BR0116785A - Processo para a sìntese da forma v de atorvastatina e fenilboronatos como compostos intermediários - Google Patents

Processo para a sìntese da forma v de atorvastatina e fenilboronatos como compostos intermediários

Info

Publication number
BR0116785A
BR0116785A BR0116785-5A BR0116785A BR0116785A BR 0116785 A BR0116785 A BR 0116785A BR 0116785 A BR0116785 A BR 0116785A BR 0116785 A BR0116785 A BR 0116785A
Authority
BR
Brazil
Prior art keywords
atorvastatin
phenylboronates
intermediate compounds
synthesizing form
synthesizing
Prior art date
Application number
BR0116785-5A
Other languages
English (en)
Inventor
Sumitra Srinath
Joy Mathew
Sandhya Ujire
Madhavan Sridharan
Ganesh Sambasivam
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Publication of BR0116785A publication Critical patent/BR0116785A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

"PROCESSO PARA A SìNTESE DA FORMA V DE ATORVASTATINA E FENILBORONATOS COMO COMPOSTOS INTERMEDIáRIOS". A presente invenção refere-se a um novo processo para síntese de cálcio de hemiácido R-(R*,R*)]-2-(4-fluorofenil)-B,D-diidróxi-5-(1-metiletil)3-fenil-4-[(fenilami no)carbonil]-1H-pirrol-1-heptanóico, a forma V de atorvastatina. O composto assim preparado é útil como inibidor da enzima HMGCoA redutase, sendo usado como agente hipolipidêmico e hipocolesterolêmico.
BR0116785-5A 2001-01-19 2001-06-14 Processo para a sìntese da forma v de atorvastatina e fenilboronatos como compostos intermediários BR0116785A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/IN2001/000006 WO2002057229A1 (en) 2001-01-19 2001-01-19 FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
PCT/IN2001/000114 WO2002057274A1 (en) 2001-01-19 2001-06-14 A process for the synthesis of atorvastatin form v and phenylboronates as intermediate compounds

Publications (1)

Publication Number Publication Date
BR0116785A true BR0116785A (pt) 2004-03-09

Family

ID=11076297

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0116785-5A BR0116785A (pt) 2001-01-19 2001-06-14 Processo para a sìntese da forma v de atorvastatina e fenilboronatos como compostos intermediários

Country Status (11)

Country Link
US (1) US6867306B2 (pt)
EP (1) EP1351963B1 (pt)
JP (1) JP2004517900A (pt)
AT (1) ATE478079T1 (pt)
BR (1) BR0116785A (pt)
CA (1) CA2436122A1 (pt)
CZ (1) CZ20031946A3 (pt)
DE (1) DE60142854D1 (pt)
MX (1) MXPA03006475A (pt)
RU (1) RU2269515C2 (pt)
WO (2) WO2002057229A1 (pt)

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MX2007004722A (es) 2004-10-28 2007-06-15 Warner Lambert Co Procedimiento para formar atorvastatina amorfa.
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KR100881617B1 (ko) * 2007-02-22 2009-02-17 (주) 성운파마코피아 아토바스타틴 제조를 위한 중간체 및 그의 제조방법
KR100933172B1 (ko) 2007-11-30 2009-12-21 씨제이제일제당 (주) 아토르바스타틴 칼슘염의 개선된 제조방법
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KR101339648B1 (ko) * 2012-05-10 2013-12-09 (주) 에프엔지리서치 신규한 아토바스타틴 중간체 및 이를 이용한 아토바스타틴의 제조 방법
CN104983702A (zh) * 2015-07-23 2015-10-21 青岛蓝盛洋医药生物科技有限责任公司 一种治疗高胆固醇血症的药物阿托伐他汀钙组合物片剂
CN111909048B (zh) * 2020-09-07 2021-03-16 浙江宏元药业股份有限公司 一种多组分一锅法合成阿托伐他汀钙中间体的方法

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Also Published As

Publication number Publication date
US6867306B2 (en) 2005-03-15
WO2002057274A1 (en) 2002-07-25
WO2002057229A1 (en) 2002-07-25
US20040072893A1 (en) 2004-04-15
CA2436122A1 (en) 2002-07-25
RU2003125647A (ru) 2005-02-20
MXPA03006475A (es) 2004-10-15
JP2004517900A (ja) 2004-06-17
ATE478079T1 (de) 2010-09-15
EP1351963B1 (en) 2010-08-18
CZ20031946A3 (cs) 2003-12-17
RU2269515C2 (ru) 2006-02-10
DE60142854D1 (de) 2010-09-30
EP1351963A1 (en) 2003-10-15

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