UA73745C2 - Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis - Google Patents

Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis Download PDF

Info

Publication number
UA73745C2
UA73745C2 UA2002021472A UA2002021472A UA73745C2 UA 73745 C2 UA73745 C2 UA 73745C2 UA 2002021472 A UA2002021472 A UA 2002021472A UA 2002021472 A UA2002021472 A UA 2002021472A UA 73745 C2 UA73745 C2 UA 73745C2
Authority
UA
Ukraine
Prior art keywords
cells
sep
adhesion
apa
inhibitors
Prior art date
Application number
UA2002021472A
Other languages
English (en)
Ukrainian (uk)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of UA73745C2 publication Critical patent/UA73745C2/uk

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07Tetrapeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
UA2002021472A 1999-07-22 2000-07-17 Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis UA73745C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13104799A IL131047A0 (en) 1999-07-22 1999-07-22 Use of il-18 inhibitors
PCT/IL2000/000419 WO2001007480A2 (en) 1999-07-22 2000-07-17 Use of interleukin-18 inhibitors to inhibit tumor metastasis

Publications (1)

Publication Number Publication Date
UA73745C2 true UA73745C2 (en) 2005-09-15

Family

ID=11073044

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2002021472A UA73745C2 (en) 1999-07-22 2000-07-17 Use of il-18 inhibitors for preparing pharmaceutical composition inhibiting tumor metastasis

Country Status (31)

Country Link
US (1) US7741276B2 (ru)
EP (1) EP1206274B1 (ru)
JP (1) JP4827352B2 (ru)
KR (1) KR100682219B1 (ru)
CN (1) CN1173736C (ru)
AR (1) AR024907A1 (ru)
AT (1) ATE363288T1 (ru)
AU (1) AU782478B2 (ru)
BG (1) BG65800B1 (ru)
BR (1) BR0012675A (ru)
CA (1) CA2380216C (ru)
CY (1) CY1107932T1 (ru)
CZ (1) CZ302114B6 (ru)
DE (2) DE60035049T2 (ru)
DK (1) DK1206274T3 (ru)
EA (1) EA005419B1 (ru)
EE (1) EE04838B1 (ru)
ES (1) ES2186596T3 (ru)
HK (1) HK1048248B (ru)
HU (1) HU228780B1 (ru)
IL (2) IL131047A0 (ru)
MX (1) MXPA02000838A (ru)
NO (1) NO329827B1 (ru)
NZ (1) NZ516535A (ru)
PL (1) PL202477B1 (ru)
PT (1) PT1206274E (ru)
SK (1) SK287522B6 (ru)
TR (1) TR200200169T2 (ru)
UA (1) UA73745C2 (ru)
WO (1) WO2001007480A2 (ru)
ZA (1) ZA200200390B (ru)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110032012A (ko) 2000-02-10 2011-03-29 아보트 러보러터리즈 사람 인터류킨-18에 결합하는 항체 및 이를 제조하고 사용하는 방법
US6894155B2 (en) 2000-10-11 2005-05-17 Viron Therapeutics Nucleic acid molecules and polypeptides for immune modulation
US7718368B2 (en) 2000-12-04 2010-05-18 Viron Therapeutics Inc. Immunomodulatory protein and useful embodiments thereof
WO2004032837A2 (en) * 2002-10-08 2004-04-22 Ares Trading S.A. The use of cytokine able to bind il-18bp and of inhibiting the activity of a second cytokine
US7968684B2 (en) 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
ATE517917T1 (de) 2005-06-03 2011-08-15 Ares Trading Sa Herstellung eines rekombinanten il-18-bindenden proteins
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
CL2008002153A1 (es) 2007-07-24 2009-06-05 Amgen Inc Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r.
US9812033B2 (en) * 2013-03-06 2017-11-07 Venkatesh R. Chari Tactile graphic display
WO2023178192A1 (en) 2022-03-15 2023-09-21 Compugen Ltd. Il-18bp antagonist antibodies and their use in monotherapy and combination therapy in the treatment of cancer

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69332668T2 (de) * 1992-09-02 2003-12-18 Isis Pharmaceutical Inc Beeinflussing der zelladhäsie durch oligonukleotide
US7141393B2 (en) * 1996-12-26 2006-11-28 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo Interleukin-18-receptor proteins
ID22975A (id) * 1997-03-18 1999-12-23 Basf Ag Metode dan komposisi untuk memodulasi respons terhadap kortikosteroid
IL121860A0 (en) * 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use

Also Published As

Publication number Publication date
NO20020153D0 (no) 2002-01-11
DE1206274T1 (de) 2002-11-14
IL147675A (en) 2009-05-04
KR100682219B1 (ko) 2007-02-12
EE200200032A (et) 2003-02-17
CZ2002195A3 (cs) 2002-06-12
CN1173736C (zh) 2004-11-03
DE60035049T2 (de) 2007-09-27
BR0012675A (pt) 2002-04-09
EA200200189A1 (ru) 2002-12-26
BG65800B1 (bg) 2009-12-31
NO20020153L (no) 2002-03-11
US7741276B2 (en) 2010-06-22
DE60035049D1 (de) 2007-07-12
CN1364086A (zh) 2002-08-14
EA005419B1 (ru) 2005-02-24
AU782478B2 (en) 2005-08-04
JP4827352B2 (ja) 2011-11-30
SK882002A3 (en) 2002-07-02
WO2001007480A2 (en) 2001-02-01
HK1048248A1 (en) 2003-03-28
HK1048248B (zh) 2005-04-22
MXPA02000838A (es) 2002-07-30
PL202477B1 (pl) 2009-06-30
AU5843200A (en) 2001-02-13
NZ516535A (en) 2004-04-30
AR024907A1 (es) 2002-10-30
CA2380216C (en) 2012-01-31
CA2380216A1 (en) 2001-02-01
HUP0202107A3 (en) 2005-01-28
WO2001007480A3 (en) 2001-05-10
ZA200200390B (en) 2003-04-30
SK287522B6 (sk) 2011-01-04
CY1107932T1 (el) 2013-09-04
HUP0202107A2 (en) 2002-10-28
CZ302114B6 (cs) 2010-10-20
PL353732A1 (en) 2003-12-01
BRPI0012675B1 (pt) 2001-02-01
NO329827B1 (no) 2011-01-03
PT1206274E (pt) 2007-07-06
EP1206274A2 (en) 2002-05-22
BRPI0012675B8 (ru) 2021-05-25
HU228780B1 (en) 2013-05-28
EP1206274B1 (en) 2007-05-30
BG106311A (en) 2002-08-30
ES2186596T1 (es) 2003-05-16
KR20020027493A (ko) 2002-04-13
US20080003216A1 (en) 2008-01-03
TR200200169T2 (tr) 2002-06-21
IL131047A0 (en) 2001-01-28
EE04838B1 (et) 2007-06-15
ES2186596T3 (es) 2007-11-16
DK1206274T3 (da) 2007-08-13
JP2003505472A (ja) 2003-02-12
ATE363288T1 (de) 2007-06-15

Similar Documents

Publication Publication Date Title
Bi et al. Key triggers of osteoclast-related diseases and available strategies for targeted therapies: a review
Noack et al. Selected cytokine pathways in rheumatoid arthritis
Graves The potential role of chemokines and inflammatory cytokines in periodontal disease progression
Brennan et al. TNF inhibitors are produced spontaneously by rheumatoid and osteoarthritic synovial joint cell cultures: evidence of feedback control of TNF action
Feldmann et al. Cytokine blockade in rheumatoid arthritis
US7741276B2 (en) Use of interleukin-18 inhibitors to inhibit tumor metastasis
TW201006926A (en) Agent for the treatment and/or prophylaxis of an autoimmune disease and for the formation of regulatory T cells
AU2015231777B2 (en) IL-21 antibodies
Hueber et al. Embracing novel cytokines in RA–complexity grows as does opportunity!
JP2006514057A (ja) 哺乳類のサイトカイン;関連試薬の使用
CN110396133A (zh) 一种以白介素12为活性成分的融合蛋白型药物前体
Gowen Interleukin 1 and tumor necrosis factor
Hooper et al. IL-6 upregulates protein S expression in the HepG-2 hepatoma cells
Choy Inhibiting interleukin-6 in rheumatoid arthritis
Martin et al. Leukaemia inhibitory factor and bone cell function
SA92120509B1 (ar) تآزر وتضافر (tnf) مع il-4
Lazenby et al. IL-1 synergy with IL-2 in the generation of lymphokine activated killer cells is mediated by TNF-α and β (lymphotoxin)
Candela et al. Fibroblast growth factor increases TNFα-mediated prostaglandin E 2 production and TNFα receptor expression in human fibroblasts
Lowin Positive and negative cooperativity of TNF and Interferon-[ypsilon] in regulating synovial fibroblast function and B cell survival in fibroblast/B cell co-cultures
HALAKA Development of Remote Inflammation through Interneuron Network in the Spinal Cord
KR101769122B1 (ko) 케모카인 발현 조절제
Pinijpaitoon THE EFFECT OF INTERLEUKIN-6 ON THE EXPRESSION OF RECEPTOR ACTIVATOR OF NF-κB LIGAND, OSTEOPROTEGERIN AND MACROPHAGE COLONY STIMULATING FACTOR IN HUMAN DENTAL PULP FIBROBLAST