ATE224382T1 - Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten - Google Patents

Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten

Info

Publication number
ATE224382T1
ATE224382T1 AT96942010T AT96942010T ATE224382T1 AT E224382 T1 ATE224382 T1 AT E224382T1 AT 96942010 T AT96942010 T AT 96942010T AT 96942010 T AT96942010 T AT 96942010T AT E224382 T1 ATE224382 T1 AT E224382T1
Authority
AT
Austria
Prior art keywords
hiv
thiophencarbothioamide
mutants
furan
replication
Prior art date
Application number
AT96942010T
Other languages
English (en)
Inventor
Walter Gerhard Brouwer
Ewa Maria Osika
Benjamin James Pierce
Original Assignee
Uniroyal Chem Co Inc
Crompton Co Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Chem Co Inc, Crompton Co Cie filed Critical Uniroyal Chem Co Inc
Application granted granted Critical
Publication of ATE224382T1 publication Critical patent/ATE224382T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
AT96942010T 1995-11-30 1996-11-15 Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten ATE224382T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/565,493 US5696151A (en) 1995-11-30 1995-11-30 Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants
PCT/US1996/018394 WO1997019940A1 (en) 1995-11-30 1996-11-15 Furan- and thiophenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of hiv-1 and hiv-1 mutants

Publications (1)

Publication Number Publication Date
ATE224382T1 true ATE224382T1 (de) 2002-10-15

Family

ID=24258853

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96942010T ATE224382T1 (de) 1995-11-30 1996-11-15 Furan- und thiophencarbothioamid derivate, deren herstellung und deren verwendung als inhibitoren der replikation von hiv-1 und hiv-1 mutanten

Country Status (21)

Country Link
US (1) US5696151A (de)
EP (1) EP0874839B1 (de)
JP (1) JP3027771B2 (de)
KR (1) KR100505841B1 (de)
CN (1) CN1098847C (de)
AP (1) AP902A (de)
AT (1) ATE224382T1 (de)
AU (1) AU704086B2 (de)
BR (1) BR9611838A (de)
CA (1) CA2237194C (de)
DE (1) DE69623819T2 (de)
DK (1) DK0874839T3 (de)
ES (1) ES2183986T3 (de)
HK (1) HK1016601A1 (de)
HU (1) HU223660B1 (de)
NZ (1) NZ324118A (de)
OA (1) OA10864A (de)
PT (1) PT874839E (de)
TW (1) TW448169B (de)
WO (1) WO1997019940A1 (de)
ZA (1) ZA969490B (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143780A (en) * 1999-09-17 2000-11-07 Uniroyal Chemical Company, Inc. N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
US6017947A (en) * 1999-09-17 2000-01-25 Brouwer; Walter Gerhard Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV
US6498254B1 (en) * 2001-10-29 2002-12-24 Uniroyal Chemical Company, Inc. Antiretroviral compounds and compositions
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) * 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
US10246420B2 (en) 2014-07-24 2019-04-02 Bayer Cropscience Aktiengesellschaft Pyrazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268389A (en) * 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases

Also Published As

Publication number Publication date
HK1016601A1 (en) 1999-11-05
DK0874839T3 (da) 2003-01-27
ES2183986T3 (es) 2003-04-01
JPH11504657A (ja) 1999-04-27
HUP9901990A3 (en) 2000-08-28
AU704086B2 (en) 1999-04-15
HUP9901990A2 (en) 2000-07-28
CN1098847C (zh) 2003-01-15
CN1203596A (zh) 1998-12-30
KR100505841B1 (ko) 2005-12-14
NZ324118A (en) 1999-02-25
JP3027771B2 (ja) 2000-04-04
US5696151A (en) 1997-12-09
WO1997019940A1 (en) 1997-06-05
DE69623819T2 (de) 2003-05-28
CA2237194C (en) 2006-06-13
BR9611838A (pt) 1999-03-09
DE69623819D1 (de) 2002-10-24
KR19990071682A (ko) 1999-09-27
CA2237194A1 (en) 1997-06-05
EP0874839A1 (de) 1998-11-04
HU223660B1 (hu) 2004-11-29
TW448169B (en) 2001-08-01
EP0874839B1 (de) 2002-09-18
AP902A (en) 2000-11-23
OA10864A (en) 2003-02-18
ZA969490B (en) 1997-06-02
PT874839E (pt) 2003-02-28
AU1119997A (en) 1997-06-19
AP9801245A0 (en) 1998-06-30

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