TR199700464A2 - Antihistaminik etkili yeni benzimidazole türevleri. - Google Patents

Antihistaminik etkili yeni benzimidazole türevleri.

Info

Publication number
TR199700464A2
TR199700464A2 TR97/00464A TR9700464A TR199700464A2 TR 199700464 A2 TR199700464 A2 TR 199700464A2 TR 97/00464 A TR97/00464 A TR 97/00464A TR 9700464 A TR9700464 A TR 9700464A TR 199700464 A2 TR199700464 A2 TR 199700464A2
Authority
TR
Turkey
Prior art keywords
benzimidazole derivatives
new benzimidazole
short
antihistaminic action
new
Prior art date
Application number
TR97/00464A
Other languages
English (en)
Other versions
TR199700464A3 (tr
Inventor
Orjales Aurelio
Rubio Victor
Bordell Maravillas
Original Assignee
Fabrica Espanola De Productos Quimicos Y Farmaceuticos,
S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Quimicos Y Farmaceuticos,, S.A. filed Critical Fabrica Espanola De Productos Quimicos Y Farmaceuticos,
Publication of TR199700464A3 publication Critical patent/TR199700464A3/tr
Publication of TR199700464A2 publication Critical patent/TR199700464A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Asagidaki formülün yeni benzimidazol türevleri tanimlanmistir. Burada, R1 hidrojendir veya metil, etil, izopropil, siklopropil veya vinil gibi kisa zincirli hidrokarbon grubudur, ve R2, CH2OH, COOH, COOR ve 4,4-dimetil-2-oksazolinil arasindan seçilmis bir gruptur; R3 ise yukarida tanimlandigi gibi kisa zincirli bir alkil grubudur ve farmakolojik olarak kabul edilebilir asitler veya bazlarla, ilave tuzlaridir. Ayrica, yüksek bir H1 antihistaminik ve antiallerjik etkisi olup merkezi sinir sistemi ve kardiyovasküler sistem üzerinde olumsuz etkileri olmayan bu bilesimlerin hazirlanmasi da açiklanmistir.
TR97/00464A 1996-06-04 1997-06-04 Antihistaminik etkili yeni benzimidazole türevleri. TR199700464A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (2)

Publication Number Publication Date
TR199700464A3 TR199700464A3 (tr) 1997-12-21
TR199700464A2 true TR199700464A2 (tr) 1997-12-21

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00464A TR199700464A2 (tr) 1996-06-04 1997-06-04 Antihistaminik etkili yeni benzimidazole türevleri.

Country Status (27)

Country Link
US (1) US5877187A (tr)
EP (1) EP0818454B1 (tr)
JP (1) JP4218991B2 (tr)
CN (1) CN1105716C (tr)
AR (1) AR008386A1 (tr)
AT (1) ATE264317T1 (tr)
AU (1) AU725700B2 (tr)
BR (1) BR9703276A (tr)
CA (1) CA2206754C (tr)
CZ (1) CZ289278B6 (tr)
DE (2) DE122011000006I1 (tr)
DK (1) DK0818454T3 (tr)
ES (1) ES2124167B1 (tr)
FR (1) FR11C0023I2 (tr)
HR (1) HRP970307B1 (tr)
HU (1) HU227598B1 (tr)
IN (1) IN186319B (tr)
LU (1) LU91798I2 (tr)
MX (1) MXPA97004127A (tr)
NO (2) NO313195B1 (tr)
PL (1) PL188908B1 (tr)
PT (1) PT818454E (tr)
RU (1) RU2182150C2 (tr)
SI (1) SI0818454T1 (tr)
TR (1) TR199700464A2 (tr)
TW (1) TW438794B (tr)
ZA (1) ZA974893B (tr)

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IL140422A0 (en) 1998-07-01 2002-02-10 Retinoid Related Receptor Func Retinoid-related receptor function regulating agent
SK285529B6 (sk) 1998-11-27 2007-03-01 Basf Aktiengesellschaft Substituované benzimidazoly, farmaceutická kompozícia s ich obsahom a ich použitie ako inhibítorov PARP
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
AU2002255017B2 (en) * 2002-04-19 2008-11-13 Faes Farma, S.A. Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1H-benzimidazole-2-yl]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic acid
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
EP2240464A4 (en) 2008-02-12 2011-09-14 Yuhan Corp PROCESS FOR THE PREPARATION OF 2-METHYL-2'-PHENYLPROPIONIC ACID DERIVATIVES AND NOVEL INTERMEDIATE COMPOUNDS
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
US20140271504A1 (en) * 2013-03-15 2014-09-18 Hercules Incorporated Composition and method of producing personal care compositions with improved deposition properties
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
CN107849007A (zh) * 2015-07-24 2018-03-27 乌奎玛公司 比拉斯汀的晶型及其制备方法
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center SOLID STATE FORMS OF 2- [4- (2- {4- [1- (2-ETHOXYETHYL) -1H-BENZIMIDAZOL-2-YL] -1-PIPERIDINYL} ETHYL) PHENYL] -2-METHYLPROPANOIC ACID AND PREPARATION METHOD THEREOF
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
MA50247B1 (fr) 2017-10-16 2021-02-26 Faes Farma Sa Compositions aqueuses comprenant de la bilastine et du mométasone
ES2773756R1 (es) 2017-12-18 2021-04-12 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
MX2020007692A (es) 2018-01-18 2020-09-14 Faes Farma Sa Composiciones oftalmicas que comprenden bilastina, una beta-ciclodextrina y al menos un agente de gelificacion.
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
WO2022023463A1 (en) 2020-07-30 2022-02-03 Faes Farma, S.A. Decongestant drug delivery system
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
EP4267109A1 (en) 2020-12-23 2023-11-01 Noucor Health S.A. A non-micronized bilastine composition
WO2023156559A1 (en) 2022-02-17 2023-08-24 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica
ES2190442T3 (es) * 1993-06-25 2003-08-01 Merrell Pharma Inc Nuevos productos intermedios para la preparacion de derivados de 4-difenilmetil/difenilmetoxi piperidina antihistaminicos.

Also Published As

Publication number Publication date
DE69728608D1 (de) 2004-05-19
TR199700464A3 (tr) 1997-12-21
LU91798I2 (fr) 2011-05-23
CZ172397A3 (en) 1997-12-17
ES2124167B1 (es) 1999-09-16
NO972525D0 (no) 1997-06-03
BR9703276A (pt) 2004-08-17
TW438794B (en) 2001-06-07
JP4218991B2 (ja) 2009-02-04
PL188908B1 (pl) 2005-05-31
CA2206754C (en) 2007-01-23
HU9700997D0 (en) 1997-07-28
FR11C0023I2 (fr) 2012-03-16
DE122011000006I1 (de) 2011-06-16
ATE264317T1 (de) 2004-04-15
HRP970307B1 (en) 2002-02-28
US5877187A (en) 1999-03-02
PT818454E (pt) 2004-08-31
NO313195B1 (no) 2002-08-26
CA2206754A1 (en) 1997-12-04
FR11C0023I1 (tr) 2011-08-19
NO972525L (no) 1997-12-05
MXPA97004127A (es) 2005-07-25
EP0818454B1 (en) 2004-04-14
HRP970307A2 (en) 1998-04-30
CN1105716C (zh) 2003-04-16
AR008386A1 (es) 2000-01-19
SI0818454T1 (en) 2004-08-31
NO2011008I1 (no) 2011-06-06
CN1176964A (zh) 1998-03-25
ES2124167A1 (es) 1999-01-16
IN186319B (tr) 2001-08-04
PL320358A1 (en) 1997-12-08
RU2182150C2 (ru) 2002-05-10
DK0818454T3 (da) 2004-07-12
CZ289278B6 (cs) 2001-12-12
JPH1059961A (ja) 1998-03-03
AU725700B2 (en) 2000-10-19
DE69728608T2 (de) 2005-04-21
NO2011008I2 (no) 2012-05-14
EP0818454A1 (en) 1998-01-14
AU2467297A (en) 1997-12-11
HU227598B1 (en) 2011-09-28
HUP9700997A1 (hu) 1999-09-28
ZA974893B (en) 1997-12-30

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