US20050245483A1 - Matrix for sustained, invariant and independent release of active compounds - Google Patents

Matrix for sustained, invariant and independent release of active compounds Download PDF

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Publication number
US20050245483A1
US20050245483A1 US10/510,673 US51067305A US2005245483A1 US 20050245483 A1 US20050245483 A1 US 20050245483A1 US 51067305 A US51067305 A US 51067305A US 2005245483 A1 US2005245483 A1 US 2005245483A1
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US
United States
Prior art keywords
naloxone
pharmaceutical formulation
release
oxycodone
matrix
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/510,673
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English (en)
Inventor
Bianca Brogmann
Silke Muhlau
Christof Spitzley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Pharma LP
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28676052&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=US20050245483(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10215067A external-priority patent/DE10215067A1/de
Priority claimed from DE10215131A external-priority patent/DE10215131A1/de
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Assigned to EURO-CELTIQUE, S.A. reassignment EURO-CELTIQUE, S.A. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: SPITZLEY, CHRISTOF, BROGMAN, BRIANCA, MUHLAU, SILKE
Publication of US20050245483A1 publication Critical patent/US20050245483A1/en
Priority to US13/348,617 priority Critical patent/US8846090B2/en
Priority to US14/058,108 priority patent/US8846091B2/en
Priority to US14/489,452 priority patent/US9655855B2/en
Assigned to PURDUE PHARMA L.P. reassignment PURDUE PHARMA L.P. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: EURO-CELTIQUE S.A.
Priority to US15/582,119 priority patent/US20170231978A1/en
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/36—Opioid-abuse
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US10/510,673 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds Abandoned US20050245483A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
US13/348,617 US8846090B2 (en) 2002-04-05 2012-01-11 Matrix for sustained, invariant and independent release of active compounds
US14/058,108 US8846091B2 (en) 2002-04-05 2013-10-18 Matrix for sustained, invariant and independent release of active compounds
US14/489,452 US9655855B2 (en) 2002-04-05 2014-09-17 Matrix for sustained, invariant and independent release of active compounds
US15/582,119 US20170231978A1 (en) 2002-04-05 2017-04-28 Matrix for sustained, invariant and independent release of active compounds

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DE10215067A DE10215067A1 (de) 2002-04-05 2002-04-05 Lagerstabiles pharmazeutisches Präparat, das Oxycodon und Naloxon umfasst
DE10215131A DE10215131A1 (de) 2002-04-05 2002-04-05 Matrix zur verzögerten, gleichbleibenden und unabhängigen Freisetzung von Wirkstoffen
DE10215067.2 2002-04-05
DE10215131.8 2002-04-05
PCT/EP2003/003541 WO2003084504A2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2003/003541 A-371-Of-International WO2003084504A2 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US13/348,617 Continuation US8846090B2 (en) 2002-04-05 2012-01-11 Matrix for sustained, invariant and independent release of active compounds

Publications (1)

Publication Number Publication Date
US20050245483A1 true US20050245483A1 (en) 2005-11-03

Family

ID=28676052

Family Applications (11)

Application Number Title Priority Date Filing Date
US10/510,673 Abandoned US20050245483A1 (en) 2002-04-05 2003-04-04 Matrix for sustained, invariant and independent release of active compounds
US10/510,674 Abandoned US20050245556A1 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
US13/251,172 Abandoned US20120108621A1 (en) 2002-04-05 2011-09-30 Pharmaceutical preparation containing oxycodone and naloxone
US13/348,617 Expired - Lifetime US8846090B2 (en) 2002-04-05 2012-01-11 Matrix for sustained, invariant and independent release of active compounds
US14/058,068 Abandoned US20140045877A1 (en) 2002-04-05 2013-10-18 Pharmaceutical preparation containing oxycodone and naloxone
US14/058,108 Expired - Lifetime US8846091B2 (en) 2002-04-05 2013-10-18 Matrix for sustained, invariant and independent release of active compounds
US14/305,785 Expired - Lifetime US9555000B2 (en) 2002-04-05 2014-06-16 Pharmaceutical preparation containing oxycodone and naloxone
US14/489,452 Expired - Lifetime US9655855B2 (en) 2002-04-05 2014-09-17 Matrix for sustained, invariant and independent release of active compounds
US15/399,487 Expired - Lifetime US9907793B2 (en) 2002-04-05 2017-01-05 Pharmaceutical preparation containing oxycodone and naloxone
US15/582,119 Abandoned US20170231978A1 (en) 2002-04-05 2017-04-28 Matrix for sustained, invariant and independent release of active compounds
US15/881,459 Expired - Lifetime US10420762B2 (en) 2002-04-05 2018-01-26 Pharmaceutical preparation containing oxycodone and naloxone

Family Applications After (10)

Application Number Title Priority Date Filing Date
US10/510,674 Abandoned US20050245556A1 (en) 2002-04-05 2003-04-04 Pharmaceutical preparation containing oxycodone and naloxone
US13/251,172 Abandoned US20120108621A1 (en) 2002-04-05 2011-09-30 Pharmaceutical preparation containing oxycodone and naloxone
US13/348,617 Expired - Lifetime US8846090B2 (en) 2002-04-05 2012-01-11 Matrix for sustained, invariant and independent release of active compounds
US14/058,068 Abandoned US20140045877A1 (en) 2002-04-05 2013-10-18 Pharmaceutical preparation containing oxycodone and naloxone
US14/058,108 Expired - Lifetime US8846091B2 (en) 2002-04-05 2013-10-18 Matrix for sustained, invariant and independent release of active compounds
US14/305,785 Expired - Lifetime US9555000B2 (en) 2002-04-05 2014-06-16 Pharmaceutical preparation containing oxycodone and naloxone
US14/489,452 Expired - Lifetime US9655855B2 (en) 2002-04-05 2014-09-17 Matrix for sustained, invariant and independent release of active compounds
US15/399,487 Expired - Lifetime US9907793B2 (en) 2002-04-05 2017-01-05 Pharmaceutical preparation containing oxycodone and naloxone
US15/582,119 Abandoned US20170231978A1 (en) 2002-04-05 2017-04-28 Matrix for sustained, invariant and independent release of active compounds
US15/881,459 Expired - Lifetime US10420762B2 (en) 2002-04-05 2018-01-26 Pharmaceutical preparation containing oxycodone and naloxone

Country Status (33)

Country Link
US (11) US20050245483A1 (ru)
EP (17) EP2425823A1 (ru)
JP (5) JP4755810B2 (ru)
KR (3) KR100784341B1 (ru)
CN (4) CN1646102B (ru)
AP (2) AP2043A (ru)
AR (3) AR039378A1 (ru)
AT (1) ATE418967T2 (ru)
AU (2) AU2003224040B2 (ru)
BR (2) BR0309004A (ru)
CA (3) CA2478523A1 (ru)
CO (2) CO5611100A2 (ru)
CY (5) CY1108914T1 (ru)
DE (6) DE20321531U1 (ru)
DK (6) DK2425821T5 (ru)
ES (7) ES2627300T3 (ru)
FI (1) FI7846U1 (ru)
GE (3) GEP20074022B (ru)
HK (5) HK1072367A1 (ru)
HU (4) HUE032529T2 (ru)
IL (5) IL163990A0 (ru)
LT (3) LT2425821T (ru)
MA (2) MA27249A1 (ru)
MX (2) MXPA04009713A (ru)
NZ (1) NZ535286A (ru)
PH (1) PH12018000176A1 (ru)
PT (5) PT2425821T (ru)
RU (3) RU2297225C2 (ru)
SI (5) SI2425821T1 (ru)
TN (1) TNSN04192A1 (ru)
TW (3) TWI337077B (ru)
WO (2) WO2003084504A2 (ru)
ZA (2) ZA200407267B (ru)

Cited By (51)

* Cited by examiner, † Cited by third party
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US20050245556A1 (en) * 2002-04-05 2005-11-03 Bianca Brogmann Pharmaceutical preparation containing oxycodone and naloxone
US20060194826A1 (en) * 2003-09-25 2006-08-31 Euro-Celtique S.A. Pharmaceutical combinations of hydrocodone and naltrexone
US20070185147A1 (en) * 2004-06-08 2007-08-09 Euro-Celtique S.A. Opioids for the treatment of the restless leg syndrome
US20070259045A1 (en) * 2005-01-28 2007-11-08 Euro-Celtique S.A. Alcohol Resistant Dosage Forms
US20080145429A1 (en) * 2005-02-28 2008-06-19 Petra Leyendecker Dosage Form Containing Oxycodone and Naloxone
US20090142398A1 (en) * 2007-11-21 2009-06-04 Pharmascience Inc. Novel pharmaceutical compositions comprising a disintegration matrix
US20090169626A1 (en) * 2006-01-27 2009-07-02 Euro-Celtique S.A. Tamper resistant dosage forms
US7658939B2 (en) 2000-02-08 2010-02-09 Purdue Pharma L.P. Tamper-resistant oral opioid agonist formulations
US20100047340A1 (en) * 2008-08-20 2010-02-25 Board Of Regents, The University Of Texas System Hot-melt extrusion of modified release multi-particulates
US20100056554A1 (en) * 2006-08-29 2010-03-04 Jo Woodward Use of opioid formulations in needle-less drug delivery devices
WO2010140007A2 (en) * 2009-06-05 2010-12-09 Euro-Celtique S.A. Dosage form
US20110002985A1 (en) * 2007-08-13 2011-01-06 Abuse Deterrent Pharmaceutical, Llc Abuse resistant drugs, method of use and method of making
US7914818B2 (en) 2001-08-06 2011-03-29 Purdue Pharma L.P. Opioid agonist formulations with releasable and sequestered antagonist
US7943173B2 (en) 2001-07-18 2011-05-17 Purdue Pharma L.P. Pharmaceutical combinations of oxycodone and naloxone
US8268349B2 (en) 2003-08-28 2012-09-18 Abbott Laboratories Solid pharmaceutical dosage form
US8362029B2 (en) 2008-12-31 2013-01-29 Upsher-Smith Laboratories, Inc. Opioid-containing oral pharmaceutical compositions and methods
US8377952B2 (en) 2003-08-28 2013-02-19 Abbott Laboratories Solid pharmaceutical dosage formulation
US8445018B2 (en) 2006-09-15 2013-05-21 Cima Labs Inc. Abuse resistant drug formulation
US8518925B2 (en) 2004-06-08 2013-08-27 Euro-Celtique S.A. Opioids for the treatment of the chronic obstructive pulmonary disease (COPD)
US8673355B2 (en) 1997-12-22 2014-03-18 Purdue Pharma L.P. Opioid agonist/antagonist combinations
US8822487B2 (en) 1997-12-22 2014-09-02 Purdue Pharma L.P. Opioid agonist/opioid antagonist/acetaminophen combinations
US8927025B2 (en) 2010-05-11 2015-01-06 Cima Labs Inc. Alcohol-resistant metoprolol-containing extended-release oral dosage forms
US8951555B1 (en) 2000-10-30 2015-02-10 Purdue Pharma L.P. Controlled release hydrocodone formulations
US8969369B2 (en) 2001-05-11 2015-03-03 Purdue Pharma L.P. Abuse-resistant controlled-release opioid dosage form
US8975273B2 (en) 1999-10-29 2015-03-10 Purdue Pharma L.P. Controlled release hydrocodone formulations
US9023390B2 (en) 2009-09-17 2015-05-05 Upsher-Smith Laboratories, Inc. Sustained-release product comprising a combination of a non-opioid amine and a non-steroidal anti-inflammatory drug
US9101625B2 (en) 2006-08-30 2015-08-11 Purdue Pharma L.P. Buprenorphine-wafer for drug substitution therapy
US9149436B2 (en) 2003-04-21 2015-10-06 Purdue Pharma L.P. Pharmaceutical product comprising a sequestered agent
US9192570B2 (en) 2013-12-20 2015-11-24 AntiOP, Inc. Intranasal naloxone compositions and methods of making and using same
US9271940B2 (en) 2009-03-10 2016-03-01 Purdue Pharma L.P. Immediate release pharmaceutical compositions comprising oxycodone and naloxone
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9642801B2 (en) 2008-10-30 2017-05-09 Gruenenthal Gmbh And potent tapentadol dosage forms
US9700508B2 (en) 2010-05-10 2017-07-11 Euro-Celtique S.A. Pharmaceutical compositions comprising hydromorphone and naloxone
US9707184B2 (en) 2014-07-17 2017-07-18 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
US9707224B2 (en) 2013-10-31 2017-07-18 Cima Labs Inc. Immediate release abuse-deterrent granulated dosage forms
US9814710B2 (en) 2013-11-13 2017-11-14 Euro-Celtique S.A. Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
US9861629B1 (en) 2015-10-07 2018-01-09 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
US9901540B2 (en) 2010-05-10 2018-02-27 Euro-Celtique S.A. Combination of active loaded granules with additional actives
US9974751B2 (en) 2006-09-15 2018-05-22 Cima Labs Inc. Abuse resistant drug formulation
US9993433B2 (en) 2010-05-10 2018-06-12 Euro-Celtique S.A. Manufacturing of active-free granules and tablets comprising the same
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