ZA200308731B - Crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin). - Google Patents
Crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin). Download PDFInfo
- Publication number
- ZA200308731B ZA200308731B ZA200308731A ZA200308731A ZA200308731B ZA 200308731 B ZA200308731 B ZA 200308731B ZA 200308731 A ZA200308731 A ZA 200308731A ZA 200308731 A ZA200308731 A ZA 200308731A ZA 200308731 B ZA200308731 B ZA 200308731B
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- South Africa
- Prior art keywords
- broad
- atorvastatin
- crystalline form
- ray powder
- powder diffraction
- Prior art date
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- XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 title claims description 182
- XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 title claims description 181
- 229960005370 atorvastatin Drugs 0.000 title claims description 181
- 239000011575 calcium Substances 0.000 title description 2
- 229910052791 calcium Inorganic materials 0.000 title 1
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- 229960001770 atorvastatin calcium Drugs 0.000 description 36
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- JNDMLEXHDPKVFC-UHFFFAOYSA-N aluminum;oxygen(2-);yttrium(3+) Chemical compound [O-2].[O-2].[O-2].[Al+3].[Y+3] JNDMLEXHDPKVFC-UHFFFAOYSA-N 0.000 description 1
- 238000004164 analytical calibration Methods 0.000 description 1
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- RMSWBHUVFNFNIZ-ZETCQYMHSA-N n-{(4s)-4-amino-5-[(2-aminoethyl)amino]pentyl}-n'-nitroguanidine Chemical compound NCCNC[C@@H](N)CCCNC(=N)N[N+]([O-])=O RMSWBHUVFNFNIZ-ZETCQYMHSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30204901P | 2001-06-29 | 2001-06-29 |
Publications (1)
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ZA200308731A ZA200308731B (en) | 2001-06-29 | 2003-11-10 | Crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin). |
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US (5) | US6605729B1 (de) |
EP (2) | EP3009423A3 (de) |
JP (2) | JP3965155B2 (de) |
KR (1) | KR100609371B1 (de) |
CN (2) | CN101215253A (de) |
AP (1) | AP1571A (de) |
AR (1) | AR036118A1 (de) |
AU (1) | AU2002258092B2 (de) |
BG (1) | BG108393A (de) |
BR (1) | BR0210666A (de) |
CA (1) | CA2450111C (de) |
CR (2) | CR7170A (de) |
CZ (1) | CZ20033478A3 (de) |
DO (1) | DOP2002000413A (de) |
EA (1) | EA005317B1 (de) |
EC (1) | ECSP034928A (de) |
EE (1) | EE200300597A (de) |
ES (1) | ES2558565T3 (de) |
GE (1) | GEP20053546B (de) |
HR (1) | HRP20031039A2 (de) |
HU (1) | HUP0400381A2 (de) |
IL (1) | IL158790A0 (de) |
MA (1) | MA27044A1 (de) |
MX (1) | MXPA03010266A (de) |
MY (1) | MY122907A (de) |
NO (1) | NO326170B1 (de) |
NZ (1) | NZ529557A (de) |
OA (1) | OA12636A (de) |
PA (1) | PA8549501A1 (de) |
PE (1) | PE20030124A1 (de) |
PL (1) | PL367943A1 (de) |
RS (1) | RS100003A (de) |
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TW (1) | TWI319396B (de) |
UA (1) | UA74075C2 (de) |
UY (1) | UY27359A1 (de) |
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- 2003-12-22 MA MA27456A patent/MA27044A1/fr unknown
- 2003-12-29 EC EC2003004928A patent/ECSP034928A/es unknown
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2006
- 2006-05-25 US US11/441,268 patent/US20060241169A1/en not_active Abandoned
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2007
- 2007-04-11 JP JP2007103465A patent/JP2007182460A/ja active Pending
- 2007-10-25 US US11/977,459 patent/US20080214651A1/en not_active Abandoned
-
2008
- 2008-02-15 CR CR9741A patent/CR9741A/es not_active Application Discontinuation
- 2008-07-14 US US12/172,503 patent/US20080287521A1/en not_active Abandoned
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