BR0310008A - Preparação, método e uso de revestimentos hemocompatìveis para a prevenção de restenose - Google Patents

Preparação, método e uso de revestimentos hemocompatìveis para a prevenção de restenose

Info

Publication number
BR0310008A
BR0310008A BR0310008-1A BR0310008A BR0310008A BR 0310008 A BR0310008 A BR 0310008A BR 0310008 A BR0310008 A BR 0310008A BR 0310008 A BR0310008 A BR 0310008A
Authority
BR
Brazil
Prior art keywords
oligosaccharides
polysaccharides
stents
hemocompatible
well
Prior art date
Application number
BR0310008-1A
Other languages
English (en)
Inventor
Roland Horres
Marita Katharina Linssen
Michael Hoffmann
Volker Faust
Erika Hoffmann
Donato Di Biase
Original Assignee
Hemoteq Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10221055A external-priority patent/DE10221055B4/de
Application filed by Hemoteq Gmbh filed Critical Hemoteq Gmbh
Publication of BR0310008A publication Critical patent/BR0310008A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/08—Materials for coatings
    • A61L31/10—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/075—Ethers or acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/722—Chitin, chitosan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/10—Heparin; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
    • C09D105/00—Coating compositions based on polysaccharides or on their derivatives, not provided for in groups C09D101/00 or C09D103/00
    • C09D105/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

"PREPARAçãO, MéTODO E USO DE REVESTIMENTOS HEMOCOMPATìVEIS PARA A PREVENçãO DE RESTENOSE". A invenção refere-se ao uso de polissacarídeos, que compreendem N-acilglicosamina de unidade de construção de açúcar, para a preparação de superfícies hemocompatíveis bem como métodos para o revestimento hemocompatível de superfícies com estes polissacarídeos, que são classificados serem as substâncias precursoras biossintéticas comuns de heparina e sulfato de heparanas. Descritos são os dispositivos médicos revestidos de acordo com a invenção, especialmente stents, que compreendem paclitaxel como agente ativo antiproliferativo bem como o uso destes stents para a prevenção de restenose.
BR0310008-1A 2002-05-09 2003-04-15 Preparação, método e uso de revestimentos hemocompatìveis para a prevenção de restenose BR0310008A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US37867602P 2002-05-09 2002-05-09
DE10221055A DE10221055B4 (de) 2002-05-10 2002-05-10 Verbindungen zur hämokompatiblen Beschichtung von Oberflächen, Verfahren zu deren Herstellung und deren Verwendung
PCT/DE2003/001254 WO2003094991A1 (de) 2002-05-09 2003-04-15 Hemokompatibel beschichtete medizinprodukte, deren herstellung und verwendung

Publications (1)

Publication Number Publication Date
BR0310008A true BR0310008A (pt) 2005-02-15

Family

ID=29421502

Family Applications (2)

Application Number Title Priority Date Filing Date
BR0311446-5A BR0311446A (pt) 2002-05-09 2003-04-15 Compostos e processos para o revestimentos hemocompatìvel de superfìcies
BR0310008-1A BR0310008A (pt) 2002-05-09 2003-04-15 Preparação, método e uso de revestimentos hemocompatìveis para a prevenção de restenose

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BR0311446-5A BR0311446A (pt) 2002-05-09 2003-04-15 Compostos e processos para o revestimentos hemocompatìvel de superfìcies

Country Status (20)

Country Link
US (3) US20050176678A1 (pt)
EP (2) EP1501565B1 (pt)
JP (3) JP5106750B2 (pt)
CN (2) CN1665554B (pt)
AT (2) ATE404232T1 (pt)
AU (2) AU2003240391B8 (pt)
BR (2) BR0311446A (pt)
CA (2) CA2484374C (pt)
DE (4) DE10393060D2 (pt)
DK (2) DK1501566T3 (pt)
EA (1) EA009092B1 (pt)
ES (2) ES2276065T3 (pt)
IL (3) IL164947A (pt)
MX (2) MXPA04011112A (pt)
NZ (2) NZ536330A (pt)
PL (2) PL208115B1 (pt)
PT (2) PT1501566E (pt)
SI (1) SI1501566T1 (pt)
WO (2) WO2003094991A1 (pt)
ZA (2) ZA200408791B (pt)

Families Citing this family (174)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6001067A (en) 1997-03-04 1999-12-14 Shults; Mark C. Device and method for determining analyte levels
US8527026B2 (en) 1997-03-04 2013-09-03 Dexcom, Inc. Device and method for determining analyte levels
US20030032874A1 (en) 2001-07-27 2003-02-13 Dexcom, Inc. Sensor head for use with implantable devices
US7613491B2 (en) 2002-05-22 2009-11-03 Dexcom, Inc. Silicone based membranes for use in implantable glucose sensors
US7379765B2 (en) 2003-07-25 2008-05-27 Dexcom, Inc. Oxygen enhancing membrane systems for implantable devices
US8364229B2 (en) 2003-07-25 2013-01-29 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
BR0311446A (pt) * 2002-05-09 2005-03-15 Hemoteq Gmbh Compostos e processos para o revestimentos hemocompatìvel de superfìcies
US7226978B2 (en) 2002-05-22 2007-06-05 Dexcom, Inc. Techniques to improve polyurethane membranes for implantable glucose sensors
AU2003261100A1 (en) * 2002-07-25 2004-02-16 Avantec Vascular Corporation Devices delivering therapeutic agents and methods regarding the same
AU2003283399B2 (en) * 2002-11-15 2007-04-19 Novartis Ag Drug delivery system
FR2847474B1 (fr) * 2002-11-25 2006-03-24 Inst Rech Developpement Ird Utilisation de la canthin-6-one, des extraits de plantes la contenant et de ses derives dans le traitement de la maladie de chagas
US7758881B2 (en) * 2004-06-30 2010-07-20 Advanced Cardiovascular Systems, Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
AR043504A1 (es) * 2003-03-17 2005-08-03 Novartis Ag Composiciones farmaceuticas que comprenden rapamicina para el tratamiento de enfermedades inflamatorias
DE10328815A1 (de) * 2003-06-21 2005-01-05 Biotronik Meß- und Therapiegeräte GmbH & Co. Ingenieurbüro Berlin Beschichtungssystem für Implantate zur Erhöhung der Gewebsverträglichkeit
WO2007120442A2 (en) 2003-07-25 2007-10-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US9763609B2 (en) 2003-07-25 2017-09-19 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
WO2005012873A2 (en) 2003-07-25 2005-02-10 Dexcom, Inc. Electrode systems for electrochemical sensors
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US7488343B2 (en) 2003-09-16 2009-02-10 Boston Scientific Scimed, Inc. Medical devices
US20050129731A1 (en) * 2003-11-03 2005-06-16 Roland Horres Biocompatible, biostable coating of medical surfaces
WO2005049105A2 (en) * 2003-11-10 2005-06-02 Angiotech International Ag Medical implants and anti-scarring agents
US9247900B2 (en) 2004-07-13 2016-02-02 Dexcom, Inc. Analyte sensor
EP2239567B1 (en) 2003-12-05 2015-09-02 DexCom, Inc. Calibration techniques for a continuous analyte sensor
US11633133B2 (en) 2003-12-05 2023-04-25 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8423114B2 (en) 2006-10-04 2013-04-16 Dexcom, Inc. Dual electrode system for a continuous analyte sensor
US8137397B2 (en) 2004-02-26 2012-03-20 Boston Scientific Scimed, Inc. Medical devices
US20050214339A1 (en) * 2004-03-29 2005-09-29 Yiwen Tang Biologically degradable compositions for medical applications
DE102004021658A1 (de) * 2004-05-03 2005-12-01 Rudy Dr. Susilo Kombinationspräparate enthaltend 2-Methylthiazolidin-2,4-dicarbonsäure
US8277713B2 (en) 2004-05-03 2012-10-02 Dexcom, Inc. Implantable analyte sensor
US7803182B2 (en) * 2004-05-28 2010-09-28 Cordis Corporation Biodegradable vascular device with buffering agent
WO2005122870A2 (en) 2004-06-14 2005-12-29 Pneumrx, Inc. Lung access device
US7678767B2 (en) 2004-06-16 2010-03-16 Pneumrx, Inc. Glue compositions for lung volume reduction
US7608579B2 (en) * 2004-06-16 2009-10-27 Pneumrx, Inc. Lung volume reduction using glue compositions
US20050281798A1 (en) * 2004-06-16 2005-12-22 Glen Gong Targeting sites of damaged lung tissue using composition
US20050281740A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue
US7468350B2 (en) 2004-06-16 2008-12-23 Pneumrx, Inc. Glue composition for lung volume reduction
US20050281739A1 (en) * 2004-06-16 2005-12-22 Glen Gong Imaging damaged lung tissue using compositions
US8709469B2 (en) 2004-06-30 2014-04-29 Abbott Cardiovascular Systems Inc. Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device
WO2006014567A2 (en) 2004-07-08 2006-02-09 Pneumrx, Inc. Pleural effusion treatment device, method and material
US7766891B2 (en) 2004-07-08 2010-08-03 Pneumrx, Inc. Lung device with sealing features
US8170803B2 (en) 2004-07-13 2012-05-01 Dexcom, Inc. Transcutaneous analyte sensor
WO2006127694A2 (en) 2004-07-13 2006-11-30 Dexcom, Inc. Analyte sensor
MX2007005361A (es) * 2004-11-05 2008-01-11 Cephalon Inc Tratamientos para cancer.
CA2587857C (en) 2004-11-23 2017-10-10 Pneumrx, Inc. Steerable device for accessing a target site and methods
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
EP2896412A1 (en) * 2005-02-18 2015-07-22 Abraxis BioScience, LLC Drugs with improved hydrophobicity for incorporation in medical devices
US20060204547A1 (en) * 2005-03-14 2006-09-14 Conor Medsystems, Inc. Drug delivery stent with extended in vivo release of anti-inflammatory
US8744546B2 (en) 2005-05-05 2014-06-03 Dexcom, Inc. Cellulosic-based resistance domain for an analyte sensor
JP5026004B2 (ja) * 2005-06-28 2012-09-12 江崎グリコ株式会社 リン酸化糖を含有するチタンインプラント材
GB0515003D0 (en) * 2005-07-21 2005-08-31 Univ Aston Medical devices and coatings therefor
DE102005040211B4 (de) 2005-08-16 2010-02-11 Maquet Cardiopulmonary Ag Verwendung von nichtionischen Estern in einer Beschichtung für mit Blut in Kontakt kommende Oberflächen und medizinische Vorrichtung
US20070048350A1 (en) * 2005-08-31 2007-03-01 Robert Falotico Antithrombotic coating for drug eluting medical devices
CA2626805C (en) * 2005-11-15 2016-05-17 Orbusneich Medical, Inc. Progenitor endothelial cell capturing with a drug eluting implantable medical device
US20070142905A1 (en) * 2005-12-16 2007-06-21 Medtronic Vascular, Inc. Medical devices to treat or inhibit restenosis
WO2007081858A2 (en) * 2006-01-05 2007-07-19 Med Institute, Inc. Zein coated medical device
US8840660B2 (en) 2006-01-05 2014-09-23 Boston Scientific Scimed, Inc. Bioerodible endoprostheses and methods of making the same
US20070212386A1 (en) * 2006-03-08 2007-09-13 Sahajanand Medical Technologies Pvt. Ltd. Coatings for implantable medical devices
US8888800B2 (en) 2006-03-13 2014-11-18 Pneumrx, Inc. Lung volume reduction devices, methods, and systems
US9402633B2 (en) 2006-03-13 2016-08-02 Pneumrx, Inc. Torque alleviating intra-airway lung volume reduction compressive implant structures
US8157837B2 (en) 2006-03-13 2012-04-17 Pneumrx, Inc. Minimally invasive lung volume reduction device and method
JP2007244601A (ja) * 2006-03-15 2007-09-27 Kanazawa Univ 心筋用パッド
WO2007120381A2 (en) 2006-04-14 2007-10-25 Dexcom, Inc. Analyte sensor
US20070254002A1 (en) * 2006-04-26 2007-11-01 Sheng-Qian Wu Biocompatible devices coated with activated protein C
US8852625B2 (en) 2006-04-26 2014-10-07 Micell Technologies, Inc. Coatings containing multiple drugs
JP2010500889A (ja) * 2006-07-03 2010-01-14 ヘモテック アーゲー 恒久的に血管を開いた状態にするための薬剤溶出医療デバイスの製造、方法、および使用
EP1887355B1 (de) 2006-08-02 2017-09-27 F. Hoffmann-La Roche AG Beschichtungsverfahren für ein mikrofluidiksystem.
US20080172124A1 (en) * 2007-01-11 2008-07-17 Robert Lamar Bjork Multiple drug-eluting coronary artery stent for percutaneous coronary artery intervention
EP2105459B1 (en) * 2007-01-16 2018-03-28 Dainichiseika Color & Chemicals Mfg. Co., Ltd. Aqueous solution composition for water-insoluble chitosan coatings
PL2136853T3 (pl) 2007-01-21 2013-08-30 Hemoteq Ag Wyrób medyczny do leczenia niedrożności układów ciała i do zapobiegania grożącej ponownej niedrożności
CA2682291C (en) * 2007-04-19 2013-08-13 Medovent Gmbh Device made at least partially of n-acetylchitosan with controlled biodissolution
WO2008139200A2 (en) * 2007-05-15 2008-11-20 Chameleon Biosurfaces Limited Polymer coatings on medical devices
US20200037875A1 (en) 2007-05-18 2020-02-06 Dexcom, Inc. Analyte sensors having a signal-to-noise ratio substantially unaffected by non-constant noise
US20100161021A1 (en) * 2007-06-07 2010-06-24 National University Corporation Kanazawa University Myocardial pad
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
US8070798B2 (en) 2007-07-20 2011-12-06 Josiah Wilcox Drug eluting medical device and method
KR20100085179A (ko) 2007-09-04 2010-07-28 가부시키가이샤 니혼 스텐토 테크놀로지 약제 서방성 스텐트
WO2009048780A1 (en) * 2007-10-08 2009-04-16 The University Of Kentucky Research Foundation Polymer-metal chelator conjugates and uses thereof
WO2009049426A1 (en) * 2007-10-19 2009-04-23 Interface Biologics Inc. Self-eliminating coatings
EP2214747A2 (en) * 2007-11-20 2010-08-11 Cook Incorporated Controlled drug delivery using a zein layer modified with levulinic acid
ATE554396T1 (de) * 2007-11-30 2012-05-15 Univ Maastricht Diagnose- und therapiewerkzeuge für krankheiten, die die gefässfunktion verändern
US8636670B2 (en) 2008-05-13 2014-01-28 The Invention Science Fund I, Llc Circulatory monitoring systems and methods
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
CN101234217B (zh) * 2008-03-07 2013-12-18 苏州盖依亚生物医药有限公司 一种功能性靶向治疗可降解的生物支架及其用途
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
US11730407B2 (en) 2008-03-28 2023-08-22 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8682408B2 (en) 2008-03-28 2014-03-25 Dexcom, Inc. Polymer membranes for continuous analyte sensors
US8583204B2 (en) 2008-03-28 2013-11-12 Dexcom, Inc. Polymer membranes for continuous analyte sensors
DE102008027133A1 (de) * 2008-05-30 2009-12-03 Ls Medcap Gmbh Vollsynthetisches Albumin-Analogon
DE102008002471A1 (de) * 2008-06-17 2009-12-24 Biotronik Vi Patent Ag Stent mit einer Beschichtung oder einem Grundkörper, der ein Lithiumsalz enthält, und Verwendung von Lithiumsalzen zur Restenoseprophylaxe
US8632605B2 (en) 2008-09-12 2014-01-21 Pneumrx, Inc. Elongated lung volume reduction devices, methods, and systems
GB0816783D0 (en) * 2008-09-15 2008-10-22 Carmeda Ab Immobilised biological entities
WO2010033724A2 (en) 2008-09-19 2010-03-25 Dexcom, Inc. Particle-containing membrane and particulate electrode for analyte sensors
AU2009296734B2 (en) * 2008-09-25 2016-02-18 Cephalon Llc Liquid formulations of bendamustine
JP2012515210A (ja) 2009-01-15 2012-07-05 セファロン、インク． ベンダムスチン遊離塩基の新規の形態
WO2010101072A1 (ja) * 2009-03-02 2010-09-10 株式会社日本ステントテクノロジー 薬剤溶出性ステント
US20110301697A1 (en) * 2009-04-10 2011-12-08 Hemoteq Ag Manufacture, method and use of drug-eluting medical devices for permanently keeping blood vessels open
WO2010118951A2 (de) * 2009-04-15 2010-10-21 Basf Se Verfahren zur herstellung von monoethylenisch ungesättigten glykosylaminen
US20100272773A1 (en) * 2009-04-24 2010-10-28 Boston Scientific Scimed, Inc. Use of Drug Polymorphs to Achieve Controlled Drug Delivery From a Coated Medical Device
DK2295132T3 (en) * 2009-05-15 2016-12-05 Interface Biologics Inc Antithrombogenic hollow-fiber membranes, molding material and blood long
WO2010135352A1 (en) 2009-05-18 2010-11-25 Pneumrx, Inc. Cross-sectional modification during deployment of an elongate lung volume reduction device
WO2011005421A2 (en) 2009-07-10 2011-01-13 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
EP2962707B1 (en) 2009-07-17 2019-07-24 Boston Scientific Scimed, Inc. Drug delivery balloons with improved crystal size and density
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
CN102933658A (zh) 2009-12-18 2013-02-13 界面生物公司 从自组装涂层局部递送药物
CN102781324B (zh) * 2010-03-03 2016-01-20 爱德华兹生命科学公司 抗凝输液源
GB201004101D0 (en) 2010-03-12 2010-04-28 Carmeda Ab Immobilised biological entities
JP5834071B2 (ja) 2010-05-14 2015-12-16 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． ステント
EP2409766A1 (de) * 2010-07-23 2012-01-25 F. Hoffmann-La Roche AG Verfahren zur Hydrophilisierung von Oberflächen fluidischer Komponenten und derartige Komponenten enthaltende Bauteile
WO2012028310A2 (en) * 2010-08-31 2012-03-08 Avidal Vascular Gmbh Pharmaceutical compositions comprising a taxane
EP2611476B1 (en) 2010-09-02 2016-08-10 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
EP2646066B1 (de) * 2010-12-04 2018-03-14 Aachen Scientific International PTE. LTD. Beschichtung und beschichtungsverfahren für den ballon eines ballonkatheters sowie ballonkatheter mit beschichtetem ballon
US10064406B2 (en) * 2011-01-06 2018-09-04 Cytosorbents Corporation Polymeric sorbent for removal of impurities from whole blood and blood products
CA2825950C (en) 2011-01-28 2019-06-18 The General Hospital Corporation Method and apparatus for skin resurfacing
US10278677B2 (en) 2011-01-28 2019-05-07 The General Hospital Corporation Apparatus and method for tissue biopsy
EP2508199B1 (en) 2011-04-07 2014-09-17 Fresenius Medical Care Deutschland GmbH Melanocyte-stimulation hormone for suppressing inflammation reactions in hemodialysis
ES2514322T3 (es) 2011-04-07 2014-10-28 Fresenius Medical Care Deutschland Gmbh Péptidos para suprimir reacciones de inflamación en hemodiálisis
TW201311774A (zh) * 2011-06-23 2013-03-16 Toray Industries 具有抗血液凝固作用的疏水性高分子化合物
AU2012283861B2 (en) 2011-07-21 2016-11-24 The General Hospital Corporation Method and apparatus for damage and removal of fat
US8669360B2 (en) 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
RU2484178C2 (ru) * 2011-09-08 2013-06-10 Федеральное Государственное Бюджетное Учреждение Науки Институт Биохимической Физики Им. Н.М. Эмануэля Российской Академии Наук (Ибхф Ран) Способ получения белковых покрытий на поверхности твердых тел, содержащих ионы металлов переменной валентности
US8669314B2 (en) 2012-02-03 2014-03-11 Sabic Innovative Plastics Ip B.V. Hydrolytic stability in polycarbonate compositions
EP2801379B1 (en) * 2012-03-27 2017-03-08 Terumo Kabushiki Kaisha Coating composition and medical device
US20130303983A1 (en) * 2012-05-09 2013-11-14 Cook Medical Technologies Llc Coated medical devices including a water-insoluble therapeutic agent
CN102691083B (zh) * 2012-05-29 2014-12-03 上海大学 一种改善金属材料表面血液相容性的电化学方法
DE102012010800A1 (de) * 2012-06-01 2013-12-05 Alexander Rübben Beschichtung von Ballonkathetern
US9395468B2 (en) 2012-08-27 2016-07-19 Ocular Dynamics, Llc Contact lens with a hydrophilic layer
WO2014112956A1 (en) 2013-01-17 2014-07-24 Center Odličnosti Polimerni Marteriali In Tehnologije Method for treatment of a vascular graft
AU2014219240B2 (en) 2013-02-20 2018-12-20 Cytrellis Biosystems, Inc. Methods and devices for skin tightening
WO2014152551A1 (en) * 2013-03-15 2014-09-25 Baxter International Inc. Immobilization of active agent on a substrate
KR102271653B1 (ko) 2013-06-07 2021-07-05 백스터 인터내셔널 인코포레이티드 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화
JP6220969B2 (ja) * 2013-10-22 2017-10-25 コンシーヴァルブ エルエルシー ステント装着した心臓弁または生体補綴弁の狭窄、閉塞、または石灰化を阻害するための方法
JP2017505922A (ja) 2013-11-15 2017-02-23 タンジブル サイエンス リミテッド ライアビリティ カンパニー 親水性層を有するコンタクトレンズ
IL229645A0 (en) * 2013-11-26 2014-03-31 Omrix Biopharmaceuticals Ltd A dry bandage containing thrombin and pectin
CN103721300B (zh) * 2013-12-19 2015-05-20 华中科技大学 一种抗凝血涂层材料及其制备方法
US11839698B2 (en) 2014-03-13 2023-12-12 W. L. Gore & Associates, Inc. Drug composition and coating
US10390838B1 (en) 2014-08-20 2019-08-27 Pneumrx, Inc. Tuned strength chronic obstructive pulmonary disease treatment
JP6389009B2 (ja) * 2014-10-30 2018-09-12 チェンデュ バイユ ファーマシューティカル カンパニー リミテッドＣｈｅｎｇｄｕ Ｂａｉｙｕ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．，Ｌｔｄ． ギンコライドＢと第Ｘａ因子阻害剤とを含有する薬物組成物及びその製造方法と用途
AU2015346141B2 (en) 2014-11-14 2021-07-22 Cytrellis Biosystems, Inc. Devices and methods for ablation of the skin
WO2016094533A1 (en) 2014-12-09 2016-06-16 Ocular Dynamics, Llc Medical device coating with a biocompatible layer
US20170145475A1 (en) 2015-11-20 2017-05-25 Streck, Inc. Single spin process for blood plasma separation and plasma composition including preservative
US11166743B2 (en) 2016-03-29 2021-11-09 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
CN106119820B (zh) 2016-06-01 2018-06-22 华南理工大学 一种利用可控接枝技术提高材料表面血液相容性的方法
US10130900B2 (en) 2016-06-16 2018-11-20 Bandera Acquisition, Llc Composite column for use in high pressure liquid chromatography
AU2017330298B2 (en) 2016-09-21 2022-09-29 Cytrellis Biosystems, Inc. Devices and methods for cosmetic skin resurfacing
BR112019007896B1 (pt) 2016-10-18 2022-11-08 Interface Biologics, Inc Composição misturada, artigo e seu método de produção
IT201700075956A1 (it) * 2017-07-12 2019-01-12 Mediplasma S R L Immobilizzazione covalente di Eparina su lenti a contatto (LAC) e dispositivi di interesse medico-chirurgico trattati via plasma
WO2019014400A1 (en) 2017-07-14 2019-01-17 Fresenius Medical Care Holdings, Inc. PROCESS FOR OBTAINING SURFACE MODIFICATION COMPOSITION WITH ENHANCED BY-PRODUCT REMOVAL
CN107456611A (zh) * 2017-07-23 2017-12-12 北京化工大学 一种抗凝血复合涂层的制备方法
JP7293244B2 (ja) * 2017-10-19 2023-06-19 ストレック， インコーポレイテッド 溶血、凝固調節および細胞外小胞の安定化のための組成物
CN109925536B (zh) * 2017-12-15 2021-01-26 先健科技(深圳)有限公司 可吸收铁基植入式器械
JP2021531061A (ja) 2018-05-22 2021-11-18 インターフェース バイオロジクス，インコーポレーテッド 薬物を脈管壁に送達するための組成物及び方法
CN108715875B (zh) * 2018-05-30 2021-05-25 上海交通大学 酶化学法合成结构明确的硫酸肝素寡糖的方法
CN109293961B (zh) * 2018-09-25 2021-08-13 湖南博隽生物医药有限公司 一种心脏瓣膜用聚合物材料及其制备方法
CN109568676A (zh) * 2018-12-29 2019-04-05 张桂玲 一种抗菌超滑医用留置导管用材料
CN109821076B (zh) * 2019-03-13 2021-05-07 陕西师范大学 一种抗凝抗感染的多功能涂层的制备方法及抗凝抗感染的多功能材料
US11931482B2 (en) 2019-03-18 2024-03-19 Brown University Auranofin-releasing antibacterial and antibiofilm polyurethane intravascular catheter coatings
CN109806850B (zh) * 2019-03-25 2021-12-10 东华大学 一种具有吸附性能的粘胶无纺布材料及其制备方法
CN109943068B (zh) * 2019-03-28 2022-01-25 金旸（厦门）新材料科技有限公司 一种耐高温尼龙材料和电镀尼龙材料及其准备方法和应用
CN110506634B (zh) * 2019-09-29 2022-07-05 上海市农业科学院 一种鸢尾化学诱变剂量筛选方法
TWI749395B (zh) * 2019-11-08 2021-12-11 高鼎精密材料股份有限公司 具有高暢通率的高分子纖維管材結構的製備方法
CN110790970B (zh) * 2019-11-22 2022-08-12 辽宁万鑫富利新材料有限公司 一种高血液相容性pet复合薄膜材料的制备方法
CN115003345A (zh) * 2019-11-30 2022-09-02 智能反应堆服务有限公司 用于医疗器械的涂层
CN111729083B (zh) * 2020-04-03 2022-08-23 广州医科大学附属第二医院 内皮蛋白c受体的新用途
CN111644084A (zh) * 2020-06-15 2020-09-11 齐松松 一种改性羧甲基壳聚糖聚四氟乙烯纳滤膜及其制备方法
CN113171499A (zh) * 2021-03-17 2021-07-27 广东粤港澳大湾区国家纳米科技创新研究院 一种抗凝血材料、双层水凝胶管路及其制备方法和应用
CN115607750B (zh) * 2021-07-16 2024-02-23 中国科学院宁波材料技术与工程研究所 一种原位抗凝改性医用pvc材料、其制备方法及应用
CN113616861A (zh) * 2021-08-03 2021-11-09 广州维力医疗器械股份有限公司 逐层自组装复合抗凝血涂层、其制备方法及医疗器械
CN113648013A (zh) * 2021-08-25 2021-11-16 心凯诺医疗科技(上海)有限公司 一种血流导向密网支架
CN114042441A (zh) * 2021-12-09 2022-02-15 云南师范大学 在血液灌流树脂微球表面修饰并固载肝素的方法及其制备的吸附剂
CN114949347B (zh) * 2022-05-31 2023-05-12 四川大学 一种改性交联生物瓣膜及其制备方法和用途
CN115490827A (zh) * 2022-11-16 2022-12-20 北京新尖科技有限公司 聚碳酸酯聚二甲基硅氧烷型聚氨酯脲及制备方法
CN117696017A (zh) * 2024-02-05 2024-03-15 四川大学华西医院 一种血液净化吸附改性材料及其制备方法

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4152513A (en) * 1977-06-01 1979-05-01 University Of Delaware Preparation of alkyl glycosides of amino sugars
DE2862107D1 (en) * 1977-12-02 1982-11-18 Takeda Chemical Industries Ltd Glucosamine-peptide derivatives and their pharmaceutical compositions
JPS56161803A (en) 1980-05-17 1981-12-12 Nitto Electric Ind Co Ltd Treatment of resin containing organic solution
US4572901A (en) * 1983-06-23 1986-02-25 Children's Hospital Medical Center Of Northern California Method and composition for protein immobilization
US4661345A (en) * 1985-02-26 1987-04-28 The Rockefeller University Method for treating pertussis
SE8501613D0 (sv) 1985-04-01 1985-04-01 Bio Carb Ab Foreningar for terapeutisk eller diagnostisk anvendning jemte forfarande for terapeutisk behandling
US5155110A (en) * 1987-10-27 1992-10-13 Warner-Lambert Company Fenamic acid hydroxamate derivatives having cyclooxygenase and 5-lipoxygenase inhibition
US5206318A (en) * 1989-04-20 1993-04-27 Mitsui Toatsu Chemicals, Inc. Styrene derivatives having N-acetylchito-oligosaccharide chains and method for the same
US5510077A (en) * 1992-03-19 1996-04-23 Dinh; Thomas Q. Method of making an intraluminal stent
US5583121A (en) * 1994-01-12 1996-12-10 Michigan State University Non-anticoagulant chemically modified heparinoids for treating hypovolemic shock and related shock syndromes
DE69531945T2 (de) 1994-07-01 2004-08-19 Seikagaku Corp. Verfahren zur herstellung von desulfatiertem polysaccharid und desulfatiertem heparin
US6179817B1 (en) * 1995-02-22 2001-01-30 Boston Scientific Corporation Hybrid coating for medical devices
US5718862A (en) * 1996-04-24 1998-02-17 Hercules Incorporated Secondary shaping of ionically crosslinked polymer compositions for medical devices
US5767269A (en) * 1996-10-01 1998-06-16 Hamilton Civic Hospitals Research Development Inc. Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics
US5997517A (en) * 1997-01-27 1999-12-07 Sts Biopolymers, Inc. Bonding layers for medical device surface coatings
DE19705366C2 (de) * 1997-02-12 2002-08-01 Fresenius Ag Trägermaterial zur Reinigung proteinhaltiger Lösungen, Verfahren zur Herstellung des Trägermaterials und Verwendung des Trägermaterials
DE19724869C2 (de) 1997-06-12 1999-05-12 Henkel Kgaa Verwendung von Citosanderivaten zur Oberflächenbeschichtung
US6306166B1 (en) * 1997-08-13 2001-10-23 Scimed Life Systems, Inc. Loading and release of water-insoluble drugs
FI974321A0 (fi) * 1997-11-25 1997-11-25 Jenny Ja Antti Wihurin Rahasto Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
IT1296581B1 (it) * 1997-11-28 1999-07-14 Istituto Scient Di Chimica E B Materiali polimerici non trombogenici e ad esaltata compatibilita' con fluidi e tessuti organici
US5922692A (en) * 1998-03-11 1999-07-13 Marino; Richard P. Concentration of glycosaminoglycans and precursors thereto in food products
US6206914B1 (en) * 1998-04-30 2001-03-27 Medtronic, Inc. Implantable system with drug-eluting cells for on-demand local drug delivery
DE69935716T2 (de) * 1998-05-05 2007-08-16 Boston Scientific Ltd., St. Michael Stent mit glatten enden
ITPD980169A1 (it) 1998-07-06 2000-01-06 Fidia Advanced Biopolymers Srl Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione.
US6299604B1 (en) 1998-08-20 2001-10-09 Cook Incorporated Coated implantable medical device
AU1923200A (en) * 1999-01-22 2000-08-07 Dow Chemical Company, The Surface modified divinylbenzene resin having a hemocompatible coating
DE19908318A1 (de) 1999-02-26 2000-08-31 Michael Hoffmann Hämokompatible Oberflächen und Verfahren zu deren Herstellung
US6258121B1 (en) * 1999-07-02 2001-07-10 Scimed Life Systems, Inc. Stent coating
US7781416B2 (en) * 2000-01-25 2010-08-24 Sigma-Tau Research Switzerland S.A. Derivatives of partially desulphated glycosaminoglycans as heparanase inhibitors, endowed with antiangiogenic activity and devoid of anticoagulating effect
AU2001255741B2 (en) * 2000-04-28 2005-08-04 Baylor College Of Medicine Decellularized vascular prostheses
US6489311B1 (en) 2000-05-02 2002-12-03 Charlotte-Mecklenburg Hospital Authoirty Method for the prevention of apoptosis
NO20013534L (no) * 2000-07-18 2002-01-21 Koyo Chemical Company Ltd Anvendelse av en blanding omfattende et glucosaminsalt eller et glucosaminderivat for fremstilling av et medikament for behandling av human trombose
US6503538B1 (en) * 2000-08-30 2003-01-07 Cornell Research Foundation, Inc. Elastomeric functional biodegradable copolyester amides and copolyester urethanes
US20020087123A1 (en) * 2001-01-02 2002-07-04 Hossainy Syed F.A. Adhesion of heparin-containing coatings to blood-contacting surfaces of medical devices
US6833488B2 (en) * 2001-03-30 2004-12-21 Exotech Bio Solution Ltd. Biocompatible, biodegradable, water-absorbent material and methods for its preparation
WO2003035135A1 (en) * 2001-09-24 2003-05-01 Boston Scientific Limited Optimized dosing for drug coated stents
DE10294792D2 (de) * 2001-10-15 2004-09-16 Hemoteq Gmbh Beschichtung von Stents zur Verhinderung von Restenose
BR0311446A (pt) * 2002-05-09 2005-03-15 Hemoteq Gmbh Compostos e processos para o revestimentos hemocompatìvel de superfìcies

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