JP5834071B2 - ステント - Google Patents
ステント Download PDFInfo
- Publication number
- JP5834071B2 JP5834071B2 JP2013510268A JP2013510268A JP5834071B2 JP 5834071 B2 JP5834071 B2 JP 5834071B2 JP 2013510268 A JP2013510268 A JP 2013510268A JP 2013510268 A JP2013510268 A JP 2013510268A JP 5834071 B2 JP5834071 B2 JP 5834071B2
- Authority
- JP
- Japan
- Prior art keywords
- stent
- copolymer
- agents
- inhibitors
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
Description
実施形態は、以下の特徴の1つ以上を含みうる。
患者たとえばヒト患者に導入された後、ステントまたはその一部分が実質的な質量低下もしくは密度低下または化学変換を呈する場合、ステントは生侵食性である。質量低下は、たとえば、ステントを形成する材料の溶解および/またはステントのフラグメント化により起こりうる。化学変換としては、酸化/還元反応、加水分解反応、置換反応、および/もしくは付加反応、またはステントもしくはその一部分を作製する材料の他の化学反応が挙げられうる。侵食は、ステントと、それが留置される生体環境たとえば生体自体または体液と、の化学的および/または生物的相互作用の結果でありうる。侵食はまた、たとえば反応速度を増加させるべく、化学反応剤やエネルギーなどの開始作用因子をステントに適用することにより開始可能である。たとえば、ステントまたはその一部分は、活性金属、たとえば、MgもしくはFeまたはそれらの合金から形成可能であり、これらは、水との反応により侵食されて対応する金属酸化物および水素ガスを生成可能である。ステントまたはその一部分はまた、水による加水分解により侵食されうる生侵食性ポリマーまたは生侵食性ポリマーのブレンドから形成可能である。ステントのフラグメント化は、たとえば、ステントのいくつかの領域が他の領域よりも迅速に侵食されるときに起こる。より速く侵食される領域は、体内プロテーゼの本体を貫通してより迅速に侵食されることにより脆弱状態となり、より遅く侵食される領域から離れてフラグメントになる。
そのほかのさらなる実施形態は、以下の特許請求の範囲内にある。
Claims (14)
- ステント本体と、
前記ステント本体上のコーティングと、を含むステントであって、
前記コーティングは、10MPa以下の弾性率を有し、かつ20日間以上にわたる表面侵食により実質的に分解を呈するコポリマーを含み、
前記コポリマーは、トリメチレンカーボネートのポリマーまたはコポリマーで形成された弾性セグメントと、ラクチド、グリコリド、またはε−カプロラクトンのポリマーまたはコポリマーから形成された剛性セグメントとを含み、かつ
前記コポリマーは架橋されている、ステント。 - 前記コポリマーが療法剤を含む、請求項1に記載のステント。
- 前記ステント本体が金属ステント本体を含む、請求項1に記載のステント。
- 前記金属が生分解性金属である、請求項3に記載のステント。
- 前記金属が、Mg、Fe、またはそれらの合金である、請求項4に記載のステント。
- 前記金属がコバルトおよびクロムを含む、請求項3に記載のステント。
- 前記コポリマーが高分子ステント本体上のコーティングである、請求項1に記載のステント。
- 前記コポリマーが無水マレイン酸で官能基化されている、請求項1に記載のステント。
- 前記コポリマーが生体内安定性金属ステント本体上の層である、請求項1に記載のステント。
- 前記ステント本体がステンレス鋼である、請求項9に記載のステント。
- 前記コーティングが前記ステント本体の管腔外表面上に存在する、請求項1に記載のステント。
- 前記剛性セグメントが200MPa以上の弾性率を有する、請求項1に記載のステント。
- 前記剛性セグメントがバルク侵食により加水分解を呈する、請求項12に記載のステント。
- 前記療法剤がパクリタキセルである、請求項2に記載のステント。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33474610P | 2010-05-14 | 2010-05-14 | |
US61/334,746 | 2010-05-14 | ||
PCT/US2011/036018 WO2011143284A1 (en) | 2010-05-14 | 2011-05-11 | Endoprosthesis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013526933A JP2013526933A (ja) | 2013-06-27 |
JP5834071B2 true JP5834071B2 (ja) | 2015-12-16 |
Family
ID=44072738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013510268A Expired - Fee Related JP5834071B2 (ja) | 2010-05-14 | 2011-05-11 | ステント |
Country Status (5)
Country | Link |
---|---|
US (1) | US9314551B2 (ja) |
EP (1) | EP2569026A1 (ja) |
JP (1) | JP5834071B2 (ja) |
CA (1) | CA2794630A1 (ja) |
WO (1) | WO2011143284A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2210625B8 (en) * | 2006-09-15 | 2012-02-29 | Boston Scientific Scimed, Inc. | Bioerodible endoprosthesis with biostable inorganic layers |
US20080069858A1 (en) * | 2006-09-20 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical devices having biodegradable polymeric regions with overlying hard, thin layers |
EP2555811B1 (en) * | 2010-04-06 | 2017-09-27 | Boston Scientific Scimed, Inc. | Endoprosthesis |
EP3562527B1 (en) | 2016-12-29 | 2020-11-18 | Boston Scientific Scimed, Inc. | Medical devices formed from polymer filaments |
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US4897255A (en) | 1985-01-14 | 1990-01-30 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
ES2043289T3 (es) | 1989-09-25 | 1993-12-16 | Schneider Usa Inc | La extrusion de capas multiples como procedimiento para hacer balones de angioplastia. |
US5195969A (en) | 1991-04-26 | 1993-03-23 | Boston Scientific Corporation | Co-extruded medical balloons and catheter using such balloons |
US5811447A (en) | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5366504A (en) | 1992-05-20 | 1994-11-22 | Boston Scientific Corporation | Tubular medical prosthesis |
US5449382A (en) * | 1992-11-04 | 1995-09-12 | Dayton; Michael P. | Minimally invasive bioactivated endoprosthesis for vessel repair |
US5741329A (en) * | 1994-12-21 | 1998-04-21 | Board Of Regents, The University Of Texas System | Method of controlling the pH in the vicinity of biodegradable implants |
US5674242A (en) | 1995-06-06 | 1997-10-07 | Quanam Medical Corporation | Endoprosthetic device with therapeutic compound |
US7611533B2 (en) * | 1995-06-07 | 2009-11-03 | Cook Incorporated | Coated implantable medical device |
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DE59913189D1 (de) | 1998-06-25 | 2006-05-04 | Biotronik Ag | Implantierbare, bioresorbierbare Gefässwandstütze, insbesondere Koronarstent |
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-
2011
- 2011-05-11 CA CA2794630A patent/CA2794630A1/en not_active Abandoned
- 2011-05-11 US US13/105,473 patent/US9314551B2/en active Active
- 2011-05-11 EP EP11720276A patent/EP2569026A1/en not_active Ceased
- 2011-05-11 JP JP2013510268A patent/JP5834071B2/ja not_active Expired - Fee Related
- 2011-05-11 WO PCT/US2011/036018 patent/WO2011143284A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
CA2794630A1 (en) | 2011-11-17 |
EP2569026A1 (en) | 2013-03-20 |
US9314551B2 (en) | 2016-04-19 |
WO2011143284A1 (en) | 2011-11-17 |
US20110282430A1 (en) | 2011-11-17 |
JP2013526933A (ja) | 2013-06-27 |
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