UA74075C2 - NOVEL CRYSTALLINE FORMS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-b, d-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1??-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)(ATORVASTATIN) (VARIANTS) - Google Patents
NOVEL CRYSTALLINE FORMS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-b, d-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1??-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)(ATORVASTATIN) (VARIANTS) Download PDFInfo
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- UA74075C2 UA74075C2 UA20031212658A UA20031212658A UA74075C2 UA 74075 C2 UA74075 C2 UA 74075C2 UA 20031212658 A UA20031212658 A UA 20031212658A UA 20031212658 A UA20031212658 A UA 20031212658A UA 74075 C2 UA74075 C2 UA 74075C2
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- atorvastatin
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30204901P | 2001-06-29 | 2001-06-29 | |
| PCT/IB2002/001796 WO2003004470A1 (en) | 2001-06-29 | 2002-05-21 | Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA74075C2 true UA74075C2 (en) | 2005-10-17 |
Family
ID=23166039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20031212658A UA74075C2 (en) | 2001-06-29 | 2002-05-21 | NOVEL CRYSTALLINE FORMS [R-(R*,R*)]-2-(4-FLUOROPHENYL)-b, d-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1??-PYRROLE-1-HEPTANOIC ACID CALCIUM SALT (2:1)(ATORVASTATIN) (VARIANTS) |
Country Status (40)
| Country | Link |
|---|---|
| US (5) | US6605729B1 (de) |
| EP (2) | EP3009423A3 (de) |
| JP (2) | JP3965155B2 (de) |
| KR (1) | KR100609371B1 (de) |
| CN (2) | CN1524073A (de) |
| AP (1) | AP1571A (de) |
| AR (1) | AR036118A1 (de) |
| AU (1) | AU2002258092B2 (de) |
| BG (1) | BG108393A (de) |
| BR (1) | BR0210666A (de) |
| CA (1) | CA2450111C (de) |
| CR (2) | CR7170A (de) |
| CZ (1) | CZ20033478A3 (de) |
| DO (1) | DOP2002000413A (de) |
| EA (1) | EA005317B1 (de) |
| EC (1) | ECSP034928A (de) |
| EE (1) | EE200300597A (de) |
| ES (1) | ES2558565T3 (de) |
| GE (1) | GEP20053546B (de) |
| HR (1) | HRP20031039A2 (de) |
| HU (1) | HUP0400381A2 (de) |
| IL (1) | IL158790A0 (de) |
| MA (1) | MA27044A1 (de) |
| MX (1) | MXPA03010266A (de) |
| MY (1) | MY122907A (de) |
| NO (1) | NO326170B1 (de) |
| NZ (1) | NZ529557A (de) |
| OA (1) | OA12636A (de) |
| PA (1) | PA8549501A1 (de) |
| PE (1) | PE20030124A1 (de) |
| PL (1) | PL367943A1 (de) |
| RS (1) | RS100003A (de) |
| SK (1) | SK16002003A3 (de) |
| SV (1) | SV2003001144A (de) |
| TN (1) | TNSN03147A1 (de) |
| TW (1) | TWI319396B (de) |
| UA (1) | UA74075C2 (de) |
| UY (1) | UY27359A1 (de) |
| WO (1) | WO2003004470A1 (de) |
| ZA (1) | ZA200308731B (de) |
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|---|---|---|---|---|
| FI94339C (fi) | 1989-07-21 | 1995-08-25 | Warner Lambert Co | Menetelmä farmaseuttisesti käyttökelpoisen /R-(R*,R*)/-2-(4-fluorifenyyli)- , -dihydroksi-5-(1-metyylietyyli)-3-fenyyli-4-/(fenyyliamino)karbonyyli/-1H-pyrroli-1-heptaanihapon ja sen farmaseuttisesti hyväksyttävien suolojen valmistamiseksi |
| DK0848705T3 (da) | 1995-07-17 | 2002-02-04 | Warner Lambert Co | Krystallinsk [R-(R*,R*)]-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrol-1- heptansyre-hemicalciumsalt (atorvastatin) |
| US20040072138A1 (en) * | 1997-11-25 | 2004-04-15 | Medical University Of South Carolina | Attenuation of ischemia/reperfusion injury |
| US20080275104A1 (en) * | 1997-11-25 | 2008-11-06 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
| WO1999026657A1 (en) * | 1997-11-25 | 1999-06-03 | Musc Foundation For Research Development | Inhibitors of nitric oxide synthase |
| US7411075B1 (en) | 2000-11-16 | 2008-08-12 | Teva Pharmaceutical Industries Ltd. | Polymorphic form of atorvastatin calcium |
| MXPA03003900A (es) * | 2000-11-03 | 2005-02-17 | Teva Pharma | Forma vii de hemicalcio de atorvastatina. |
| US7501450B2 (en) * | 2000-11-30 | 2009-03-10 | Teva Pharaceutical Industries Ltd. | Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| IL156055A0 (en) | 2000-11-30 | 2003-12-23 | Teva Pharma | Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms |
| PT1345896E (pt) * | 2000-12-27 | 2009-02-19 | Teva Pharma | Formas cristalinas de atorvastatina |
| PL367943A1 (en) * | 2001-06-29 | 2005-03-07 | Warner-Lambert Company Llc | Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
| US7074818B2 (en) * | 2001-07-30 | 2006-07-11 | Dr. Reddy's Laboratories Limited | Crystalline forms VI and VII of Atorvastatin calcium |
| US20060020137A1 (en) * | 2001-11-29 | 2006-01-26 | Limor Tessler | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
| AU2003217653A1 (en) * | 2002-02-15 | 2003-09-09 | Teva Pharmaceutical Industries Ltd. | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation, as well as novel processes for preparing atorvastatin hemi-calcium forms i, viii and ix |
| KR20090045420A (ko) * | 2002-02-19 | 2009-05-07 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토르바스타틴 헤미-칼슘 용매화합물의 탈용매화 |
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| EP1572643A2 (de) * | 2002-11-28 | 2005-09-14 | Teva Pharmaceutical Industries Ltd. | Kristalline form f von atorvastatin hemi calcium salz |
| EP1424324A1 (de) * | 2002-11-28 | 2004-06-02 | Teva Pharmaceutical Industries Limited | Kristalline Form F von Atorvastatin |
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| EP1761489A1 (de) * | 2004-03-17 | 2007-03-14 | Ranbaxy Laboratories Limited | Kristalline form von atorvastatin-hemicalcium |
| EP3581564A1 (de) | 2004-05-05 | 2019-12-18 | Pfizer Products Inc. | Diethylaminsalzformen von [r-(r*,r*)]-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrol-1-heptansäure |
| CA2672554C (en) * | 2004-07-20 | 2012-01-03 | Warner-Lambert Company Llc | Novel forms of [r-(r*,r*)]-2-(4-fluorophenyl).beta.,.delta.-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid calcium salt (2:1) |
| KR100923939B1 (ko) * | 2004-09-28 | 2009-10-29 | 테바 파마슈티컬 인더스트리즈 리미티드 | 실질적으로 불순물을 함유하지 않는 아토르바스타틴 칼슘의형태를 제조하는 방법 |
| RU2007115543A (ru) | 2004-10-28 | 2008-12-10 | Уорнер-Ламберт Компани Эл-Эл-Си (US) | Способ получения аморфного аторвастатина |
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| KR20080079646A (ko) * | 2005-11-21 | 2008-09-01 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토르바스타틴 제제 |
| KR20080007561A (ko) | 2005-12-13 | 2008-01-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토바스타틴 헤미칼슘의 결정형 및 이의 제조 방법 |
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| KR100878140B1 (ko) | 2007-01-29 | 2009-01-12 | 한미약품 주식회사 | 아토바스타틴의 스트론튬염 또는 이의 수화물, 및 이를포함하는 약학 조성물 |
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| WO2008112887A1 (en) * | 2007-03-13 | 2008-09-18 | Musc Foundation For Research Development | Methods of treating juvenile type 1 diabetes mellitus |
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| EP2473515A4 (de) | 2009-09-04 | 2013-11-27 | Univ Toledo | Verfahren zur herstellung optisch reiner beta-laktone aus aldehyden und daraus hergestellte zusammensetzungen |
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| US7074818B2 (en) * | 2001-07-30 | 2006-07-11 | Dr. Reddy's Laboratories Limited | Crystalline forms VI and VII of Atorvastatin calcium |
| KR20080007561A (ko) * | 2005-12-13 | 2008-01-22 | 테바 파마슈티컬 인더스트리즈 리미티드 | 아토바스타틴 헤미칼슘의 결정형 및 이의 제조 방법 |
| US20070265456A1 (en) * | 2006-05-09 | 2007-11-15 | Judith Aronhime | Novel crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms |
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