de substrato de antimicrobianos contendo sulfonamida
ES2792025T3 (es) 2015-10-28 2020-11-06 Carefusion 303 Inc Dispositivo de acceso IV cerrado con puerto y conector sin aguja
KR101680003B1 (ko) 2016-01-26 2016-11-25 (주)한도기공 압출스크류와 압출다이의 대칭 결합 구조를 갖는 혼련용 자동 믹싱롤
DE102016108198A1 (de) * 2016-05-03 2017-11-09 B. Braun Avitum Ag Medizintechnisches Gerät mit antimikrobieller Oberflächenbeschichtung sowie Verfahren zur Bekämpfung von Mikroorganismen auf der Oberfläche eines solchen Geräts
SI3525865T1 (sl) 2016-10-14 2023-01-31 Icu Medical, Inc. Razkuževalni pokrovčki za medicinske konektorje
WO2018136274A1 (en) * 2017-01-20 2018-07-26 Medivators Inc. Disposable valve for an endoscope having a lubricant and/or antimicrobial
USD852368S1 (en) 2017-03-27 2019-06-25 Avery Dennison Corporation Catheter dressing
WO2018204206A2 (en) 2017-05-01 2018-11-08 Icu Medical, Inc. Medical fluid connectors and methods for providing additives in medical fluid lines
KR102193014B1 (ko) * 2017-10-11 2020-12-18 주식회사 엘지화학 항균성 고분자 코팅 조성물 및 항균성 고분자 필름
US10994101B2 (en) * 2018-03-02 2021-05-04 Becton, Dickinson And Company Catheter assembly with high viscosity lubricant and related methods
KR102112057B1 (ko) * 2018-07-13 2020-05-18 (주)유니드 항균성, 항곰팡이성 및 고기능성 코팅액 조성물 및 이를 이용한 제품
US11613719B2 (en) 2018-09-24 2023-03-28 Becton, Dickinson And Company Self-lubricating medical articles
CN110938365A (zh) * 2018-09-25 2020-03-31 天津大学 一种水性聚氨酯抗菌涂料及其制备方法
CN110938359A (zh) * 2018-09-25 2020-03-31 天津大学 利用亲水性扩链剂提高聚氨酯涂料抗菌性能的方法
US11541220B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Needleless connector with antimicrobial properties
US11400195B2 (en) 2018-11-07 2022-08-02 Icu Medical, Inc. Peritoneal dialysis transfer set with antimicrobial properties
US11534595B2 (en) 2018-11-07 2022-12-27 Icu Medical, Inc. Device for delivering an antimicrobial composition into an infusion device
US11517732B2 (en) 2018-11-07 2022-12-06 Icu Medical, Inc. Syringe with antimicrobial properties
US11541221B2 (en) 2018-11-07 2023-01-03 Icu Medical, Inc. Tubing set with antimicrobial properties
JP6838037B2 (ja) * 2018-11-16 2021-03-03 イビデン株式会社 抗ウィルス性硬化物の固着方法および抗ウィルス性部材の製造方法
JP2022513096A (ja) 2018-11-21 2022-02-07 アイシーユー・メディカル・インコーポレーテッド リング及びインサートを有するキャップを備える抗菌装置
CN110041199B (zh) * 2019-01-23 2021-07-09 中山大学 一种含邻苯二甲醛的单体、由单体制备的聚合物及制备方法和应用
KR102636596B1 (ko) * 2019-01-31 2024-02-13 주식회사 엘지화학 항균성 고분자 코팅 조성물 및 항균성 고분자 필름
KR102557941B1 (ko) * 2019-03-11 2023-07-19 주식회사 엘지화학 항균성 고분자 코팅 조성물 및 항균성 고분자 필름
US11648385B2 (en) 2019-05-30 2023-05-16 Beeton, Dickinson and Company Automatic disinfection of a vascular access device connector
KR102450967B1 (ko) * 2019-12-06 2022-10-05 울산대학교 산학협력단 항균 및 탈취용 유무기 에멀젼 조성물 및 이를 포함하는 섬유 매트
US11730862B2 (en) * 2020-05-08 2023-08-22 DePuy Synthes Products, Inc. Identifier-based application of therapeutic coatings to medical implant devices
CN111955476A (zh) * 2020-09-03 2020-11-20 常熟理工学院 一种led光固化型农药微胶囊剂及其制备方法
JP2024500319A (ja) 2020-12-07 2024-01-09 アイシーユー・メディカル・インコーポレーテッド 腹膜透析キャップ、システム、及び方法
CN113694226A (zh) * 2021-08-20 2021-11-26 中山大学 一种紫外杀菌缓蚀剂协同杀菌消毒和抗生物附着的方法
CN115340901A (zh) * 2022-09-22 2022-11-15 袁培锷 生物润滑剂组合物及其制备方法

Citations (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223629A (en) * 1963-05-13 1965-12-14 Shell Oil Co Lubricant compositions
US3986508A (en) * 1973-08-22 1976-10-19 Abcor, Inc. Sterilizable, medical connector for blood processing
US4339336A (en) * 1981-03-23 1982-07-13 Texaco Inc. Quaternary ammonium succinimide salt composition and lubricating oil containing same
US4512766A (en) * 1982-12-08 1985-04-23 Whitman Medical Corporation Catheter valve
US4584192A (en) * 1984-06-04 1986-04-22 Minnesota Mining & Manufacturing Company Film-forming composition containing an antimicrobial agent and methods of use
US4629746A (en) * 1985-01-26 1986-12-16 Etablissement Dentaire Ivoclar Radiopaque dental materials
US4629743A (en) * 1985-05-20 1986-12-16 The B.F. Goodrich Company Process for preparing high bulk density vinyl resins
US4642126A (en) * 1985-02-11 1987-02-10 Norton Company Coated abrasives with rapidly curable adhesives and controllable curvature
US4677143A (en) * 1984-10-01 1987-06-30 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
US4716032A (en) * 1983-08-03 1987-12-29 Geoffrey J. Westfall Aerosol spray composition for mastitis prevention
US4915934A (en) * 1983-10-24 1990-04-10 Tomlinson Roderick P J Foamable biocide composition
US4925668A (en) * 1989-01-18 1990-05-15 Becton, Dickinson And Company Anti-infective and lubricious medical articles and method for their preparation
US4933178A (en) * 1988-10-07 1990-06-12 Biointerface Technologies, Inc. Metal-based antimicrobial coating
US5023082A (en) * 1986-05-18 1991-06-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sustained-release pharmaceutical compositions
US5077352A (en) * 1990-04-23 1991-12-31 C. R. Bard, Inc. Flexible lubricious organic coatings
US5512199A (en) * 1993-11-02 1996-04-30 Becton Dickinson And Company Hand wipe solution
US5547662A (en) * 1993-08-27 1996-08-20 Becton, Dickinson And Company Preparation of a skin surface for a surgical procedure
US5616338A (en) * 1988-02-11 1997-04-01 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US5629006A (en) * 1994-06-27 1997-05-13 Becton, Dickinson And Company Skin disinfecting formulations
US5698229A (en) * 1992-06-30 1997-12-16 Toagosei Co., Ltd. Antimicrobial composition
US5773487A (en) * 1991-05-15 1998-06-30 Uv Coatings, Inc. Finishing composition which is curable by UV light and method of using same
US5861440A (en) * 1993-04-19 1999-01-19 Beiersdorf Aktiengesellschaft Cosmetic and medicinal topical preparations
US6051609A (en) * 1997-09-09 2000-04-18 Tristrata Technology, Inc. Additives enhancing the effect of therapeutic agents
US6127320A (en) * 1998-01-19 2000-10-03 University Of Cincinnati Methods and compositions for increasing lubricity of rubber surfaces
US6242526B1 (en) * 1997-01-28 2001-06-05 Stepan Company Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes
US6248811B1 (en) * 1997-01-03 2001-06-19 Huels Aktiengesellschaft Bioactive surface coating
US20010016589A1 (en) * 1995-11-13 2001-08-23 Shanta Modak Triple antimicrobial composition
US6326417B1 (en) * 1999-10-21 2001-12-04 Jeneric/Pentron Incorporated Anti-microbial dental compositions and method
US20010053895A1 (en) * 2000-06-15 2001-12-20 Vaillancourt Vincent L. Bloodless catheter
US20010056133A1 (en) * 1998-02-19 2001-12-27 Montgomery R. Eric Curable compositions with antimicrobial properties
US6337357B1 (en) * 1997-02-24 2002-01-08 Kuraray Co., Ltd. Antimicrobial caries-detecting composition
US20020022660A1 (en) * 1998-01-20 2002-02-21 Hanuman B. Jampani Deep penetrating antimicrobial compositions
US6353041B1 (en) * 1999-10-22 2002-03-05 Kerr Corporation Dental compositions
US20020028751A1 (en) * 1999-10-27 2002-03-07 Ecolab Inc. Lubricant compositions having antimicrobial properties and methods for manufacturing and using lubricant compositions having antimicrobial properties
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US20020119111A1 (en) * 2000-06-12 2002-08-29 General Electric Company Silicone compositions
US20020144705A1 (en) * 2000-12-29 2002-10-10 Brattesani Steven J. Dental floss with usage identification capability
US6488942B1 (en) * 1997-10-18 2002-12-03 Ddg Dental Devices Gmbh Disinfecting agent
US20030072781A1 (en) * 1998-09-24 2003-04-17 Advantage Dental Products, Inc. Calcified tissue facing preparation containing antimicrobial agent
US6576633B1 (en) * 1996-02-22 2003-06-10 The Dow Chemical Company Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons
US20030119932A1 (en) * 1999-12-08 2003-06-26 Walid Al-Akhdar Novel phosphine oxide photoinitiator systems and curable compostions with low color
US20030147932A1 (en) * 2001-08-10 2003-08-07 Creavis Gesellschaft Fuer Tech. Und Innovation Mbh Self-cleaning lotus effect surfaces having antimicrobial properties
US20030162839A1 (en) * 2000-04-03 2003-08-28 Symington John Marston Use of chlorhexidine in the prevention of root caries
US20030170308A1 (en) * 2001-05-01 2003-09-11 Cleary Gary W. Hydrogel compositions
US20040039349A1 (en) * 1996-01-05 2004-02-26 Shanta Modak Tricolosan-containing medical devices
US20040058829A1 (en) * 1999-08-16 2004-03-25 Ecolab Inc. Conveyor lubricant, passivation of a thermoplastic container to stress cracking and thermoplastic stress crack inhibitor
US20040115477A1 (en) * 2002-12-12 2004-06-17 Bruce Nesbitt Coating reinforcing underlayment and method of manufacturing same
US20040185296A1 (en) * 2001-07-04 2004-09-23 Raffaello Mazzanti Method for protecting a flooring or lining material from staining substances
US20040234475A1 (en) * 2001-06-22 2004-11-25 Helene Lannibois-Drean Oil-in-oil emulsions comprising a silicone, dispersions and use of said emulsions
US6861060B1 (en) * 2000-04-21 2005-03-01 Elena Luriya Personal care formulations
US20050048005A1 (en) * 2003-08-26 2005-03-03 Stockel Richard F. Antimicrobial compositions for dental applications
US20050080158A1 (en) * 2001-10-10 2005-04-14 Ong Ivan W Antimicrobial radiation curable coating
US20050100580A1 (en) * 2003-10-14 2005-05-12 Cook Incorporated Hydrophilic coated medical device
US6896889B2 (en) * 2001-04-06 2005-05-24 L'oreal Immediate effect anti-wrinkle composition, based on an aqueous dispersion, of at least one mineral filler
US20050265931A1 (en) * 2002-06-21 2005-12-01 Kerr Corporation Silver-containing dental composition
US20060051385A1 (en) * 2004-09-07 2006-03-09 3M Innovative Properties Company Cationic antiseptic compositions and methods of use
US7074839B2 (en) * 2004-03-01 2006-07-11 3M Innovative Properties Company Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups
US20060165751A1 (en) * 2000-08-15 2006-07-27 Chudzik Stephen J Medicament incorporation matrix
US20060165903A1 (en) * 2002-10-01 2006-07-27 Raffaello Mazzanti Method for the decoration of porous ceramic materials and in particular polished porcelain stoneware
US20060239954A1 (en) * 2005-04-22 2006-10-26 Sancho Karrie A Antimicrobial spray for use on pets
US20060258780A1 (en) * 2002-12-30 2006-11-16 Rhodia Chimie Method for preparing a silica suspension in a potentially crosslinkable silicone material
US20060281663A1 (en) * 2005-06-13 2006-12-14 3M Innovative Properties Company Foamable alcohol compositions, systems and methods of use
US20070000407A1 (en) * 2003-10-09 2007-01-04 York International Corporation Nano composite photocatalytic coating
US7179849B2 (en) * 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
US7198800B1 (en) * 1999-11-23 2007-04-03 Thomas Sai Ying Ko Compositions and methods
US20070112112A1 (en) * 2005-11-15 2007-05-17 Judith Kerschner Swollen silicone composition and process of producing same
US20070112146A1 (en) * 2005-11-15 2007-05-17 Benjamin Falk Swollen silicone composition, process of producing same and products thereof
US7232540B2 (en) * 2004-05-02 2007-06-19 Ashland Licensing And Intellectual Property Llc Radiation-curable coatings for plastic substrates from multifunctional acrylate oligomers
US20070141524A1 (en) * 2005-12-20 2007-06-21 Brennan Joan V Dental compositions including radiation-to-heat converters, and the use thereof
US20070160547A1 (en) * 2006-01-11 2007-07-12 Janet Duffy Method of applying a composition
US20070166344A1 (en) * 2006-01-18 2007-07-19 Xin Qu Non-leaching surface-active film compositions for microbial adhesion prevention
US20070202177A1 (en) * 2006-02-28 2007-08-30 Becton, Dickinson And Company Antimicrobial Compositions and Methods for Locking Catheters
US20070203574A1 (en) * 2006-02-25 2007-08-30 Mcgrath Terrence S Ultraviolet activated antimicrobial surfaces
US20070225179A1 (en) * 2004-08-13 2007-09-27 Markus Schutz Lubricant for Sports Equipment
US20070275101A1 (en) * 2006-02-23 2007-11-29 Lu Helen S Removable antimicrobial coating compositions and methods of use
US20080075761A1 (en) * 2000-12-22 2008-03-27 Modak Shanta M Antimicrobial Medical Devices Containing Chlorhexidine Free Base And Salt
US20080161763A1 (en) * 2006-07-28 2008-07-03 Becton, Dickinson And Company Vascular access device antimicrobial materials and solutions
US20080182921A1 (en) * 2007-01-29 2008-07-31 Bisco, Inc. Dental Primer Adhesive System and Optional Hydrophobic Resin
US7407707B2 (en) * 2004-05-02 2008-08-05 Ashland Licensing And Intellectual Property Llc Radiation-curable coatings for metal substrates from multifunctional acrylate oligomers
US7462401B2 (en) * 2005-12-23 2008-12-09 Xerox Corporation Radiation curable composition
US7494339B2 (en) * 2005-08-10 2009-02-24 Dentsply International, Inc. Compositions for use as dental crowns and methods for preparing dental crowns
US7498367B2 (en) * 2005-02-21 2009-03-03 Kerr Corporation Acid-tolerant dental composition
US7514477B2 (en) * 2005-10-18 2009-04-07 Derve-Otoplastik Gmbh Low-viscosity radiation-curable composition for making an earpiece
US20090110844A1 (en) * 2007-10-26 2009-04-30 Dymax Corporation Photopolymerizable compositions containing an oxonol dye
US20090117164A1 (en) * 2005-08-22 2009-05-07 Quick-Med Technologies, Inc. Disinfectant with Durable Activity Based on Alcohol-Soluble Quaternary Ammonium Polymers and Copolymers
US20090114327A1 (en) * 2005-04-08 2009-05-07 Stefan Breunig Composition based on siloxane for the moulding/unmoulding of tyres
WO2009070227A1 (en) * 2007-11-30 2009-06-04 Corning Incorporated Dense homogeneous fluoride films for duv elements and method of preparing same
US20090162530A1 (en) * 2007-12-21 2009-06-25 Orion Industries, Ltd. Marked precoated medical device and method of manufacturing same
US20090176907A1 (en) * 2008-01-08 2009-07-09 Ramesh Subramanian Direct-to-metal radiation curable compositions
US20090188559A1 (en) * 2008-01-30 2009-07-30 Nesbitt Jeffrey E Ultraviolet cured coating system
US20090220739A1 (en) * 2005-12-09 2009-09-03 Chougule Vivek A Selectively permeable films
US20090226541A1 (en) * 2005-03-10 2009-09-10 3M Innovative Properties Company Methods of reducing microbial contamination
US20090317435A1 (en) * 2008-06-20 2009-12-24 Baxter International Inc. Methods for processing substrates having an antimicrobial coating
US20090324666A1 (en) * 2008-06-25 2009-12-31 Baxter International Inc. Methods for making antimicrobial resins
US20110009831A1 (en) * 2009-07-09 2011-01-13 Becton, Dickinson And Company Antimicrobial coating for dermally invasive devices

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4359564A (en) 1980-03-14 1982-11-16 Rohm & Haas Co. Addition polymer of oligomeric polyesters of acrylic acid
DE3800094C2 (de) * 1987-01-14 1998-05-14 Ciba Geigy Ag Verfahren und hydrophobe Zubereitung zur Bekämpfung von Schnittwundparasiten bei Pflanzen
US5013717A (en) 1988-04-18 1991-05-07 Becton, Dickinson And Company Blood compatible, lubricious article and composition and method therefor
CA1331333C (en) * 1988-07-20 1994-08-09 Thomas M. Gentle Antimicrobial antifoam compositions and methods
DE4011867A1 (de) 1990-04-12 1991-10-17 Herberts Gmbh Leitfaehige, strahlenhaertbare lacke
JP2666654B2 (ja) 1992-04-01 1997-10-22 住友金属工業株式会社 鋼材への水溶性防錆油の塗付方法
JPH0751651A (ja) * 1993-08-19 1995-02-28 Mitsubishi Materials Corp 汚れ防止かつ消臭用被覆材
JPH08209064A (ja) 1994-12-27 1996-08-13 Ebihara:Kk 天然木化粧合板用抗菌塗料
JPH08311373A (ja) * 1995-05-22 1996-11-26 Tokuyama Corp 抗菌性被膜用光硬化性組成物
JPH09151262A (ja) 1995-11-29 1997-06-10 Fuji Silysia Chem Ltd 表面硬化樹脂板
JPH09157548A (ja) 1995-12-01 1997-06-17 Sumitomo Chem Co Ltd 抗菌性の表面コート剤および合成樹脂成形体
DK0991702T3 (da) 1997-06-20 2001-12-03 Coloplast As Hydrofilt overtræk
US6110483A (en) 1997-06-23 2000-08-29 Sts Biopolymers, Inc. Adherent, flexible hydrogel and medicated coatings
WO1999032168A1 (en) 1997-12-22 1999-07-01 Becton Dickinson And Company A material for use in medical devices with a self-replenishing antimicrobial and/or lubricious surface
US6299980B1 (en) * 1998-09-29 2001-10-09 Medtronic Ave, Inc. One step lubricious coating
JP2000178475A (ja) 1998-12-15 2000-06-27 Nisseki Kk 抗菌消臭性コ―ティング剤
JP3824120B2 (ja) * 1999-03-18 2006-09-20 新東工業株式会社 抗菌性を有する光重合性モノマー組成物、ならびに抗菌性を有する無溶剤タイプの紫外線および電子線硬化樹脂組成物
US6156373A (en) 1999-05-03 2000-12-05 Scimed Life Systems, Inc. Medical device coating methods and devices
US6706022B1 (en) 1999-07-27 2004-03-16 Alaris Medical Systems, Inc. Needleless medical connector with expandable valve mechanism
JP2001072438A (ja) 1999-08-31 2001-03-21 Wako Kagaku Kogyo Kk 抗菌性加工板硝子材
KR100405030B1 (ko) 2001-02-10 2003-11-10 주식회사 유레이 신규 ｕｖ 경화형 항균제
JP3730529B2 (ja) 2001-03-27 2006-01-05 日本ペイント株式会社 多孔質素材の塗装方法及びその装置
DE10144531B4 (de) 2001-09-11 2006-01-19 Henkel Kgaa UV-härtende anti-fingerprint Beschichtungen, Verfahren zum Beschichten und Verwendung eines lösmittelfreien Überzugsmittels
US7361719B2 (en) 2002-01-31 2008-04-22 Micro Science Tech Co., Ltd. Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof
NO320324B1 (no) 2002-03-26 2005-11-21 Jotun As Polymerer og monomerer og anvendelse derav samt fremgangsmate for fremstilling av polymerer og begroingshindrende maling inneholdende polymerer
US20040147671A1 (en) * 2002-05-15 2004-07-29 Richard Milic Decorative coating composition for solid substrates
JP2003342402A (ja) 2002-05-27 2003-12-03 Mitsubishi Rayon Co Ltd 耐擦傷性を有する抗菌性樹脂成形品およびその製造方法
JP2004043669A (ja) 2002-07-12 2004-02-12 Dainippon Toryo Co Ltd 粉体塗料の調色方法
CN1487035A (zh) * 2002-08-07 2004-04-07 珠海东诚化工有限公司 紫外光固化的绝缘涂料
CN1247712C (zh) 2003-03-03 2006-03-29 珠海东诚化工有限公司 可见光固化金属涂料
JP2005028209A (ja) 2003-07-07 2005-02-03 Dainippon Ink & Chem Inc 抗菌性、防かび性を有する硬化皮膜及びその形成方法
WO2006036983A2 (en) 2004-09-28 2006-04-06 Atrium Medical Corporation Pre-dried drug delivery coating for use with a stent
ATE514491T1 (de) 2004-11-29 2011-07-15 Dsm Ip Assets Bv Verfahren zur verringerung der menge von migrierbaren komponenten von polymerbeschichtungen
JP2008527117A (ja) 2005-01-17 2008-07-24 ナノン アクティーゼルスカブ ポリマー含有被覆物によってポリマー表面を被覆する方法、およびポリマー被覆ポリマーを含む物品
US8009953B2 (en) * 2005-03-05 2011-08-30 Kyoto University Three-dimensional photonic crystal and its manufacturing method thereof
EP1898900B1 (en) * 2005-03-10 2011-06-08 3M Innovative Properties Company Antimicrobial compositions comprising esters of hydroxycarboxylic acids
JP2007016096A (ja) 2005-07-06 2007-01-25 Chugoku Marine Paints Ltd 硬化性組成物、コーティング用組成物、塗料、防汚塗料、その硬化物、並びに基材の防汚方法
US20070048344A1 (en) * 2005-08-31 2007-03-01 Ali Yahiaoui Antimicrobial composition
US8227050B1 (en) 2005-10-31 2012-07-24 E I Du Pont De Nemours And Company Coating composition and method for coating substrates
KR101334413B1 (ko) 2006-02-14 2013-11-29 엔투리아, 인코포레이티드 방부제로부터 부산물의 농도를 감소시키기 위한 액체 도포기 및 방법
US20100113871A1 (en) * 2006-09-13 2010-05-06 Aylvin Jorge Angelo Athanasius Dias Antimicrobial coating
AU2008240809B2 (en) 2007-04-18 2013-05-02 Basf Se Antimicrobial plastics and coatings
CN101677536A (zh) 2007-04-25 2010-03-24 巴斯夫欧洲公司 带有杀生物涂层的基底
US8034455B2 (en) 2008-06-06 2011-10-11 Novasolar Holdings Limited Coating composition, substrates coated therewith and methods of making and using same
CN101353545B (zh) 2008-08-26 2010-06-23 苏州市明大高分子科技材料有限公司 紫外光固化抗菌涂料及其制备方法
US20100135949A1 (en) 2008-12-01 2010-06-03 Becton, Dickinson And Company Antimicrobial compositions
US20110065798A1 (en) 2009-09-17 2011-03-17 Becton, Dickinson And Company Anti-infective lubricant for medical devices and methods for preparing the same

Patent Citations (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3223629A (en) * 1963-05-13 1965-12-14 Shell Oil Co Lubricant compositions
US3986508A (en) * 1973-08-22 1976-10-19 Abcor, Inc. Sterilizable, medical connector for blood processing
US4339336A (en) * 1981-03-23 1982-07-13 Texaco Inc. Quaternary ammonium succinimide salt composition and lubricating oil containing same
US4512766A (en) * 1982-12-08 1985-04-23 Whitman Medical Corporation Catheter valve
US4716032A (en) * 1983-08-03 1987-12-29 Geoffrey J. Westfall Aerosol spray composition for mastitis prevention
US4915934A (en) * 1983-10-24 1990-04-10 Tomlinson Roderick P J Foamable biocide composition
US4584192A (en) * 1984-06-04 1986-04-22 Minnesota Mining & Manufacturing Company Film-forming composition containing an antimicrobial agent and methods of use
US4677143A (en) * 1984-10-01 1987-06-30 Baxter Travenol Laboratories, Inc. Antimicrobial compositions
US4629746A (en) * 1985-01-26 1986-12-16 Etablissement Dentaire Ivoclar Radiopaque dental materials
US4642126A (en) * 1985-02-11 1987-02-10 Norton Company Coated abrasives with rapidly curable adhesives and controllable curvature
US4629743A (en) * 1985-05-20 1986-12-16 The B.F. Goodrich Company Process for preparing high bulk density vinyl resins
US5023082A (en) * 1986-05-18 1991-06-11 Yissum Research Development Company Of The Hebrew University Of Jerusalem Sustained-release pharmaceutical compositions
US5616338A (en) * 1988-02-11 1997-04-01 Trustees Of Columbia University In The City Of New York Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same
US4933178A (en) * 1988-10-07 1990-06-12 Biointerface Technologies, Inc. Metal-based antimicrobial coating
US4925668A (en) * 1989-01-18 1990-05-15 Becton, Dickinson And Company Anti-infective and lubricious medical articles and method for their preparation
US5077352A (en) * 1990-04-23 1991-12-31 C. R. Bard, Inc. Flexible lubricious organic coatings
US5773487A (en) * 1991-05-15 1998-06-30 Uv Coatings, Inc. Finishing composition which is curable by UV light and method of using same
US5698229A (en) * 1992-06-30 1997-12-16 Toagosei Co., Ltd. Antimicrobial composition
US5861440A (en) * 1993-04-19 1999-01-19 Beiersdorf Aktiengesellschaft Cosmetic and medicinal topical preparations
US5547662A (en) * 1993-08-27 1996-08-20 Becton, Dickinson And Company Preparation of a skin surface for a surgical procedure
US5512199A (en) * 1993-11-02 1996-04-30 Becton Dickinson And Company Hand wipe solution
US5629006A (en) * 1994-06-27 1997-05-13 Becton, Dickinson And Company Skin disinfecting formulations
US20010016589A1 (en) * 1995-11-13 2001-08-23 Shanta Modak Triple antimicrobial composition
US20040039349A1 (en) * 1996-01-05 2004-02-26 Shanta Modak Tricolosan-containing medical devices
US6576633B1 (en) * 1996-02-22 2003-06-10 The Dow Chemical Company Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons
US6413539B1 (en) * 1996-10-31 2002-07-02 Poly-Med, Inc. Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof
US6248811B1 (en) * 1997-01-03 2001-06-19 Huels Aktiengesellschaft Bioactive surface coating
US20020040092A1 (en) * 1997-01-28 2002-04-04 Stepan Company Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealant, adhesives and elastomers produced from such latexes
US6492445B2 (en) * 1997-01-28 2002-12-10 Stepan Company Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes
US6242526B1 (en) * 1997-01-28 2001-06-05 Stepan Company Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes
US6337357B1 (en) * 1997-02-24 2002-01-08 Kuraray Co., Ltd. Antimicrobial caries-detecting composition
US6051609A (en) * 1997-09-09 2000-04-18 Tristrata Technology, Inc. Additives enhancing the effect of therapeutic agents
US6488942B1 (en) * 1997-10-18 2002-12-03 Ddg Dental Devices Gmbh Disinfecting agent
US6127320A (en) * 1998-01-19 2000-10-03 University Of Cincinnati Methods and compositions for increasing lubricity of rubber surfaces
US20020022660A1 (en) * 1998-01-20 2002-02-21 Hanuman B. Jampani Deep penetrating antimicrobial compositions
US20010056133A1 (en) * 1998-02-19 2001-12-27 Montgomery R. Eric Curable compositions with antimicrobial properties
US20030072781A1 (en) * 1998-09-24 2003-04-17 Advantage Dental Products, Inc. Calcified tissue facing preparation containing antimicrobial agent
US20040058829A1 (en) * 1999-08-16 2004-03-25 Ecolab Inc. Conveyor lubricant, passivation of a thermoplastic container to stress cracking and thermoplastic stress crack inhibitor
US6326417B1 (en) * 1999-10-21 2001-12-04 Jeneric/Pentron Incorporated Anti-microbial dental compositions and method
US6353041B1 (en) * 1999-10-22 2002-03-05 Kerr Corporation Dental compositions
US20020028751A1 (en) * 1999-10-27 2002-03-07 Ecolab Inc. Lubricant compositions having antimicrobial properties and methods for manufacturing and using lubricant compositions having antimicrobial properties
US7198800B1 (en) * 1999-11-23 2007-04-03 Thomas Sai Ying Ko Compositions and methods
US20030119932A1 (en) * 1999-12-08 2003-06-26 Walid Al-Akhdar Novel phosphine oxide photoinitiator systems and curable compostions with low color
US7179849B2 (en) * 1999-12-15 2007-02-20 C. R. Bard, Inc. Antimicrobial compositions containing colloids of oligodynamic metals
US20030162839A1 (en) * 2000-04-03 2003-08-28 Symington John Marston Use of chlorhexidine in the prevention of root caries
US6861060B1 (en) * 2000-04-21 2005-03-01 Elena Luriya Personal care formulations
US20020119111A1 (en) * 2000-06-12 2002-08-29 General Electric Company Silicone compositions
US20010053895A1 (en) * 2000-06-15 2001-12-20 Vaillancourt Vincent L. Bloodless catheter
US20060165751A1 (en) * 2000-08-15 2006-07-27 Chudzik Stephen J Medicament incorporation matrix
US20080075761A1 (en) * 2000-12-22 2008-03-27 Modak Shanta M Antimicrobial Medical Devices Containing Chlorhexidine Free Base And Salt
US20020144705A1 (en) * 2000-12-29 2002-10-10 Brattesani Steven J. Dental floss with usage identification capability
US6896889B2 (en) * 2001-04-06 2005-05-24 L'oreal Immediate effect anti-wrinkle composition, based on an aqueous dispersion, of at least one mineral filler
US20030170308A1 (en) * 2001-05-01 2003-09-11 Cleary Gary W. Hydrogel compositions
US20040234475A1 (en) * 2001-06-22 2004-11-25 Helene Lannibois-Drean Oil-in-oil emulsions comprising a silicone, dispersions and use of said emulsions
US20040185296A1 (en) * 2001-07-04 2004-09-23 Raffaello Mazzanti Method for protecting a flooring or lining material from staining substances
US20030147932A1 (en) * 2001-08-10 2003-08-07 Creavis Gesellschaft Fuer Tech. Und Innovation Mbh Self-cleaning lotus effect surfaces having antimicrobial properties
US20050080158A1 (en) * 2001-10-10 2005-04-14 Ong Ivan W Antimicrobial radiation curable coating
US7098256B2 (en) * 2001-10-10 2006-08-29 Microban Products Company Antimicrobial radiation curable coating
US20050265931A1 (en) * 2002-06-21 2005-12-01 Kerr Corporation Silver-containing dental composition
US20060165903A1 (en) * 2002-10-01 2006-07-27 Raffaello Mazzanti Method for the decoration of porous ceramic materials and in particular polished porcelain stoneware
US20040115477A1 (en) * 2002-12-12 2004-06-17 Bruce Nesbitt Coating reinforcing underlayment and method of manufacturing same
US7261925B2 (en) * 2002-12-12 2007-08-28 Orion Industries Ltd. Coating reinforcing underlayment and method of manufacturing same
US20060258780A1 (en) * 2002-12-30 2006-11-16 Rhodia Chimie Method for preparing a silica suspension in a potentially crosslinkable silicone material
US20050048005A1 (en) * 2003-08-26 2005-03-03 Stockel Richard F. Antimicrobial compositions for dental applications
US20070000407A1 (en) * 2003-10-09 2007-01-04 York International Corporation Nano composite photocatalytic coating
US20050100580A1 (en) * 2003-10-14 2005-05-12 Cook Incorporated Hydrophilic coated medical device
US7074839B2 (en) * 2004-03-01 2006-07-11 3M Innovative Properties Company Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups
US7407707B2 (en) * 2004-05-02 2008-08-05 Ashland Licensing And Intellectual Property Llc Radiation-curable coatings for metal substrates from multifunctional acrylate oligomers
US7232540B2 (en) * 2004-05-02 2007-06-19 Ashland Licensing And Intellectual Property Llc Radiation-curable coatings for plastic substrates from multifunctional acrylate oligomers
US20070225179A1 (en) * 2004-08-13 2007-09-27 Markus Schutz Lubricant for Sports Equipment
US20060051385A1 (en) * 2004-09-07 2006-03-09 3M Innovative Properties Company Cationic antiseptic compositions and methods of use
US7498367B2 (en) * 2005-02-21 2009-03-03 Kerr Corporation Acid-tolerant dental composition
US20090226541A1 (en) * 2005-03-10 2009-09-10 3M Innovative Properties Company Methods of reducing microbial contamination
US20090114327A1 (en) * 2005-04-08 2009-05-07 Stefan Breunig Composition based on siloxane for the moulding/unmoulding of tyres
US20060239954A1 (en) * 2005-04-22 2006-10-26 Sancho Karrie A Antimicrobial spray for use on pets
US20060281663A1 (en) * 2005-06-13 2006-12-14 3M Innovative Properties Company Foamable alcohol compositions, systems and methods of use
US7494339B2 (en) * 2005-08-10 2009-02-24 Dentsply International, Inc. Compositions for use as dental crowns and methods for preparing dental crowns
US20090117164A1 (en) * 2005-08-22 2009-05-07 Quick-Med Technologies, Inc. Disinfectant with Durable Activity Based on Alcohol-Soluble Quaternary Ammonium Polymers and Copolymers
US7514477B2 (en) * 2005-10-18 2009-04-07 Derve-Otoplastik Gmbh Low-viscosity radiation-curable composition for making an earpiece
US20070112112A1 (en) * 2005-11-15 2007-05-17 Judith Kerschner Swollen silicone composition and process of producing same
US20070112146A1 (en) * 2005-11-15 2007-05-17 Benjamin Falk Swollen silicone composition, process of producing same and products thereof
US20090220739A1 (en) * 2005-12-09 2009-09-03 Chougule Vivek A Selectively permeable films
US20070141524A1 (en) * 2005-12-20 2007-06-21 Brennan Joan V Dental compositions including radiation-to-heat converters, and the use thereof
US7462401B2 (en) * 2005-12-23 2008-12-09 Xerox Corporation Radiation curable composition
US20070160547A1 (en) * 2006-01-11 2007-07-12 Janet Duffy Method of applying a composition
US20070166344A1 (en) * 2006-01-18 2007-07-19 Xin Qu Non-leaching surface-active film compositions for microbial adhesion prevention
US20080026026A1 (en) * 2006-02-23 2008-01-31 Lu Helen S Removable antimicrobial coating compositions and methods of use
US20070275101A1 (en) * 2006-02-23 2007-11-29 Lu Helen S Removable antimicrobial coating compositions and methods of use
US20070203574A1 (en) * 2006-02-25 2007-08-30 Mcgrath Terrence S Ultraviolet activated antimicrobial surfaces
US20070202177A1 (en) * 2006-02-28 2007-08-30 Becton, Dickinson And Company Antimicrobial Compositions and Methods for Locking Catheters
US20080161763A1 (en) * 2006-07-28 2008-07-03 Becton, Dickinson And Company Vascular access device antimicrobial materials and solutions
US20080182921A1 (en) * 2007-01-29 2008-07-31 Bisco, Inc. Dental Primer Adhesive System and Optional Hydrophobic Resin
US20090110844A1 (en) * 2007-10-26 2009-04-30 Dymax Corporation Photopolymerizable compositions containing an oxonol dye
WO2009070227A1 (en) * 2007-11-30 2009-06-04 Corning Incorporated Dense homogeneous fluoride films for duv elements and method of preparing same
US20090162530A1 (en) * 2007-12-21 2009-06-25 Orion Industries, Ltd. Marked precoated medical device and method of manufacturing same
US20090176907A1 (en) * 2008-01-08 2009-07-09 Ramesh Subramanian Direct-to-metal radiation curable compositions
US20090188559A1 (en) * 2008-01-30 2009-07-30 Nesbitt Jeffrey E Ultraviolet cured coating system
US20090317435A1 (en) * 2008-06-20 2009-12-24 Baxter International Inc. Methods for processing substrates having an antimicrobial coating
US20090324666A1 (en) * 2008-06-25 2009-12-31 Baxter International Inc. Methods for making antimicrobial resins
US20110009831A1 (en) * 2009-07-09 2011-01-13 Becton, Dickinson And Company Antimicrobial coating for dermally invasive devices

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GERALD MCDONNELL AND A. DENVER RUSSELL, Antiseptics and Disinfectants: Activity, Action, and Resistance. CLINICAL MICROBIOLOGY REVIEWS, Vol. 12, No. 1, Jan. 1999, p. 147-179. *

Cited By (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8754020B2 (en) 2008-12-01 2014-06-17 Becton, Dickinson And Company Antimicrobial lubricant compositions
US20100137472A1 (en) * 2008-12-01 2010-06-03 Becton, Dickinson And Company Antimicrobial coating compositions
US8691887B2 (en) 2008-12-01 2014-04-08 Becton, Dickinson And Company Antimicrobial coating compositions
US8821455B2 (en) 2009-07-09 2014-09-02 Becton, Dickinson And Company Antimicrobial coating for dermally invasive devices
US11933551B2 (en) 2011-08-05 2024-03-19 Massachusetts Institute Of Technology Liquid-impregnated surfaces, methods of making, and devices incorporating the same
US10968035B2 (en) 2012-03-23 2021-04-06 Massachusetts Institute Of Technology Self-lubricating surfaces for food packaging and food processing equipment
US20130310764A1 (en) * 2012-05-15 2013-11-21 Becton, Dickinson And Company Blood control iv catheter with antimicrobial properties
US9770580B2 (en) 2012-05-15 2017-09-26 Becton, Dickinson And Company Blood control IV catheter with antimicrobial properties
US9352119B2 (en) * 2012-05-15 2016-05-31 Becton, Dickinson And Company Blood control IV catheter with antimicrobial properties
US11058803B2 (en) 2012-05-24 2021-07-13 Massachusetts Institute Of Technology Medical devices and implements with liquid-impregnated surfaces
US11684705B2 (en) 2012-05-24 2023-06-27 Massachusetts Institute Of Technology Medical devices and implements with liquid-impregnated surfaces
US9579486B2 (en) 2012-08-22 2017-02-28 Becton, Dickinson And Company Blood control IV catheter with antimicrobial properties
US10882085B2 (en) 2012-11-19 2021-01-05 Massachusetts Institute Of Technology Apparatus and methods employing liquid-impregnated surfaces
US11492500B2 (en) 2012-11-19 2022-11-08 Massachusetts Institute Of Technology Apparatus and methods employing liquid-impregnated surfaces
US10266705B2 (en) * 2013-02-01 2019-04-23 Croda International Plc Self-disinfecting surfaces
US9750928B2 (en) 2013-02-13 2017-09-05 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
US9695323B2 (en) * 2013-02-13 2017-07-04 Becton, Dickinson And Company UV curable solventless antimicrobial compositions
US11357962B2 (en) 2013-02-13 2022-06-14 Becton, Dickinson And Company Blood control IV catheter with stationary septum activator
WO2014126862A1 (en) 2013-02-13 2014-08-21 Becton, Dickinson And Company Uv curable solventless antimicrobial compositions
US20140228466A1 (en) * 2013-02-13 2014-08-14 Becton, Dickinson And Company Uv curable solventless antimicrobial compositions
US9750927B2 (en) 2013-03-11 2017-09-05 Becton, Dickinson And Company Blood control catheter with antimicrobial needle lube
US9327095B2 (en) 2013-03-11 2016-05-03 Becton, Dickinson And Company Blood control catheter with antimicrobial needle lube
US9789280B2 (en) 2013-03-11 2017-10-17 Becton, Dickinson And Company Blood control catheter with antimicrobial needle lube
US11850331B2 (en) 2013-03-11 2023-12-26 Teleflex Medical Incorporated Devices with anti-thrombogenic and anti-microbial treatment
US11931483B2 (en) 2014-02-20 2024-03-19 Becton, Dickinson And Company Antimicrobial inserts for medical devices
US10792398B2 (en) 2014-02-20 2020-10-06 Becton, Dickinson And Company Antimicrobial inserts for medical devices
US10792399B2 (en) 2014-02-20 2020-10-06 Becton, Dickinson And Company Antimicrobial inserts for medical devices
US11291749B2 (en) 2014-02-20 2022-04-05 Becton, Dickinson And Company Antimicrobial inserts for medical devices
EP3466481A1 (en) 2014-04-23 2019-04-10 Becton, Dickinson and Company Antimicrobial caps for medical connectors
US9789279B2 (en) 2014-04-23 2017-10-17 Becton, Dickinson And Company Antimicrobial obturator for use with vascular access devices
US10376686B2 (en) 2014-04-23 2019-08-13 Becton, Dickinson And Company Antimicrobial caps for medical connectors
WO2015164129A2 (en) 2014-04-23 2015-10-29 Becton, Dickinson And Company Antimicrobial caps for medical connectors
WO2015164130A2 (en) 2014-04-23 2015-10-29 Becton, Dickinson And Company Antimicrobial stopcock medical connector
US10589063B2 (en) 2014-04-23 2020-03-17 Becton, Dickinson And Company Antimicrobial obturator for use with vascular access devices
WO2015164132A2 (en) 2014-04-23 2015-10-29 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
EP4144401A2 (en) 2014-04-23 2023-03-08 Becton, Dickinson and Company Antimicrobial caps for medical connectors
EP3453410A1 (en) 2014-04-23 2019-03-13 Becton, Dickinson and Company Catheter tubing with extraluminal antimicrobial coating
US10149971B2 (en) 2014-04-23 2018-12-11 Becton, Dickinson And Company Antimicrobial stopcock medical connector
US11357965B2 (en) 2014-04-23 2022-06-14 Becton, Dickinson And Company Antimicrobial caps for medical connectors
US9675793B2 (en) 2014-04-23 2017-06-13 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
US10994118B2 (en) 2014-04-23 2021-05-04 Becton, Dickinson And Company Antimicrobial stopcock medical connector
US9956379B2 (en) 2014-04-23 2018-05-01 Becton, Dickinson And Company Catheter tubing with extraluminal antimicrobial coating
EP3679956A1 (en) * 2014-07-08 2020-07-15 Becton, Dickinson and Company Antimicrobial coating forming kink resistant feature on a vascular access device
US10232088B2 (en) 2014-07-08 2019-03-19 Becton, Dickinson And Company Antimicrobial coating forming kink resistant feature on a vascular access device
US11219705B2 (en) 2014-07-08 2022-01-11 Becton, Dickinson And Company Antimicrobial coating forming kink resistant feature on a vascular access device
US20160008569A1 (en) * 2014-07-08 2016-01-14 Becton, Dickinson And Company Antimicrobial actuator for opening the side port of a ported catheter
WO2016007439A1 (en) * 2014-07-08 2016-01-14 Becton, Dickinson And Company Antimicrobial coating forming kink resistant feature on a vascular access device
US11077293B2 (en) 2015-01-27 2021-08-03 Becton, Dickinson And Company Antimicrobial inserts for stopcock medical connectors
US10004890B2 (en) 2015-01-27 2018-06-26 Becton, Dickinson And Company Antimicrobial inserts for stopcock medical connectors
US11554259B2 (en) 2015-01-27 2023-01-17 Becton, Dickinson And Company Antimicrobial inserts for stopcock medical connectors
US20180213789A1 (en) * 2015-07-24 2018-08-02 Teleflex Medical Incorporated Antimicrobial compositions for surgical applications
US11904114B2 (en) 2015-10-28 2024-02-20 Becton, Dickinson And Company Extension tubing strain relief
US10493244B2 (en) 2015-10-28 2019-12-03 Becton, Dickinson And Company Extension tubing strain relief
US11452857B2 (en) 2017-09-27 2022-09-27 Beeton, Dickinson and Company Peripheral intravenous catheters having flow diverting features
US10543354B2 (en) 2017-09-27 2020-01-28 Becton, Dickinson And Company Peripheral intravenous catheters having flow diverting features
CN111282777A (zh) * 2020-03-26 2020-06-16 苏州微比特自动化有限公司 一种涂覆固化产线

Also Published As

Publication number Publication date
WO2010065421A1 (en) 2010-06-10
WO2010065422A1 (en) 2010-06-10
ES2643600T3 (es) 2017-11-23
BRPI0922354A2 (pt) 2018-05-29
CA2745149C (en) 2017-01-03
EP2370210A2 (en) 2011-10-05
CA2745149A1 (en) 2010-06-10
AU2009322694B2 (en) 2016-04-21
EP2370525B1 (en) 2017-01-25
MX336185B (es) 2016-01-11
US8426348B2 (en) 2013-04-23
MX2011005738A (es) 2011-08-17
US20100136209A1 (en) 2010-06-03
US20100137472A1 (en) 2010-06-03
JP5730213B2 (ja) 2015-06-03
BRPI0922699A2 (pt) 2018-08-28
CN102272274A (zh) 2011-12-07
US20130330387A1 (en) 2013-12-12
MX2011005729A (es) 2011-07-29
CN102272245A (zh) 2011-12-07
KR101691679B1 (ko) 2016-12-30
MX2011005730A (es) 2011-07-29
JP6022771B2 (ja) 2016-11-09
CA2745191A1 (en) 2010-06-10
CN102272244A (zh) 2011-12-07
EP2370559A1 (en) 2011-10-05
AU2009322694A1 (en) 2011-06-23
ES2618803T3 (es) 2017-06-22
AU2009322693A1 (en) 2011-06-23
CA2745194C (en) 2017-05-09
JP5615289B2 (ja) 2014-10-29
JP2012510339A (ja) 2012-05-10
EP2370559B1 (en) 2018-09-12
BRPI0922354B1 (pt) 2020-09-15
EP2370526A1 (en) 2011-10-05
KR20110106328A (ko) 2011-09-28
WO2010065445A1 (en) 2010-06-10
BRPI0922697A2 (pt) 2018-08-28
EP2370526B1 (en) 2017-07-12
JP2012510560A (ja) 2012-05-10
AU2009322693B2 (en) 2015-01-29
AU2009322644A1 (en) 2011-06-23
JP2012510367A (ja) 2012-05-10
CN102271826A (zh) 2011-12-07
US20100137379A1 (en) 2010-06-03
AU2009322626B2 (en) 2015-06-25
KR20110100247A (ko) 2011-09-09
MX2011005739A (es) 2011-07-29
JP5628195B2 (ja) 2014-11-19
MX349482B (es) 2017-07-28
EP2370525A1 (en) 2011-10-05
KR20110099293A (ko) 2011-09-07
ZA201104197B (en) 2012-02-29
JP2012510559A (ja) 2012-05-10
CA2745158A1 (en) 2010-06-10
WO2010065463A2 (en) 2010-06-10
CA2745191C (en) 2017-01-03
CA2745194A1 (en) 2010-06-10
KR20110100248A (ko) 2011-09-09
ZA201104282B (en) 2012-02-29
KR101691678B1 (ko) 2016-12-30
ZA201104198B (en) 2012-02-29
BRPI0922357A2 (pt) 2018-05-29
ES2701624T3 (es) 2019-02-25
US8754020B2 (en) 2014-06-17
CN102272274B (zh) 2015-04-08
WO2010065463A3 (en) 2010-11-04
AU2009322626A1 (en) 2011-06-23
US8691887B2 (en) 2014-04-08
CN102272244B (zh) 2014-08-27

Similar Documents

Publication Publication Date Title
CA2745191C (en) Antimicrobial uv curable coating compositions
US9695323B2 (en) UV curable solventless antimicrobial compositions

Legal Events

Date Code Title Description
AS Assignment

Owner name: BECTON, DICKINSON AND COMPANY,NEW JERSEY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:OU-YANG, DAVID TIEN-TUNG;REEL/FRAME:022344/0725

Effective date: 20090226

AS Assignment

Owner name: BECTON, DICKINSON AND COMPANY, NEW JERSEY

Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:OU-YANG, DAVID TIEN-TUNG;REEL/FRAME:026771/0391

Effective date: 20110729

STCB Information on status: application discontinuation

Free format text: ABANDONED -- AFTER EXAMINER'S ANSWER OR BOARD OF APPEALS DECISION