CN102272274A - 抗微生物润滑剂组合物 - Google Patents

抗微生物润滑剂组合物 Download PDF

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Publication number
CN102272274A
CN102272274A CN2009801542813A CN200980154281A CN102272274A CN 102272274 A CN102272274 A CN 102272274A CN 2009801542813 A CN2009801542813 A CN 2009801542813A CN 200980154281 A CN200980154281 A CN 200980154281A CN 102272274 A CN102272274 A CN 102272274A
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antimicrobial
lubricant
weight parts
lubricant compositions
compositions
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CN102272274B (zh
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D·T-T·奥-扬
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Becton Dickinson and Co
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Becton Dickinson and Co
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    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/08—Materials for coatings
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    • A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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Abstract

公开了抗微生物润滑剂组合物。所述抗微生物润滑剂组合物在向广泛的医疗器械提供抗微生物能力方面特别有用。所述组合物包括油类润滑剂。代表性润滑剂可包括聚二甲基硅氧烷、三氟丙基共聚物聚硅氧烷、和二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。所述组合物包括所需要的流变改性剂。所述组合物还包括抗微生物试剂，所述抗微生物试剂可选自多种试剂。代表性抗微生物试剂包括醛、N-酰苯胺、双胍、双酚、季铵化合物、氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛。

Description

抗微生物润滑剂组合物
发明背景
本发明涉及抗微生物组合物和在各种医疗应用中使用这些组合物的方法。现代医学治疗的一个主要挑战是控制感染和微生物有机体的传播。
始终存在这种挑战的一个领域是各种类型的输液治疗。输液治疗是一种最普通的健康护理程序。就医、家庭护理和其他患者通过插入血管系统中的血管接入器械来接收流体、医药品和血液产品。可使用输液治疗来治疗感染、提供麻醉或使得痛觉缺失、提供营养支持、治疗肿瘤的生长、保持血压和心律、或用于许多其他临床上重要的用途。
通过血管接入器械可有助于输液治疗。所述血管接入器械可接入患者的外周或中心血管系统。所述血管接入器械可短期(数天)、中期(数周)或长期(数月到数年)留置。可将所述血管接入器械用于连续输液治疗或间歇治疗。
普通的血管接入器械是一种置入患者静脉内的塑料导管。所述导管的长度可从用于外周接入的几个厘米到用于中心接入的许多厘米且可包括诸如经外周中心静脉置管(PICC)的器械。所述导管可经皮植入或通过外科手术植入患者皮肤之下。所述导管或连接到所述导管的任意一种其他血管接入器械可具有单一内腔或多个内腔以用于同时输入多种流体。
血管接入器械通常包括可连接到其他医疗器械的Luer适配器。例如，可将给药设备可一端连接到血管接入器械，而另一端连接脉注射物(IV)袋。所述给药设备是用于连续灌输流体和医药品的流体导管。通常，IV接入器械是可连接到另一个血管接入器械的血管接入器械，其可关闭所述血管接入器械并使得可间歇灌输或注射流体和医药品。IV辅助器械可包括外壳和用于关闭所述系统的隔片。所述隔片可用医疗装置的钝套管或阳式Luer打开。
当血管接入器械的隔片不能正常打开或设计特征具有缺陷时，可造成特定的并发症。与输液治疗相关的并发症可造成明显的病态，甚至死亡。一种显著的并发症是导管相关性血流感染(CRBSI)。在美国的医院中每年发生大约250000～400000个与BSI相关的中心静脉导管(CVC)病例。
血管接入器械可充当感染的滋生地，导致散布BSI(血流感染)。因难以有规律地对所述器械进行冲洗、未消毒的置入技术、或因通过所述通道的任一端进入流体流动通道并随后进入导管置入物中的病原体可造成这种情况。当血管接入器械发生污染时，病原体粘附到所述血管接入器械，发生繁殖并形成生物膜。所述生物膜可抵抗大部分生物杀灭剂并为病原体提供了补充来源而进入到患者血流中，造成BSI。由此，需要具有抗微生物性能的器械。
阻止生物膜的形成和患者感染的一种方法是在医疗器械和元件上提供抗微生物涂层。许多医疗器械是由金属材料或聚合物材料制成的。这些材料通常具有高的摩擦系数。通常将具有低摩擦系数的低分子量材料混入材料主体或涂覆在基材表面上以有助于器械的功能性。
在过去35年间，通常实践的是将热塑性聚氨酯溶液用作抗微生物涂料的载体。溶剂通常为四氢呋喃(THF)、二甲基甲酰胺(DMF)或所述两者的共混物。因为THF能够非常快速被氧化且非常易于爆炸，所以需要昂贵的防爆涂覆设施。这些苛刻的溶剂也会攻击通常使用的许多聚合物材料，所述聚合物材料包括聚氨酯、有机硅、聚异戊二烯、丁基橡胶、聚碳酸酯、硬质聚氨酯、硬质聚氯乙烯、丙烯酸系材料和丁苯橡胶(SBR)。因此，由这些材料制成的医疗器械能够随时间而变形和/或在其表面上形成微裂缝。这种涂料的另一个问题是将溶剂完全热蒸发掉需要花费几乎24小时。因此，常规技术永远存在加工、性能和成本的问题。
另一个限制是合适的抗微生物试剂在这种涂料中的可用性。在涂覆医疗器械中所使用的最常用的抗微生物试剂是银。银盐和银元素在医疗外科行业和普通行业两者中都是熟知的抗微生物试剂。通常将其并入聚合物本体材料中或通过等离子体、热蒸发、电镀、或通过常规的溶剂涂覆技术将其涂覆在医疗器械表面上。这些技术冗长、昂贵且环境不友好。
另外，银涂覆的医疗器械的性能至多算作中等。例如，在由银盐或银元素的离子化而得到的银离子实现作为抗微生物试剂的功效之前，需花费高达八(8)小时。因此，在银涂层恰好发挥功效之前，大量的微生物活性也已发生。此外，银化合物或银元素具有从暗琥珀色到黑色的令人不悦的颜色。
这种类型的血管接入器械可需要润滑剂或从使用润滑剂中受益。为了有助于隔片的启动，能够将润滑剂应用到所述器械的可移动部分上。然而，利用常规润滑剂，细菌和其他微生物还会寄生在润滑剂中。常规润滑剂不能阻止或明显抑制微生物的生长和繁殖。实际上，常规润滑剂会发挥传播微生物试剂的作用。
因此，本领域中需要改进的方法以为各种医疗器械、尤其是关于输液治疗的器械提供抗微生物能力。具体地，需要一种能够与各种医疗器械一起使用的高效抗微生物润滑剂。需要一种润滑剂，以有助于防止微生物传播并在接触时在杀死微生物试剂方面是有用的且是高效的。
发明概述
针对本领域中通过目前可获得的抗微生物组合物和方法尚未完全解决的问题和需要，完成了本发明。因此，通过提供与医疗器械一起使用的抗微生物组合物和方法，开发了这些组合物和方法以减少诸如CRBSI的并发症的危险和几率。
如上所述，为了平稳且有效地运行，特定类型的医疗器械需要润滑剂。如果器械从一个位置到另一个位置反复移动，则通常使用润滑剂。这种器械的一个实例是上文所述类型的IV接入器械。这些器械可例如具有反复开动的内部隔片。例如，可利用钝的套管或医疗器械的阳式Luer将所述隔片打开。一旦所述套管或Luer发生移动，则所述隔片必须移回其最初的关闭构型。因此，为了有助于所述器械平稳且可靠的开动，可使用润滑剂。
因此，在一个方面中，本发明包含具有抗微生物性能的润滑剂并将其用在医疗器械表面上。本发明的润滑剂在上述类型的血管内辅助器械如无针阀上特别有用。所述医疗器械自身由聚合物基材、尤其是弹性体基材(例如聚氨酯、有机硅、聚异戊二烯、丁基橡胶)构成。利用润滑剂对其表面进行涂覆，所述润滑剂含有均匀分布在其整个基体中的抗微生物试剂。所述抗微生物试剂能够扩散通过所述基体并将与所述润滑剂表面接触的微观有机体杀死。
本发明中的润滑剂制剂由一种或多种油类润滑剂、任选的流变改性剂和抗微生物试剂的混合物或组合物构成。在所述混合物中，纳米级或微米级的抗微生物试剂颗粒均匀并永久地分布在整个润滑剂基体中。根据需要，使用流变改性剂来控制制得的混合物的性质。所述润滑剂制剂是无溶剂的。由此，避免了在使用苛刻的溶剂如THF和DMF时所造成的上述问题。
所述油类润滑剂能够为聚二甲基硅氧烷、聚三氟丙基甲基硅氧烷、或二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。优选这些材料具有小于50000cps的粘度。
如上所述，在某些实施方案中，优选向上述材料中添加流变改性剂。这种流变改性剂的实例包括有机粘土、蓖麻蜡、聚酰胺蜡、聚氨酯和热解二氧化硅。将与润滑剂和所述抗微生物试剂相容的任何流变改性剂用于所述组合物中是可接受的。
还可向所述润滑剂组合物中添加抗微生物试剂。所述抗微生物试剂可以是与所述润滑剂制剂中的其他成分相容的任何试剂。另外，优选的是，所述抗微生物试剂克服了现有技术的某些限制。在某些实施方案中，所述抗微生物试剂可选自醛、N-酰苯胺、双胍、银元素或其化合物、双酚、季铵化合物、氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛。
在本发明的某些实施方案中，为了制造本发明的抗微生物润滑剂，将这些成分进行均匀混合。由此，制造和处理相对容易且廉价。此外，由于将抗微生物试剂均匀分布在润滑剂基体中，所述它们逐渐扩散出基体。这导致可控制微生物试剂并尤其是在微生物与润滑剂表面接触时将其杀死。
由此，本发明提供在与医疗器械一起使用时有效的抗微生物润滑剂。所述润滑剂对医疗器械提供有效润滑，同时提供显著的抗微生物性能。在不使用苛刻溶剂或其他商业试剂的条件下配制该润滑剂，所述苛刻溶剂或其他商业试剂将使得处理和配制复杂化。另外，所述制剂作为抗微生物试剂是有效的，因为所述抗微生物试剂易于扩散通过润滑剂中并达到微生物活动的位置。
附图简述
为了使得所获得本发明的上述和其他特征和优势易于理解，通过参考附图中所例示的本发明的具体实施方案而对上面简单描述的本发明进行了更具体地说明。该附图仅显示了本发明的典型实施方案并因此不能将其用于限制本发明的范围。
图1是根据本发明的导管组件的实施方案的透视图。
发明详述
参考图1，使用血管接入器械(也称作血管外器械、血管内接入器械、入口和/或连接到血管外系统或与血管外系统一起起作用的任何器械)10通过导管12将物质透过皮肤14并引入患者18的血管16内。所述血管接入器械10包括具有内腔的主体20和放置在所述内腔内的隔片22。所述隔片22具有裂缝24，通过所述裂缝，单独的血管外器械26例如注射器可将物质引入血管接入器械10内。
所述器械10还包括应用到隔片22上的抗微生物润滑剂40，以有助于所述器械的运行并抑制微生物有机体的生长和繁殖。所述润滑剂有助于阻止血管接入器械10内(包括导管12和导管12的末端32)和/或连接到所述血管接入器械10的血管外系统28内的微生物病原体。所述润滑剂在微生物病原体进入隔片22时与它们接触，以在连接了血管接入器械10或任何在血管外系统28上的其他器械的患者中减少血液流股的感染几率。
病原体可以以许多方式中的任何方式进入所述器械10或系统28。例如，病原体可存在于初次使用之前的器械10或系统28内。在诸如单独器械26的尖端30的结构通过隔片22的裂缝24插入器械10中时，病原体还可从器械的外表面、单独器械26的外表面、和/或周围环境中引入器械10内。所述病原体可在从单独器械26灌输到系统内的流体内被引入。最后，在使用器械10时，在血液抽取期间或血液回流周期内通过导管12末端32的进入，可将病原体从血管16引入系统28内。微生物病原体包括可造成疾病或其他伤害或在接收入患者的血管系统时可能对患者造成伤害可能的所有试剂，包括病原体、细菌、寄生虫、微生物、生物膜、真菌、病毒、喂养病原体的蛋白质、原生动物、和/或其他有害的微生物和/或试剂及其产物。
如上所述，本发明的抗微生物润滑剂可由油类润滑剂、流变改性剂、和抗微生物试剂组成。所述油类润滑剂是能够对所应用的选定的医疗器械进行润滑的任何物质。关于本文中所述的许多种器械，所述油类润滑剂通常选自聚二甲基硅氧烷、聚三氟丙基甲基硅氧烷和二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。在某些优选实施方案中，所述油类润滑剂是二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。在某些实施方案中，所述油类润滑剂具有50000cps以下、优选1000cps以下的粘度。
所述抗微生物润滑剂组合物可还包含一种或多种流变改性剂。在某些优选实施方案中，以在100重量份油类润滑剂中约0.2～约30重量份的量添加所述流变改性剂。在其他优选实施方案中，所述润滑剂组合物可以以在100重量份油类润滑剂中约0.2～约20重量份流变改性剂的量包含流变改性剂。在其他优选实施方案中，所述润滑剂组合物可以以在100重量份油类润滑剂中约0.2～约10重量份流变改性剂的量包含流变改性剂。
如上所述，在某些实施方案中，所述流变改性剂选自有机粘土、蓖麻蜡、聚酰胺蜡、聚氨酯和热解二氧化硅。在特定情况中，优选热解二氧化硅。然而，可根据需要使用其他流变改性剂。
所述组合物可还含有一种或多种抗微生物试剂。以与抗微生物润滑剂组合物的其他成分相容的方式选择抗微生物试剂。此外，所述抗微生物试剂与应用所述抗微生物润滑剂组合物的医疗器械相容。
通常，在抗微生物润滑剂组合物中，在100份的油类润滑剂中抗微生物试剂存在的量为约0.5～约50重量份。在某些其他实施方案中，在100重量份的油类润滑剂中，所述抗微生物试剂存在的量为约0.5～约30重量份。在某些其他实施方案中，在100重量份的油类润滑剂中，所述抗微生物试剂存在的量为约0.5～约20重量份。
可接受的抗微生物试剂可包括但不限于，醛、N-酰苯胺、双胍、双酚、和季铵化合物。在某些实施方案中，所述抗微生物试剂选自氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛。
总之，在某些实施方案中，所述抗微生物润滑剂组合物可由下列物质配制：选自聚二甲基硅氧烷、聚三氟丙基甲基硅氧烷、和二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物的润滑剂；选自有机粘土、蓖麻蜡、聚酰胺蜡、聚氨酯和热解二氧化硅的流变改性剂；和选自氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛的抗微生物试剂。
实施例
实施例1
表1显示了不同润滑剂制剂的接触杀灭和抑制区域。如表1中所示，银元素(10)和银化合物(3、4和5)直至8小时之后都具有相对低的接触杀灭。氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐和苯扎氯铵在1分钟内都具有显著的接触杀灭。
表1不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
Figure BDA0000075081790000081
注释1.润滑剂制剂：
Med.-460(350cps)
流变改性剂：M-5
抗微生物试剂
注释2.抗微生物试剂
试样#1.氯己定二乙酸盐
2.阿来西定
3.磺胺嘧啶银
4.醋酸银
5.柠檬酸银水合物
6.西曲溴铵
7.氯化十六烷基非那吡啶
8.苯扎氯铵
9.邻苯二甲醛
10.银元素
注释3.微生物
表皮葡萄球菌
铜绿假单胞菌
白色念珠菌
注释4.ND＝无数据，所有微生物都被杀死。
实施例2
根据初始试验数据，按如下配制了润滑剂发明的一个优选实施方案：
1.润滑剂-Med-460，350cps，得自Nusil Silicone Technology(Carpinteria，CA)
2.流变改性剂-热解二氧化硅，得自Cabot Corporation(Tuscola，IL)
3.抗微生物试剂-氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐或苯扎氯铵
实施例3
表2显示了不同润滑剂组合物的接触杀灭和抑制区域。试样1～5包括由具有350cps粘度的聚二甲基硅氧烷构成的润滑剂Med.-360。所述抗微生物试剂按如下进行变化：
1.氯己定二乙酸盐
2.西曲溴铵
3.氯化十六烷基非那吡啶
4.苯扎氯铵
5.邻苯二甲醛
表2不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
实施例4
表3显示了不同润滑剂组合物的接触杀灭和抑制区域。试样6～10润滑剂Med.-360，其由具有1000cps粘度的聚二甲基硅氧烷构成。所述抗微生物试剂按如下进行变化：
6.氯己定二乙酸盐
7.西曲溴铵
8.氯化十六烷基非那吡啶
9.苯扎氯铵
10.邻苯二甲醛
表3不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
Figure BDA0000075081790000102
实施例5
表4显示了不同润滑剂组合物的接触杀灭和抑制区域。试样11～15包括由具有350cps粘度的聚三氟丙基甲基硅氧烷构成的润滑剂Med.-400。所述抗微生物试剂按如下进行变化：
11.氯己定二乙酸盐
12.西曲溴铵
13.氯化十六烷基非那吡啶
14.苯扎氯铵
15.邻苯二甲醛
表4不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
Figure BDA0000075081790000111
实施例6
表5显示了不同润滑剂组合物的接触杀灭和抑制区域。试样16～20包括由具有1000cps粘度的聚三氟丙基甲基硅氧烷构成的润滑剂Med.-400。所述抗微生物试剂按如下进行变化：
16.氯己定二乙酸盐
17.西曲溴铵
18.氯化十六烷基非那吡啶
19.苯扎氯铵
20.邻苯二甲醛
表5不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
实施例7
表6显示了不同润滑剂组合物的接触杀灭和抑制区域。试样21～25包括由具有350cps粘度的二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物构成的润滑剂Med.-420。所述抗微生物试剂按如下进行变化：
21.氯己定二乙酸盐
22.西曲溴铵
23.氯化十六烷基非那吡啶
24.苯扎氯铵
25.邻苯二甲醛
表6不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
Figure BDA0000075081790000122
实施例8
表7显示了不同润滑剂组合物的接触杀灭和抑制区域。试样26～30包括由具有1000cps粘度的二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物构成的润滑剂Med.-420。所述抗微生物试剂按如下进行变化：
26.氯己定二乙酸盐
27.西曲溴铵
28.氯化十六烷基非那吡啶
29.苯扎氯铵
30.邻苯二甲醛
表7不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
Figure BDA0000075081790000131
实施例9
表8显示了不同润滑剂组合物的接触杀灭和抑制区域。试样31～35包括由具有1000cps粘度的二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物构成的润滑剂Med.-460。所述抗微生物试剂按如下进行变化：
31.氯己定二乙酸盐
32.西曲溴铵
33.氯化十六烷基非那吡啶
34.苯扎氯铵
35.邻苯二甲醛
表8不同润滑剂制剂1的接触杀灭(％杀灭)和抑制区域(mm)
Figure BDA0000075081790000141
此外应理解，通常优选粘度小于50000cps的润滑剂。这种润滑剂可如下：具有小于50000cps粘度的聚二甲基硅氧烷；具有小于50000cps粘度的三氟丙基共聚物聚硅氧烷；和具有小于50000cps粘度的二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。
如上所述，所述流变改性剂能够为有机粘土、蓖麻蜡、聚酰胺蜡、聚氨酯、热解二氧化硅等。在100重量份的润滑剂中，所述改性剂的量应小于30重量份，优选小于20重量份，在100份润滑剂中最优选为0.2～10重量份。
所述抗微生物试剂能够为醛、N-酰苯胺、双胍、银元素或其化合物、双酚、和季铵化合物以用于制剂。在某些优选实施方案中，所述试剂选自氯化十六烷基非那吡啶、西曲溴铵、和苯扎氯铵、阿来西定、或氯己定二乙酸盐。所述试剂在制剂中的量应为在100重量份的润滑剂中小于50重量份，优选小于30重量份，最优选在100重量份润滑剂中为0.5～20重量份。
可在不背离如本文中所广泛描述的和下文中所要求保护的本发明的结构、方法或其他基本特征的条件下以其他具体形式对本发明进行改变。所述实施方案在各方面都仅是示例性的，而不是限制性的。因此，本发明的范围由附属的权利要求书来限定，而不是由上述实施方案限定。在与权利要求书等价的含义和范围内的所有变化都包括在本发明的范围内。

Claims (18)

1.一种抗微生物润滑剂组合物，其包含：
油类润滑剂；
流变改性剂；和
抗微生物试剂，其选自醛、N-酰苯胺、双胍、双酚、季铵化合物、氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛。
2.权利要求1的抗微生物润滑剂组合物，其中所述抗微生物试剂选自醛、N-酰苯胺、双胍、银、银化合物、双酚和季铵化合物。
3.权利要求1的抗微生物润滑剂组合物，其中所述抗微生物试剂选自氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛。
4.权利要求1的抗微生物润滑剂组合物，其中所述润滑剂选自聚二甲基硅氧烷、聚三氟丙基甲基硅氧烷、以及二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。
5.权利要求1的抗微生物润滑剂组合物，其中所述润滑剂是二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物。
6.权利要求1的抗微生物润滑剂组合物，其中所述润滑剂具有50000cps以下的粘度。
7.权利要求1的抗微生物润滑剂组合物，其中所述流变改性剂选自有机粘土、蓖麻蜡、聚酰胺蜡、聚氨酯和热解二氧化硅。
8.权利要求7的抗微生物润滑剂组合物，其中所述组合物以在100重量份的油类润滑剂中约0.2重量份～约30重量份的量包含流变改性剂。
9.权利要求7的抗微生物润滑剂组合物，其中所述组合物以在100重量份的油类润滑剂中约0.2重量份～约20重量份的量包含流变改性剂。
10.权利要求7的抗微生物润滑剂组合物，其中所述组合物以在100重量份的油类润滑剂中约0.2重量份～约10重量份的量包含流变改性剂。
11.权利要求1的抗微生物润滑剂组合物，其中所述流变改性剂是热解二氧化硅。
12.权利要求1的抗微生物润滑剂组合物，其中所述组合物以在100重量份的油类润滑剂中约0.5重量份～约50重量份的量包含抗微生物试剂。
13.权利要求1的抗微生物润滑剂组合物，其中所述组合物以在100重量份的油类润滑剂中约0.5重量份～约30重量份的量包含抗微生物试剂。
14.权利要求1的抗微生物润滑剂组合物，其中所述组合物以在100重量份的油类润滑剂中约0.5重量份～约20重量份的量包含抗微生物试剂。
15.一种抗微生物润滑剂组合物，包含：
油类润滑剂，其选自聚二甲基硅氧烷、聚三氟丙基甲基硅氧烷、以及二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物；
流变改性剂，其选自有机粘土、蓖麻蜡、聚酰胺蜡、聚氨酯和热解二氧化硅；以及
抗微生物试剂，其选自氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐、苯扎氯铵和邻苯二甲醛。
16.权利要求15的抗微生物润滑剂，其中所述组合物以在100重量份的油类润滑剂中约0.2重量份～约30重量份的量包含流变改性剂。
17.权利要求15的抗微生物润滑剂，其中所述组合物以在约100重量份的油类润滑剂中约0.5重量份～约50重量份的量包含抗微生物试剂。
18.一种抗微生物润滑剂组合物，包含：
包含二甲基硅氧烷和三氟丙基甲基硅氧烷的共聚物的油类润滑剂；
包含热解二氧化硅的流变改性剂；以及
选自氯化十六烷基非那吡啶、西曲溴铵、阿来西定、氯己定二乙酸盐和苯扎氯铵的抗微生物试剂。
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