BR112016012469A2 - Isopropil triazolo piridina, seus usos, seu processo de preparação e seus intermediários, composição farmacêutica - Google Patents
Isopropil triazolo piridina, seus usos, seu processo de preparação e seus intermediários, composição farmacêuticaInfo
- Publication number
- BR112016012469A2 BR112016012469A2 BR112016012469A BR112016012469A BR112016012469A2 BR 112016012469 A2 BR112016012469 A2 BR 112016012469A2 BR 112016012469 A BR112016012469 A BR 112016012469A BR 112016012469 A BR112016012469 A BR 112016012469A BR 112016012469 A2 BR112016012469 A2 BR 112016012469A2
- Authority
- BR
- Brazil
- Prior art keywords
- group
- intermediates
- isopropyl
- pharmaceutical composition
- preparation process
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
ISOPROPIL TRIAZOLO PIRIDINA, SEUS USOS, SEU PROCESSO DE PREPARAÇÃO E SEUS INTERMEDIÁRIOS, COMPOSIÇÃO FARMACÊUTICA. A presente invenção refere-se a um composto da fórmula I, abaixo: em que R1 é selecionado do grupo que consiste em H, CH3, CN, CH2CN, C(CH3)2CN, e F; R2 é selecionado do grupo que consiste em H, O(C1-C3 alquila) R5, CH2CN, e CN; R3 é selecionado do grupo que consiste em H, OCH3, CN, C(CH3)2CN, e CH2CN; R4 é selecionado do grupo que consiste em H e CH3; R5 é selecionado do grupo que consiste em H, CN, C(CH3)2CN, OCH3, S(O)2CH3, e C(CH3)2OH; contanto que pelo menos um selecionado do grupo que consiste em R1, R2, R3 e R4 seja H; ou um sal farmaceuticamente aceitável do mesmo, método de tratamento de diabetes usando o composto e um processo para preparação do composto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461925797P | 2014-01-10 | 2014-01-10 | |
| PCT/US2015/010277 WO2015105779A1 (en) | 2014-01-10 | 2015-01-06 | Isopropyl triazolo pyridine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112016012469A2 true BR112016012469A2 (pt) | 2017-08-08 |
Family
ID=52359017
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112016012469A BR112016012469A2 (pt) | 2014-01-10 | 2015-01-06 | Isopropil triazolo piridina, seus usos, seu processo de preparação e seus intermediários, composição farmacêutica |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9809592B2 (pt) |
| EP (1) | EP3092240B1 (pt) |
| JP (1) | JP6170255B2 (pt) |
| KR (1) | KR20160095114A (pt) |
| CN (1) | CN105899509B (pt) |
| AU (1) | AU2015204916B2 (pt) |
| BR (1) | BR112016012469A2 (pt) |
| CA (1) | CA2931817A1 (pt) |
| EA (1) | EA201691150A1 (pt) |
| ES (1) | ES2705039T3 (pt) |
| MX (1) | MX2016008909A (pt) |
| WO (1) | WO2015105779A1 (pt) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112016013874A2 (pt) | 2014-01-10 | 2017-08-08 | Lilly Co Eli | Fenil-triazolo-piridina, seus usos, seus processo de produção e seus intermediários, e composição farmacêutica |
| WO2019057946A1 (en) | 2017-09-25 | 2019-03-28 | F. Hoffmann-La Roche Ag | MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS |
| TWI796596B (zh) | 2018-02-13 | 2023-03-21 | 美商基利科學股份有限公司 | Pd‐1/pd‐l1抑制劑 |
| CA3093130C (en) | 2018-04-19 | 2023-10-17 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| KR20230159715A (ko) | 2018-07-13 | 2023-11-21 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| KR102635333B1 (ko) | 2018-10-24 | 2024-02-15 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| WO2021071837A1 (en) | 2019-10-07 | 2021-04-15 | Kallyope, Inc. | Gpr119 agonists |
| CA3178994A1 (en) | 2020-05-19 | 2021-11-25 | Iyassu Sebhat | Ampk activators |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| JP4805552B2 (ja) * | 2003-05-30 | 2011-11-02 | 武田薬品工業株式会社 | 縮合環化合物 |
| BRPI0508098A (pt) * | 2004-02-27 | 2007-07-17 | Amgen Inc | compostos, composições farmacêuticas e métodos para uso no tratamento de distúrbios metabólicos |
| US7465804B2 (en) * | 2005-05-20 | 2008-12-16 | Amgen Inc. | Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders |
| EP1924546A1 (en) * | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| TW200838526A (en) * | 2006-12-01 | 2008-10-01 | Astellas Pharma Inc | Carboxylic acid derivatives |
| ES2423793T3 (es) | 2008-05-26 | 2013-09-24 | Genfit | Compuestos agonistas de PPAR, preparación y usos para el tratamiento de la diabetes y/o dislipidemias |
| JP5512665B2 (ja) * | 2008-06-20 | 2014-06-04 | ジェネンテック， インコーポレイテッド | トリアゾロピリジンｊａｋ阻害剤化合物と方法 |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| US9271969B2 (en) * | 2012-02-07 | 2016-03-01 | Kainos Medicine, Inc. | Compounds as inhibitors of diacylglycerol O-acyltransferase type 1 enzyme |
| TWI692469B (zh) * | 2012-11-09 | 2020-05-01 | 南韓商Ｌｇ化學股份有限公司 | Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物 |
| TW201609722A (zh) | 2013-12-13 | 2016-03-16 | 美國禮來大藥廠 | 新穎三唑并吡啶化合物 |
| BR112016013874A2 (pt) | 2014-01-10 | 2017-08-08 | Lilly Co Eli | Fenil-triazolo-piridina, seus usos, seus processo de produção e seus intermediários, e composição farmacêutica |
-
2015
- 2015-01-06 JP JP2016545805A patent/JP6170255B2/ja not_active Expired - Fee Related
- 2015-01-06 WO PCT/US2015/010277 patent/WO2015105779A1/en active Application Filing
- 2015-01-06 EA EA201691150A patent/EA201691150A1/ru unknown
- 2015-01-06 EP EP15700618.0A patent/EP3092240B1/en active Active
- 2015-01-06 MX MX2016008909A patent/MX2016008909A/es unknown
- 2015-01-06 CN CN201580004121.6A patent/CN105899509B/zh active Active
- 2015-01-06 BR BR112016012469A patent/BR112016012469A2/pt not_active IP Right Cessation
- 2015-01-06 ES ES15700618T patent/ES2705039T3/es active Active
- 2015-01-06 AU AU2015204916A patent/AU2015204916B2/en not_active Expired - Fee Related
- 2015-01-06 US US15/106,953 patent/US9809592B2/en active Active
- 2015-01-06 KR KR1020167018131A patent/KR20160095114A/ko not_active Application Discontinuation
- 2015-01-06 CA CA2931817A patent/CA2931817A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015204916B2 (en) | 2017-02-23 |
| US20160333005A1 (en) | 2016-11-17 |
| CA2931817A1 (en) | 2015-07-16 |
| US9809592B2 (en) | 2017-11-07 |
| CN105899509A (zh) | 2016-08-24 |
| EP3092240B1 (en) | 2018-12-05 |
| EA201691150A1 (ru) | 2016-10-31 |
| ES2705039T3 (es) | 2019-03-21 |
| JP6170255B2 (ja) | 2017-07-26 |
| MX2016008909A (es) | 2016-10-04 |
| WO2015105779A1 (en) | 2015-07-16 |
| AU2015204916A1 (en) | 2016-06-09 |
| EP3092240A1 (en) | 2016-11-16 |
| KR20160095114A (ko) | 2016-08-10 |
| JP2017507115A (ja) | 2017-03-16 |
| CN105899509B (zh) | 2018-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2495 DE 30-10-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |