DE69717537D1 - 6-Benzyl-2H-pyridazin-3-on Derivate,deren Herstellung und deren Verwendung als Inhibitoren der Prostaglandin G/H Synthase I and II (COX I and COX II) - Google Patents
6-Benzyl-2H-pyridazin-3-on Derivate,deren Herstellung und deren Verwendung als Inhibitoren der Prostaglandin G/H Synthase I and II (COX I and COX II)Info
- Publication number
- DE69717537D1 DE69717537D1 DE69717537T DE69717537T DE69717537D1 DE 69717537 D1 DE69717537 D1 DE 69717537D1 DE 69717537 T DE69717537 T DE 69717537T DE 69717537 T DE69717537 T DE 69717537T DE 69717537 D1 DE69717537 D1 DE 69717537D1
- Authority
- DE
- Germany
- Prior art keywords
- cox
- pyridazin
- prostaglandin
- synthase
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/14—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1867296P | 1996-05-30 | 1996-05-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69717537D1 true DE69717537D1 (de) | 2003-01-16 |
DE69717537T2 DE69717537T2 (de) | 2003-11-06 |
Family
ID=21789188
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69717537T Expired - Fee Related DE69717537T2 (de) | 1996-05-30 | 1997-05-22 | 6-Benzyl-2H-pyridazin-3-on Derivate,deren Herstellung und deren Verwendung als Inhibitoren der Prostaglandin G/H Synthase I and II (COX I and COX II) |
Country Status (13)
Country | Link |
---|---|
US (1) | US5886178A (de) |
EP (1) | EP0810218B1 (de) |
JP (1) | JP2790450B2 (de) |
CN (1) | CN1136197C (de) |
AR (1) | AR008377A1 (de) |
AT (1) | ATE229007T1 (de) |
BR (1) | BR9703332A (de) |
CA (1) | CA2205757C (de) |
DE (1) | DE69717537T2 (de) |
DK (1) | DK0810218T3 (de) |
ES (1) | ES2186821T3 (de) |
PT (1) | PT810218E (de) |
TR (1) | TR199700419A2 (de) |
Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999029732A2 (en) | 1997-12-08 | 1999-06-17 | Lexigen Pharmaceuticals Corporation | Heterodimeric fusion proteins useful for targeted immune therapy and general immune stimulation |
US20030105294A1 (en) * | 1998-02-25 | 2003-06-05 | Stephen Gillies | Enhancing the circulating half life of antibody-based fusion proteins |
DE69931908T2 (de) * | 1998-04-15 | 2007-01-11 | Lexigen Pharmaceuticals Corp., Lexington | Steigerung der antikörper-zytokin-fusionsproteinmediierten immunantwort durch mitverabreichung mit einem angiogeneseinhibitor |
MXPA01012494A (es) | 1999-06-01 | 2002-07-02 | Univ Texas Southwestern Med Ct | Metodo para tratar perdida capilar con el uso de compuestos sulfonil tiromimeticos. |
US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
US7067110B1 (en) | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
SK782002A3 (en) | 1999-07-21 | 2003-08-05 | Lexigen Pharm Corp | FC fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
MXPA02001417A (es) * | 1999-08-09 | 2002-08-12 | Lexigen Pharm Corp | Complejos multiples de citosina-anticuerpo. |
JP2003514552A (ja) | 1999-11-12 | 2003-04-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | 改善された性質を有するエリトロポエチンの形態 |
EP1252192B1 (de) | 2000-02-11 | 2006-08-16 | MERCK PATENT GmbH | Steigerung der zirkulierenden halbwertzeit von auf antikörpern basierenden fusionsproteinen |
RU2272644C2 (ru) * | 2000-06-29 | 2006-03-27 | Мерк Патент Гмбх | Усиление иммунной реакции, медиатором которой является слитый протеин антитело-цитокин, при помощи комбинированного лечения агентами, увеличивающими поглощение иммуноцитокина |
US7151102B2 (en) * | 2000-10-30 | 2006-12-19 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
DK1366067T3 (da) * | 2001-03-07 | 2012-10-22 | Merck Patent Gmbh | Ekspressionsteknologi for proteiner indeholdende en hybrid isotype-antistof-enhed |
US6992174B2 (en) * | 2001-03-30 | 2006-01-31 | Emd Lexigen Research Center Corp. | Reducing the immunogenicity of fusion proteins |
BR0209177A (pt) * | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Anticorpo especìfico a tumor recombinante e uso do mesmo |
PT1454138E (pt) * | 2001-12-04 | 2012-03-28 | Merck Patent Gmbh | Imunocitoquinas com seletividade modulada |
US7196085B2 (en) * | 2002-04-30 | 2007-03-27 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
CA2510180C (en) * | 2002-12-17 | 2012-09-11 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Humanized antibody (h14.18) of the mouse 14.18 antibody binding to gd2 and its fusion with il-2 |
GB0305681D0 (en) | 2003-03-12 | 2003-04-16 | Kudos Pharm Ltd | Phthalazinone derivatives |
US7449464B2 (en) * | 2003-03-12 | 2008-11-11 | Kudos Pharmaceuticals Limited | Phthalazinone derivatives |
WO2004085406A1 (en) | 2003-03-24 | 2004-10-07 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
CN1934092A (zh) * | 2004-03-23 | 2007-03-21 | 弗·哈夫曼-拉罗切有限公司 | 非核苷逆转录酶抑制剂 |
CN1942449A (zh) * | 2004-04-15 | 2007-04-04 | 弗·哈夫曼-拉罗切有限公司 | 制备哒嗪酮化合物的方法 |
GB0419072D0 (en) * | 2004-08-26 | 2004-09-29 | Kudos Pharm Ltd | Phthalazinone derivatives |
CA2577191A1 (en) * | 2004-08-26 | 2006-03-02 | Kudos Pharmaceuticals Limited | 4-heteroarylmethyl substituted phthalazinone derivatives |
GB0428111D0 (en) * | 2004-12-22 | 2005-01-26 | Kudos Pharm Ltd | Pthalazinone derivatives |
AU2006298853A1 (en) * | 2005-09-30 | 2007-04-12 | F. Hoffmann-La Roche Ag | NNRT inhibitors |
GB0521373D0 (en) | 2005-10-20 | 2005-11-30 | Kudos Pharm Ltd | Pthalazinone derivatives |
GB0610680D0 (en) | 2006-05-31 | 2006-07-12 | Istituto Di Ricerche D Biolog | Therapeutic compounds |
WO2007144652A2 (en) * | 2006-06-15 | 2007-12-21 | Kudos Pharmaceuticals Limited | Parp inhibitors |
CN101484421A (zh) * | 2006-06-15 | 2009-07-15 | 库多斯药物有限公司 | 作为parp抑制剂的2-氧基苯甲酰胺衍生物 |
EP2041110A1 (de) * | 2006-06-15 | 2009-04-01 | Kudos Pharmaceuticals Limited | 2-oxyheteroarylamidderivate als parp-inhibitoren |
US20080280910A1 (en) * | 2007-03-22 | 2008-11-13 | Keith Allan Menear | Phthalazinone derivatives |
TW200900396A (en) * | 2007-04-10 | 2009-01-01 | Kudos Pharm Ltd | Phthalazinone derivatives |
US20090023727A1 (en) * | 2007-07-05 | 2009-01-22 | Muhammad Hashim Javaid | Phthalazinone derivatives |
AU2008299721A1 (en) | 2007-09-14 | 2009-03-19 | Astrazeneca Ab | Phthalazinone derivatives |
KR101598231B1 (ko) * | 2007-10-17 | 2016-02-26 | 쿠도스 파마슈티칼스 리미티드 | 4-[3-(4-시클로프로판카르보닐-피페라진-1-카르보닐)-4-플루오로-벤질]-2h-프탈라진-1-온 |
MX2010005070A (es) | 2007-11-15 | 2010-05-24 | Angeletti P Ist Richerche Bio | Derivados de piridazinona como inhibidores de parp. |
UY31603A1 (es) | 2008-01-23 | 2009-08-31 | Derivados de ftalazinona | |
HUE030800T2 (en) * | 2008-10-07 | 2017-05-29 | Astrazeneca Uk Ltd | Pharmaceutical Form No. 514 |
UY32790A (es) * | 2009-07-15 | 2011-02-28 | Astrazeneca Ab | Compuesto de ftalazinona |
GB201219820D0 (en) | 2012-11-05 | 2012-12-19 | Isis Innovation | Compounds |
ES2544869B2 (es) * | 2014-03-04 | 2016-01-18 | Universidade De Vigo | Derivados de piridazin-3(2H)-ona inhibidores selectivos de la isoforma B de la monoaminooxidasa |
CN106146404B (zh) * | 2015-04-15 | 2020-03-20 | 江苏恩华药业股份有限公司 | 哒嗪酮类衍生物及其应用 |
DK3423440T3 (da) * | 2016-03-04 | 2021-03-15 | Otsuka Pharma Co Ltd | 5-methyl-6-phenyl-4,5-dihydro-2h-pyridazin-3-on-derivat til behandlingen af hjernetumorer |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3752826A (en) * | 1970-01-26 | 1973-08-14 | Mcneilab Inc | Aroyl substituted pyrroles |
US4599332A (en) * | 1983-12-07 | 1986-07-08 | Warner-Lambert Company | 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)-pyridazinones and related compounds |
IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
US5622948A (en) * | 1994-12-01 | 1997-04-22 | Syntex (U.S.A.) Inc. | Pyrrole pyridazine and pyridazinone anti-inflammatory agents |
-
1997
- 1997-05-21 CA CA002205757A patent/CA2205757C/en not_active Expired - Fee Related
- 1997-05-21 CN CNB97111479XA patent/CN1136197C/zh not_active Expired - Fee Related
- 1997-05-22 EP EP97108260A patent/EP0810218B1/de not_active Expired - Lifetime
- 1997-05-22 DE DE69717537T patent/DE69717537T2/de not_active Expired - Fee Related
- 1997-05-22 AT AT97108260T patent/ATE229007T1/de not_active IP Right Cessation
- 1997-05-22 PT PT97108260T patent/PT810218E/pt unknown
- 1997-05-22 DK DK97108260T patent/DK0810218T3/da active
- 1997-05-22 ES ES97108260T patent/ES2186821T3/es not_active Expired - Lifetime
- 1997-05-23 TR TR97/00419A patent/TR199700419A2/xx unknown
- 1997-05-26 JP JP9134941A patent/JP2790450B2/ja not_active Expired - Fee Related
- 1997-05-28 US US08/864,708 patent/US5886178A/en not_active Expired - Fee Related
- 1997-05-29 AR ARP970102293A patent/AR008377A1/es unknown
- 1997-05-30 BR BR9703332A patent/BR9703332A/pt not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
ATE229007T1 (de) | 2002-12-15 |
US5886178A (en) | 1999-03-23 |
TR199700419A2 (xx) | 1997-12-21 |
CA2205757C (en) | 2006-01-24 |
CN1136197C (zh) | 2004-01-28 |
ES2186821T3 (es) | 2003-05-16 |
EP0810218A1 (de) | 1997-12-03 |
BR9703332A (pt) | 1998-09-22 |
JP2790450B2 (ja) | 1998-08-27 |
DE69717537T2 (de) | 2003-11-06 |
EP0810218B1 (de) | 2002-12-04 |
PT810218E (pt) | 2003-03-31 |
JPH1045723A (ja) | 1998-02-17 |
AR008377A1 (es) | 2000-01-19 |
CN1169426A (zh) | 1998-01-07 |
DK0810218T3 (da) | 2003-03-24 |
CA2205757A1 (en) | 1997-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69717537D1 (de) | 6-Benzyl-2H-pyridazin-3-on Derivate,deren Herstellung und deren Verwendung als Inhibitoren der Prostaglandin G/H Synthase I and II (COX I and COX II) | |
DE69833223D1 (de) | 4-aminothiazol derivate, deren herstellung und deren verwendung als inhibitoren cyclin-abhängiger kinasen | |
DE69718351T2 (de) | Diaminobenzoesäure derivate als farbstoffvorläufer | |
ATE421954T1 (de) | Heteroaryl-hexansäureamid-derivate, ihre herstellung und ihre verwendung als selektive inhibitoren der bindung von mip-1-alpha an seinen ccr1 rezeptor | |
ATE323700T1 (de) | Tetrahydropyridinderivate, deren herstellung und deren verwendung als inhibitoren der zellproliferation | |
DE59913617D1 (de) | Indolderivate und deren Verwendung als Inhibitoren der Phosphodiesterase 4. | |
DE69838829D1 (de) | N-Phenyl-alkylsulfonamid-Derivate, deren Herstellung und deren Verwendung als alpha1A/1L-Adrenoceptor Agonisten | |
DE69719193T2 (de) | Substituierte pyrido- oder pyrimidogruppen enthaltende 6,6- oder 6,7-bicyclische derivate | |
ATE224910T1 (de) | Derivate von dolestatin, deren herstellung und verwendung | |
DE69723446D1 (de) | Oxindole derivate | |
ATE245649T1 (de) | 2,3-diaryl-pyrazolo(1,5-b)pyridazin derivate, deren herstellung und deren verwendung als cyclooxygenase 2 (cox-2) inhibitoren | |
AR010062A1 (es) | Nuevos benzamidaldehidos y su utilizacion | |
DE69805334T2 (de) | Derivate des vitamin e | |
ATE229034T1 (de) | 3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen | |
ATE212346T1 (de) | 3-substituierte tetrahydropyridopyrimidinon- derivate, ihre herstellung und verwendung | |
DE69802692D1 (de) | Derivate der chinoloncarbonsäure | |
NO990913D0 (no) | Naftylforbindelser, intermediater, sammensetninger og metoder for anvendelse | |
ATE224382T1 (de) | Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten | |
ATE237614T1 (de) | Benzo(c)chinolizin derivate,deren herstellung und verwendung als 5-alfa-reduktase inhibitoren | |
ATE249451T1 (de) | Benzofuranderivate, ihre herstellung und verwendung | |
EE9900116A (et) | Pentaerütriidi uued derivaadid, nende valmistamine, kasutamine ja vaheühendid nende sünteesiks | |
EE9900568A (et) | Pentaerütriidi uued derivaadid, nende valmistamine, kasutamine ja vaheühendid nende sünteesiks | |
ATE218138T1 (de) | N-substituierte azabicycloheptan-derivate, ihre herstellung und verwendung | |
DE59914948D1 (de) | Verwendung von 1-(aminoalkyl)-3-chinoxalin-2-on-derivaten zur herstellung von als antioxidantien wirkenden zusammensetzungen | |
DE59706478D1 (de) | Chromanyl-ascorbinsäurederivate, deren Herstellung und Verwendung |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |