UA77303C2 - Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use - Google Patents

Info

Publication number

UA77303C2

UA77303C2 UA20041210250A UA20041210250A UA77303C2 UA 77303 C2 UA77303 C2 UA 77303C2 UA 20041210250 A UA20041210250 A UA 20041210250A UA 20041210250 A UA20041210250 A UA 20041210250A UA 77303 C2 UA77303 C2 UA 77303C2

Authority

UA

Ukraine

Prior art keywords

alkyl

compound

aryl

indole

carboxylic acid

Prior art date

2002-06-14

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• 238000000034 method Methods 0.000 title claims abstract description 50
• 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 30
• 239000003814 drug Substances 0.000 title description 9
• 229940124597 therapeutic agent Drugs 0.000 title description 3
• 229940125670 thienopyridine Drugs 0.000 title description 2
• 239000002175 thienopyridine Substances 0.000 title description 2
• 150000001875 compounds Chemical class 0.000 claims abstract description 433
• 150000003839 salts Chemical class 0.000 claims abstract description 70
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• -1 methylureido group Chemical group 0.000 claims description 80
• 125000000217 alkyl group Chemical group 0.000 claims description 64
• 125000000623 heterocyclic group Chemical group 0.000 claims description 61
• 125000003118 aryl group Chemical group 0.000 claims description 50
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• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 37
• 229910052757 nitrogen Inorganic materials 0.000 claims description 32
• 229910052799 carbon Inorganic materials 0.000 claims description 31
• 229910052739 hydrogen Inorganic materials 0.000 claims description 28
• 125000001424 substituent group Chemical group 0.000 claims description 28
• 201000010099 disease Diseases 0.000 claims description 22
• 206010028980 Neoplasm Diseases 0.000 claims description 20
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 19
• 229910052740 iodine Inorganic materials 0.000 claims description 18
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 18
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• 229910052736 halogen Inorganic materials 0.000 claims description 14
• 150000002367 halogens Chemical class 0.000 claims description 14
• 125000002757 morpholinyl group Chemical group 0.000 claims description 14
• 125000005045 dihydroisoquinolinyl group Chemical group C1(NC=CC2=CC=CC=C12)* 0.000 claims description 12
• 125000001072 heteroaryl group Chemical group 0.000 claims description 12
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• 239000000126 substance Substances 0.000 description 43
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