JP2008279278A - 薬物送達脈管内ステントおよび再狭窄を処置するための方法 - Google Patents
薬物送達脈管内ステントおよび再狭窄を処置するための方法 Download PDFInfo
- Publication number
- JP2008279278A JP2008279278A JP2008209130A JP2008209130A JP2008279278A JP 2008279278 A JP2008279278 A JP 2008279278A JP 2008209130 A JP2008209130 A JP 2008209130A JP 2008209130 A JP2008209130 A JP 2008209130A JP 2008279278 A JP2008279278 A JP 2008279278A
- Authority
- JP
- Japan
- Prior art keywords
- stent
- coating
- polymer
- restenosis
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/16—Biologically active materials, e.g. therapeutic substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
- A61L31/022—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
- A61F2/06—Blood vessels
- A61F2/07—Stent-grafts
- A61F2002/072—Encapsulated stents, e.g. wire or whole stent embedded in lining
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/91533—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/86—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
- A61F2/90—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
- A61F2/91—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
- A61F2/915—Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
- A61F2002/9155—Adjacent bands being connected to each other
- A61F2002/91575—Adjacent bands being connected to each other connected peak to trough
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2230/00—Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2230/0002—Two-dimensional shapes, e.g. cross-sections
- A61F2230/0028—Shapes in the form of latin or greek characters
- A61F2230/0054—V-shaped
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2240/00—Manufacturing or designing of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2240/001—Designing or manufacturing processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0067—Means for introducing or releasing pharmaceutical products into the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/416—Anti-neoplastic or anti-proliferative or anti-restenosis or anti-angiogenic agents, e.g. paclitaxel, sirolimus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/08—Coatings comprising two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Neurosurgery (AREA)
- Inorganic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Materials For Medical Uses (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Prostheses (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
【解決手段】ステントは、拡張可能な、フィラメントと連結した本体および脈管損傷部位と接触するためのステント本体フィラメントから形成される薬物放出コーティングを有する。コーティングは、化合物の炭素位置40でのアルキル基置換を有する大環状トリエンである化合物の再狭窄抑制量を放出する。ステントは、脈管損傷を処置するために使用される場合、臨床的再狭窄に対する良好な保護を与える。
【選択図】なし
Description
本発明は、脈管内薬物送達ステントおよび再狭窄を処置するための方法に関する。
ステントは、脈管内インプラントの一種であり、通常、一般的に形状が管状であり、代表的に、格子接続ワイヤ管状構造体を有し、この構造体は、血管に永久的に挿入されて血管に対する機械的支持を提供し、かつ、血管形成術後の間またはその後のフローチャネルを維持もしくは再確立するように拡張可能である。ステントの支持構造体は、血管形成術によって脆くなったか、または損傷した血管の早期の崩壊を予防するように設計される。ステントの挿入は、損傷した血管壁の治癒が数ヶ月にわたって進行する間に、血管のネガティブリモデリングおよび痙攣を予防することが示されている。
本発明は、1つの局面において、脈管損傷部位での配置のための、その部位で再狭窄を抑制するための脈管内ステントを含む。ステントは、構造部材または1つ以上のフィラメントから形成される本体から構築され、そしてステント本体フィラメント上で支えられ、生体侵食性薬物放出コーティングは、3〜15ミクロンの厚さを有し、そして(i)20〜60重量パーセントのポリ−dl−ラクチドポリマー基材および(ii)40〜80重量パーセントの抗再狭窄化合物を有する。1〜5ミクロンの厚さを有し、そしてステント本体フィラメントとコーティングとの間に配置されるポリマーアンダーコーティングは、ステントフィラメント上のコーティングの安定化を助ける。ステントは、ステントがカテーテルを介して脈管損傷部位に送達され得る収縮した状態からステントコーティングが損傷部位にて脈管と接触して配置され得る拡張した状態へと拡張可能である。ステントコーティングは、ステントが脈管損傷部位に配置された後、少なくとも4週間にわたって再狭窄を抑制する量の化合物を放出するのに効果的である。
の一般的な形態を有し、ここで、(i)RはHまたはCH2−X−OHであり、そしてXは1〜7個の炭素原子を含む直鎖アルキル基または分枝鎖アルキル基であり、ここでR’はHであり(R’は、28位のOでHを置き換える)、あるいは(ii)RおよびR’の少なくとも1つが、以下:
の形態を有し、ここで、mは1〜3の整数であり、R1およびR2は、各々水素、または1〜3個の炭素原子を有するアルキルラジカルであるか、またはあるいは、ここで、R1およびR2が結合される窒素原子と一緒になって、4個の炭素原子を有する飽和ヘテロ環式環を形成する。エベロリムス(everolimus)として公知である例示的な化合物において、R’はHであり、そしてXは−CH2である。
の式を有し、ここで、RはCH2−X−OHであり、そして、Xは1〜7個の炭素原子を含む直鎖アルキル基である。1つの例示的な化合物において、Xは、−CH2−である
ステント組成物の種々の例示的な実施形態は、上記に与えられる。
(I.脈管内ステント)
図1および2は、それぞれ、ステントの収縮した状態および拡張した状態の本発明に従って構築されたステント20を示す。ステントは、図3および4を参照してさらに以下に記載される場合、構造部材または本体22および抗再狭窄化合物を保持し、そして放出するための外部コーティングを含む。
示される実施形態において、ステント本体は、フィラメント(例えば、部材24、26)によって、複数の連結された管状部材から形成される。各部材は、拡張可能なジグザク、鋸歯状、または正弦波状の構造を有する。この部材は、隣接する部材の頂点および谷底をつなぎ合わせる軸連結(例えば、連結28、30)によって連結される。理解され得るように、この構成によって、ステントが、ステントの長さをほとんどまたは全く変化させることなく、図1に示される収縮された状態から、図2に示される拡張された状態に拡張され得る。同時に、隣接する管状部材の頂点と谷底との間の比較的まれな連結によって、ステントが、曲げに適応し得る。この特徴は、ステントが、カテーテル内でまたはカテーテル上で、その収縮された状態で脈管部位に送達される場合に、特に重要であり得る。ステントは、0.5〜2mmの間、より好ましくは、0.71〜1.65mmの間の代表的な収縮状態の直径(図1)、および5〜100mmの間の長さを有する。図2に示されるような拡張状態において、ステントの直径は、その収縮状態のおけるステントの直径の少なくとも2倍、8〜9倍までである。従って、0.7〜1.5mmの収縮直径を有するステントは、2〜8mmの間またはそれ以上の選択された拡張状態へと半径方向に拡張され得る。
本発明の重要な特徴に従って、ステントフィラメントが、ポリマーマトリックスおよび少なくとも数週間、代表的には4〜8週間、そして必要に応じて2〜3ヶ月以上の期間にわたる、ステントからの放出のためにマトリックス中に分散される抗再狭窄化合物(活性化合物)から構成される、薬物放出コーティングでコーティングされる。
ここで(i)Rは、HまたはCH2−X−OHであり、R’がHである場合(R’は28位のOでHに置換される)、Xは、Hまたは1〜7個の炭素原子を含む直鎖アルキル基もしくは分岐鎖アルキル基であり、または(ii)RおよびR’の少なくとも1つが、以下の形態を有し:
ここでmは1〜3の整数であり、そしてR1およびR2は、各々水素または1〜3個の炭素原子を有するアルキルラジカルであり、またはあるいは、ここでR1およびR2は、これらが結合される窒素原子と一緒になって、4個の炭素原子を有する飽和ヘテロ環式環を形成する。エベロリムスのように公知である、例示的な化合物において、R’は、Hであり、Xは、−CH2である。
ここでRは、CH2−X−OHであり、Xは、1〜7個の炭素原子を含む直鎖アルキル基である。好ましい化合物は、エベロリムスであり、ここでX=−CH2。エベロリムスを含む前記の化合物の酢酸エステルの塗布と同様に、Xが2、3、4、5、6または7個の炭素のアルキル基である化合物がまた、単独でまたは任意の組み合わせで、本発明について適切である。
別の一般的な実施形態において、ステント本体およびポリマーコーティングの両方が、生物侵食性ポリマーで形成され、経時的にステントが完全に再吸収されることを可能にする。ステントは、好ましくは、ステント本体を形成しているらせん状のリボンフィラメントを有する拡張可能なコイル型ステントである(示さず)。自己拡張可能なコイルステントは、血管中への移植についての米国特許第4,990,155号に記載されており、本明細書に参考として援用される。
ここで図面をより詳細に参照して、図5Aおよび5Bは、本発明に従うステントコーティングプロセスの概略図である。ポリマー溶液40を、ポリマーを親和的溶媒に溶解させることで作製する。少なくとも1つの抗再狭窄性化合物および、所望の場合には第2の薬剤を、同じ溶媒または異なる溶媒を使用する懸濁液または溶液のいずれかとして、この溶液に加える。この完成した混合物を、耐圧性リザーバ42に入れる。リザーバを粒体加圧ポンプ44に接続する。
この節は、本発明に従う脈管処置方法、および本発明に従って構築されるステントの性能特徴を記載する。
本発明の方法は、局所的な脈管損傷を受けた患者、または脈管閉塞の危険のある患者において、狭窄の危険性および/または程度を最小にするように設計される。代表的に、脈管損傷は、血管造影手順の間に生じ、部分的に閉塞された脈管(例えば、冠状動脈または末梢脈管動脈)を開く。脈管造影手順において、バルーンカテーテルが閉塞部位に配置され、そして遠位バルーンが1回以上膨張および収縮されて、閉塞された脈管を強制的に開く。この脈管の膨張(特に、斑が外れ得る脈管壁における表面の外傷を伴うもの)は、しばしば、脈管が、細胞増殖および再閉塞によって、経時的に応答するために十分な局在した損傷を生じる。驚くべきことではないが、狭窄の発生または重篤度は、しばしば、脈管造影手順に関与する脈管伸長の程度に関連する。特に、過度伸長が35%以上である場合、狭窄が、高い頻度で、そしてしばしばかなりの重篤度(すなわち、脈管閉塞)を伴って、起こる。
(エベロリムスおよびその誘導体の調製)
(工程A.2−(t−ブチルジメチルシリル)オキシエタノール(TBSグリコール)の合成)
154mlの乾燥THFおよび1.88gのNaHを、窒素雰囲気下で、500mLの丸底フラスコ冷却器中で攪拌する。4.4mLの乾燥エチレングリコールをこのフラスコに添加し、45分間の攪拌後に、大きい沈殿物を生じる。11.8gのtert−ブチルジメチルシリルクロリドをこのフラスコに添加し、そして激しい攪拌を45分間続ける。得られた混合物を950mLのエチルエーテルに注ぐ。このエーテルを420mLのブラインで洗浄し、そして溶液を硫酸ナトリウムで乾燥する。この生成物を、減圧下でのエーテルのエバポレーションによって濃縮し、そしてシリカゲルを充填された27×5.75cmのカラムを使用する、ヘキサン/Et2O(75:25 v/v)溶媒系を使用するフラッシュクロマトグラフィーによって精製する。その生成物を、0℃で保存する。
4.22gのTBSグリコールおよび5.2gの2,6−ルチジンを、冷却器を備えた100mLの二つ口フラスコ中で、窒素下で激しく攪拌しながら合わせる。10.74gのトリフルオロメタンスルホン酸無水物を、このフラスコに、35〜45分間かけてゆっくりと添加し、黄色がかった褐色溶液を得る。次いで、この反応を、1mLのブラインを添加することによってクエンチし、そしてこの溶液を、100mLのブライン中で5回洗浄して、最終pH値を6〜7にする。この溶液を硫酸ナトリウムを使用して乾燥し、そして減圧下での塩化メチレンのエバポレーションによって濃縮する。その生成物を、シリカゲルを充填した約24×3cmのフラッシュクロマトグラフィーカラムを使用して、ヘキサン/Et2O(85:15 v/v)溶媒系を使用して精製し、次いで、0℃で保存する。
400mgのラパマイシン、10mLのトルエン、および1.9mLの2,6−ルチジンを、55〜57℃に維持した50mLのフラスコ中で混合し、そして撹拌する。別の3mLのセプタムバイアル中で、940μLの2,6−ルチジンを1mLのトルエンに添加し、次いで、2.47gのTBSグリコールTrifを添加する。このバイアルの内容物を50mLフラスコに添加し、そして撹拌しながら、反応を1.5時間進行させる。480μLの2,6−ルチジンおよびさらなる1.236gのTBSグリコールTrifを、この反応フラスコに添加する。撹拌を、さらに1時間続ける。最後に、第二の部分の480μLの2,6−ルチジンおよび1.236gのTBSグリコールTrifをこの混合物に添加し、そしてこの混合物を、さらに1〜1.5時間攪拌する。得られる褐色の溶液を、多孔質ガラスフィルタを通して、減圧を使用して注ぐ。結晶様の沈澱物を、全ての色が除かれるまでトルエンで洗浄する。次いで、その濾液を、60mLの飽和NaHCO3溶液で2回洗浄し、次いで、ブラインで再度洗浄する。得られた溶液を硫酸ナトリウムで乾燥し、そして減圧下で濃縮する。少量のヘキサン/EtOAc(40:60 v/v)溶媒を使用して生成物を溶解し、そしてシリカゲルを充填した33×2cmのフラッシュクロマトグラフィーカラムを使用し、そして同じ溶媒で展開して、精製を達成する。この溶媒を減圧下で除去し、そして生成物を5℃で保存する。
パイレックス(登録商標)ガラス皿(150×75mm)を、氷で満たし、そして撹拌プレート上に置く。少量の水を加えて、氷のスラリーを得る。第1に、60〜65mgのTBS−Rapを、8mLのメタノールを加えることによりガラスバイアル中で溶解する。0.8mL 1N HClを、バイアルに加え、この溶液を45分間撹拌し、次いで、3mL飽和NaHCO3水溶液を加えることにより中和する。5mLのブライン、続いて20mLのEtOAcを溶液に加え、その結果、二相が形成される。これらの相の混合後、分液ロートを使用して水層を除く。残る溶媒をブラインで洗って6〜7の最終pHにし、硫酸ナトリウムで乾燥する。硫酸ナトリウムを多孔性ガラスフィルターを使用して除き、そして溶媒を真空中で除去する。生じる濃縮物を、EtOAc/メタノール(97:3)中に溶解し、次いで、シリカゲルで充填された23×2cmフラッシュクロマトグラフィーカラムを使用し、同じ溶媒系を使用して展開して精製する。この溶媒を真空中で除去し、そして生成物を5℃で保存する。
(ポリ−dl−ラクチドコーティングにおけるエベロリムスを含むステントの調製)
100mgのポリ(dl−ラクチド)を、室温にて2mLアセトン中に溶解した。5mgのエベロリムスをバイアル中に置き、400μLのラクチド溶液を加えた。マイクロプロセッサ制御シリンジポンプを使用して、ステントストラット頂部表面にラクチド溶液を含む10μLの薬物を正確に分配した。溶媒の蒸発が、ステント上の単一ポリマー層を含む均一な薬物を生じた。
(ポリ−dl−ラクチドコーティングにおけるエベロリムスを含むステントからのインビトロでの薬物放出)
インビトロ薬物放出を、コーティングされたステントを25%EtOHを含む2mLのpH7.4リン酸緩衝化生理食塩水溶液中に配置し、0.05%(w/v)アジドナトリウムとともに保存し、37℃に保つことにより行なった。サンプリングを、全緩衝液体積を薬物測定のために回収しながら、溶液を同じ体積の新鮮な緩衝液(無限の沈降)で置換することにより定期的に行なった。図7は、この様式で微小分配される単一のポリマー層でコーティングされる2つの同じステントからの薬物放出を例示する。
(動物移植試験)
(A.ブタにおける安全および用量設定試験のQCA結果)
原理:
薬物溶出ステントのための最も問題のある処置条件が、再狭窄(新脈管内膜形成)の程度が脈管損傷の程度と共に直接増加することが公知であるために、ひどく損傷した血管であると考えられていた。実験がブタにおいて行われ、薬物でコーティングされたステント移植物の標的であった脈管のかなりの数が、血管形成術バルーンを使用して重篤に損傷された(平均およそ36%過度に伸ばした脈管の損傷)。これは、脈管の内膜および中間層の重篤な引き裂きおよび伸びを引き起こし、移植後28日で極端な再狭窄を引き起こした。このように、薬物の種々の用量の相対有効性および移植後28日での再狭窄の減少についての同じ金属ステント/ポリマープラットフォームにおけるポリマーに対する薬物重量比を評価することが可能であった。
「剥き出しのステント」とは、波形の環設計の18.7mmの剥き出しの金属ステントをいう(すなわち、Biosensors Intl.,Inc.により製造されるような、現在市販される「S−ステント」)。
波形環設計の金属ワイヤメッシュ骨格を使用する薬物溶出ステント(すなわち、S−ステント)およびポリマーコーティングを、異なる用量の薬物エベロリムスまたは薬物シロリムスのいずれかを使用して、外で育った未成育のブタ(あるいは28日以上続く移植研究についてはYucatan Minipig)に移植した。移植の際に、Quantitative Coronary Angiography(QCA)を実施して、ステント移植の前および後の脈管の直径を測定した。28日目、または以下の表に具体的に示される場合にはそれより長期間にて、動物をステントの領域においてQCAを再び受けさせ、その後安楽死させる。
PCベースのシステムのためのA.G. Heinzeスライド顕微鏡を通したコンピューター化された画像化システムImage Pro Plus 4.0を、以下の組織形態学的測定のために使用した:
1.平均断面積および管腔厚(脈管内膜/新脈管内膜境界により制限される領域);新脈管内膜(管腔と内弾性板(IEL)との間の領域、IELが欠けている場合、管腔と中間弾性板または外弾性板(EEL)の残りとの間の領域);中間(IELとEELとの間の領域);管サイズ(外膜領域を除くEELにより制限される領域);および外膜領域(周辺外膜組織、脂肪組織および心筋層ならびにEELの間の領域)。
2.損傷スコア。脈管損傷の程度を定量化するために、異なる壁構造の裂け目の量および長さに基づくスコアが、使用された。損傷の程度が、以下のように計算された:
0=インタクトなIEL
1=媒体浅層に曝される裂かれたIEL(少ない損傷)
2=より深い媒体層に曝される裂かれたIEL(媒体切開)
3=外膜領域に曝された裂かれたEEL
以下の表は、追跡管理QCAでのQCA分析(再狭窄に起因する平均管腔喪失の測定)の結果を示す。以下の表の「新脈管内膜」と題される欄の下のデータは、追跡管理(f/u)でのブタから除かれたステントおよび管の形態学的分析の結果を報告する:
(表1:「高度損傷」実験の結果)
(B.低損傷研究)
どれほどのエベロリムスの用量が軽く損傷した脈管(合併症でない冠動脈疾患および1つの新しい損傷を有する患者により代表的である)において最良であるかをさらに決定するために、エベロリムス溶出ステントを、中程度から低い過度伸長損傷(およそ15%)を作製するために移植した。農場のブタを30日の実験のために使用し、そして成体のYucatan minipigを三ヶ月の安全研究のために移植した。血管造影法の結果は、以下の通りであった:
(表2:「低い損傷」実験のQCA結果)
ステント内に形成された、各々のステント内の全切断面領域および新しい組織(新脈管内膜)の切断面領域が、コンピューターにより測定され、狭窄領域の割合が、計算された。薬物およびポリマーの各々の形成のための、平均的管損傷スコア、新脈管内膜領域、および狭窄領域の割合、ステント当たりの3つのスライスの平均化が、以下の表に示される。
形態学的分析は、ブタ冠動脈モデルにおけるステント内狭窄を測定する高度に正確な方法と考えられる。高度損傷モデルにおいて、C−High調合は、28日での「高度損傷」実験における新脈管内膜形成の最も低い量を作製した;しかし、C−Uhighは、群の最も高度な損傷スコアを有し、0.45の非常に低い狭窄領域の割合をなお管理した。従って、データは、QCA分析の発見を独立して確かめ、そして臨床試験のための好ましいい調合としてC−Uhighの選択を支持する。
(D.組織学的分析)
C−Uhighおよびsirolimus−lowについてのスライドを、経験を積んだ癌病理学者に提出した。彼は、炎症、フィブリンおよび新しく治療した管腔の内皮を示す証拠について管断面を再調査した。シロリムス溶出ステントとエベロリムス溶出ステントとの間の違いは、見出せなかった。一般に、良く定着した内皮を有する管は、良く治療されており、完成した治療の証拠であり、28日での管恒常性であると見られる。図13は、移植後28日での管腔内部の内皮層の治療および定着を示す倍率91倍の管断面図の例である。
Carterらは、ブタにおいてPalmaz Schatz金属ステントを使用してシロリムスでコーティングしたステントの結果を発表した。発表されたCarterの結果のBiosensorの実験結果に対して比較する表を、下に示す:
(表4)
(実施例5)
(高度な薬物装填を有するステントの調製)
長さ14.6mmの印付けられた金属波形環ステント(S−ステント、波形環設計)を、血漿堆積プロセスを使用してパリレン「C」プライマーのおよそ2ミクロンの層でコーティングした。パリレンでコーティングしたステントを周囲温度で終夜キシレン中においた。50μg/μlのポリ乳酸(PDLA)を含む貯蔵ポリ(d、l)−乳酸溶液を、2mL中100mgのPDLAに溶解することにより調製した。
Claims (13)
- 脈管損傷部位において配置し、その部位での再狭窄を抑制するための脈管内ステントであって、該ステントが、以下:
1つ以上のフィラメントから形成される本体、
該1つ以上のフィラメント上で支えられる、(i)20〜60重量パーセントのポリマー基材および(ii)40〜80重量パーセントの抗再狭窄化合物から構成される薬物放出コーティングならびに
該ステント本体フィラメントと該コーティングとの間に配置されるポリマーアンダーコーティングを含み、
該ステントは、該ステントがカテーテルを介して脈管損傷部位に送達され得る収縮した状態からステントコーティングが該損傷部位にて該脈管と接触して配置され得る拡張した状態へと拡張可能であり、
該コーティングは、該部位にて再狭窄を抑制する量の化合物を放出するのに効果的である、脈管内ステント。 - 請求項1に記載のステントであって、前記ステント本体が、金属フィラメント構造であり、前記アンダーコーティングが、パリレンポリマーから形成され、かつ1〜5ミクロンの間の厚みを有し、該コーティングが、生分解性ポリマーから構成され、約3〜30ミクロンの間の厚さを有する、ステント。
- 請求項1に記載のステントであって、前記ステント本体が、金属フィラメント構造であり、前記薬物放出コーティングが、ポリメチルメタクリレート、エチレンビニルアルコールおよびポリ−dl−ラクチドポリマーからなる群より選択されるポリマーから形成される、ステント。
- 請求項1に記載のステントであって、前記ステント本体が、ポリ−l−乳酸ポリマーまたはポリ−dl−乳酸ポリマーから形成され、前記薬物放出コーティングが、ポリ−dl−ラクチドから形成される、ステント。
- 請求項1〜4のいずれか1項に記載のステントであって、前記抗再狭窄化合物が、大環状トリエン化合物である、ステント。
- 請求項6に記載のステントであって、R’がHであり、RがCH2−X−OHであり、そしてXが−CH2である、ステント。
- 請求項6〜8のいずれか1項に記載のステントであって、前記化合物が、50重量%〜75重量%の間の量でコーティング中に存在する、ステント。
- 脈管損傷部位における再狭窄を抑制するための、請求項1〜9のいずれか1項に記載のステント。
- 前記脈管損傷が、脈管領域が直径で少なくとも30%過度伸長する血管造影手順の間に生成される場合の使用のための、請求項10に記載のステント。
- 脈管損傷部位に配置し、該部位にて再狭窄を抑制するための脈管内ステントであって、該脈管内ステントが、以下:
1つ以上のフィラメントから形成される本体、
該1つ以上のフィラメント上に支えられる、ポリマー基材および以下:
の形態の抗再狭窄化合物から構成される薬物放出コーティングであって、RがCH2−X−OH、そしてXが1〜7個の炭素原子を含む直鎖アルキル基または分岐鎖アルキル基である、薬物放出コーティング、ならびに
該ステント本体フィラメントと該コーティングとの間に配置されるポリマーアンダーコーティングを含み、
該ステントは、該ステントがカテーテルを介して脈管損傷部位に送達され得る収縮した状態からステントコーティングが該損傷部位にて該脈管と接触して配置され得る拡張した状態まで拡張可能であり、該コーティングは、該部位にて再狭窄を抑制する量の化合物を放出するのに効果的である、脈管内ステント。 - 請求項12に記載のステントであって、XがCH2である、ステント。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/133,814 US6939376B2 (en) | 2001-11-05 | 2002-04-24 | Drug-delivery endovascular stent and method for treating restenosis |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003587443A Division JP2005523119A (ja) | 2002-04-24 | 2003-04-24 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012274329A Division JP2013121509A (ja) | 2002-04-24 | 2012-12-17 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
JP2008279278A true JP2008279278A (ja) | 2008-11-20 |
Family
ID=29268785
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003587323A Expired - Lifetime JP4315817B2 (ja) | 2002-04-24 | 2003-04-24 | 大環状トリエン化合物を含むポリマー組成物 |
JP2003587443A Pending JP2005523119A (ja) | 2002-04-24 | 2003-04-24 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
JP2008209130A Pending JP2008279278A (ja) | 2002-04-24 | 2008-08-15 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
JP2008209129A Expired - Lifetime JP5113667B2 (ja) | 2002-04-24 | 2008-08-15 | 大環状トリエン化合物を含むポリマー組成物 |
JP2012274329A Pending JP2013121509A (ja) | 2002-04-24 | 2012-12-17 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
JP2014030790A Expired - Lifetime JP5827355B2 (ja) | 2002-04-24 | 2014-02-20 | 大環状トリエン化合物を含むポリマー組成物 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003587323A Expired - Lifetime JP4315817B2 (ja) | 2002-04-24 | 2003-04-24 | 大環状トリエン化合物を含むポリマー組成物 |
JP2003587443A Pending JP2005523119A (ja) | 2002-04-24 | 2003-04-24 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
Family Applications After (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008209129A Expired - Lifetime JP5113667B2 (ja) | 2002-04-24 | 2008-08-15 | 大環状トリエン化合物を含むポリマー組成物 |
JP2012274329A Pending JP2013121509A (ja) | 2002-04-24 | 2012-12-17 | 薬物送達脈管内ステントおよび再狭窄を処置するための方法 |
JP2014030790A Expired - Lifetime JP5827355B2 (ja) | 2002-04-24 | 2014-02-20 | 大環状トリエン化合物を含むポリマー組成物 |
Country Status (10)
Country | Link |
---|---|
US (6) | US6939376B2 (ja) |
EP (6) | EP2113230A3 (ja) |
JP (6) | JP4315817B2 (ja) |
CN (3) | CN1735402A (ja) |
AT (1) | ATE451075T1 (ja) |
AU (3) | AU2003231757B2 (ja) |
DE (1) | DE60330455D1 (ja) |
ES (4) | ES2514391T3 (ja) |
HK (3) | HK1156494A1 (ja) |
WO (2) | WO2003090684A2 (ja) |
Families Citing this family (369)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
US7208011B2 (en) * | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US6241762B1 (en) | 1998-03-30 | 2001-06-05 | Conor Medsystems, Inc. | Expandable medical device with ductile hinges |
US7208010B2 (en) | 2000-10-16 | 2007-04-24 | Conor Medsystems, Inc. | Expandable medical device for delivery of beneficial agent |
US7713297B2 (en) | 1998-04-11 | 2010-05-11 | Boston Scientific Scimed, Inc. | Drug-releasing stent with ceramic-containing layer |
US6790228B2 (en) | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US20050238686A1 (en) * | 1999-12-23 | 2005-10-27 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6908624B2 (en) * | 1999-12-23 | 2005-06-21 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US7419678B2 (en) * | 2000-05-12 | 2008-09-02 | Cordis Corporation | Coated medical devices for the prevention and treatment of vascular disease |
US7175658B1 (en) * | 2000-07-20 | 2007-02-13 | Multi-Gene Vascular Systems Ltd. | Artificial vascular grafts, their construction and use |
HUP0300810A2 (hu) | 2000-07-20 | 2003-08-28 | M.G.V.S. Ltd. | Mesterséges értranszplantátum, valamint ennek létrehozása és alkalmazása |
DE60133053T2 (de) | 2000-10-16 | 2009-02-26 | Conor Medsystems, Inc., Menlo Park | Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens |
EP1258230A3 (en) | 2001-03-29 | 2003-12-10 | CardioSafe Ltd | Balloon catheter device |
US6764505B1 (en) | 2001-04-12 | 2004-07-20 | Advanced Cardiovascular Systems, Inc. | Variable surface area stent |
US7247313B2 (en) * | 2001-06-27 | 2007-07-24 | Advanced Cardiovascular Systems, Inc. | Polyacrylates coatings for implantable medical devices |
US8741378B1 (en) | 2001-06-27 | 2014-06-03 | Advanced Cardiovascular Systems, Inc. | Methods of coating an implantable device |
US7842083B2 (en) | 2001-08-20 | 2010-11-30 | Innovational Holdings, Llc. | Expandable medical device with improved spatial distribution |
US7056338B2 (en) * | 2003-03-28 | 2006-06-06 | Conor Medsystems, Inc. | Therapeutic agent delivery device with controlled therapeutic agent release rates |
GB0121980D0 (en) * | 2001-09-11 | 2001-10-31 | Cathnet Science Holding As | Expandable stent |
US20030077310A1 (en) | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7682387B2 (en) | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US20030135266A1 (en) * | 2001-12-03 | 2003-07-17 | Xtent, Inc. | Apparatus and methods for delivery of multiple distributed stents |
US7182779B2 (en) | 2001-12-03 | 2007-02-27 | Xtent, Inc. | Apparatus and methods for positioning prostheses for deployment from a catheter |
US8080048B2 (en) | 2001-12-03 | 2011-12-20 | Xtent, Inc. | Stent delivery for bifurcated vessels |
US7309350B2 (en) * | 2001-12-03 | 2007-12-18 | Xtent, Inc. | Apparatus and methods for deployment of vascular prostheses |
US20040186551A1 (en) * | 2003-01-17 | 2004-09-23 | Xtent, Inc. | Multiple independent nested stent structures and methods for their preparation and deployment |
US7147656B2 (en) | 2001-12-03 | 2006-12-12 | Xtent, Inc. | Apparatus and methods for delivery of braided prostheses |
US7351255B2 (en) | 2001-12-03 | 2008-04-01 | Xtent, Inc. | Stent delivery apparatus and method |
US7137993B2 (en) | 2001-12-03 | 2006-11-21 | Xtent, Inc. | Apparatus and methods for delivery of multiple distributed stents |
US7270668B2 (en) * | 2001-12-03 | 2007-09-18 | Xtent, Inc. | Apparatus and methods for delivering coiled prostheses |
US7892273B2 (en) | 2001-12-03 | 2011-02-22 | Xtent, Inc. | Custom length stent apparatus |
US7294146B2 (en) | 2001-12-03 | 2007-11-13 | Xtent, Inc. | Apparatus and methods for delivery of variable length stents |
US20040024450A1 (en) * | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US6645547B1 (en) * | 2002-05-02 | 2003-11-11 | Labcoat Ltd. | Stent coating device |
US7270675B2 (en) * | 2002-05-10 | 2007-09-18 | Cordis Corporation | Method of forming a tubular membrane on a structural frame |
EP1516597A4 (en) * | 2002-06-27 | 2010-11-10 | Microport Medical Shanghai Co | MEDICINES ELUTIONSSTENT |
ES2428354T3 (es) | 2002-09-18 | 2013-11-07 | Trustees Of The University Of Pennsylvania | Rapamicina para usar en la inhibición o prevención de la neovascularización coroidea |
US8303511B2 (en) | 2002-09-26 | 2012-11-06 | Pacesetter, Inc. | Implantable pressure transducer system optimized for reduced thrombosis effect |
WO2004028348A2 (en) | 2002-09-26 | 2004-04-08 | Savacor, Inc. | Cardiovascular anchoring device and method of deploying same |
US6971813B2 (en) * | 2002-09-27 | 2005-12-06 | Labcoat, Ltd. | Contact coating of prostheses |
WO2004034874A2 (en) * | 2002-10-15 | 2004-04-29 | Norbert Thompson | Parylene-coated silicone t-tubes and method of use thereof |
WO2004043509A1 (en) * | 2002-11-08 | 2004-05-27 | Conor Medsystems, Inc. | Expandable medical device and method for treating chronic total occlusions with local delivery of an angiogenic factor |
US7169178B1 (en) * | 2002-11-12 | 2007-01-30 | Advanced Cardiovascular Systems, Inc. | Stent with drug coating |
US9770349B2 (en) * | 2002-11-13 | 2017-09-26 | University Of Virginia Patent Foundation | Nanoporous stents with enhanced cellular adhesion and reduced neointimal formation |
US20050070989A1 (en) * | 2002-11-13 | 2005-03-31 | Whye-Kei Lye | Medical devices having porous layers and methods for making the same |
KR100826574B1 (ko) * | 2002-11-13 | 2008-04-30 | 유니버시티 오브 버지니아 페이턴트 파운데이션 | 다공성 층을 갖는 의료장치 및 이를 제조하는 방법 |
US20060121080A1 (en) * | 2002-11-13 | 2006-06-08 | Lye Whye K | Medical devices having nanoporous layers and methods for making the same |
US20060002968A1 (en) * | 2004-06-30 | 2006-01-05 | Gordon Stewart | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders |
US8435550B2 (en) | 2002-12-16 | 2013-05-07 | Abbot Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US7758881B2 (en) | 2004-06-30 | 2010-07-20 | Advanced Cardiovascular Systems, Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US20090093875A1 (en) * | 2007-05-01 | 2009-04-09 | Abbott Laboratories | Drug eluting stents with prolonged local elution profiles with high local concentrations and low systemic concentrations |
US8715771B2 (en) * | 2003-02-26 | 2014-05-06 | Abbott Cardiovascular Systems Inc. | Coated stent and method of making the same |
AU2004222340B2 (en) | 2003-03-14 | 2009-11-12 | Intersect Ent, Inc. | Sinus delivery of sustained release therapeutics |
ATE526038T1 (de) | 2003-03-28 | 2011-10-15 | Innovational Holdings Llc | Implantierbares medizinprodukt mit kontinuierlichem mittel-konzentrationsgefälle |
US20040202692A1 (en) * | 2003-03-28 | 2004-10-14 | Conor Medsystems, Inc. | Implantable medical device and method for in situ selective modulation of agent delivery |
US7241308B2 (en) | 2003-06-09 | 2007-07-10 | Xtent, Inc. | Stent deployment systems and methods |
US7229979B2 (en) * | 2003-06-23 | 2007-06-12 | Immune Modulation, Inc. | Hypoestoxides, derivatives and agonists thereof for use as stent-coating agents |
US20050118344A1 (en) | 2003-12-01 | 2005-06-02 | Pacetti Stephen D. | Temperature controlled crimping |
US6840569B1 (en) * | 2003-07-22 | 2005-01-11 | Arthur Donald Leigh | Caravan |
US20050043786A1 (en) * | 2003-08-18 | 2005-02-24 | Medtronic Ave, Inc. | Methods and apparatus for treatment of aneurysmal tissue |
US20050049693A1 (en) * | 2003-08-25 | 2005-03-03 | Medtronic Vascular Inc. | Medical devices and compositions for delivering biophosphonates to anatomical sites at risk for vascular disease |
US20050048194A1 (en) * | 2003-09-02 | 2005-03-03 | Labcoat Ltd. | Prosthesis coating decision support system |
US20050058768A1 (en) * | 2003-09-16 | 2005-03-17 | Eyal Teichman | Method for coating prosthetic stents |
US20050080475A1 (en) * | 2003-10-14 | 2005-04-14 | Xtent, Inc. A Delaware Corporation | Stent delivery devices and methods |
US7553324B2 (en) * | 2003-10-14 | 2009-06-30 | Xtent, Inc. | Fixed stent delivery devices and methods |
WO2005037339A1 (en) * | 2003-10-14 | 2005-04-28 | Cube Medical A/S | A balloon for use in angioplasty |
US7192440B2 (en) * | 2003-10-15 | 2007-03-20 | Xtent, Inc. | Implantable stent delivery devices and methods |
US20050100577A1 (en) * | 2003-11-10 | 2005-05-12 | Parker Theodore L. | Expandable medical device with beneficial agent matrix formed by a multi solvent system |
US7220755B2 (en) * | 2003-11-12 | 2007-05-22 | Biosensors International Group, Ltd. | 42-O-alkoxyalkyl rapamycin derivatives and compositions comprising same |
US7403966B2 (en) * | 2003-12-08 | 2008-07-22 | Freescale Semiconductor, Inc. | Hardware for performing an arithmetic function |
US20070156225A1 (en) * | 2003-12-23 | 2007-07-05 | Xtent, Inc. | Automated control mechanisms and methods for custom length stent apparatus |
US7326236B2 (en) | 2003-12-23 | 2008-02-05 | Xtent, Inc. | Devices and methods for controlling and indicating the length of an interventional element |
JP2007517550A (ja) * | 2004-01-02 | 2007-07-05 | アドヴァンスド カーディオヴァスキュラー システムズ, インコーポレイテッド | 高比重リポ蛋白をコーティングした医療デバイス |
DE102004029611A1 (de) * | 2004-02-06 | 2005-08-25 | Restate Patent Ag | Implantat zur Freisetzung eines Wirkstoffs in ein von einem Körpermedium durchströmtes Gefäß |
MXPA06009770A (es) * | 2004-02-28 | 2007-02-20 | Hemoteq Gmbh | Revestimiento biocompatible, metodo y utilizacion de superficies medicas. |
EP1571151B1 (en) * | 2004-03-01 | 2008-12-24 | Terumo Kabushiki Kaisha | Process for production of O-alkylated rapamycin derivatives |
US7695731B2 (en) * | 2004-03-22 | 2010-04-13 | Cordis Corporation | Local vascular delivery of etoposide in combination with rapamycin to prevent restenosis following vascular injury |
US7323006B2 (en) | 2004-03-30 | 2008-01-29 | Xtent, Inc. | Rapid exchange interventional devices and methods |
US8778014B1 (en) | 2004-03-31 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Coatings for preventing balloon damage to polymer coated stents |
US20050228477A1 (en) * | 2004-04-09 | 2005-10-13 | Xtent, Inc. | Topographic coatings and coating methods for medical devices |
US8361013B2 (en) | 2004-04-19 | 2013-01-29 | The Invention Science Fund I, Llc | Telescoping perfusion management system |
US8019413B2 (en) | 2007-03-19 | 2011-09-13 | The Invention Science Fund I, Llc | Lumen-traveling biological interface device and method of use |
US8337482B2 (en) | 2004-04-19 | 2012-12-25 | The Invention Science Fund I, Llc | System for perfusion management |
US7850676B2 (en) | 2004-04-19 | 2010-12-14 | The Invention Science Fund I, Llc | System with a reservoir for perfusion management |
US7857767B2 (en) | 2004-04-19 | 2010-12-28 | Invention Science Fund I, Llc | Lumen-traveling device |
US9011329B2 (en) | 2004-04-19 | 2015-04-21 | Searete Llc | Lumenally-active device |
US8353896B2 (en) | 2004-04-19 | 2013-01-15 | The Invention Science Fund I, Llc | Controllable release nasal system |
US7998060B2 (en) | 2004-04-19 | 2011-08-16 | The Invention Science Fund I, Llc | Lumen-traveling delivery device |
US9801527B2 (en) | 2004-04-19 | 2017-10-31 | Gearbox, Llc | Lumen-traveling biological interface device |
US8092549B2 (en) | 2004-09-24 | 2012-01-10 | The Invention Science Fund I, Llc | Ciliated stent-like-system |
US20060246109A1 (en) * | 2005-04-29 | 2006-11-02 | Hossainy Syed F | Concentration gradient profiles for control of agent release rates from polymer matrices |
US8293890B2 (en) | 2004-04-30 | 2012-10-23 | Advanced Cardiovascular Systems, Inc. | Hyaluronic acid based copolymers |
EP1750728A4 (en) * | 2004-05-10 | 2009-04-29 | Novacea Inc | PREVENTION AGAINST ARTERIAL RESTENOSIS USING ACTIVE VITAMIN D COMPOUNDS |
US20050255230A1 (en) * | 2004-05-17 | 2005-11-17 | Clerc Claude O | Method of manufacturing a covered stent |
US20050288766A1 (en) * | 2004-06-28 | 2005-12-29 | Xtent, Inc. | Devices and methods for controlling expandable prostheses during deployment |
US8317859B2 (en) | 2004-06-28 | 2012-11-27 | J.W. Medical Systems Ltd. | Devices and methods for controlling expandable prostheses during deployment |
US20050287184A1 (en) * | 2004-06-29 | 2005-12-29 | Hossainy Syed F A | Drug-delivery stent formulations for restenosis and vulnerable plaque |
US8709469B2 (en) * | 2004-06-30 | 2014-04-29 | Abbott Cardiovascular Systems Inc. | Anti-proliferative and anti-inflammatory agent combination for treatment of vascular disorders with an implantable medical device |
US20060029720A1 (en) * | 2004-08-03 | 2006-02-09 | Anastasia Panos | Methods and apparatus for injection coating a medical device |
US8980300B2 (en) | 2004-08-05 | 2015-03-17 | Advanced Cardiovascular Systems, Inc. | Plasticizers for coating compositions |
US7901451B2 (en) * | 2004-09-24 | 2011-03-08 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US20060069424A1 (en) * | 2004-09-27 | 2006-03-30 | Xtent, Inc. | Self-constrained segmented stents and methods for their deployment |
US20060085065A1 (en) * | 2004-10-15 | 2006-04-20 | Krause Arthur A | Stent with auxiliary treatment structure |
US7481835B1 (en) * | 2004-10-29 | 2009-01-27 | Advanced Cardiovascular Systems, Inc. | Encapsulated covered stent |
US20060095122A1 (en) * | 2004-10-29 | 2006-05-04 | Advanced Cardiovascular Systems, Inc. | Implantable devices comprising biologically absorbable star polymers and methods for fabricating the same |
US8388677B2 (en) * | 2004-10-29 | 2013-03-05 | Boston Scientific Scimed, Inc. | Anti-thrombogenic and anti-restenotic vascular medical devices |
US20060127443A1 (en) * | 2004-12-09 | 2006-06-15 | Helmus Michael N | Medical devices having vapor deposited nanoporous coatings for controlled therapeutic agent delivery |
US7632307B2 (en) | 2004-12-16 | 2009-12-15 | Advanced Cardiovascular Systems, Inc. | Abluminal, multilayer coating constructs for drug-delivery stents |
US8057543B2 (en) * | 2005-01-28 | 2011-11-15 | Greatbatch Ltd. | Stent coating for eluting medication |
US7749553B2 (en) * | 2005-01-31 | 2010-07-06 | Boston Scientific Scimed, Inc. | Method and system for coating a medical device using optical drop volume verification |
KR20070104931A (ko) | 2005-02-09 | 2007-10-29 | 마커사이트, 인코포레이티드 | 안구 치료용 제제 |
US7700659B2 (en) * | 2005-03-24 | 2010-04-20 | Advanced Cardiovascular Systems, Inc. | Implantable devices formed of non-fouling methacrylate or acrylate polymers |
US9381279B2 (en) | 2005-03-24 | 2016-07-05 | Abbott Cardiovascular Systems Inc. | Implantable devices formed on non-fouling methacrylate or acrylate polymers |
US7955639B2 (en) * | 2005-03-31 | 2011-06-07 | Innovational Holdings, Llc. | System and method for loading a beneficial agent into a medical device |
EP2298319A1 (en) | 2005-04-04 | 2011-03-23 | Sinexus, Inc. | Device and methods for treating paranasal sinus conditions |
US7402168B2 (en) * | 2005-04-11 | 2008-07-22 | Xtent, Inc. | Custom-length stent delivery system with independently operable expansion elements |
US8778375B2 (en) * | 2005-04-29 | 2014-07-15 | Advanced Cardiovascular Systems, Inc. | Amorphous poly(D,L-lactide) coating |
US20060257355A1 (en) * | 2005-05-10 | 2006-11-16 | Abiomed, Inc. | Impregnated polymer compositions and devices using them |
US8961586B2 (en) | 2005-05-24 | 2015-02-24 | Inspiremd Ltd. | Bifurcated stent assemblies |
WO2006126182A2 (en) | 2005-05-24 | 2006-11-30 | Inspire M.D Ltd. | Stent apparatuses for treatment via body lumens and methods of use |
US8043323B2 (en) * | 2006-10-18 | 2011-10-25 | Inspiremd Ltd. | In vivo filter assembly |
US8157851B2 (en) * | 2005-06-08 | 2012-04-17 | Xtent, Inc. | Apparatus and methods for deployment of multiple custom-length prostheses |
WO2007011708A2 (en) | 2005-07-15 | 2007-01-25 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
US8298565B2 (en) | 2005-07-15 | 2012-10-30 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
AU2011256902B2 (en) * | 2005-07-15 | 2015-03-12 | Micell Technologies, Inc. | Polymer coatings containing drug powder of controlled morphology |
US20070020312A1 (en) * | 2005-07-20 | 2007-01-25 | Desnoyer Jessica R | Method of fabricating a bioactive agent-releasing implantable medical device |
WO2007040485A1 (en) * | 2005-09-22 | 2007-04-12 | Novovascular, Inc. | Stent covered by a layer having a layer opening |
US20070104753A1 (en) * | 2005-11-04 | 2007-05-10 | Aiden Flanagan | Medical device with a coating comprising an active form and an inactive form of therapeutic agent(s) |
US20070196423A1 (en) * | 2005-11-21 | 2007-08-23 | Med Institute, Inc. | Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent |
ATE498027T1 (de) * | 2005-12-07 | 2011-02-15 | Univ Ramot | Wirkstoffabgebende verbundkörper |
US20070142903A1 (en) * | 2005-12-15 | 2007-06-21 | Dave Vipul B | Laser cut intraluminal medical devices |
US7842312B2 (en) | 2005-12-29 | 2010-11-30 | Cordis Corporation | Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same |
WO2007081530A2 (en) * | 2006-01-03 | 2007-07-19 | Med Institute, Inc. | Endoluminal medical device for local delivery of cathepsin inhibitors |
US20090214496A1 (en) * | 2006-01-30 | 2009-08-27 | Licentia Ltd. | Bmx/etk tyrosine kinase gene therapy materials and methods |
US20070179587A1 (en) * | 2006-01-30 | 2007-08-02 | Xtent, Inc. | Apparatus and methods for deployment of custom-length prostheses |
EP1984040A1 (en) | 2006-01-31 | 2008-10-29 | Multi Gene Vascular Systems, Inc. | Drug-eluting intravascular prostheses and methods of use |
US20070178137A1 (en) * | 2006-02-01 | 2007-08-02 | Toby Freyman | Local control of inflammation |
CA2635797C (en) | 2006-02-09 | 2015-03-31 | Macusight, Inc. | Stable formulations, and methods of their preparation and use |
AU2007217355B2 (en) | 2006-02-27 | 2012-06-21 | Vertex Pharmaceuticals Incorporated | Co-crystals comprising VX-950 and pharmaceutical compositions comprising the same |
US7622477B2 (en) * | 2006-02-28 | 2009-11-24 | Cordis Corporation | Isomers and 42-epimers of rapamycin alkyl ether analogs, methods of making and using the same |
WO2007109621A2 (en) | 2006-03-20 | 2007-09-27 | Xtent, Inc. | Apparatus and methods for deployment of linked prosthetic segments |
DK2001466T3 (en) | 2006-03-23 | 2016-02-29 | Santen Pharmaceutical Co Ltd | LOW-DOSAGE RAPAMYCINE FOR TREATMENT OF VASCULAR PERMEABILITY-RELATED DISEASES |
US20070224235A1 (en) | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
US8187620B2 (en) | 2006-03-27 | 2012-05-29 | Boston Scientific Scimed, Inc. | Medical devices comprising a porous metal oxide or metal material and a polymer coating for delivering therapeutic agents |
WO2007119423A1 (ja) * | 2006-03-30 | 2007-10-25 | Terumo Kabushiki Kaisha | 生体内留置物 |
JPWO2007116646A1 (ja) * | 2006-04-04 | 2009-08-20 | テルモ株式会社 | 生体内留置物 |
US20120035540A1 (en) | 2006-04-12 | 2012-02-09 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Event-based control of a lumen traveling device |
US9220917B2 (en) | 2006-04-12 | 2015-12-29 | The Invention Science Fund I, Llc | Systems for autofluorescent imaging and target ablation |
US7879086B2 (en) * | 2006-04-20 | 2011-02-01 | Boston Scientific Scimed, Inc. | Medical device having a coating comprising an adhesion promoter |
PL2019657T3 (pl) | 2006-04-26 | 2015-10-30 | Micell Technologies Inc | Powłoki zawierające wiele leków |
US20070254003A1 (en) * | 2006-05-01 | 2007-11-01 | Pu Zhou | Non-sticky coatings with therapeutic agents for medical devices |
US20070276486A1 (en) * | 2006-05-25 | 2007-11-29 | E. Benson Hood Laboratories | Coated tracheostomy tube and stoma stent or cannula |
US20080097620A1 (en) * | 2006-05-26 | 2008-04-24 | Nanyang Technological University | Implantable article, method of forming same and method for reducing thrombogenicity |
US9561351B2 (en) * | 2006-05-31 | 2017-02-07 | Advanced Cardiovascular Systems, Inc. | Drug delivery spiral coil construct |
US20070281117A1 (en) * | 2006-06-02 | 2007-12-06 | Xtent, Inc. | Use of plasma in formation of biodegradable stent coating |
US20080095918A1 (en) * | 2006-06-14 | 2008-04-24 | Kleiner Lothar W | Coating construct with enhanced interfacial compatibility |
US8246973B2 (en) | 2006-06-21 | 2012-08-21 | Advanced Cardiovascular Systems, Inc. | Freeze-thaw method for modifying stent coating |
US8679573B2 (en) * | 2006-06-28 | 2014-03-25 | Advanced Cardiovascular Systems, Inc. | Stent coating method and apparatus |
US8388573B1 (en) | 2006-06-28 | 2013-03-05 | Abbott Cardiovascular Systems Inc. | Local delivery with a balloon covered by a cage |
US8815275B2 (en) | 2006-06-28 | 2014-08-26 | Boston Scientific Scimed, Inc. | Coatings for medical devices comprising a therapeutic agent and a metallic material |
US8956640B2 (en) * | 2006-06-29 | 2015-02-17 | Advanced Cardiovascular Systems, Inc. | Block copolymers including a methoxyethyl methacrylate midblock |
JP2009542359A (ja) | 2006-06-29 | 2009-12-03 | ボストン サイエンティフィック リミテッド | 選択的被覆部を備えた医療装置 |
US20080008736A1 (en) * | 2006-07-06 | 2008-01-10 | Thierry Glauser | Random copolymers of methacrylates and acrylates |
US20080091262A1 (en) * | 2006-10-17 | 2008-04-17 | Gale David C | Drug delivery after biodegradation of the stent scaffolding |
US8016879B2 (en) | 2006-08-01 | 2011-09-13 | Abbott Cardiovascular Systems Inc. | Drug delivery after biodegradation of the stent scaffolding |
CN100465209C (zh) * | 2006-08-17 | 2009-03-04 | 同济大学 | 用于形状记忆管腔内支架的可降解高分子材料的制备方法 |
EP2068757B1 (en) | 2006-09-14 | 2011-05-11 | Boston Scientific Limited | Medical devices with drug-eluting coating |
US20080069858A1 (en) * | 2006-09-20 | 2008-03-20 | Boston Scientific Scimed, Inc. | Medical devices having biodegradable polymeric regions with overlying hard, thin layers |
US8636767B2 (en) * | 2006-10-02 | 2014-01-28 | Micell Technologies, Inc. | Surgical sutures having increased strength |
EP2076212B1 (en) | 2006-10-18 | 2017-03-29 | Inspiremd Ltd. | Knitted stent jackets |
EP1913960A1 (en) * | 2006-10-19 | 2008-04-23 | Albert Schömig | Coated implant |
EP1916006A1 (en) * | 2006-10-19 | 2008-04-30 | Albert Schömig | Implant coated with a wax or a resin |
US20080097591A1 (en) | 2006-10-20 | 2008-04-24 | Biosensors International Group | Drug-delivery endovascular stent and method of use |
US8067055B2 (en) * | 2006-10-20 | 2011-11-29 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method of use |
CN101678388B (zh) | 2006-10-23 | 2013-12-11 | 米歇尔技术公司 | 用于在涂覆过程中为基底充电的保持器 |
US20080103584A1 (en) * | 2006-10-25 | 2008-05-01 | Biosensors International Group | Temporal Intraluminal Stent, Methods of Making and Using |
US7981150B2 (en) | 2006-11-09 | 2011-07-19 | Boston Scientific Scimed, Inc. | Endoprosthesis with coatings |
US20080294236A1 (en) * | 2007-05-23 | 2008-11-27 | Boston Scientific Scimed, Inc. | Endoprosthesis with Select Ceramic and Polymer Coatings |
WO2008062414A2 (en) | 2006-11-22 | 2008-05-29 | Inspiremd Ltd. | Optimized stent jacket |
WO2008088537A2 (en) * | 2006-12-20 | 2008-07-24 | Boston Scientific Limited | Stent with a coating for delivering a therapeutic agent |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
CA2679712C (en) | 2007-01-08 | 2016-11-15 | Micell Technologies, Inc. | Stents having biodegradable layers |
US8221496B2 (en) * | 2007-02-01 | 2012-07-17 | Cordis Corporation | Antithrombotic and anti-restenotic drug eluting stent |
US20080199510A1 (en) | 2007-02-20 | 2008-08-21 | Xtent, Inc. | Thermo-mechanically controlled implants and methods of use |
TW200846343A (en) | 2007-02-27 | 2008-12-01 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
US8431149B2 (en) | 2007-03-01 | 2013-04-30 | Boston Scientific Scimed, Inc. | Coated medical devices for abluminal drug delivery |
US8070797B2 (en) | 2007-03-01 | 2011-12-06 | Boston Scientific Scimed, Inc. | Medical device with a porous surface for delivery of a therapeutic agent |
US8486132B2 (en) | 2007-03-22 | 2013-07-16 | J.W. Medical Systems Ltd. | Devices and methods for controlling expandable prostheses during deployment |
US8067054B2 (en) | 2007-04-05 | 2011-11-29 | Boston Scientific Scimed, Inc. | Stents with ceramic drug reservoir layer and methods of making and using the same |
US9433516B2 (en) | 2007-04-17 | 2016-09-06 | Micell Technologies, Inc. | Stents having controlled elution |
AU2008242844A1 (en) * | 2007-04-17 | 2008-10-30 | Micell Technologies, Inc. | Stents having biodegradable layers |
US7976915B2 (en) | 2007-05-23 | 2011-07-12 | Boston Scientific Scimed, Inc. | Endoprosthesis with select ceramic morphology |
EP2170418B1 (en) * | 2007-05-25 | 2016-03-16 | Micell Technologies, Inc. | Polymer films for medical device coating |
US8084077B2 (en) * | 2007-05-25 | 2011-12-27 | Abbott Laboratories | One-step phosphorylcholine-linked polymer coating and drug loading of stent |
US20100070020A1 (en) | 2008-06-11 | 2010-03-18 | Nanovasc, Inc. | Implantable Medical Device |
US8002823B2 (en) | 2007-07-11 | 2011-08-23 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US7942926B2 (en) | 2007-07-11 | 2011-05-17 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
EP2187988B1 (en) | 2007-07-19 | 2013-08-21 | Boston Scientific Limited | Endoprosthesis having a non-fouling surface |
DE102007034364A1 (de) * | 2007-07-24 | 2009-01-29 | Biotronik Vi Patent Ag | Degradierbarer Metallstent mit wirkstoffhaltiger Beschichtung |
US8815273B2 (en) | 2007-07-27 | 2014-08-26 | Boston Scientific Scimed, Inc. | Drug eluting medical devices having porous layers |
US7931683B2 (en) | 2007-07-27 | 2011-04-26 | Boston Scientific Scimed, Inc. | Articles having ceramic coated surfaces |
WO2009018340A2 (en) | 2007-07-31 | 2009-02-05 | Boston Scientific Scimed, Inc. | Medical device coating by laser cladding |
EP2185103B1 (en) | 2007-08-03 | 2014-02-12 | Boston Scientific Scimed, Inc. | Coating for medical device having increased surface area |
US20090041845A1 (en) * | 2007-08-08 | 2009-02-12 | Lothar Walter Kleiner | Implantable medical devices having thin absorbable coatings |
US20090043380A1 (en) * | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Coatings for promoting endothelization of medical devices |
US20090043330A1 (en) * | 2007-08-09 | 2009-02-12 | Specialized Vascular Technologies, Inc. | Embolic protection devices and methods |
ATE530546T1 (de) | 2007-08-30 | 2011-11-15 | Vertex Pharma | Kokristalle und pharmazeutische zusammensetzungen damit |
WO2009033026A1 (en) * | 2007-09-06 | 2009-03-12 | Boston Scientific Scimed, Inc. | Methods and devices for local therapeutic agent delivery to heart valves |
US8100855B2 (en) * | 2007-09-17 | 2012-01-24 | Abbott Cardiovascular Systems, Inc. | Methods and devices for eluting agents to a vessel |
US20090076584A1 (en) * | 2007-09-19 | 2009-03-19 | Xtent, Inc. | Apparatus and methods for deployment of multiple custom-length prostheses |
KR100930167B1 (ko) * | 2007-09-19 | 2009-12-07 | 삼성전기주식회사 | 초광각 광학계 |
US9814553B1 (en) | 2007-10-10 | 2017-11-14 | Abbott Cardiovascular Systems Inc. | Bioabsorbable semi-crystalline polymer for controlling release of drug from a coating |
US8661630B2 (en) | 2008-05-21 | 2014-03-04 | Abbott Cardiovascular Systems Inc. | Coating comprising an amorphous primer layer and a semi-crystalline reservoir layer |
US8142490B2 (en) | 2007-10-24 | 2012-03-27 | Cordis Corporation | Stent segments axially connected by thin film |
US8642062B2 (en) | 2007-10-31 | 2014-02-04 | Abbott Cardiovascular Systems Inc. | Implantable device having a slow dissolving polymer |
US20090112239A1 (en) * | 2007-10-31 | 2009-04-30 | Specialized Vascular Technologies, Inc. | Sticky dilatation balloon and methods of using |
US7938855B2 (en) | 2007-11-02 | 2011-05-10 | Boston Scientific Scimed, Inc. | Deformable underlayer for stent |
US8029554B2 (en) | 2007-11-02 | 2011-10-04 | Boston Scientific Scimed, Inc. | Stent with embedded material |
US8216632B2 (en) | 2007-11-02 | 2012-07-10 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090118812A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US20090118821A1 (en) * | 2007-11-02 | 2009-05-07 | Boston Scientific Scimed, Inc. | Endoprosthesis with porous reservoir and non-polymer diffusion layer |
EP2219700B1 (en) | 2007-11-14 | 2024-03-20 | Biosensors International Group, Ltd. | Automated coating apparatus and method |
JP2011506341A (ja) | 2007-12-07 | 2011-03-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | 固形型の1−エチル−3−(5−(5−フルオロピリジン−3−イル)−7−(ピリミジン−2−イル)−1H−ベンゾ[d]イミダゾール−2−イル)ウレア |
DK2231065T3 (da) * | 2007-12-18 | 2021-02-01 | Intersect Ent Inc | Selvekspanderende anordninger |
US20090186068A1 (en) * | 2008-01-18 | 2009-07-23 | Chameleon Scientific Corporation | Atomic plasma deposited coatings for drug release |
US20090196900A1 (en) * | 2008-02-01 | 2009-08-06 | Medtronic Vascular, Inc. | Use of Phosphodiesterase Inhibitor as a Component of Implantable Medical Devices |
US9603980B2 (en) * | 2008-02-26 | 2017-03-28 | CARDINAL HEALTH SWITZERLAND 515 GmbH | Layer-by-layer stereocomplexed polymers as drug depot carriers or coatings in medical devices |
US9101503B2 (en) | 2008-03-06 | 2015-08-11 | J.W. Medical Systems Ltd. | Apparatus having variable strut length and methods of use |
US8377116B2 (en) * | 2008-03-20 | 2013-02-19 | Abbott Cardiovascular Systems Inc. | Implantable medical device coatings with improved mechanical stability |
CN101264351B (zh) * | 2008-04-07 | 2011-08-24 | 易生科技(北京)有限公司 | 复合涂层心血管药物洗脱支架及其制备方法 |
US20100121437A1 (en) | 2008-04-16 | 2010-05-13 | Cardiovascular Technologies, Llc | Transvalvular intraannular band and chordae cutting for ischemic and dilated cardiomyopathy |
US20100121435A1 (en) | 2008-04-16 | 2010-05-13 | Cardiovascular Technologies, Llc | Percutaneous transvalvular intrannular band for mitral valve repair |
US11083579B2 (en) | 2008-04-16 | 2021-08-10 | Heart Repair Technologies, Inc. | Transvalvular intraanular band and chordae cutting for ischemic and dilated cardiomyopathy |
US11013599B2 (en) | 2008-04-16 | 2021-05-25 | Heart Repair Technologies, Inc. | Percutaneous transvalvular intraannular band for mitral valve repair |
US10456259B2 (en) | 2008-04-16 | 2019-10-29 | Heart Repair Technologies, Inc. | Transvalvular intraannular band for mitral valve repair |
MX2010011485A (es) | 2008-04-17 | 2011-03-01 | Micell Technologies Inc | Stents que contienen capas bioadsorbibles. |
US8916188B2 (en) * | 2008-04-18 | 2014-12-23 | Abbott Cardiovascular Systems Inc. | Block copolymer comprising at least one polyester block and a poly (ethylene glycol) block |
US20090285873A1 (en) * | 2008-04-18 | 2009-11-19 | Abbott Cardiovascular Systems Inc. | Implantable medical devices and coatings therefor comprising block copolymers of poly(ethylene glycol) and a poly(lactide-glycolide) |
JP5581311B2 (ja) | 2008-04-22 | 2014-08-27 | ボストン サイエンティフィック サイムド,インコーポレイテッド | 無機材料のコーティングを有する医療デバイス及びその製造方法 |
WO2009132176A2 (en) | 2008-04-24 | 2009-10-29 | Boston Scientific Scimed, Inc. | Medical devices having inorganic particle layers |
US9126025B2 (en) | 2008-05-01 | 2015-09-08 | Bayer Intellectual Property Gmbh | Method of coating a folded catheter balloon |
US8986728B2 (en) | 2008-05-30 | 2015-03-24 | Abbott Cardiovascular Systems Inc. | Soluble implantable device comprising polyelectrolyte with hydrophobic counterions |
US9943614B2 (en) | 2008-06-17 | 2018-04-17 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
US8449603B2 (en) | 2008-06-18 | 2013-05-28 | Boston Scientific Scimed, Inc. | Endoprosthesis coating |
US10898620B2 (en) | 2008-06-20 | 2021-01-26 | Razmodics Llc | Composite stent having multi-axial flexibility and method of manufacture thereof |
US8206635B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US8206636B2 (en) | 2008-06-20 | 2012-06-26 | Amaranth Medical Pte. | Stent fabrication via tubular casting processes |
US8562669B2 (en) * | 2008-06-26 | 2013-10-22 | Abbott Cardiovascular Systems Inc. | Methods of application of coatings composed of hydrophobic, high glass transition polymers with tunable drug release rates |
AU2009270849B2 (en) | 2008-07-17 | 2013-11-21 | Micell Technologies, Inc. | Drug delivery medical device |
US9510856B2 (en) | 2008-07-17 | 2016-12-06 | Micell Technologies, Inc. | Drug delivery medical device |
AU2009276505B2 (en) | 2008-08-01 | 2015-04-23 | Intersect Ent, Inc. | Methods and devices for crimping self-expanding devices |
US8642063B2 (en) | 2008-08-22 | 2014-02-04 | Cook Medical Technologies Llc | Implantable medical device coatings with biodegradable elastomer and releasable taxane agent |
US20100055145A1 (en) * | 2008-08-29 | 2010-03-04 | Biosensors International Group | Stent coatings for reducing late stent thrombosis |
WO2010036982A1 (en) | 2008-09-25 | 2010-04-01 | Henry Bourang | Partially crimped stent |
US8828071B2 (en) | 2008-09-25 | 2014-09-09 | Advanced Bifurcation Systems, Inc. | Methods and systems for ostial stenting of a bifurcation |
US8821562B2 (en) | 2008-09-25 | 2014-09-02 | Advanced Bifurcation Systems, Inc. | Partially crimped stent |
US11298252B2 (en) | 2008-09-25 | 2022-04-12 | Advanced Bifurcation Systems Inc. | Stent alignment during treatment of a bifurcation |
GB0819296D0 (en) * | 2008-10-21 | 2008-11-26 | Smith & Nephew | Coating II |
US20100119578A1 (en) * | 2008-11-07 | 2010-05-13 | Specialized Vascular Technologies, Inc. | Extracellular matrix modulating coatings for medical devices |
US8231980B2 (en) | 2008-12-03 | 2012-07-31 | Boston Scientific Scimed, Inc. | Medical implants including iridium oxide |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
CN102378756A (zh) | 2009-02-13 | 2012-03-14 | 沃泰克斯药物股份有限公司 | 2-(2,4-二氟苯基)-6-(1-(2,6-二氟苯基)脲基)烟酰胺的固体形式 |
US8071156B2 (en) | 2009-03-04 | 2011-12-06 | Boston Scientific Scimed, Inc. | Endoprostheses |
WO2010111232A2 (en) * | 2009-03-23 | 2010-09-30 | Micell Technologies, Inc. | Drug delivery medical device |
JP2012522589A (ja) | 2009-04-01 | 2012-09-27 | ミシェル テクノロジーズ,インコーポレイテッド | 被覆ステント |
EP2417211A4 (en) * | 2009-04-03 | 2012-08-29 | Ashland Licensing & Intellectu | ACRYLIC ADHESIVE STICKER CURABLE BY ULTRAVIOLET RADIATION |
US8287937B2 (en) | 2009-04-24 | 2012-10-16 | Boston Scientific Scimed, Inc. | Endoprosthese |
US10357640B2 (en) | 2009-05-15 | 2019-07-23 | Intersect Ent, Inc. | Expandable devices and methods for treating a nasal or sinus condition |
US9265633B2 (en) | 2009-05-20 | 2016-02-23 | 480 Biomedical, Inc. | Drug-eluting medical implants |
CA2762811C (en) * | 2009-05-20 | 2023-03-21 | Arsenal Medical, Inc. | Self-expandable medical device comprising polymeric strands and coatings thereon |
CA2767994C (en) | 2009-09-30 | 2017-07-04 | Terumo Kabushiki Kaisha | Stent |
WO2011044533A2 (en) | 2009-10-09 | 2011-04-14 | Specialized Vascular Technologies, Inc. | Coating system and method for drug elution management |
EP2338534A2 (de) * | 2009-12-21 | 2011-06-29 | Biotronik VI Patent AG | Medizinisches Implantat, Beschichtungsverfahren sowie Implantationsverfahren |
EP2531140B1 (en) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent and stent delivery system with improved deliverability |
WO2011119536A1 (en) | 2010-03-22 | 2011-09-29 | Abbott Cardiovascular Systems Inc. | Stent delivery system having a fibrous matrix covering with improved stent retention |
AU2011232360B2 (en) | 2010-03-24 | 2015-10-08 | Advanced Bifurcation Systems Inc. | Methods and systems for treating a bifurcation with provisional side branch stenting |
AU2011232361B2 (en) | 2010-03-24 | 2015-05-28 | Advanced Bifurcation Systems Inc. | Stent alignment during treatment of a bifurcation |
WO2011119884A1 (en) | 2010-03-24 | 2011-09-29 | Advanced Bifurcation Systems, Inc | System and methods for treating a bifurcation |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US8685433B2 (en) | 2010-03-31 | 2014-04-01 | Abbott Cardiovascular Systems Inc. | Absorbable coating for implantable device |
EP2555811B1 (en) | 2010-04-06 | 2017-09-27 | Boston Scientific Scimed, Inc. | Endoprosthesis |
EP2560576B1 (en) | 2010-04-22 | 2018-07-18 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
DE102010018541A1 (de) * | 2010-04-28 | 2011-11-03 | Acandis Gmbh & Co. Kg | Verfahren zur Herstellung einer medizinischen Vorrichtung |
US20130032967A1 (en) * | 2010-05-07 | 2013-02-07 | Abbott Cardiovascular Systems Inc. | Cold ethylene oxide sterilization of a biodegradable polymeric stent |
EP2593039B1 (en) | 2010-07-16 | 2022-11-30 | Micell Technologies, Inc. | Drug delivery medical device |
CN102464669B (zh) * | 2010-11-17 | 2014-04-16 | 浙江海正药业股份有限公司 | 无定形依维莫司及其制备方法 |
ES2753529T3 (es) * | 2010-11-19 | 2020-04-13 | Biocon Ltd | Procesos para la preparación de everolimús y productos intermedios del mismo |
AU2012205419B2 (en) | 2011-01-14 | 2016-12-15 | Spero Therapeutics, Inc. | Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea |
KR101897952B1 (ko) | 2011-01-14 | 2018-09-12 | 스페로 트리넴, 인코포레이티드 | 피리미딘 자이라제 및 토포이소머라제 iv 억제제 |
EP4230631A3 (en) | 2011-02-04 | 2024-03-27 | Synthon B.V. | Process for making trisubstituted silyloxyethyl triflates |
CA2826760A1 (en) | 2011-02-08 | 2012-08-16 | Advanced Bifurcation Systems, Inc. | Multi-stent and multi-balloon apparatus for treating bifurcations and methods of use |
EP3449879B1 (en) | 2011-02-08 | 2020-09-23 | Advanced Bifurcation Systems Inc. | System for treating a bifurcation with a fully crimped stent |
US9187953B2 (en) | 2011-03-23 | 2015-11-17 | Rytec Corporation | Side column configuration for overhead roll-up door assemblies |
EP2696815B1 (en) * | 2011-04-13 | 2019-03-20 | Micell Technologies, Inc. | Stents having controlled elution |
WO2012166819A1 (en) | 2011-05-31 | 2012-12-06 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
WO2012177707A1 (en) | 2011-06-20 | 2012-12-27 | Vertex Pharmaceuticals Incorporated | Phosphate esters of gyrase and topoisomerase inhibitors |
CN102389585B (zh) * | 2011-07-07 | 2014-04-23 | 中山大学 | 一种在生物医用材料表面负载活性分子的方法 |
CA2841360A1 (en) | 2011-07-15 | 2013-01-24 | Micell Technologies, Inc. | Drug delivery medical device |
ES2728135T3 (es) | 2011-07-20 | 2019-10-22 | Univ Brigham Young | Materiales de hidrogel que incorporan un compuesto de elución de ceragenina |
US8945217B2 (en) * | 2011-08-25 | 2015-02-03 | Brigham Young University | Medical devices incorporating ceragenin-containing composites |
US9603859B2 (en) | 2011-09-13 | 2017-03-28 | Brigham Young University | Methods and products for increasing the rate of healing of tissue wounds |
BR112014005914B1 (pt) | 2011-09-13 | 2021-11-09 | Brigham Young University | Produtos para cicatrização de feridas tecidulares |
US9155746B2 (en) | 2011-09-13 | 2015-10-13 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US9694019B2 (en) | 2011-09-13 | 2017-07-04 | Brigham Young University | Compositions and methods for treating bone diseases and broken bones |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
UA113298C2 (xx) | 2011-12-21 | 2017-01-10 | Композиція для догляду за порожниною рота | |
US9220759B2 (en) | 2012-02-23 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a drug eluting stent and adjunctive therapy |
US9533063B1 (en) | 2012-03-01 | 2017-01-03 | Brigham Young University | Aerosols incorporating ceragenin compounds and methods of use thereof |
US9220584B2 (en) | 2012-03-30 | 2015-12-29 | Abbott Cardiovascular Systems Inc. | Treatment of diabetic patients with a stent and locally administered adjunctive therapy |
WO2013165574A2 (en) | 2012-05-02 | 2013-11-07 | Brigham Young University | Ceragenin particulate materials and methods for making same |
CN102786534A (zh) * | 2012-05-25 | 2012-11-21 | 上海现代制药股份有限公司 | 一种依维莫司的制备方法 |
WO2013182503A1 (en) * | 2012-06-08 | 2013-12-12 | Biotronik Ag | Rapamycin 40-o-cyclic hydrocarbon esters, compositions and methods |
US20140024992A1 (en) * | 2012-07-10 | 2014-01-23 | M.I. Tech Co., Ltd. | Cylindrical Structure Having Lumen to Be Implanted Into Human Body |
AR093226A1 (es) | 2012-07-18 | 2015-05-27 | Vertex Pharma | Formas solidas de dihidrogeno fosfato de (r)-2-(5-(2-(3-etilureido)-6-fluoro-7-(tetrahidrofuran-2-il)-1h-benzo[d]imidazol-5-il)pirimidin-2-il)propan-2-ilo y sus sales |
CN102784418B (zh) * | 2012-08-10 | 2014-04-16 | 中国医学科学院生物医学工程研究所 | 可程序性释放的生物药物纳米微孔血管支架及其制备方法与用途 |
WO2014026173A1 (en) * | 2012-08-10 | 2014-02-13 | Cragg Andrew H | Stent delivery systems and associated methods |
CA2870170C (en) * | 2012-09-12 | 2018-06-12 | Boston Scientific Scimed, Inc. | Adhesive stent coating for anti-migration |
US9314472B2 (en) | 2012-10-17 | 2016-04-19 | Brigham Young University | Treatment and prevention of mastitis |
EP2737894A1 (en) | 2012-12-03 | 2014-06-04 | Debiotech S.A. | Smart coating for implantable devices |
WO2014107740A2 (en) | 2013-01-07 | 2014-07-10 | Brigham Young University | Methods for reducing cellular proliferation and treating certain diseases |
CN110269959A (zh) | 2013-03-12 | 2019-09-24 | 脉胜医疗技术公司 | 可生物吸收的生物医学植入物 |
CN112089505B (zh) | 2013-03-14 | 2024-01-05 | 因特尔赛克特耳鼻喉公司 | 用于治疗鼻窦病状的系统、装置以及方法 |
US10568893B2 (en) | 2013-03-15 | 2020-02-25 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
EP2970280B1 (en) | 2013-03-15 | 2021-07-07 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US11524015B2 (en) | 2013-03-15 | 2022-12-13 | Brigham Young University | Methods for treating inflammation, autoimmune disorders and pain |
US9387215B2 (en) | 2013-04-22 | 2016-07-12 | Brigham Young University | Animal feed including cationic cholesterol additive and related methods |
CA2912387C (en) | 2013-05-15 | 2019-04-16 | Micell Technologies, Inc. | Bioabsorbable biomedical implants |
WO2015020527A1 (en) | 2013-08-09 | 2015-02-12 | Maastricht University | Biodegradable radiopaque stents and other implants |
CN105814036B (zh) | 2013-10-17 | 2018-10-26 | 沃泰克斯药物股份有限公司 | 作为dna-pk抑制剂的共晶 |
US11690855B2 (en) | 2013-10-17 | 2023-07-04 | Brigham Young University | Methods for treating lung infections and inflammation |
US9459193B2 (en) * | 2013-12-18 | 2016-10-04 | Abbott Cardiovascular Systems Inc. | Stent holder having a reduced profile |
US20150203527A1 (en) | 2014-01-23 | 2015-07-23 | Brigham Young University | Cationic steroidal antimicrobials |
CA2844321C (en) | 2014-02-27 | 2021-03-16 | Brigham Young University | Cationic steroidal antimicrobial compounds |
US10220045B2 (en) | 2014-03-13 | 2019-03-05 | Brigham Young University | Compositions and methods for forming stabilized compositions with reduced CSA agglomeration |
US9867836B2 (en) | 2014-03-13 | 2018-01-16 | Brigham Young University | Lavage and/or infusion using CSA compounds for increasing fertility in a mammal |
US9931350B2 (en) | 2014-03-14 | 2018-04-03 | Brigham Young University | Anti-infective and osteogenic compositions and methods of use |
US9622891B2 (en) | 2014-04-17 | 2017-04-18 | Abbott Cardiovascular Systems Inc. | Coatings for braided medical devices and methods of forming same |
EP3136807A4 (en) | 2014-04-21 | 2017-12-20 | Kabushiki Kaisha Toshiba | Integrated circuit for radio communication |
WO2015163335A1 (ja) | 2014-04-21 | 2015-10-29 | 株式会社 東芝 | 無線通信端末、メモリーカード、および無線通信方法 |
US9686966B2 (en) | 2014-04-30 | 2017-06-27 | Brigham Young University | Methods and apparatus for cleaning or disinfecting a water delivery system |
US10441595B2 (en) | 2014-06-26 | 2019-10-15 | Brigham Young University | Methods for treating fungal infections |
US10238665B2 (en) | 2014-06-26 | 2019-03-26 | Brigham Young University | Methods for treating fungal infections |
EP3166950A1 (en) | 2014-08-04 | 2017-05-17 | Cipla Limited | Process for the synthesis of everolimus and intermediates thereof |
DE102014111117B4 (de) * | 2014-08-05 | 2017-11-16 | Acandis Gmbh & Co. Kg | Medizinische Vorrichtung zur Behandlung von neurovaskulären Erkrankungen, System und Set mit einer derartigen Vorrichtung sowie Herstellungsverfahren |
US10227376B2 (en) | 2014-08-22 | 2019-03-12 | Brigham Young University | Radiolabeled cationic steroid antimicrobials and diagnostic methods |
US10155788B2 (en) | 2014-10-07 | 2018-12-18 | Brigham Young University | Cationic steroidal antimicrobial prodrug compositions and uses thereof |
CN104478898A (zh) * | 2014-11-18 | 2015-04-01 | 连云港恒运医药科技有限公司 | 依维莫司及其中间体的制备方法 |
WO2016114216A1 (ja) * | 2015-01-13 | 2016-07-21 | テルモ株式会社 | 生分解性ステント |
CN104592254B (zh) * | 2015-02-08 | 2016-07-13 | 福建省微生物研究所 | 依维莫司的合成方法 |
US10370403B2 (en) | 2015-04-22 | 2019-08-06 | Brigham Young University | Methods for the synthesis of ceragenins |
WO2016172553A1 (en) | 2015-04-22 | 2016-10-27 | Savage Paul B | Methods for the synthesis of ceragenins |
US9434759B1 (en) | 2015-05-18 | 2016-09-06 | Brigham Young University | Cationic steroidal antimicrobial compounds and methods of manufacturing such compounds |
CA2996673A1 (en) * | 2015-09-25 | 2017-03-30 | Spirox, Inc. | Nasal implants and systems and method of use |
CN105566348A (zh) * | 2015-12-31 | 2016-05-11 | 哈药集团技术中心 | 一种依维莫司的制备方法 |
US10226550B2 (en) | 2016-03-11 | 2019-03-12 | Brigham Young University | Cationic steroidal antimicrobial compositions for the treatment of dermal tissue |
US20180161185A1 (en) * | 2016-12-14 | 2018-06-14 | eLum Technologies, Inc. | Electrospun stents, flow diverters, and occlusion devices and methods of making the same |
EP3558407B1 (en) * | 2016-12-22 | 2023-03-15 | Biotronik AG | Drug releasing coatings for medical devices and methods of making same |
US11033391B2 (en) | 2016-12-22 | 2021-06-15 | Heart Repair Technologies, Inc. | Percutaneous delivery systems for anchoring an implant in a cardiac valve annulus |
US10959433B2 (en) | 2017-03-21 | 2021-03-30 | Brigham Young University | Use of cationic steroidal antimicrobials for sporicidal activity |
WO2019143717A1 (en) * | 2018-01-16 | 2019-07-25 | Sintra Medical Llc | Stents with increased flexibility |
CN108720971A (zh) * | 2018-01-28 | 2018-11-02 | 杭州市第人民医院 | 一种可控抗菌气管支架 |
US11224512B2 (en) * | 2018-03-21 | 2022-01-18 | Edwards Lifesciences Corporation | Coronary artery check valve |
ES2899183T3 (es) | 2018-03-29 | 2022-03-10 | Sahajanand Medical Tech Limited | Stent |
RU2686747C1 (ru) * | 2018-11-08 | 2019-04-30 | Федеральное государственное бюджетное учреждение науки Институт металлургии и материаловедения им. А.А. Байкова Российской академии наук (ИМЕТ РАН) | Способ получения биодеградируемого полимерного покрытия на основе полилактида на проволоке TiNbTaZr |
EP3880266A1 (en) * | 2018-11-14 | 2021-09-22 | Lutonix, Inc. | Medical device with drug-eluting coating on modified device surface |
CN114105836B (zh) * | 2020-08-27 | 2024-03-15 | 鲁南制药集团股份有限公司 | 一种乙二醇的衍生化合物 |
WO2024068153A1 (en) * | 2022-09-30 | 2024-04-04 | Biotronik Ag | Macrocyclic triene immunosuppressive compounds for perivascular medical treatment of vascular access fistulas, grafts and other vascular conditions |
CN116869715B (zh) * | 2023-07-10 | 2024-02-09 | 上海心玮医疗科技股份有限公司 | 一种抗凝药物洗脱支架 |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997037617A1 (en) * | 1996-04-08 | 1997-10-16 | Swaminathan Jayaraman | Multiple interconnected stents and method of coating stents |
JPH1157020A (ja) * | 1997-08-01 | 1999-03-02 | Schneider Usa Inc | 放射線不透過性成分を有する生体吸収型標識及びその使用方法 |
JP2000051367A (ja) * | 1998-06-30 | 2000-02-22 | Ethicon Inc | ステントコ―ティング方法 |
JP2000507226A (ja) * | 1996-03-27 | 2000-06-13 | ノバルティス アクチエンゲゼルシャフト | 血管疾病および異種移植におけるラパマイシン誘導体の使用 |
JP2000513988A (ja) * | 1997-06-18 | 2000-10-24 | ボストン サイエンティフィック リミテッド | 抗血栓性コーティングのためのポリカーボネート−ポリウレタン分散液 |
WO2001045763A1 (en) * | 1999-12-23 | 2001-06-28 | Advanced Cardiovascular Systems, Inc. | Biocomptabible coating |
WO2002009617A1 (en) * | 2000-07-27 | 2002-02-07 | Bionx Implants, Inc. | Self-expanding stent with enhanced radial expansion and shape memory |
WO2002026281A1 (en) * | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US517698A (en) | 1894-04-03 | Druggist s weighing-scale | ||
ZA737247B (en) | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
US4885171A (en) | 1978-11-03 | 1989-12-05 | American Home Products Corporation | Use of rapamycin in treatment of certain tumors |
US4316885A (en) | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
US4650803A (en) | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
US5527337A (en) | 1987-06-25 | 1996-06-18 | Duke University | Bioabsorbable stent and method of making the same |
US5059211A (en) | 1987-06-25 | 1991-10-22 | Duke University | Absorbable vascular stent |
US5176908A (en) | 1988-12-19 | 1993-01-05 | American Cyanamid Company | Method for the treatment of endotoxic shock in mammal |
US4990155A (en) | 1989-05-19 | 1991-02-05 | Wilkoff Howard M | Surgical stent method and apparatus |
US5100899A (en) | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5545208A (en) * | 1990-02-28 | 1996-08-13 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
EP0470246B1 (en) | 1990-02-28 | 1995-06-28 | Medtronic, Inc. | Intralumenal drug eluting prosthesis |
WO1991017724A1 (en) * | 1990-05-17 | 1991-11-28 | Harbor Medical Devices, Inc. | Medical device polymer |
US5258020A (en) * | 1990-09-14 | 1993-11-02 | Michael Froix | Method of using expandable polymeric stent with memory |
JP2842943B2 (ja) | 1991-03-08 | 1999-01-06 | 敬二 伊垣 | 脈管ステントとその保持構造体および脈管ステント挿着装置 |
US5120842A (en) | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
US5151413A (en) | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
US5516781A (en) * | 1992-01-09 | 1996-05-14 | American Home Products Corporation | Method of treating restenosis with rapamycin |
CA2086642C (en) | 1992-01-09 | 2004-06-15 | Randall E. Morris | Method of treating hyperproliferative vascular disease |
US6013853A (en) | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
US5288711A (en) | 1992-04-28 | 1994-02-22 | American Home Products Corporation | Method of treating hyperproliferative vascular disease |
US5540712A (en) | 1992-05-01 | 1996-07-30 | Nitinol Medical Technologies, Inc. | Stent and method and apparatus for forming and delivering the same |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5258389A (en) | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
US5342348A (en) | 1992-12-04 | 1994-08-30 | Kaplan Aaron V | Method and device for treating and enlarging body lumens |
US5443458A (en) * | 1992-12-22 | 1995-08-22 | Advanced Cardiovascular Systems, Inc. | Multilayered biodegradable stent and method of manufacture |
US6663881B2 (en) * | 1993-01-28 | 2003-12-16 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
DE4303181A1 (de) | 1993-02-04 | 1994-08-11 | Angiomed Ag | Implantierbarer Katheter |
US5252579A (en) * | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
US5824048A (en) | 1993-04-26 | 1998-10-20 | Medtronic, Inc. | Method for delivering a therapeutic substance to a body lumen |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
ATE191218T1 (de) * | 1993-12-17 | 2000-04-15 | Novartis Ag | Rapamycin-derivate als immunosuppressoren |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5649977A (en) * | 1994-09-22 | 1997-07-22 | Advanced Cardiovascular Systems, Inc. | Metal reinforced polymer stent |
EP0761251B1 (en) | 1994-10-17 | 2004-12-29 | Kabushikikaisha Igaki Iryo Sekkei | Drug-releasing stent |
US5707385A (en) | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
US5565772A (en) | 1994-11-30 | 1996-10-15 | Eastman Kodak Company | High sensitivity magnetic viewer using anhysteretic transfer for viewing weak magnetic patterns |
US6231600B1 (en) | 1995-02-22 | 2001-05-15 | Scimed Life Systems, Inc. | Stents with hybrid coating for medical devices |
US5869127A (en) * | 1995-02-22 | 1999-02-09 | Boston Scientific Corporation | Method of providing a substrate with a bio-active/biocompatible coating |
US6179817B1 (en) * | 1995-02-22 | 2001-01-30 | Boston Scientific Corporation | Hybrid coating for medical devices |
US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
US6099562A (en) | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
US6120536A (en) * | 1995-04-19 | 2000-09-19 | Schneider (Usa) Inc. | Medical devices with long term non-thrombogenic coatings |
US5609629A (en) * | 1995-06-07 | 1997-03-11 | Med Institute, Inc. | Coated implantable medical device |
AU716005B2 (en) | 1995-06-07 | 2000-02-17 | Cook Medical Technologies Llc | Implantable medical device |
FR2736550B1 (fr) * | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
PT956034E (pt) * | 1996-07-30 | 2002-12-31 | Novartis Ag | Composicoes farmaceuticas para o tratamento da rejeicao de transplantes estados inflamatorios ou auto-imunes compreendendo ciclosporina a e 40-o-(2-hidroxietil)-rapamicina |
US6174329B1 (en) * | 1996-08-22 | 2001-01-16 | Advanced Cardiovascular Systems, Inc. | Protective coating for a stent with intermediate radiopaque coating |
US5980972A (en) | 1996-12-20 | 1999-11-09 | Schneider (Usa) Inc | Method of applying drug-release coatings |
DE69831938T2 (de) | 1997-02-20 | 2006-07-06 | Cook Inc., Bloomington | Beschichtetes, implantierbares medizinisches geräte |
US6273913B1 (en) * | 1997-04-18 | 2001-08-14 | Cordis Corporation | Modified stent useful for delivery of drugs along stent strut |
US5879697A (en) * | 1997-04-30 | 1999-03-09 | Schneider Usa Inc | Drug-releasing coatings for medical devices |
US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
JP2001513359A (ja) * | 1997-08-08 | 2001-09-04 | サンスコープ インターナショナル インコーポレイテッド | 微細多孔性ステントおよび移植装置 |
US6159488A (en) | 1997-08-14 | 2000-12-12 | Agricultural Research Org. Ministry Of Agriculture (Gov.) | Intracoronary stents containing quinazolinone derivatives |
US6042606A (en) | 1997-09-29 | 2000-03-28 | Cook Incorporated | Radially expandable non-axially contracting surgical stent |
US6129755A (en) | 1998-01-09 | 2000-10-10 | Nitinol Development Corporation | Intravascular stent having an improved strut configuration |
US6190406B1 (en) | 1998-01-09 | 2001-02-20 | Nitinal Development Corporation | Intravascular stent having tapered struts |
US7208011B2 (en) * | 2001-08-20 | 2007-04-24 | Conor Medsystems, Inc. | Implantable medical device with drug filled holes |
US20010029351A1 (en) | 1998-04-16 | 2001-10-11 | Robert Falotico | Drug combinations and delivery devices for the prevention and treatment of vascular disease |
DE69926017T2 (de) * | 1998-04-27 | 2005-12-22 | SurModics, Inc., Eden Prairie | Bioaktive Wirkstoffe freisetzende Beschichtungen |
US20020038146A1 (en) * | 1998-07-29 | 2002-03-28 | Ulf Harry | Expandable stent with relief cuts for carrying medicines and other materials |
US6299604B1 (en) | 1998-08-20 | 2001-10-09 | Cook Incorporated | Coated implantable medical device |
US6335029B1 (en) | 1998-08-28 | 2002-01-01 | Scimed Life Systems, Inc. | Polymeric coatings for controlled delivery of active agents |
EP1112346A1 (de) | 1998-09-14 | 2001-07-04 | Vesifact Ag | Verwendung von nanocells in kulturmedien-endprodukten |
WO2000045763A1 (en) | 1999-02-02 | 2000-08-10 | The Procter & Gamble Company | Elastic laminate including spunbonded nonwoven of polypropylene/polyethylene copolymer and disposable article using the same |
US6368658B1 (en) * | 1999-04-19 | 2002-04-09 | Scimed Life Systems, Inc. | Coating medical devices using air suspension |
US6607598B2 (en) * | 1999-04-19 | 2003-08-19 | Scimed Life Systems, Inc. | Device for protecting medical devices during a coating process |
AU783158B2 (en) * | 1999-08-24 | 2005-09-29 | Ariad Pharmaceuticals, Inc. | 28-epirapalogs |
US6790228B2 (en) * | 1999-12-23 | 2004-09-14 | Advanced Cardiovascular Systems, Inc. | Coating for implantable devices and a method of forming the same |
US6277983B1 (en) * | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
IL133312A (en) | 1999-12-05 | 2006-09-05 | Orbotech Ltd | Method for testing a printed circuit |
CA2394897C (en) * | 1999-12-23 | 2010-03-23 | Combe International Ltd. | Denture adhesive laminated product and method for producing same |
DE60142677D1 (de) * | 2000-01-14 | 2010-09-09 | Univ Pennsylvania | O-methylierte rapamycinderivate zur milderung oder vermeidung lymphoproliferativer erkrankungen |
US7220276B1 (en) * | 2000-03-06 | 2007-05-22 | Surmodics, Inc. | Endovascular graft coatings |
JP4786113B2 (ja) * | 2000-05-16 | 2011-10-05 | オーソーマクニール ファーマシューティカル, インコーポレイテッド | 超臨界二酸化炭素を用いる医療用装置のコーティング方法 |
DE10046448A1 (de) * | 2000-09-18 | 2002-03-28 | Daimler Chrysler Ag | Verfahren zur Bestimmung des Momentes an der Kurbelwelle einer Brennkraftmaschine |
AU2001288809A1 (en) * | 2000-09-26 | 2002-04-08 | Advanced Cardiovascular Systems Inc. | A method of loading a substance onto an implantable device |
US6863685B2 (en) * | 2001-03-29 | 2005-03-08 | Cordis Corporation | Radiopacity intraluminal medical device |
US20020051730A1 (en) * | 2000-09-29 | 2002-05-02 | Stanko Bodnar | Coated medical devices and sterilization thereof |
US6746773B2 (en) | 2000-09-29 | 2004-06-08 | Ethicon, Inc. | Coatings for medical devices |
US20020111590A1 (en) * | 2000-09-29 | 2002-08-15 | Davila Luis A. | Medical devices, drug coatings and methods for maintaining the drug coatings thereon |
DE60133053T2 (de) * | 2000-10-16 | 2009-02-26 | Conor Medsystems, Inc., Menlo Park | Ausdehnbare medizinische Vorrichtung zur Abgabe eines nützlichen Agens |
US7077859B2 (en) * | 2000-12-22 | 2006-07-18 | Avantec Vascular Corporation | Apparatus and methods for variably controlled substance delivery from implanted prostheses |
US7083642B2 (en) * | 2000-12-22 | 2006-08-01 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US20030050692A1 (en) * | 2000-12-22 | 2003-03-13 | Avantec Vascular Corporation | Delivery of therapeutic capable agents |
US20020082679A1 (en) * | 2000-12-22 | 2002-06-27 | Avantec Vascular Corporation | Delivery or therapeutic capable agents |
US20030033007A1 (en) * | 2000-12-22 | 2003-02-13 | Avantec Vascular Corporation | Methods and devices for delivery of therapeutic capable agents with variable release profile |
US7247338B2 (en) * | 2001-05-16 | 2007-07-24 | Regents Of The University Of Minnesota | Coating medical devices |
US6641611B2 (en) * | 2001-11-26 | 2003-11-04 | Swaminathan Jayaraman | Therapeutic coating for an intravascular implant |
US6908622B2 (en) * | 2001-09-24 | 2005-06-21 | Boston Scientific Scimed, Inc. | Optimized dosing for drug coated stents |
US20030077310A1 (en) * | 2001-10-22 | 2003-04-24 | Chandrashekhar Pathak | Stent coatings containing HMG-CoA reductase inhibitors |
US8740973B2 (en) * | 2001-10-26 | 2014-06-03 | Icon Medical Corp. | Polymer biodegradable medical device |
US7179283B2 (en) * | 2001-11-02 | 2007-02-20 | Scimed Life Systems, Inc. | Vapor deposition process for producing a stent-graft and a stent-graft produced therefrom |
US7682387B2 (en) * | 2002-04-24 | 2010-03-23 | Biosensors International Group, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US6939376B2 (en) * | 2001-11-05 | 2005-09-06 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US20030088307A1 (en) * | 2001-11-05 | 2003-05-08 | Shulze John E. | Potent coatings for stents |
US6743463B2 (en) * | 2002-03-28 | 2004-06-01 | Scimed Life Systems, Inc. | Method for spray-coating a medical device having a tubular wall such as a stent |
US20040024450A1 (en) * | 2002-04-24 | 2004-02-05 | Sun Biomedical, Ltd. | Drug-delivery endovascular stent and method for treating restenosis |
US7294145B2 (en) * | 2004-02-26 | 2007-11-13 | Boston Scientific Scimed, Inc. | Stent with differently coated inside and outside surfaces |
-
2002
- 2002-04-24 US US10/133,814 patent/US6939376B2/en not_active Expired - Lifetime
-
2003
- 2003-03-05 US US10/382,429 patent/US20030225450A1/en not_active Abandoned
- 2003-04-24 ES ES12191560.7T patent/ES2514391T3/es not_active Expired - Lifetime
- 2003-04-24 AU AU2003231757A patent/AU2003231757B2/en not_active Expired
- 2003-04-24 CN CNA03809309XA patent/CN1735402A/zh active Pending
- 2003-04-24 EP EP09160438A patent/EP2113230A3/en not_active Withdrawn
- 2003-04-24 WO PCT/US2003/012746 patent/WO2003090684A2/en active Application Filing
- 2003-04-24 JP JP2003587323A patent/JP4315817B2/ja not_active Expired - Lifetime
- 2003-04-24 AT AT04078429T patent/ATE451075T1/de not_active IP Right Cessation
- 2003-04-24 ES ES10185483.4T patent/ES2523870T3/es not_active Expired - Lifetime
- 2003-04-24 CN CN2010102003218A patent/CN101862233B/zh not_active Expired - Lifetime
- 2003-04-24 CN CN038093111A patent/CN1649551B/zh not_active Expired - Lifetime
- 2003-04-24 WO PCT/US2003/012750 patent/WO2003090818A2/en active Application Filing
- 2003-04-24 AU AU2003231759A patent/AU2003231759B2/en not_active Expired
- 2003-04-24 ES ES03747310.5T patent/ES2522277T3/es not_active Expired - Lifetime
- 2003-04-24 EP EP04078429A patent/EP1518517B1/en not_active Expired - Lifetime
- 2003-04-24 DE DE60330455T patent/DE60330455D1/de not_active Expired - Lifetime
- 2003-04-24 EP EP11185222.4A patent/EP2417943B1/en not_active Revoked
- 2003-04-24 ES ES04078429T patent/ES2335406T3/es not_active Expired - Lifetime
- 2003-04-24 EP EP12191560.7A patent/EP2578186B1/en not_active Revoked
- 2003-04-24 EP EP10185483.4A patent/EP2316377B1/en not_active Revoked
- 2003-04-24 JP JP2003587443A patent/JP2005523119A/ja active Pending
- 2003-04-24 EP EP03747310.5A patent/EP1505930B1/en not_active Expired - Lifetime
-
2004
- 2004-09-20 US US10/946,275 patent/US7727275B2/en active Active
-
2008
- 2008-08-15 JP JP2008209130A patent/JP2008279278A/ja active Pending
- 2008-08-15 JP JP2008209129A patent/JP5113667B2/ja not_active Expired - Lifetime
-
2009
- 2009-04-27 AU AU2009201655A patent/AU2009201655B2/en not_active Expired
-
2010
- 2010-01-29 US US12/696,318 patent/US8308795B2/en not_active Expired - Lifetime
- 2010-04-29 HK HK11110804A patent/HK1156494A1/xx not_active IP Right Cessation
- 2010-04-29 HK HK13104941.7A patent/HK1177882A1/xx not_active IP Right Cessation
-
2011
- 2011-04-20 HK HK11104004.3A patent/HK1150229A1/xx not_active IP Right Cessation
-
2012
- 2012-10-09 US US13/647,977 patent/US8715341B2/en not_active Expired - Lifetime
- 2012-12-17 JP JP2012274329A patent/JP2013121509A/ja active Pending
-
2014
- 2014-02-20 JP JP2014030790A patent/JP5827355B2/ja not_active Expired - Lifetime
- 2014-03-18 US US14/217,948 patent/US20140200654A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000507226A (ja) * | 1996-03-27 | 2000-06-13 | ノバルティス アクチエンゲゼルシャフト | 血管疾病および異種移植におけるラパマイシン誘導体の使用 |
WO1997037617A1 (en) * | 1996-04-08 | 1997-10-16 | Swaminathan Jayaraman | Multiple interconnected stents and method of coating stents |
JP2000513988A (ja) * | 1997-06-18 | 2000-10-24 | ボストン サイエンティフィック リミテッド | 抗血栓性コーティングのためのポリカーボネート−ポリウレタン分散液 |
JPH1157020A (ja) * | 1997-08-01 | 1999-03-02 | Schneider Usa Inc | 放射線不透過性成分を有する生体吸収型標識及びその使用方法 |
JP2000051367A (ja) * | 1998-06-30 | 2000-02-22 | Ethicon Inc | ステントコ―ティング方法 |
WO2001045763A1 (en) * | 1999-12-23 | 2001-06-28 | Advanced Cardiovascular Systems, Inc. | Biocomptabible coating |
WO2002009617A1 (en) * | 2000-07-27 | 2002-02-07 | Bionx Implants, Inc. | Self-expanding stent with enhanced radial expansion and shape memory |
WO2002026281A1 (en) * | 2000-09-29 | 2002-04-04 | Cordis Corporation | Coated medical devices |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EP2417943B1 (en) | Drug-delivery endovascular stent for treating restenosis | |
US7682387B2 (en) | Drug-delivery endovascular stent and method for treating restenosis | |
US20040024450A1 (en) | Drug-delivery endovascular stent and method for treating restenosis | |
JP5726777B6 (ja) | 大環状トリエン化合物を含むポリマー組成物 | |
JP5461624B6 (ja) | 大環状トリエン化合物を含むポリマー組成物 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080912 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20111018 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120117 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120120 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120217 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120222 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20120316 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20120322 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120418 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20120418 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20120817 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20121217 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20130206 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20130305 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20130412 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140421 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140424 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140520 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140523 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140620 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140627 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20140722 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20141225 |