MX2016008909A - Compuestos de isopropil triazolo piridina. - Google Patents

Compuestos de isopropil triazolo piridina.

Info

Publication number
MX2016008909A
MX2016008909A MX2016008909A MX2016008909A MX2016008909A MX 2016008909 A MX2016008909 A MX 2016008909A MX 2016008909 A MX2016008909 A MX 2016008909A MX 2016008909 A MX2016008909 A MX 2016008909A MX 2016008909 A MX2016008909 A MX 2016008909A
Authority
MX
Mexico
Prior art keywords
group
isopropyl
pyridine compounds
triazolo pyridine
ch2cn
Prior art date
Application number
MX2016008909A
Other languages
English (en)
Inventor
Hamdouchi Chafiq
Maiti Pranab
Reifel Miller Anne
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2016008909A publication Critical patent/MX2016008909A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a un compuesto de la Fórmula I a continuación: en donde R1 se selecciona del grupo que consiste de H, CH3, CN, CH2CN, C(CH3)2CN y F; R2 se selecciona del grupo que consiste de H, O(alquilo de C1-C3)R5, CH2CN y CN; R3 se selecciona del grupo que consiste de H, OCH3, CN, C(CH3)2CN y CH2CN; R4 se selecciona del grupo que consiste de H y CH3; R5 se selecciona del grupo que consiste de H, CN, C(CH3)2CN, OCH3, S(O)2CH3 y C(CH3)2OH; siempre que al menos uno seleccionado del grupo que consiste de R1, R2, R3 y R4 sea H; o una sal del mismo farmacéuticamente aceptable, métodos para tratar la diabetes utilizando el compuesto y un proceso para preparar el compuesto. (ver Fórmula).
MX2016008909A 2014-01-10 2015-01-06 Compuestos de isopropil triazolo piridina. MX2016008909A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461925797P 2014-01-10 2014-01-10
PCT/US2015/010277 WO2015105779A1 (en) 2014-01-10 2015-01-06 Isopropyl triazolo pyridine compounds

Publications (1)

Publication Number Publication Date
MX2016008909A true MX2016008909A (es) 2016-10-04

Family

ID=52359017

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016008909A MX2016008909A (es) 2014-01-10 2015-01-06 Compuestos de isopropil triazolo piridina.

Country Status (12)

Country Link
US (1) US9809592B2 (es)
EP (1) EP3092240B1 (es)
JP (1) JP6170255B2 (es)
KR (1) KR20160095114A (es)
CN (1) CN105899509B (es)
AU (1) AU2015204916B2 (es)
BR (1) BR112016012469A2 (es)
CA (1) CA2931817A1 (es)
EA (1) EA201691150A1 (es)
ES (1) ES2705039T3 (es)
MX (1) MX2016008909A (es)
WO (1) WO2015105779A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6211200B2 (ja) 2014-01-10 2017-10-11 イーライ リリー アンド カンパニー フェニル−トリアゾロ−ピリジン化合物
WO2019057946A1 (en) 2017-09-25 2019-03-28 F. Hoffmann-La Roche Ag MULTI-CYCLIC AROMATIC COMPOUNDS AS D-FACTOR INHIBITORS
IL300572A (en) 2018-02-13 2023-04-01 Gilead Sciences Inc PD–1/PD–L1 inhibitors
EP3781556A1 (en) 2018-04-19 2021-02-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
KR20230159715A (ko) 2018-07-13 2023-11-21 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
US11236085B2 (en) 2018-10-24 2022-02-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004041266A1 (ja) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited 受容体機能調節剤
JP4805552B2 (ja) * 2003-05-30 2011-11-02 武田薬品工業株式会社 縮合環化合物
CN1946666A (zh) * 2004-02-27 2007-04-11 埃姆艮股份有限公司 用于治疗代谢性疾病的化合物、药物组合物和方法
US7465804B2 (en) * 2005-05-20 2008-12-16 Amgen Inc. Compounds, pharmaceutical compositions and methods for their use in treating metabolic disorders
CA2621949A1 (en) * 2005-09-14 2007-03-22 Amgen Inc. Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders
TW200838526A (en) * 2006-12-01 2008-10-01 Astellas Pharma Inc Carboxylic acid derivatives
ES2423793T3 (es) * 2008-05-26 2013-09-24 Genfit Compuestos agonistas de PPAR, preparación y usos para el tratamiento de la diabetes y/o dislipidemias
MX2010014005A (es) * 2008-06-20 2011-02-15 Genentech Inc Compuestos de triazolopiridina inhibidores de jak y los metodos.
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
WO2013119040A1 (en) * 2012-02-07 2013-08-15 Kainos Medicine, Inc. Compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme
TWI692469B (zh) * 2012-11-09 2020-05-01 南韓商Ｌｇ化學股份有限公司 Ｇｐｒ４０受體促效劑，製造該促效劑的方法以及含有該促效劑作爲活性劑的醫藥組成物
TW201609722A (zh) 2013-12-13 2016-03-16 美國禮來大藥廠 新穎三唑并吡啶化合物
JP6211200B2 (ja) 2014-01-10 2017-10-11 イーライ リリー アンド カンパニー フェニル−トリアゾロ−ピリジン化合物

Also Published As

Publication number Publication date
EP3092240A1 (en) 2016-11-16
EP3092240B1 (en) 2018-12-05
JP6170255B2 (ja) 2017-07-26
JP2017507115A (ja) 2017-03-16
KR20160095114A (ko) 2016-08-10
ES2705039T3 (es) 2019-03-21
AU2015204916A1 (en) 2016-06-09
CN105899509A (zh) 2016-08-24
EA201691150A1 (ru) 2016-10-31
CN105899509B (zh) 2018-01-02
CA2931817A1 (en) 2015-07-16
WO2015105779A1 (en) 2015-07-16
US20160333005A1 (en) 2016-11-17
US9809592B2 (en) 2017-11-07
BR112016012469A2 (pt) 2017-08-08
AU2015204916B2 (en) 2017-02-23

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