CA2558585C - Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders - Google Patents
Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders Download PDFInfo
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- CA2558585C CA2558585C CA2558585A CA2558585A CA2558585C CA 2558585 C CA2558585 C CA 2558585C CA 2558585 A CA2558585 A CA 2558585A CA 2558585 A CA2558585 A CA 2558585A CA 2558585 C CA2558585 C CA 2558585C
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- Prior art keywords
- compound
- phenyl
- alkyl
- mmol
- acid
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- 239000000203 mixture Substances 0.000 claims abstract description 111
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims abstract description 40
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- 125000003118 aryl group Chemical group 0.000 claims description 126
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- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 claims description 69
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- 125000001424 substituent group Chemical group 0.000 claims description 25
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- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 21
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- 239000000546 pharmaceutical excipient Substances 0.000 claims description 10
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- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 5
- 238000007911 parenteral administration Methods 0.000 claims 2
- 238000011200 topical administration Methods 0.000 claims 2
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- YJBKVPRVZAQTPY-UHFFFAOYSA-J tetrachlorostannane;dihydrate Chemical compound O.O.Cl[Sn](Cl)(Cl)Cl YJBKVPRVZAQTPY-UHFFFAOYSA-J 0.000 description 1
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Classifications
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- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/30—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Reproductive Health (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Quinoline Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54874104P | 2004-02-27 | 2004-02-27 | |
| US60/548,741 | 2004-02-27 | ||
| US60157904P | 2004-08-12 | 2004-08-12 | |
| US60/601,579 | 2004-08-12 | ||
| PCT/US2005/005815 WO2005086661A2 (en) | 2004-02-27 | 2005-02-24 | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2558585A1 CA2558585A1 (en) | 2005-09-22 |
| CA2558585C true CA2558585C (en) | 2010-10-12 |
Family
ID=34976072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2558585A Expired - Fee Related CA2558585C (en) | 2004-02-27 | 2005-02-24 | Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7816367B2 (enExample) |
| EP (1) | EP1737809B1 (enExample) |
| JP (1) | JP5299810B2 (enExample) |
| KR (1) | KR20070004769A (enExample) |
| CN (1) | CN1946666A (enExample) |
| AR (1) | AR048306A1 (enExample) |
| AU (1) | AU2005220728B2 (enExample) |
| BR (1) | BRPI0508098A (enExample) |
| CA (1) | CA2558585C (enExample) |
| CR (1) | CR8642A (enExample) |
| EA (1) | EA011010B1 (enExample) |
| EC (1) | ECSP066887A (enExample) |
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-
2005
- 2005-02-24 KR KR1020067019713A patent/KR20070004769A/ko not_active Withdrawn
- 2005-02-24 US US10/591,214 patent/US7816367B2/en active Active
- 2005-02-24 JP JP2007500959A patent/JP5299810B2/ja not_active Expired - Fee Related
- 2005-02-24 WO PCT/US2005/005815 patent/WO2005086661A2/en not_active Ceased
- 2005-02-24 ES ES05723623T patent/ES2433466T3/es not_active Expired - Lifetime
- 2005-02-24 EP EP05723623.4A patent/EP1737809B1/en not_active Expired - Lifetime
- 2005-02-24 CA CA2558585A patent/CA2558585C/en not_active Expired - Fee Related
- 2005-02-24 EA EA200601388A patent/EA011010B1/ru not_active IP Right Cessation
- 2005-02-24 AU AU2005220728A patent/AU2005220728B2/en not_active Ceased
- 2005-02-24 BR BRPI0508098-3A patent/BRPI0508098A/pt not_active IP Right Cessation
- 2005-02-24 CN CNA2005800127092A patent/CN1946666A/zh active Pending
- 2005-02-25 US US11/067,377 patent/US7649110B2/en active Active
- 2005-02-28 AR ARP050100748A patent/AR048306A1/es unknown
- 2005-03-01 TW TW094106166A patent/TW200539854A/zh unknown
-
2006
- 2006-08-27 IL IL177717A patent/IL177717A0/en unknown
- 2006-09-13 MA MA29319A patent/MA28466B1/fr unknown
- 2006-09-20 CR CR8642A patent/CR8642A/es not_active Application Discontinuation
- 2006-09-26 NO NO20064362A patent/NO20064362L/no not_active Application Discontinuation
- 2006-09-27 IS IS8542A patent/IS8542A/is unknown
- 2006-09-27 EC EC2006006887A patent/ECSP066887A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR048306A1 (es) | 2006-04-19 |
| EA200601388A1 (ru) | 2007-02-27 |
| US7649110B2 (en) | 2010-01-19 |
| US20070142384A1 (en) | 2007-06-21 |
| MA28466B1 (fr) | 2007-03-01 |
| AU2005220728A2 (en) | 2005-09-22 |
| KR20070004769A (ko) | 2007-01-09 |
| IS8542A (is) | 2006-09-27 |
| EP1737809A2 (en) | 2007-01-03 |
| ECSP066887A (enExample) | 2006-11-24 |
| WO2005086661A2 (en) | 2005-09-22 |
| EP1737809A4 (en) | 2007-10-17 |
| EA011010B1 (ru) | 2008-12-30 |
| ES2433466T3 (es) | 2013-12-11 |
| CN1946666A (zh) | 2007-04-11 |
| WO2005086661A3 (en) | 2006-05-04 |
| US20060004012A1 (en) | 2006-01-05 |
| US7816367B2 (en) | 2010-10-19 |
| CR8642A (es) | 2008-11-28 |
| AU2005220728A1 (en) | 2005-09-22 |
| JP2007525516A (ja) | 2007-09-06 |
| NO20064362L (no) | 2006-11-22 |
| BRPI0508098A (pt) | 2007-07-17 |
| JP5299810B2 (ja) | 2013-09-25 |
| AU2005220728B2 (en) | 2009-08-06 |
| TW200539854A (en) | 2005-12-16 |
| CA2558585A1 (en) | 2005-09-22 |
| EP1737809B1 (en) | 2013-09-18 |
| IL177717A0 (en) | 2006-12-31 |
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