IL160077A0 - Processes for preparing calcium salt forms of statins - Google Patents

Processes for preparing calcium salt forms of statins

Info

Publication number
IL160077A0
IL160077A0 IL16007702A IL16007702A IL160077A0 IL 160077 A0 IL160077 A0 IL 160077A0 IL 16007702 A IL16007702 A IL 16007702A IL 16007702 A IL16007702 A IL 16007702A IL 160077 A0 IL160077 A0 IL 160077A0
Authority
IL
Israel
Prior art keywords
statins
processes
calcium salt
salt forms
preparing calcium
Prior art date
Application number
IL16007702A
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/037,412 external-priority patent/US6528661B2/en
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of IL160077A0 publication Critical patent/IL160077A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/55—Acids; Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
IL16007702A 2001-08-16 2002-08-16 Processes for preparing calcium salt forms of statins IL160077A0 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31281201P 2001-08-16 2001-08-16
US10/037,412 US6528661B2 (en) 2000-11-16 2001-10-24 Hydrolysis of [R(R*,R*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino) carbonyl]-1H-pyrrole-1-heptanoic acid esters with calcium hydroxide
PCT/US2002/026012 WO2003016317A1 (en) 2001-08-16 2002-08-16 Processes for preparing calcium salt forms of statins

Publications (1)

Publication Number Publication Date
IL160077A0 true IL160077A0 (en) 2004-06-20

Family

ID=26714105

Family Applications (2)

Application Number Title Priority Date Filing Date
IL16007702A IL160077A0 (en) 2001-08-16 2002-08-16 Processes for preparing calcium salt forms of statins
IL160077A IL160077A (en) 2001-08-16 2004-01-27 Processes for preparing calcium salt forms of statins

Family Applications After (1)

Application Number Title Priority Date Filing Date
IL160077A IL160077A (en) 2001-08-16 2004-01-27 Processes for preparing calcium salt forms of statins

Country Status (17)

Country Link
EP (1) EP1425287A4 (en)
JP (2) JP4188826B2 (en)
CN (1) CN100430405C (en)
AU (1) AU2002324715B2 (en)
CA (1) CA2450820C (en)
CZ (1) CZ2004337A3 (en)
HR (1) HRPK20040255B3 (en)
HU (1) HUP0500616A3 (en)
IL (2) IL160077A0 (en)
IS (1) IS7148A (en)
MX (1) MXPA04001451A (en)
NO (1) NO20041082L (en)
NZ (1) NZ529913A (en)
PL (1) PL370407A1 (en)
SK (1) SK1402004A3 (en)
TR (1) TR200302281T2 (en)
WO (1) WO2003016317A1 (en)

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US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
HUP0303555A3 (en) * 2000-11-16 2005-08-29 Teva Pharma Hydrolysis of [r(r
IL156055A0 (en) * 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
US7501450B2 (en) 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
WO2002057229A1 (en) 2001-01-19 2002-07-25 Biocon India Limited FORM V CRYSTALLINE [R-(R*,R*)]-2-(4-FLUOROPHENYL)-ß,$G(D)-DIHYDROXY-5-(1-METHYLETHYL)-3-PHENYL-4-[(PHENYLAMINO)CARBONYL]-1H-PYRROLE-1- HEPTANOIC ACID HEMI CALCIUM SALT. (ATORVASTATIN)
US7361772B2 (en) 2001-08-16 2008-04-22 Biocon Limited Process for the production of atorvastatin calcium
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WO2003078379A1 (en) 2002-03-18 2003-09-25 Biocon Limited AMORPHOUS Hmg-CoA REDUCTASE INHIBITORS OF DESIRED PARTICLE SIZE
BR0311195A (en) * 2002-05-21 2005-02-22 Ranbaxy Lab Ltd Rosuvastatin Preparation Process
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GB0218781D0 (en) 2002-08-13 2002-09-18 Astrazeneca Ab Chemical process
CA2785954A1 (en) * 2003-02-12 2004-08-26 Nissan Chemical Industries, Ltd. Crystalline forms of pitavastatin calcium
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GB0312896D0 (en) 2003-06-05 2003-07-09 Astrazeneca Ab Chemical process
CA2530163C (en) * 2003-07-25 2012-10-02 Avecia Pharmaceuticals Limited Process and intermediate compounds useful in the preparation of statins, particularly atorvastatin
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EP1816126A1 (en) * 2003-08-28 2007-08-08 Teva Pharmaceutical Industries Limited Process for preparation of rosuvastatin calcium
CA2537271A1 (en) 2003-08-28 2005-03-17 Teva Pharmaceutical Industries, Ltd. Process for preparation of rosuvastatin calcium
UY28501A1 (en) 2003-09-10 2005-04-29 Astrazeneca Uk Ltd CHEMICAL COMPOUNDS
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US20070191318A1 (en) * 2003-10-22 2007-08-16 Yatendra Kumar Process for the preparation of amorphous rosuvastatin calcium
GB0324791D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Chemical process
WO2005051921A1 (en) 2003-11-24 2005-06-09 Teva Pharmaceutical Industries Ltd. Crystalline ammonium salts of rosuvastatin
MY147202A (en) * 2003-11-26 2012-11-14 Novartis Ag Compositions comprising organic compounds
DE602004032465D1 (en) 2003-12-02 2011-06-09 Teva Pharma REFERENCE STANDARD FOR THE CHARACTERIZATION OF ROSUVASTATIN
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WO2005063741A1 (en) * 2003-12-29 2005-07-14 Lek Pharmaceuticals D.D. Process for preparing amorphous (4r-cis)-6-[2-[3-phenyl-4-(phenylcarbamoyl)-2-(4-fluorophenyl)-5-(1-methylethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]-dioxane-4-yl-acetic acid
CZ200486A3 (en) * 2004-01-16 2005-08-17 Zentiva, A.S. Process for preparing hemicalcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid
WO2005077917A1 (en) * 2004-01-19 2005-08-25 Ranbaxy Laboratories Limited Amorphous salts of rosuvastatin
SI21745A (en) * 2004-04-09 2005-10-31 Krka, Tovarna Zdravil, D.D., Novo Mesto Polymorphs of 1-pyrrol-1-heptanoic acid derivative, intermediat for preparation of atorvastatin
CA2573857A1 (en) 2004-07-13 2006-02-16 Teva Pharmaceutical Industries Ltd. A process for the preparation of rosuvastatin involving a tempo-mediated oxidation step
EP1786414A4 (en) * 2004-08-06 2008-04-09 Transform Pharmaceuticals Inc Novel statin pharmaceutical compositions and related methods of treatment
US7612203B2 (en) 2005-02-22 2009-11-03 Teva Pharmaceutical Industries Ltd. Rosuvastatin and salts thereof free of rosuvastatin alkylether and a process for the preparation thereof
CZ299215B6 (en) * 2005-06-29 2008-05-21 Zentiva, A. S. Process for preparing hemi-calcium salt of rosuvastatin, i.e. (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxy-6-heptenoic acid
RU2008108078A (en) * 2005-08-04 2009-09-10 Трансформ Фармасьютикалз, Инк. (Us) NEW PREPARATORY FORMS INCLUDING PHENOFIBRATE AND STATIN, AND RELATED METHODS OF TREATMENT
WO2007022488A2 (en) 2005-08-16 2007-02-22 Teva Pharmaceutical Industries Ltd. Crystalline rosuvastatin intermediate
CN100371709C (en) * 2005-12-12 2008-02-27 重庆医药工业研究院有限责任公司 Method for separating and determining pitavastatin and its optical isomer by means of liquid chromatography
SI2024341T1 (en) 2006-05-03 2016-04-29 Msn Laboratories Private Limited Novel process for statins and its pharmaceutically acceptable salts thereof
ES2567171T3 (en) 2006-10-09 2016-04-20 Msn Laboratories Private Limited New procedure for the preparation of statins and their pharmaceutically acceptable salts
EP2022784A1 (en) 2007-08-08 2009-02-11 LEK Pharmaceuticals D.D. Process for the preparation of methyl ester of rosuvastatin
EP2387561A4 (en) 2009-01-19 2012-07-25 Msn Lab Ltd Improved process for the preparation of highly pure (3r,5s)-7-ý2-cyclopropyl-4-(4-fluorophenyl) quinolin-3-yl¨-3,5-dihydroxy-6(e)-heptenoic acid and pharmaceutically acceptable salts thereof
WO2011086584A2 (en) 2010-01-18 2011-07-21 Msn Laboratories Limited Improved process for the preparation of amide intermediates and their use thereof
HUP1000299A2 (en) 2010-06-08 2012-02-28 Nanoform Cardiovascular Therapeutics Ltd Nanostructured atorvastatin, its pharmaceutically acceptable salts and pharmaceutical compositions containing them and process for their preparation
US8912333B2 (en) * 2010-11-12 2014-12-16 Hetero Research Foundation Polymorphs of pitavastatin calcium
HU229260B1 (en) * 2010-11-29 2013-10-28 Egis Gyogyszergyar Nyrt Process for preparation of rosuvastatin salts
CN102875504A (en) * 2011-07-13 2013-01-16 华南理工大学 Application of 4,5,6,7-tetrahydro pravastatin and salts thereof in cardiovascular diseases
CN102302452B (en) * 2011-09-14 2012-11-21 海南美大制药有限公司 Pitavastatin calcium lipid solid preparation
CN102796036B (en) * 2012-09-12 2014-06-04 江苏阿尔法药业有限公司 Preparation method of atorvastatin calcium
CN103724278B (en) * 2013-12-12 2019-03-29 江苏阿尔法药业有限公司 The preparation method of Statins intermediate and its derivative
JP6596339B2 (en) * 2014-02-06 2019-10-23 株式会社エーピーアイ コーポレーション Method for producing rosuvastatin calcium and intermediates thereof
KR20160126700A (en) 2015-04-24 2016-11-02 미래파인켐 주식회사 New Statin intermediate, the preparation of the same and the preparation of Rosuvastatin using the same
CN105017231B (en) * 2015-06-26 2018-01-26 上海应用技术学院 Polysubstituted fluorine-containing trim of indoles statin and application thereof
CN105111173B (en) * 2015-06-26 2017-06-23 上海应用技术学院 Statin fluorine-containing derivant and application thereof
EP3333155B1 (en) 2015-08-05 2023-05-24 API Corporation Method for producing pitavastatin calcium
CN111362856B (en) * 2020-04-29 2023-08-18 福建海西新药创制股份有限公司 Method for producing atorvastatin calcium by utilizing micro-reaction device

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Also Published As

Publication number Publication date
WO2003016317A1 (en) 2003-02-27
CA2450820A1 (en) 2003-02-27
HUP0500616A3 (en) 2011-07-28
HUP0500616A2 (en) 2005-11-28
EP1425287A4 (en) 2005-09-07
NO20041082L (en) 2004-03-15
SK1402004A3 (en) 2005-01-03
NZ529913A (en) 2005-03-24
HRP20040255A2 (en) 2004-08-31
AU2002324715B2 (en) 2009-03-12
CN1543468A (en) 2004-11-03
JP2005500382A (en) 2005-01-06
IS7148A (en) 2004-02-11
HRPK20040255B3 (en) 2006-02-28
IL160077A (en) 2007-10-31
MXPA04001451A (en) 2005-02-17
EP1425287A1 (en) 2004-06-09
PL370407A1 (en) 2005-05-30
CA2450820C (en) 2011-03-15
TR200302281T2 (en) 2004-09-21
JP2009024008A (en) 2009-02-05
JP4188826B2 (en) 2008-12-03
CN100430405C (en) 2008-11-05
CZ2004337A3 (en) 2005-01-12

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