US20050176678A1 - Compounds and method for coating surfaces in a haemocompatibe manner - Google Patents

Compounds and method for coating surfaces in a haemocompatibe manner Download PDF

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Publication number
US20050176678A1
US20050176678A1 US10/513,982 US51398204A US2005176678A1 US 20050176678 A1 US20050176678 A1 US 20050176678A1 US 51398204 A US51398204 A US 51398204A US 2005176678 A1 US2005176678 A1 US 2005176678A1
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United States
Prior art keywords
acid
layer
hemocompatible
heparin
active agent
Prior art date
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Abandoned
Application number
US10/513,982
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English (en)
Inventor
Roland Horres
Marita Linssen
Michael Hoffmann
Erika Hoffmann
Donato Di Baise
Volker Faust
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hemoteq AG
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10221055A external-priority patent/DE10221055B4/de
Application filed by Individual filed Critical Individual
Priority to US10/513,982 priority Critical patent/US20050176678A1/en
Assigned to HEMOTEQ GMBH reassignment HEMOTEQ GMBH ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: HORRES, ROLAND, DI BIASE, DONATO, FAUST, VOLKER, HOFFMANN, ERIKA, HOFFMANN, MICHAEL, LINSSEN, MARITA KATARINA
Publication of US20050176678A1 publication Critical patent/US20050176678A1/en
Priority to US12/827,710 priority patent/US8784862B2/en
Assigned to HEMOTEQ AG reassignment HEMOTEQ AG CHANGE OF NAME (SEE DOCUMENT FOR DETAILS). Assignors: HORRES, ROLAND, DI BIASE, DONATO, FAUST, VOLKER, HOFFMANN, ERIKA, HOFFMANN, MICHAEL, LINSSEN, MARITA KATARINA
Abandoned legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
    • C09D105/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Materials Engineering (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Transplantation (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Application Of Or Painting With Fluid Materials (AREA)
US10/513,982 2002-05-09 2003-04-15 Compounds and method for coating surfaces in a haemocompatibe manner Abandoned US20050176678A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US10/513,982 US20050176678A1 (en) 2002-05-09 2003-04-15 Compounds and method for coating surfaces in a haemocompatibe manner
US12/827,710 US8784862B2 (en) 2002-05-09 2010-06-30 Compounds and method for coating surfaces in a hemocompatible manner

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37867602P 2002-05-09 2002-05-09
DE10221055.1 2002-05-10
DE10221055A DE10221055B4 (de) 2002-05-10 2002-05-10 Verbindungen zur hämokompatiblen Beschichtung von Oberflächen, Verfahren zu deren Herstellung und deren Verwendung
US10/513,982 US20050176678A1 (en) 2002-05-09 2003-04-15 Compounds and method for coating surfaces in a haemocompatibe manner
PCT/DE2003/001253 WO2003094990A1 (de) 2002-05-09 2003-04-15 Verbindungen und verfahren zur hemokompatiblen beschichtung von oberflächen

Related Child Applications (1)

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US12/827,710 Division US8784862B2 (en) 2002-05-09 2010-06-30 Compounds and method for coating surfaces in a hemocompatible manner

Publications (1)

Publication Number Publication Date
US20050176678A1 true US20050176678A1 (en) 2005-08-11

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Family Applications (3)

Application Number Title Priority Date Filing Date
US10/513,982 Abandoned US20050176678A1 (en) 2002-05-09 2003-04-15 Compounds and method for coating surfaces in a haemocompatibe manner
US10/483,545 Abandoned US20040234575A1 (en) 2002-05-09 2003-04-15 Medical products comprising a haemocompatible coating, production and use thereof
US12/827,710 Expired - Fee Related US8784862B2 (en) 2002-05-09 2010-06-30 Compounds and method for coating surfaces in a hemocompatible manner

Family Applications After (2)

Application Number Title Priority Date Filing Date
US10/483,545 Abandoned US20040234575A1 (en) 2002-05-09 2003-04-15 Medical products comprising a haemocompatible coating, production and use thereof
US12/827,710 Expired - Fee Related US8784862B2 (en) 2002-05-09 2010-06-30 Compounds and method for coating surfaces in a hemocompatible manner

Country Status (20)

Country Link
US (3) US20050176678A1 (de)
EP (2) EP1501565B1 (de)
JP (3) JP5106750B2 (de)
CN (2) CN1665554B (de)
AT (2) ATE344064T1 (de)
AU (2) AU2003240391B8 (de)
BR (2) BR0311446A (de)
CA (2) CA2484374C (de)
DE (4) DE10393059D2 (de)
DK (2) DK1501566T3 (de)
EA (1) EA009092B1 (de)
ES (2) ES2276065T3 (de)
IL (3) IL164947A (de)
MX (2) MXPA04011111A (de)
NZ (2) NZ536330A (de)
PL (2) PL208277B1 (de)
PT (2) PT1501566E (de)
SI (1) SI1501566T1 (de)
WO (2) WO2003094990A1 (de)
ZA (2) ZA200408757B (de)

Cited By (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040234575A1 (en) * 2002-05-09 2004-11-25 Roland Horres Medical products comprising a haemocompatible coating, production and use thereof
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US20060128777A1 (en) * 2004-11-05 2006-06-15 Bendall Heather H Cancer treatments
US20060159713A1 (en) * 2005-01-14 2006-07-20 Cephalon, Inc. Bendamustine pharmaceutical compositions
US20060165962A1 (en) * 2003-06-21 2006-07-27 Borck Alexander J Coating system for implants for increasing tissue compatibility
US20070048350A1 (en) * 2005-08-31 2007-03-01 Robert Falotico Antithrombotic coating for drug eluting medical devices
US20070142905A1 (en) * 2005-12-16 2007-06-21 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20070207183A1 (en) * 2006-01-05 2007-09-06 Med Institute, Inc. Zein coated medical device
US20070212393A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Compositions and coatings for implantable medical devices
US20070213382A1 (en) * 2004-05-03 2007-09-13 Susilo Rudy 2-methylthiazolidine-2, 4-dicarboxylic acid-containing combination preparations
US20070254002A1 (en) * 2006-04-26 2007-11-01 Sheng-Qian Wu Biocompatible devices coated with activated protein C
EP1887355A1 (de) * 2006-08-02 2008-02-13 F.Hoffmann-La Roche Ag Mikrofluidiksystem und Beschichtungsverfahren dafür
WO2008128567A1 (en) * 2007-04-19 2008-10-30 Medovent Gmbh Device made at least partially of n-acetylchitosan with controlled biodissolution
US20080299170A1 (en) * 2005-07-21 2008-12-04 Aston University Medical Devices and Coatings Therefor
US20090092664A1 (en) * 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
EP2105459A1 (de) * 2007-01-16 2009-09-30 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Wässrige lösungszusammensetzung
US20090258050A1 (en) * 2007-11-20 2009-10-15 Med Institute, Inc. Controlled Drug Delivery Using a Zein Layer Modified with Levulinic Acid
US20090264488A1 (en) * 2008-03-26 2009-10-22 Cephalon, Inc. Novel solid forms of bendamustine hydrochloride
US20100161021A1 (en) * 2007-06-07 2010-06-24 National University Corporation Kanazawa University Myocardial pad
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20100210701A1 (en) * 2009-01-15 2010-08-19 Cephalon, Inc. Novel Forms of Bendamustine Free Base
US7792562B2 (en) 1997-03-04 2010-09-07 Dexcom, Inc. Device and method for determining analyte levels
US20100272773A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of Drug Polymorphs to Achieve Controlled Drug Delivery From a Coated Medical Device
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US20100322992A1 (en) * 2004-06-30 2010-12-23 Stephen Dugan Anti-Proliferative And Anti-Inflammatory Agent Combination For Treatment Of Vascular Disorders With An Implantable Medical Device
US20110008260A1 (en) * 2009-07-10 2011-01-13 Boston Scientific Scimed, Inc. Use of Nanocrystals for Drug Delivery from a Balloon
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US20110117139A1 (en) * 2008-05-30 2011-05-19 Ls Medcap Gmbh Fully synthetic albumin analog
US20110190363A1 (en) * 2008-09-25 2011-08-04 Cephalon, Inc. Liquid formulations of bendamustine
US8050731B2 (en) 2002-05-22 2011-11-01 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US8064977B2 (en) 2002-05-22 2011-11-22 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8070798B2 (en) 2007-07-20 2011-12-06 Josiah Wilcox Drug eluting medical device and method
US20110301697A1 (en) * 2009-04-10 2011-12-08 Hemoteq Ag Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open
WO2012094565A1 (en) * 2011-01-06 2012-07-12 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
US8255032B2 (en) 2003-07-25 2012-08-28 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US8317776B2 (en) 2007-12-18 2012-11-27 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8409132B2 (en) 2007-12-18 2013-04-02 The Invention Science Fund I, Llc Treatment indications informed by a priori implant information
US20130136657A1 (en) * 2010-07-23 2013-05-30 Roche Diagnostics Operations, Inc. Method for hydrophilizing surfaces of fluidic components and parts containing such components
US8509871B2 (en) 2001-07-27 2013-08-13 Dexcom, Inc. Sensor head for use with implantable devices
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8591571B2 (en) 2009-03-02 2013-11-26 Japan Stent Technology Co., Ltd. Drug-eluting stent
US8597720B2 (en) 2007-01-21 2013-12-03 Hemoteq Ag Medical product for treating stenosis of body passages and for preventing threatening restenosis
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US8641756B2 (en) 2007-09-04 2014-02-04 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8929968B2 (en) 2003-12-05 2015-01-06 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US9439589B2 (en) 1997-03-04 2016-09-13 Dexcom, Inc. Device and method for determining analyte levels
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US9986942B2 (en) 2004-07-13 2018-06-05 Dexcom, Inc. Analyte sensor
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US10610137B2 (en) 2005-03-10 2020-04-07 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10791928B2 (en) 2007-05-18 2020-10-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US10813577B2 (en) 2005-06-21 2020-10-27 Dexcom, Inc. Analyte sensor
US11007307B2 (en) 2006-04-26 2021-05-18 Micell Technologies, Inc. Coatings containing multiple drugs
US11399745B2 (en) 2006-10-04 2022-08-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors

Families Citing this family (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1539041A1 (de) * 2002-07-25 2005-06-15 Avantec Vascular Corporation Vorrichtungen zur abgabe von therapeutischen mitteln und relevante verfahren
RU2005118750A (ru) * 2002-11-15 2006-03-20 Новартис АГ (CH) Органические соединения
FR2847474B1 (fr) * 2002-11-25 2006-03-24 Inst Rech Developpement Ird Utilisation de la canthin-6-one, des extraits de plantes la contenant et de ses derives dans le traitement de la maladie de chagas
US7758881B2 (en) * 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
AR043504A1 (es) * 2003-03-17 2005-08-03 Novartis Ag Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias
EP1649260A4 (de) 2003-07-25 2010-07-07 Dexcom Inc Elektrodensysteme für elektochemische sensoren
US7488343B2 (en) 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
WO2005049105A2 (en) * 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US8137397B2 (en) 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US20050214339A1 (en) 2004-03-29 2005-09-29 Yiwen Tang Biologically degradable compositions for medical applications
US7803182B2 (en) * 2004-05-28 2010-09-28 Cordis Corporation Biodegradable vascular device with buffering agent
JP4767252B2 (ja) 2004-06-14 2011-09-07 ヌームアールエックス・インコーポレーテッド 肺のアクセス装置
US20050281799A1 (en) 2004-06-16 2005-12-22 Glen Gong Targeting damaged lung tissue using compositions
US20050281739A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue using compositions
US20050281740A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue
US20050281798A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue using composition
US7608579B2 (en) * 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
EP1781182B1 (de) 2004-07-08 2019-11-13 PneumRx, Inc. Vorrichtung zur behandlung von pleuralerguss
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US9125639B2 (en) 2004-11-23 2015-09-08 Pneumrx, Inc. Steerable device for accessing a target site and methods
CA2598213C (en) * 2005-02-18 2011-04-19 Abraxis Bioscience, Inc. Drugs with improved hydrophobicity for incorporation in medical devices
WO2006099381A1 (en) * 2005-03-14 2006-09-21 Conor Medsystems, Inc. Drug delivery stent with extended in vivo and in vitro release of anti-inflammatory
JP5026004B2 (ja) * 2005-06-28 2012-09-12 江崎グリコ株式会社 リン酸化糖を含有するチタンインプラント材
DE102005040211B4 (de) 2005-08-16 2010-02-11 Maquet Cardiopulmonary Ag Verwendung von nichtionischen Estern in einer Beschichtung für mit Blut in Kontakt kommende Oberflächen und medizinische Vorrichtung
EP1948069B1 (de) * 2005-11-15 2020-01-22 Orbusneich Medical Pte. Ltd Vorläufer-endothelialzellen-erfassung mit einer implantierbaren medizinischen vorrichtung zur wirkstofffreisetzung
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
US8721734B2 (en) 2009-05-18 2014-05-13 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
JP2007244601A (ja) * 2006-03-15 2007-09-27 Kanazawa Univ 心筋用パッド
NZ574597A (en) * 2006-07-03 2011-11-25 Hemoteq Ag Stent coated with a biodegradable polymer and rapamycin
EP2101683A4 (de) * 2007-01-11 2014-12-03 Robert Lamar Bjork Jr Koronararterienstent zur freisetzung mehrerer medikamente und für perkutane koronararterieneingriffe
CA2687031A1 (en) * 2007-05-15 2008-11-20 Chameleon Biosurfaces Limited Polymer coatings on medical devices
US20110104228A1 (en) * 2007-10-19 2011-05-05 Interface Biologics, Inc Self-eliminating coatings
BRPI0821105A2 (pt) * 2007-11-30 2015-10-06 Academisch Ziekenhuis Maastricht ferramentas terapêuticas e de diagnóstico para doenças que alteram a função vascular
CN101234217B (zh) * 2008-03-07 2013-12-18 苏州盖依亚生物医药有限公司 一种功能性靶向治疗可降解的生物支架及其用途
DE102008002471A1 (de) * 2008-06-17 2009-12-24 Biotronik Vi Patent Ag Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
GB0816783D0 (en) * 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
JP2012524131A (ja) * 2009-04-15 2012-10-11 ビーエーエスエフ ソシエタス・ヨーロピア モノエチレン系不飽和グリコシルアミンの製造方法
DK2295132T3 (en) 2009-05-15 2016-12-05 Interface Biologics Inc Antithrombogenic hollow-fiber membranes, molding material and blood long
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
WO2011072398A1 (en) 2009-12-18 2011-06-23 Interface Biologics, Inc. Local delivery of drugs from self assembled coatings
JP2013521836A (ja) * 2010-03-03 2013-06-13 エドワーズ ライフサイエンシーズ コーポレイション 抗凝固輸液流体源
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
US9314551B2 (en) 2010-05-14 2016-04-19 Boston Scientific Scimed, Inc. Block copolymer-coated endoprosthesis
WO2012028310A2 (en) * 2010-08-31 2012-03-08 Avidal Vascular Gmbh Pharmaceutical compositions comprising a taxane
JP6034795B2 (ja) * 2010-12-04 2016-11-30 アレクサンダー リュベンＡｌｅｘａｎｄｅｒ Ｒｕｅｂｂｅｎ バルーンカテーテルのバルーンのためのコーティング及びコーティング方法並びにコーティングされたバルーンを備えるバルーンカテーテル
WO2012103483A2 (en) * 2011-01-28 2012-08-02 The General Hospital Corporation Apparatus and method for tissue biopsy
CA2825950C (en) 2011-01-28 2019-06-18 The General Hospital Corporation Method and apparatus for skin resurfacing
ES2514322T3 (es) 2011-04-07 2014-10-28 Fresenius Medical Care Deutschland Gmbh Péptidos para suprimir reacciones de inflamación en hemodiálisis
EP2508199B1 (de) 2011-04-07 2014-09-17 Fresenius Medical Care Deutschland GmbH Melanozytenstimulierendes Hormon zur Unterdrückung von Entzündungsreaktionen bei Hämodialyse
TW201311774A (zh) * 2011-06-23 2013-03-16 Toray Industries 具有抗血液凝固作用的疏水性高分子化合物
BR112014001248B1 (pt) 2011-07-21 2020-12-08 The General Hospital Corporation aparelho e método para afetar o tecido adiposo subcutâneo
RU2484178C2 (ru) * 2011-09-08 2013-06-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Биохимической Физики Им. Н.М. Эмануэля Российской Академии Наук (Ибхф Ран) Способ получения белковых покрытий на поверхности твердых тел, содержащих ионы металлов переменной валентности
US8669314B2 (en) 2012-02-03 2014-03-11 Sabic Innovative Plastics Ip B.V. Hydrolytic stability in polycarbonate compositions
JP6104232B2 (ja) 2012-03-27 2017-03-29 テルモ株式会社 コーティング組成物および医療機器
US20130303983A1 (en) * 2012-05-09 2013-11-14 Cook Medical Technologies Llc Coated medical devices including a water-insoluble therapeutic agent
CN102691083B (zh) * 2012-05-29 2014-12-03 上海大学 一种改善金属材料表面血液相容性的电化学方法
DE102012010800A1 (de) * 2012-06-01 2013-12-05 Alexander Rübben Beschichtung von Ballonkathetern
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2014112956A1 (en) 2013-01-17 2014-07-24 Center Odličnosti Polimerni Marteriali In Tehnologije Method for treatment of a vascular graft
AU2014219240B2 (en) 2013-02-20 2018-12-20 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
CA2906621A1 (en) * 2013-03-15 2014-09-25 Baxter International Inc. Immobilization of active agent on a substrate
KR102271653B1 (ko) 2013-06-07 2021-07-05 백스터 인터내셔널 인코포레이티드 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화
EP3060174B1 (de) * 2013-10-22 2020-05-27 Concievalve LLC Verfahren zur hemmung von stenose, obstruktionen oder verkalkung einer gestenteten herzklappe oder bioprothese
AU2014348502B2 (en) 2013-11-15 2019-08-15 Tangible Science, Inc. Contact lens with a hydrophilic layer
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin
CN103721300B (zh) * 2013-12-19 2015-05-20 华中科技大学 一种抗凝血涂层材料及其制备方法
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
JP6389009B2 (ja) * 2014-10-30 2018-09-12 チェンデュ バイユ ファーマシューティカル カンパニー リミテッドＣｈｅｎｇｄｕ Ｂａｉｙｕ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ． ギンコライドＢと第Ｘａ因子阻害剤とを含有する薬物組成物及びその製造方法と用途
AU2015346141B2 (en) 2014-11-14 2021-07-22 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
US10525170B2 (en) * 2014-12-09 2020-01-07 Tangible Science, Llc Medical device coating with a biocompatible layer
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
AU2017245174A1 (en) 2016-03-29 2018-10-04 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
CN106119820B (zh) * 2016-06-01 2018-06-22 华南理工大学 一种利用可控接枝技术提高材料表面血液相容性的方法
US10130900B2 (en) 2016-06-16 2018-11-20 Bandera Acquisition, Llc Composite column for use in high pressure liquid chromatography
EP3515323A4 (de) 2016-09-21 2020-06-10 Cytrellis Biosystems, Inc. Vorrichtungen und verfahren zur kosmetischen hauterneuerung
CN110167995B (zh) 2016-10-18 2022-07-01 界面生物公司 具有表面改性大分子的塑化pvc混合物和由其制成的制品
IT201700075956A1 (it) * 2017-07-12 2019-01-12 Mediplasma S R L Immobilizzazione covalente di Eparina su lenti a contatto (LAC) e dispositivi di interesse medico-chirurgico trattati via plasma
WO2019014400A1 (en) 2017-07-14 2019-01-17 Fresenius Medical Care Holdings, Inc. PROCESS FOR OBTAINING SURFACE MODIFICATION COMPOSITION WITH ENHANCED BY-PRODUCT REMOVAL
CN107456611A (zh) * 2017-07-23 2017-12-12 北京化工大学 一种抗凝血复合涂层的制备方法
CN111372451B (zh) * 2017-10-19 2022-08-12 斯特雷克股份有限公司 用于胞外囊泡的溶血和凝血调节以及稳定化的组合物
CN109925536B (zh) * 2017-12-15 2021-01-26 先健科技(深圳)有限公司 可吸收铁基植入式器械
EP3796948A4 (de) 2018-05-22 2022-03-02 Interface Biologics Inc. Zusammensetzungen und verfahren zur verabreichung von arzneimitteln an eine gefässwand
CN108715875B (zh) * 2018-05-30 2021-05-25 上海交通大学 酶化学法合成结构明确的硫酸肝素寡糖的方法
CN112111080A (zh) * 2018-09-25 2020-12-22 湖南博隽生物医药有限公司 一种抗钙化心脏瓣膜用聚合物材料
CN109568676A (zh) * 2018-12-29 2019-04-05 张桂玲 一种抗菌超滑医用留置导管用材料
CN109821076B (zh) * 2019-03-13 2021-05-07 陕西师范大学 一种抗凝抗感染的多功能涂层的制备方法及抗凝抗感染的多功能材料
US11931482B2 (en) 2019-03-18 2024-03-19 Brown University Auranofin-releasing antibacterial and antibiofilm polyurethane intravascular catheter coatings
CN109806850B (zh) * 2019-03-25 2021-12-10 东华大学 一种具有吸附性能的粘胶无纺布材料及其制备方法
CN109943068B (zh) * 2019-03-28 2022-01-25 金旸（厦门）新材料科技有限公司 一种耐高温尼龙材料和电镀尼龙材料及其准备方法和应用
CN110506634B (zh) * 2019-09-29 2022-07-05 上海市农业科学院 一种鸢尾化学诱变剂量筛选方法
TWI749395B (zh) * 2019-11-08 2021-12-11 高鼎精密材料股份有限公司 具有高暢通率的高分子纖維管材結構的製備方法
CN110790970B (zh) * 2019-11-22 2022-08-12 辽宁万鑫富利新材料有限公司 一种高血液相容性pet复合薄膜材料的制备方法
CN115003345A (zh) * 2019-11-30 2022-09-02 智能反应堆服务有限公司 用于医疗器械的涂层
CN111729083B (zh) * 2020-04-03 2022-08-23 广州医科大学附属第二医院 内皮蛋白c受体的新用途
CN111644084A (zh) * 2020-06-15 2020-09-11 齐松松 一种改性羧甲基壳聚糖聚四氟乙烯纳滤膜及其制备方法
CN113171499A (zh) * 2021-03-17 2021-07-27 广东粤港澳大湾区国家纳米科技创新研究院 一种抗凝血材料、双层水凝胶管路及其制备方法和应用
CN115607750B (zh) * 2021-07-16 2024-02-23 中国科学院宁波材料技术与工程研究所 一种原位抗凝改性医用pvc材料、其制备方法及应用
CN113616861A (zh) * 2021-08-03 2021-11-09 广州维力医疗器械股份有限公司 逐层自组装复合抗凝血涂层、其制备方法及医疗器械
CN113648013A (zh) * 2021-08-25 2021-11-16 心凯诺医疗科技(上海)有限公司 一种血流导向密网支架
CN114042441B (zh) * 2021-12-09 2024-05-03 云南师范大学 在血液灌流树脂微球表面修饰并固载肝素的方法及其制备的吸附剂
CN114949347B (zh) * 2022-05-31 2023-05-12 四川大学 一种改性交联生物瓣膜及其制备方法和用途
CN115490827A (zh) * 2022-11-16 2022-12-20 北京新尖科技有限公司 聚碳酸酯聚二甲基硅氧烷型聚氨酯脲及制备方法
CN117696017B (zh) * 2024-02-05 2024-05-07 四川大学华西医院 一种血液净化吸附改性材料及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5718862A (en) * 1996-04-24 1998-02-17 Hercules Incorporated Secondary shaping of ionically crosslinked polymer compositions for medical devices
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
US20010000802A1 (en) * 1998-04-30 2001-05-03 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US20020193516A1 (en) * 2001-03-30 2002-12-19 Bucevschi Mircea Dan Biocompatible, Biodegradable, water-absorbent material and methods for its preparation
US20030059454A1 (en) * 2001-09-24 2003-03-27 Barry James J. Optimized dosing for drug coated stents

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
EP0002677B1 (de) * 1977-12-02 1982-10-13 Takeda Chemical Industries, Ltd. Glucosamin-peptid-Derivate und ihre pharmazeutischen Zusammensetzungen
JPS56161803A (en) 1980-05-17 1981-12-12 Nitto Electric Ind Co Ltd Treatment of resin containing organic solution
US4572901A (en) * 1983-06-23 1986-02-25 Children's Hospital Medical Center Of Northern California Method and composition for protein immobilization
US4661345A (en) * 1985-02-26 1987-04-28 The Rockefeller University Method for treating pertussis
SE8501613D0 (sv) 1985-04-01 1985-04-01 Bio Carb Ab Foreningar for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutisk behandling
US5155110A (en) * 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
US5206318A (en) * 1989-04-20 1993-04-27 Mitsui Toatsu Chemicals, Inc. Styrene derivatives having N-acetylchito-oligosaccharide chains and method for the same
US5510077A (en) * 1992-03-19 1996-04-23 Dinh; Thomas Q. Method of making an intraluminal stent
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
EP1371666B1 (de) * 1994-07-01 2007-08-15 Seikagaku Corporation Verwendung von desulfatiertem Heparin
US5997517A (en) * 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
DE19705366C2 (de) * 1997-02-12 2002-08-01 Fresenius Ag Trägermaterial zur Reinigung proteinhaltiger Lösungen, Verfahren zur Herstellung des Trägermaterials und Verwendung des Trägermaterials
DE19724869C2 (de) 1997-06-12 1999-05-12 Henkel Kgaa Verwendung von Citosanderivaten zur Oberflächenbeschichtung
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
IT1296581B1 (it) * 1997-11-28 1999-07-14 Istituto Scient Di Chimica E B Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici
US5922692A (en) * 1998-03-11 1999-07-13 Marino; Richard P. Concentration of glycosaminoglycans and precursors thereto in food products
JP4583597B2 (ja) * 1998-05-05 2010-11-17 ボストン サイエンティフィック リミテッド 末端が滑らかなステント
ITPD980169A1 (it) * 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
AU771367B2 (en) * 1998-08-20 2004-03-18 Cook Medical Technologies Llc Coated implantable medical device
WO2000043120A1 (en) * 1999-01-22 2000-07-27 The Dow Chemical Company Surface modified divinylbenzene resin having a hemocompatible coating
DE19908318A1 (de) * 1999-02-26 2000-08-31 Michael Hoffmann Hämokompatible Oberflächen und Verfahren zu deren Herstellung
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US7781416B2 (en) * 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
DE60133377T2 (de) * 2000-04-28 2009-01-02 Baylor College Of Medicine, Houston Dezellularisierte gefässprothesen
US6489311B1 (en) * 2000-05-02 2002-12-03 Charlotte-Mecklenburg Hospital Authoirty Method for the prevention of apoptosis
DE60114724T2 (de) * 2000-07-18 2006-06-01 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Blutflussverbesserer und Mittel zur Vorbeugung oder Heilung von Thrombose
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US20020087123A1 (en) * 2001-01-02 2002-07-04 Hossainy Syed F.A. Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices
CN1568166A (zh) * 2001-10-15 2005-01-19 荷姆泰克股份有限公司 预防再狭窄的涂层支架
PT1501566E (pt) * 2002-05-09 2008-11-13 Hemoteq Ag Produtos médicos que compreendem um revestimento hemocompatível, produção e utilização do mesmo

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
US5718862A (en) * 1996-04-24 1998-02-17 Hercules Incorporated Secondary shaping of ionically crosslinked polymer compositions for medical devices
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US20010000802A1 (en) * 1998-04-30 2001-05-03 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
US20020193516A1 (en) * 2001-03-30 2002-12-19 Bucevschi Mircea Dan Biocompatible, Biodegradable, water-absorbent material and methods for its preparation
US20030059454A1 (en) * 2001-09-24 2003-03-27 Barry James J. Optimized dosing for drug coated stents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Casu, b., Grazioli, G., Hannesson, H., Jann, B., Jann, K., Lindahl, U., Naggi, A., Oreste, P., Razi, N., Torri, G., Tursi, F., Zoppetti, G. (1994) Biologically Active, Heparan Sulfate-Like Species by Combined Chemical and Enzymic Modification of the Escherichia coli Polysaccharide K5. Carbohydrate Letters, vol. 1, p. 107-114. *
Hirano, S., Ohashi, W. (1976) N-Acylation of N-Desulfated Heparin. Agricultural and Biological Chemistry, vol. 40, no. 12, p. 2501-2502. *

Cited By (184)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7974672B2 (en) 1997-03-04 2011-07-05 Dexcom, Inc. Device and method for determining analyte levels
US7792562B2 (en) 1997-03-04 2010-09-07 Dexcom, Inc. Device and method for determining analyte levels
US8676288B2 (en) 1997-03-04 2014-03-18 Dexcom, Inc. Device and method for determining analyte levels
US9339223B2 (en) 1997-03-04 2016-05-17 Dexcom, Inc. Device and method for determining analyte levels
US9439589B2 (en) 1997-03-04 2016-09-13 Dexcom, Inc. Device and method for determining analyte levels
US7835777B2 (en) 1997-03-04 2010-11-16 Dexcom, Inc. Device and method for determining analyte levels
US9931067B2 (en) 1997-03-04 2018-04-03 Dexcom, Inc. Device and method for determining analyte levels
US8527025B1 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US7970448B2 (en) 1997-03-04 2011-06-28 Dexcom, Inc. Device and method for determining analyte levels
US9328371B2 (en) 2001-07-27 2016-05-03 Dexcom, Inc. Sensor head for use with implantable devices
US8509871B2 (en) 2001-07-27 2013-08-13 Dexcom, Inc. Sensor head for use with implantable devices
US9804114B2 (en) 2001-07-27 2017-10-31 Dexcom, Inc. Sensor head for use with implantable devices
US8784862B2 (en) 2002-05-09 2014-07-22 Hemoteq Ag Compounds and method for coating surfaces in a hemocompatible manner
US20110009955A1 (en) * 2002-05-09 2011-01-13 Hemoteq Gmbh Compounds and method for coating surfaces in a hemocompatible manner
US20040234575A1 (en) * 2002-05-09 2004-11-25 Roland Horres Medical products comprising a haemocompatible coating, production and use thereof
US8053018B2 (en) 2002-05-22 2011-11-08 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US8865249B2 (en) 2002-05-22 2014-10-21 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US9801574B2 (en) 2002-05-22 2017-10-31 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US9179869B2 (en) 2002-05-22 2015-11-10 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US8050731B2 (en) 2002-05-22 2011-11-01 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US9549693B2 (en) 2002-05-22 2017-01-24 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US10052051B2 (en) 2002-05-22 2018-08-21 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US8064977B2 (en) 2002-05-22 2011-11-22 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US11020026B2 (en) 2002-05-22 2021-06-01 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US10154807B2 (en) 2002-05-22 2018-12-18 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
US8543184B2 (en) 2002-05-22 2013-09-24 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US20060165962A1 (en) * 2003-06-21 2006-07-27 Borck Alexander J Coating system for implants for increasing tissue compatibility
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US10376143B2 (en) 2003-07-25 2019-08-13 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8255032B2 (en) 2003-07-25 2012-08-28 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US7828728B2 (en) 2003-07-25 2010-11-09 Dexcom, Inc. Analyte sensor
US8255033B2 (en) 2003-07-25 2012-08-28 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US9993186B2 (en) 2003-07-25 2018-06-12 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US10610140B2 (en) 2003-07-25 2020-04-07 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US9597027B2 (en) 2003-07-25 2017-03-21 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US8909314B2 (en) 2003-07-25 2014-12-09 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US8255030B2 (en) 2003-07-25 2012-08-28 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US7761130B2 (en) 2003-07-25 2010-07-20 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
US8929968B2 (en) 2003-12-05 2015-01-06 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US10188333B2 (en) 2003-12-05 2019-01-29 Dexcom, Inc. Calibration techniques for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20070213382A1 (en) * 2004-05-03 2007-09-13 Susilo Rudy 2-methylthiazolidine-2, 4-dicarboxylic acid-containing combination preparations
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US9138337B2 (en) 2004-06-30 2015-09-22 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US8709469B2 (en) 2004-06-30 2014-04-29 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US20100322992A1 (en) * 2004-06-30 2010-12-23 Stephen Dugan Anti-Proliferative And Anti-Inflammatory Agent Combination For Treatment Of Vascular Disorders With An Implantable Medical Device
US9566373B2 (en) 2004-06-30 2017-02-14 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
US7885697B2 (en) 2004-07-13 2011-02-08 Dexcom, Inc. Transcutaneous analyte sensor
US11064917B2 (en) 2004-07-13 2021-07-20 Dexcom, Inc. Analyte sensor
US10709363B2 (en) 2004-07-13 2020-07-14 Dexcom, Inc. Analyte sensor
US10993642B2 (en) 2004-07-13 2021-05-04 Dexcom, Inc. Analyte sensor
US10993641B2 (en) 2004-07-13 2021-05-04 Dexcom, Inc. Analyte sensor
US10980452B2 (en) 2004-07-13 2021-04-20 Dexcom, Inc. Analyte sensor
US11026605B1 (en) 2004-07-13 2021-06-08 Dexcom, Inc. Analyte sensor
US10932700B2 (en) 2004-07-13 2021-03-02 Dexcom, Inc. Analyte sensor
US11045120B2 (en) 2004-07-13 2021-06-29 Dexcom, Inc. Analyte sensor
US10827956B2 (en) 2004-07-13 2020-11-10 Dexcom, Inc. Analyte sensor
US10799158B2 (en) 2004-07-13 2020-10-13 Dexcom, Inc. Analyte sensor
US10709362B2 (en) 2004-07-13 2020-07-14 Dexcom, Inc. Analyte sensor
US8792953B2 (en) 2004-07-13 2014-07-29 Dexcom, Inc. Transcutaneous analyte sensor
US10722152B2 (en) 2004-07-13 2020-07-28 Dexcom, Inc. Analyte sensor
US9414777B2 (en) 2004-07-13 2016-08-16 Dexcom, Inc. Transcutaneous analyte sensor
US10813576B2 (en) 2004-07-13 2020-10-27 Dexcom, Inc. Analyte sensor
US11883164B2 (en) 2004-07-13 2024-01-30 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10524703B2 (en) 2004-07-13 2020-01-07 Dexcom, Inc. Transcutaneous analyte sensor
US10918314B2 (en) 2004-07-13 2021-02-16 Dexcom, Inc. Analyte sensor
US10918315B2 (en) 2004-07-13 2021-02-16 Dexcom, Inc. Analyte sensor
US10918313B2 (en) 2004-07-13 2021-02-16 Dexcom, Inc. Analyte sensor
US9986942B2 (en) 2004-07-13 2018-06-05 Dexcom, Inc. Analyte sensor
US10799159B2 (en) 2004-07-13 2020-10-13 Dexcom, Inc. Analyte sensor
US20060128777A1 (en) * 2004-11-05 2006-06-15 Bendall Heather H Cancer treatments
US20090209606A1 (en) * 2004-11-05 2009-08-20 Heather Helene Bendall Cancer Treatments
US8461350B2 (en) 2005-01-14 2013-06-11 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8791270B2 (en) 2005-01-14 2014-07-29 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8895756B2 (en) 2005-01-14 2014-11-25 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8609863B2 (en) 2005-01-14 2013-12-17 Cephalon, Inc. Bendamustine pharmaceutical compositions
US20060159713A1 (en) * 2005-01-14 2006-07-20 Cephalon, Inc. Bendamustine pharmaceutical compositions
US10925524B2 (en) 2005-03-10 2021-02-23 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10856787B2 (en) 2005-03-10 2020-12-08 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10918318B2 (en) 2005-03-10 2021-02-16 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10709364B2 (en) 2005-03-10 2020-07-14 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10617336B2 (en) 2005-03-10 2020-04-14 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10918317B2 (en) 2005-03-10 2021-02-16 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10610137B2 (en) 2005-03-10 2020-04-07 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10743801B2 (en) 2005-03-10 2020-08-18 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10898114B2 (en) 2005-03-10 2021-01-26 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10918316B2 (en) 2005-03-10 2021-02-16 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US11051726B2 (en) 2005-03-10 2021-07-06 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US11000213B2 (en) 2005-03-10 2021-05-11 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10610135B2 (en) 2005-03-10 2020-04-07 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10610136B2 (en) 2005-03-10 2020-04-07 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10716498B2 (en) 2005-03-10 2020-07-21 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US10300507B2 (en) 2005-05-05 2019-05-28 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
US10813577B2 (en) 2005-06-21 2020-10-27 Dexcom, Inc. Analyte sensor
US20080299170A1 (en) * 2005-07-21 2008-12-04 Aston University Medical Devices and Coatings Therefor
US20070048350A1 (en) * 2005-08-31 2007-03-01 Robert Falotico Antithrombotic coating for drug eluting medical devices
EP1759724A1 (de) * 2005-08-31 2007-03-07 Cordis Corporation Antithrombotische Beschichtung für die mit den Medikamenten beschichteten medizinischen Vorrichtungen
US7947302B2 (en) 2005-08-31 2011-05-24 Cordis Corporation Antithrombotic coating for drug eluting medical devices
US20090311299A1 (en) * 2005-08-31 2009-12-17 Robert Falotico Antithrombotic coating for drug eluting medical devices
US20070142905A1 (en) * 2005-12-16 2007-06-21 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
US20070207183A1 (en) * 2006-01-05 2007-09-06 Med Institute, Inc. Zein coated medical device
US20070212393A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Compositions and coatings for implantable medical devices
US20070212387A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Coatings for implantable medical devices
US20070212386A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Coatings for implantable medical devices
US20070254002A1 (en) * 2006-04-26 2007-11-01 Sheng-Qian Wu Biocompatible devices coated with activated protein C
US11850333B2 (en) 2006-04-26 2023-12-26 Micell Medtech Inc. Coatings containing multiple drugs
US11007307B2 (en) 2006-04-26 2021-05-18 Micell Technologies, Inc. Coatings containing multiple drugs
US8961901B2 (en) 2006-08-02 2015-02-24 Roche Diagnostics Operations, Inc. Microfluidic system and coating method therefor
EP1887355A1 (de) * 2006-08-02 2008-02-13 F.Hoffmann-La Roche Ag Mikrofluidiksystem und Beschichtungsverfahren dafür
US11399745B2 (en) 2006-10-04 2022-08-02 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US20100062262A1 (en) * 2007-01-16 2010-03-11 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Aqueous solution composition
EP2105459A4 (de) * 2007-01-16 2013-05-22 Dainichiseika Color Chem Wässrige lösungszusammensetzung
EP2105459A1 (de) * 2007-01-16 2009-09-30 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Wässrige lösungszusammensetzung
US9359718B2 (en) 2007-01-16 2016-06-07 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Aqueous solution composition
US8597720B2 (en) 2007-01-21 2013-12-03 Hemoteq Ag Medical product for treating stenosis of body passages and for preventing threatening restenosis
US20100129423A1 (en) * 2007-04-19 2010-05-27 Medovent Gmbh Device made at least partially of n-acetylchitosan with controlled biodissolution
WO2008128567A1 (en) * 2007-04-19 2008-10-30 Medovent Gmbh Device made at least partially of n-acetylchitosan with controlled biodissolution
US10791928B2 (en) 2007-05-18 2020-10-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US20100161021A1 (en) * 2007-06-07 2010-06-24 National University Corporation Kanazawa University Myocardial pad
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8070798B2 (en) 2007-07-20 2011-12-06 Josiah Wilcox Drug eluting medical device and method
US8968392B2 (en) 2007-09-04 2015-03-03 Japan Stent Technology Co., Ltd. Method of inhibiting vascular intimal hyperplasia using stent
US8641756B2 (en) 2007-09-04 2014-02-04 Japan Stent Technology Co., Ltd. Sustained drug-releasing stent
US9040111B2 (en) 2007-09-04 2015-05-26 Japan Stent Technology Co., Ltd. Method of making a stent
US20090092664A1 (en) * 2007-10-08 2009-04-09 University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
US20090258050A1 (en) * 2007-11-20 2009-10-15 Med Institute, Inc. Controlled Drug Delivery Using a Zein Layer Modified with Levulinic Acid
US8523937B2 (en) 2007-11-20 2013-09-03 Cook Medical Technologies Llc Controlled drug delivery using a zein layer modified with levulinic acid
US8870813B2 (en) 2007-12-18 2014-10-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US8317776B2 (en) 2007-12-18 2012-11-27 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US8403881B2 (en) 2007-12-18 2013-03-26 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US8409132B2 (en) 2007-12-18 2013-04-02 The Invention Science Fund I, Llc Treatment indications informed by a priori implant information
US8445524B2 (en) 2008-03-26 2013-05-21 Cephalon, Inc. Solid forms of bendamustine hydrochloride
US10517852B2 (en) 2008-03-26 2019-12-31 Cephalon, Inc. Solid forms of bendamustine hydrochloride
US8669279B2 (en) 2008-03-26 2014-03-11 Cephalon, Inc. Solid forms of bendamustine hydrochloride
US20090264488A1 (en) * 2008-03-26 2009-10-22 Cephalon, Inc. Novel solid forms of bendamustine hydrochloride
US10039750B2 (en) 2008-03-26 2018-08-07 Cephalon, Inc. Solid forms of bendamustine hydrochloride
US8883836B2 (en) 2008-03-26 2014-11-11 Cephalon, Inc. Solid forms of bendamustine hydrochloride
US9533955B2 (en) 2008-03-26 2017-01-03 Cephalon, Inc. Solid forms of bendamustine hydrochloride
US9566026B2 (en) 2008-03-28 2017-02-14 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US9173606B2 (en) 2008-03-28 2015-11-03 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11147483B2 (en) 2008-03-28 2021-10-19 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US10143410B2 (en) 2008-03-28 2018-12-04 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8954128B2 (en) 2008-03-28 2015-02-10 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US9173607B2 (en) 2008-03-28 2015-11-03 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US9549699B2 (en) 2008-03-28 2017-01-24 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US9572523B2 (en) 2008-03-28 2017-02-21 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US9693721B2 (en) 2008-03-28 2017-07-04 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US8309520B2 (en) 2008-05-30 2012-11-13 Ls Medcap Gmbh Fully synthetic albumin analog
US20110117139A1 (en) * 2008-05-30 2011-05-19 Ls Medcap Gmbh Fully synthetic albumin analog
US10028684B2 (en) 2008-09-19 2018-07-24 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US11918354B2 (en) 2008-09-19 2024-03-05 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US8560039B2 (en) 2008-09-19 2013-10-15 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US10561352B2 (en) 2008-09-19 2020-02-18 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US9339222B2 (en) 2008-09-19 2016-05-17 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US10028683B2 (en) 2008-09-19 2018-07-24 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
US20110190363A1 (en) * 2008-09-25 2011-08-04 Cephalon, Inc. Liquid formulations of bendamustine
US8344006B2 (en) 2008-09-25 2013-01-01 Cephalon, Inc. Liquid formulations of bendamustine
US8076366B2 (en) 2009-01-15 2011-12-13 Cephalon, Inc. Forms of bendamustine free base
US20100210701A1 (en) * 2009-01-15 2010-08-19 Cephalon, Inc. Novel Forms of Bendamustine Free Base
US8591571B2 (en) 2009-03-02 2013-11-26 Japan Stent Technology Co., Ltd. Drug-eluting stent
US20110301697A1 (en) * 2009-04-10 2011-12-08 Hemoteq Ag Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open
US20100272773A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of Drug Polymorphs to Achieve Controlled Drug Delivery From a Coated Medical Device
US20110008260A1 (en) * 2009-07-10 2011-01-13 Boston Scientific Scimed, Inc. Use of Nanocrystals for Drug Delivery from a Balloon
US10369256B2 (en) 2009-07-10 2019-08-06 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US11278648B2 (en) 2009-07-10 2022-03-22 Boston Scientific Scimed, Inc. Use of nanocrystals for drug delivery from a balloon
US10080821B2 (en) 2009-07-17 2018-09-25 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US20130136657A1 (en) * 2010-07-23 2013-05-30 Roche Diagnostics Operations, Inc. Method for hydrophilizing surfaces of fluidic components and parts containing such components
US9623440B2 (en) * 2010-07-23 2017-04-18 Roche Diagnostics Operations, Inc. Method for hydrophilizing surfaces of fluidic components and parts containing such components
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
CN109847403A (zh) * 2011-01-06 2019-06-07 西托索尔本茨公司 用于从全血和血液制品中移除杂质的聚合物吸附剂
WO2012094565A1 (en) * 2011-01-06 2012-07-12 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
CN103533830A (zh) * 2011-01-06 2014-01-22 西托索尔本茨公司 用于从全血和血液制品中移除杂质的聚合物吸附剂
US10064406B2 (en) 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating

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