ES2558565T3 - Formas cristalinas de sal de calcio del ácido [R-(R*,R*)]-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-fenilamino)carbonil]-1H-pirrol-1-heptanoico (2:1) (atorvastatina) - Google Patents
Formas cristalinas de sal de calcio del ácido [R-(R*,R*)]-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-fenilamino)carbonil]-1H-pirrol-1-heptanoico (2:1) (atorvastatina) Download PDFInfo
- Publication number
- ES2558565T3 ES2558565T3 ES02727946.2T ES02727946T ES2558565T3 ES 2558565 T3 ES2558565 T3 ES 2558565T3 ES 02727946 T ES02727946 T ES 02727946T ES 2558565 T3 ES2558565 T3 ES 2558565T3
- Authority
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- Prior art keywords
- atorvastatin
- width
- diffractometer
- phenylamino
- methylethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Una forma VII cristalina de atorvastatina sesquihidratada que tienen una difracción de rayos X de polvo que contiene los siguientes valores de 2θ medidos usando radiación CuKα: 8,6, 10,2, 12,4 (ancho), 12,8 (ancho), 17,6, 18,3 (ancho), 19,3, 22,2 (ancho), 23,4 (ancho), 23,8 (ancho) y 25,5 (ancho).
Description
Adicionalmente, la presente invención se refiere a la forma VII cristalina de atorvastatina sesquihidratada caracterizada mediante el siguiente espectro Raman que tiene picos expresados en cm-1:
Espectro Raman 3060 2927 1649 1603 1524 1476 1412 1397 1368 1159 1034 998 824 114
La forma VIII cristalina de atorvastatina e hidratos de la misma se caracterizan por el siguiente patrón de difracción de rayos X de polvo expresado en términos de 2θ e intensidades relativas con una intensidad relativa de >10 % medida con un difractómetro Shimadzu con radiación CuKα:
2θ Intensidad relativa (>10 %)a
- 7,5
- 61
- 9,2
- 29
- 10,0
- 16
- 12,1
- 10
- 12,8
- 6
- 13,8
- 4
- 15,1
- 13
- 16,7 (ancho)
- 64
- 18,6 (ancho)
- 100
- 20,3 (ancho)
- 79
- 21,2
- 24
- 21,9
- 30
- 22,4
- 19
- 25,8
- 33
- 26,5
- 20
- 27,4 (ancho)
- 38
- 30,5
- 20
a Intensidad relativa de 12,8 2θ es 6 y 13,8 2θ es 4.
10 Adicionalmente, el siguiente patrón de difracción de rayos X de polvo de la forma VIII cristalina de atorvastatina expresada en términos de valores de 2θ se midió en un difractómetro Inel (capilar):
2θ
7,5
9,3
10,1
12,2
12,8
7
- 9,9
- 36
- 10,4 (ancho)
- 24
- 12,5
- 18
- 13,9 (ancho)
- 9
- 16,2
- 10
- 17,8
- 70
- 19,4
- 100
- 20,8
- 51
- 21,7
- 13
- 22,4-22,6 (ancho)
- 18
- 24,3
- 19
- 25,5
- 24
- 26,2
- 11
- 27,1
- 8
a Intensidad relativa de 13,9 (ancho) 2θ es 9y 27,12θ es 8.
Adicionalmente, el siguiente patrón de difracción de rayos X de polvo de la forma cristalina XII de atorvastatina expresada en términos de valores de 2θ se midió en un difractómetro Inel (capilar):
2θ 5,4 7,7 8,1 8,6 8,9 10,0 10,5 12,6 14,0 (ancho) 2θ 16,2 17,9 19,4 20,9 21,8 22,5-22,8 (ancho)
24,4
25,6 26,4 27,2
Adicionalmente, la forma cristalina XII de atorvastatina e hidratos de la misma se caracterizan mediante el siguiente espectro Raman que tiene picos expresados en cm-1:
Espectro Raman 3064 2973 2926 1652 1603 1527
12
5
15
25
35
45
55
65
Figura 10 Difractograma de la Forma XIV de atorvastatina llevado a cabo en un difractómetro Bruker D 5000.
Figura 11 Difractograma de la Forma XV de atorvastatina llevado a cabo en un difractómetro Bruker D 5000.
Figura 12 Difractograma de la Forma XVI de atorvastatina llevado a cabo en un difractómetro Bruker D 5000.
Figura 13 Difractograma de la Forma XVII de atorvastatina llevado a cabo en un difractómetro Bruker D 5000.
Figura 14 Difractograma de la Forma XVIII de atorvastatina llevado a cabo en un difractómetro Bruker D 5000.
Figura 15 Difractograma de la Forma XIX de atorvastatina llevado a cabo en un difractómetro Bruker D 5000.
Figura 16 Difractograma de la Forma V de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 17 Difractograma de la Forma VI de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 18 Difractograma de la Forma VII de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 19 Difractograma de la Forma VIII de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 20 Difractograma de la Forma IX de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 21 Difractograma de la Forma X de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 22 Difractograma de la Forma XII de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 23 Difractograma de la Forma XVI de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 24 Difractograma de la Forma XVIII de atorvastatina llevado a cabo en un difractómetro Inel XRG-3000.
Figura 25 Espectro de resonancia magnética nuclear de 13C en estado sólido con bandas laterales de rotación identificadas por un asterisco de la Forma V de atorvastatina.
Figura 26 Espectro de resonancia magnética nuclear de 13C en estado sólido con bandas laterales de rotación identificadas por un asterisco de la Forma VI de atorvastatina.
Figura 27 Espectro de resonancia magnética nuclear de 13C en estado sólido con bandas laterales de rotación identificadas por un asterisco de la Forma VII de atorvastatina.
Figura 28 Espectro de resonancia magnética nuclear de 13C en estado sólido con bandas laterales de rotación identificadas por un asterisco de la Forma VIII de atorvastatina.
Figura 29 Espectro de resonancia magnética nuclear de 13C en estado sólido de la Forma X de atorvastatina.
Figura 30 Espectro Raman de la Forma V.
17
Claims (1)
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imagen1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US30204901P | 2001-06-29 | 2001-06-29 | |
| US302049P | 2001-06-29 | ||
| PCT/IB2002/001796 WO2003004470A1 (en) | 2001-06-29 | 2002-05-21 | Crystalline forms of 'r-(r*,r*)!-2-(4-fluorophenyl)-beta, delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-'phenylamino)carbonyl!-1h-pyrrole-1-heptanoic acid calcium salt (2:1) (atorvastatin) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2558565T3 true ES2558565T3 (es) | 2016-02-05 |
Family
ID=23166039
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES02727946.2T Expired - Lifetime ES2558565T3 (es) | 2001-06-29 | 2002-05-21 | Formas cristalinas de sal de calcio del ácido [R-(R*,R*)]-2-(4-fluorofenil)-beta,delta-dihidroxi-5-(1-metiletil)-3-fenil-4-fenilamino)carbonil]-1H-pirrol-1-heptanoico (2:1) (atorvastatina) |
Country Status (40)
| Country | Link |
|---|---|
| US (5) | US6605729B1 (es) |
| EP (2) | EP1423364B1 (es) |
| JP (2) | JP3965155B2 (es) |
| KR (1) | KR100609371B1 (es) |
| CN (2) | CN1524073A (es) |
| AP (1) | AP1571A (es) |
| AR (1) | AR036118A1 (es) |
| AU (1) | AU2002258092B2 (es) |
| BG (1) | BG108393A (es) |
| BR (1) | BR0210666A (es) |
| CA (1) | CA2450111C (es) |
| CR (2) | CR7170A (es) |
| CZ (1) | CZ20033478A3 (es) |
| DO (1) | DOP2002000413A (es) |
| EA (1) | EA005317B1 (es) |
| EC (1) | ECSP034928A (es) |
| EE (1) | EE200300597A (es) |
| ES (1) | ES2558565T3 (es) |
| GE (1) | GEP20053546B (es) |
| HR (1) | HRP20031039A2 (es) |
| HU (1) | HUP0400381A2 (es) |
| IL (1) | IL158790A0 (es) |
| MA (1) | MA27044A1 (es) |
| MX (1) | MXPA03010266A (es) |
| MY (1) | MY122907A (es) |
| NO (1) | NO326170B1 (es) |
| NZ (1) | NZ529557A (es) |
| OA (1) | OA12636A (es) |
| PA (1) | PA8549501A1 (es) |
| PE (1) | PE20030124A1 (es) |
| PL (1) | PL367943A1 (es) |
| RS (1) | RS100003A (es) |
| SK (1) | SK16002003A3 (es) |
| SV (1) | SV2003001144A (es) |
| TN (1) | TNSN03147A1 (es) |
| TW (1) | TWI319396B (es) |
| UA (1) | UA74075C2 (es) |
| UY (1) | UY27359A1 (es) |
| WO (1) | WO2003004470A1 (es) |
| ZA (1) | ZA200308731B (es) |
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| DE69616808T2 (de) | 1995-07-17 | 2002-05-29 | Warner Lambert Co | Kristallines (r-(r*,r*))-2-(4-fluorphenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-((phenylamino)carbonyl)-1h-pyrrol-1-heptancarbonsäure hemi calcium salz (atorvastatin) |
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| AU2003297594A1 (en) * | 2002-11-28 | 2004-06-23 | Teva Pharmaceutical Industries Ltd. | Crystalline form f of atorvastatin hemi-calcium salt |
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