TW200539854A - Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders - Google Patents

Info

Publication number

TW200539854A

TW200539854A TW094106166A TW94106166A TW200539854A TW 200539854 A TW200539854 A TW 200539854A TW 094106166 A TW094106166 A TW 094106166A TW 94106166 A TW94106166 A TW 94106166A TW 200539854 A TW200539854 A TW 200539854A

Authority

TW

Taiwan

Prior art keywords

compound

acid

group

doc

phenyl

Prior art date

2004-02-27

Links

• Espacenet
• Global Dossier
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• 150000001875 compounds Chemical class 0.000 title claims abstract description 336
• 238000000034 method Methods 0.000 title claims abstract description 150
• 239000008194 pharmaceutical composition Substances 0.000 title claims description 18
• 208000030159 metabolic disease Diseases 0.000 title description 4
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 102
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 91
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• 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims description 9
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• 125000003983 fluorenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3CC12)* 0.000 claims description 8
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• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 8
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• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 8
• XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 claims description 7
• 206010060378 Hyperinsulinaemia Diseases 0.000 claims description 7
• 208000001145 Metabolic Syndrome Diseases 0.000 claims description 7
• ZCQWOFVYLHDMMC-UHFFFAOYSA-N Oxazole Chemical compound C1=COC=N1 ZCQWOFVYLHDMMC-UHFFFAOYSA-N 0.000 claims description 7
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• UJOBWOGCFQCDNV-UHFFFAOYSA-N 9H-carbazole Chemical compound C1=CC=C2C3=CC=CC=C3NC2=C1 UJOBWOGCFQCDNV-UHFFFAOYSA-N 0.000 claims description 6
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