TR199700419A2 - Yeni piridazinon türevleri. - Google Patents

Yeni piridazinon türevleri.

Info

Publication number
TR199700419A2
TR199700419A2 TR97/00419A TR9700419A TR199700419A2 TR 199700419 A2 TR199700419 A2 TR 199700419A2 TR 97/00419 A TR97/00419 A TR 97/00419A TR 9700419 A TR9700419 A TR 9700419A TR 199700419 A2 TR199700419 A2 TR 199700419A2
Authority
TR
Turkey
Prior art keywords
pyridazinone derivatives
new pyridazinone
new
derivatives
fulcule
Prior art date
Application number
TR97/00419A
Other languages
English (en)
Inventor
Arthur Allen Darin
Patrick Dunn James
Brian Sjogren Eric
Bernard Smit David
Original Assignee
F. Hoffmann-La Roche & Co. Ag.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann-La Roche & Co. Ag. filed Critical F. Hoffmann-La Roche & Co. Ag.
Publication of TR199700419A2 publication Critical patent/TR199700419A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
    • C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D237/14—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Formül I"in bilesimleri: Burada R10 fromül (A), (B) ya da (C) ile temsil edilen bir gruptur, ve diger ikameler tarifnamede tanimlandigi gibidir; ve onlarin farmasötik olarak uygun tuzlari prostaglandin G/H sintazinin önleyicileridirler ve iltihap ve analgesik maddeleridir.
TR97/00419A 1996-05-30 1997-05-23 Yeni piridazinon türevleri. TR199700419A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1867296P 1996-05-30 1996-05-30

Publications (1)

Publication Number Publication Date
TR199700419A2 true TR199700419A2 (tr) 1997-12-21

Family

ID=21789188

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00419A TR199700419A2 (tr) 1996-05-30 1997-05-23 Yeni piridazinon türevleri.

Country Status (13)

Country Link
US (1) US5886178A (tr)
EP (1) EP0810218B1 (tr)
JP (1) JP2790450B2 (tr)
CN (1) CN1136197C (tr)
AR (1) AR008377A1 (tr)
AT (1) ATE229007T1 (tr)
BR (1) BR9703332A (tr)
CA (1) CA2205757C (tr)
DE (1) DE69717537T2 (tr)
DK (1) DK0810218T3 (tr)
ES (1) ES2186821T3 (tr)
PT (1) PT810218E (tr)
TR (1) TR199700419A2 (tr)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
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ATE267215T1 (de) 1997-12-08 2004-06-15 Lexigen Pharm Corp Heterodimäre fusionsproteine zur verwendung für gezielte immuntherapie und allgemeine immunerregung
US20030105294A1 (en) * 1998-02-25 2003-06-05 Stephen Gillies Enhancing the circulating half life of antibody-based fusion proteins
JP2002511432A (ja) * 1998-04-15 2002-04-16 レキシジェン ファーマシューティカルズ コーポレイション 新脈管形成インヒビターの同時投与による抗体−サイトカイン融合タンパク質媒介性免疫応答の増強
AU3712100A (en) 1999-06-01 2000-12-18 University Of Texas Southwestern Medical Center, The Method of treating hair loss using sulfonyl thyromimetic compounds
US6680344B1 (en) 1999-06-01 2004-01-20 The University Of Texas Southwestern Medical Center Method of treating hair loss using diphenylmethane derivatives
SK782002A3 (en) 1999-07-21 2003-08-05 Lexigen Pharm Corp FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens
US7067110B1 (en) 1999-07-21 2006-06-27 Emd Lexigen Research Center Corp. Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens
HUP0202442A3 (en) * 1999-08-09 2005-01-28 Lexigen Pharmaceuticals Corp L Multiple cytokine-antibody complexes
EP1228214A2 (en) 1999-11-12 2002-08-07 MERCK PATENT GmbH Erythropoietin forms with improved properties
ATE336514T1 (de) * 2000-02-11 2006-09-15 Merck Patent Gmbh Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen
PT1294401E (pt) * 2000-06-29 2007-11-09 Merck Patent Gmbh Aumento das respostas imunológicas mediadas por proteínas de fusão anticorpo-citoquina por tratamento combinado com agentes que aumentam a captação de imunocitoquinas
US7151102B2 (en) * 2000-10-30 2006-12-19 Kudos Pharmaceuticals Limited Phthalazinone derivatives
KR20090010127A (ko) * 2001-03-07 2009-01-28 메르크 파텐트 게엠베하 하이브리드 이소타입 항체 부분구조를 포함하는 단백질을 위한 발현 기술
WO2002079415A2 (en) * 2001-03-30 2002-10-10 Lexigen Pharmaceuticals Corp. Reducing the immunogenicity of fusion proteins
DK1383785T3 (da) * 2001-05-03 2011-05-23 Merck Patent Gmbh Rekombinant tumorspecifikt antistof og anvendelse deraf
ATE542137T1 (de) * 2001-12-04 2012-02-15 Merck Patent Gmbh Immunocytokine mit modulierter selektivität
EP1501822B1 (en) * 2002-04-30 2010-12-15 Kudos Pharmaceuticals Limited Phthalazinone derivatives
WO2004055056A1 (en) * 2002-12-17 2004-07-01 Merck Patent Gmbh Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2
US7449464B2 (en) * 2003-03-12 2008-11-11 Kudos Pharmaceuticals Limited Phthalazinone derivatives
GB0305681D0 (en) 2003-03-12 2003-04-16 Kudos Pharm Ltd Phthalazinone derivatives
BRPI0408704A (pt) 2003-03-24 2006-03-07 Hoffmann La Roche benzil-piridazinonas como inibidores de transcriptase reversa
WO2005090317A1 (en) * 2004-03-23 2005-09-29 F.Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
EP1737827A1 (en) * 2004-04-15 2007-01-03 F.Hoffmann-La Roche Ag Process for preparing pyridazinone compounds
GB0419072D0 (en) * 2004-08-26 2004-09-29 Kudos Pharm Ltd Phthalazinone derivatives
BRPI0514632A (pt) * 2004-08-26 2008-06-17 Kudos Pharm Ltd derivados de ftalazinona 4-heteroarilmetila substituìdos
GB0428111D0 (en) * 2004-12-22 2005-01-26 Kudos Pharm Ltd Pthalazinone derivatives
ES2317584T3 (es) * 2005-09-30 2009-04-16 F. Hoffmann-La Roche Ag Inhibidores de nnrt.
GB0521373D0 (en) 2005-10-20 2005-11-30 Kudos Pharm Ltd Pthalazinone derivatives
GB0610680D0 (en) * 2006-05-31 2006-07-12 Istituto Di Ricerche D Biolog Therapeutic compounds
EP2035380A2 (en) * 2006-06-15 2009-03-18 Kudos Pharmaceuticals Limited Parp inhibitors
CN101484436A (zh) * 2006-06-15 2009-07-15 库多斯药物有限公司 作为parp抑制剂的2-氧基杂芳基酰胺衍生物
WO2007144639A1 (en) * 2006-06-15 2007-12-21 Kudos Pharmaceuticals Limited 2 -oxybenzamide derivatives as parp inhibitors
US20080280910A1 (en) * 2007-03-22 2008-11-13 Keith Allan Menear Phthalazinone derivatives
TW200900396A (en) * 2007-04-10 2009-01-01 Kudos Pharm Ltd Phthalazinone derivatives
US20090023727A1 (en) * 2007-07-05 2009-01-22 Muhammad Hashim Javaid Phthalazinone derivatives
JP2010539149A (ja) 2007-09-14 2010-12-16 アストラゼネカ アクチボラグ フタラジノン誘導体
AU2008313467B2 (en) * 2007-10-17 2013-08-29 Kudos Pharmaceuticals Limited 4- [3- (4-cyclopropanecarbonyl-piperazine-1-carbonyl) -4 -fluoro-benzyl] -2H-phthalazin-1-one
NZ585395A (en) * 2007-11-15 2012-03-30 Angeletti P Ist Richerche Bio Pyridazinone derivatives as parp inhibitors
UY31603A1 (es) 2008-01-23 2009-08-31 Derivados de ftalazinona
JP5524220B2 (ja) 2008-10-07 2014-06-18 アストラゼネカ・ユーケイ・リミテッド 医薬配合物５１４
UY32790A (es) * 2009-07-15 2011-02-28 Astrazeneca Ab Compuesto de ftalazinona
GB201219820D0 (en) 2012-11-05 2012-12-19 Isis Innovation Compounds
ES2544869B2 (es) * 2014-03-04 2016-01-18 Universidade De Vigo Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa
CN106146404B (zh) * 2015-04-15 2020-03-20 江苏恩华药业股份有限公司 哒嗪酮类衍生物及其应用
SI3423440T1 (sl) * 2016-03-04 2021-07-30 Otsuka Pharmaceutical Co., Ltd. 5-metil-6-fenil-4,5-dihidro-2H-piridazin-3-ON derivat za zdravljenje možganskih tumorjev

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US3752826A (en) * 1970-01-26 1973-08-14 Mcneilab Inc Aroyl substituted pyrroles
US4599332A (en) * 1983-12-07 1986-07-08 Warner-Lambert Company 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives
US5622948A (en) * 1994-12-01 1997-04-22 Syntex (U.S.A.) Inc. Pyrrole pyridazine and pyridazinone anti-inflammatory agents

Also Published As

Publication number Publication date
CA2205757C (en) 2006-01-24
ATE229007T1 (de) 2002-12-15
CN1169426A (zh) 1998-01-07
EP0810218A1 (en) 1997-12-03
CA2205757A1 (en) 1997-11-30
DK0810218T3 (da) 2003-03-24
US5886178A (en) 1999-03-23
EP0810218B1 (en) 2002-12-04
AR008377A1 (es) 2000-01-19
BR9703332A (pt) 1998-09-22
DE69717537T2 (de) 2003-11-06
CN1136197C (zh) 2004-01-28
PT810218E (pt) 2003-03-31
DE69717537D1 (de) 2003-01-16
JPH1045723A (ja) 1998-02-17
ES2186821T3 (es) 2003-05-16
JP2790450B2 (ja) 1998-08-27

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