ES2183986T3 - Derivados de furano- y tiofeno-carbotioamida, su preparacion y su uso como inhibidores de la replicacion de hiv-1 y mutantes de hiv-1. - Google Patents

Derivados de furano- y tiofeno-carbotioamida, su preparacion y su uso como inhibidores de la replicacion de hiv-1 y mutantes de hiv-1.

Info

Publication number
ES2183986T3
ES2183986T3 ES96942010T ES96942010T ES2183986T3 ES 2183986 T3 ES2183986 T3 ES 2183986T3 ES 96942010 T ES96942010 T ES 96942010T ES 96942010 T ES96942010 T ES 96942010T ES 2183986 T3 ES2183986 T3 ES 2183986T3
Authority
ES
Spain
Prior art keywords
hiv
mutants
replication
carbotioamide
furano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96942010T
Other languages
English (en)
Inventor
Walter Gerhard Brouwer
Ewa Maria Osika
Benjamin James Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lanxess Canada Co
Uniroyal Chemical Co Inc
Original Assignee
Crompton Co
Uniroyal Chemical Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crompton Co, Uniroyal Chemical Co Inc filed Critical Crompton Co
Application granted granted Critical
Publication of ES2183986T3 publication Critical patent/ES2183986T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

COMPUESTOS DE FORMULA (I), EN DONDE X ES O O S. LOS COMPUESTOS DE ESTA INVENCION SON UTILES PARA LA INHIBICION DE LA REPLICACION DE LOS MUTANTES Y DE LA TRANSCRIPTASA INVERSA (RT) DEL VIRUS DE LA INMUNODEFICIENCIA HUMANA (HIV-1), IN VITRO E IN VIVO. LOS COMPUESTOS SON UTILES EN EL TRATAMIENTO TERAPEUTICO O PREVENTIVO DE ENFERMEDADES CAUSADAS POR MUTANTES DE HIV-1 Y RT, TAL COMO SINDROME DE INMUNODEFICIENCIA ADQUIRIDA (SIDA).
ES96942010T 1995-11-30 1996-11-15 Derivados de furano- y tiofeno-carbotioamida, su preparacion y su uso como inhibidores de la replicacion de hiv-1 y mutantes de hiv-1. Expired - Lifetime ES2183986T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/565,493 US5696151A (en) 1995-11-30 1995-11-30 Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants

Publications (1)

Publication Number Publication Date
ES2183986T3 true ES2183986T3 (es) 2003-04-01

Family

ID=24258853

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96942010T Expired - Lifetime ES2183986T3 (es) 1995-11-30 1996-11-15 Derivados de furano- y tiofeno-carbotioamida, su preparacion y su uso como inhibidores de la replicacion de hiv-1 y mutantes de hiv-1.

Country Status (21)

Country Link
US (1) US5696151A (es)
EP (1) EP0874839B1 (es)
JP (1) JP3027771B2 (es)
KR (1) KR100505841B1 (es)
CN (1) CN1098847C (es)
AP (1) AP902A (es)
AT (1) ATE224382T1 (es)
AU (1) AU704086B2 (es)
BR (1) BR9611838A (es)
CA (1) CA2237194C (es)
DE (1) DE69623819T2 (es)
DK (1) DK0874839T3 (es)
ES (1) ES2183986T3 (es)
HK (1) HK1016601A1 (es)
HU (1) HU223660B1 (es)
NZ (1) NZ324118A (es)
OA (1) OA10864A (es)
PT (1) PT874839E (es)
TW (1) TW448169B (es)
WO (1) WO1997019940A1 (es)
ZA (1) ZA969490B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143780A (en) * 1999-09-17 2000-11-07 Uniroyal Chemical Company, Inc. N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
US6017947A (en) * 1999-09-17 2000-01-25 Brouwer; Walter Gerhard Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV
US6498254B1 (en) * 2001-10-29 2002-12-24 Uniroyal Chemical Company, Inc. Antiretroviral compounds and compositions
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) * 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
CN106715401A (zh) 2014-07-24 2017-05-24 拜耳作物科学股份公司 杀真菌的吡唑衍生物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5268389A (en) * 1989-10-16 1993-12-07 Uniroyal Chemical Company, Inc. Thiocarboxylate ester compounds compositions containing the same
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases

Also Published As

Publication number Publication date
JP3027771B2 (ja) 2000-04-04
EP0874839B1 (en) 2002-09-18
OA10864A (en) 2003-02-18
KR100505841B1 (ko) 2005-12-14
DE69623819D1 (de) 2002-10-24
TW448169B (en) 2001-08-01
PT874839E (pt) 2003-02-28
KR19990071682A (ko) 1999-09-27
CA2237194C (en) 2006-06-13
DE69623819T2 (de) 2003-05-28
WO1997019940A1 (en) 1997-06-05
JPH11504657A (ja) 1999-04-27
US5696151A (en) 1997-12-09
AU1119997A (en) 1997-06-19
AP902A (en) 2000-11-23
AP9801245A0 (en) 1998-06-30
CN1098847C (zh) 2003-01-15
EP0874839A1 (en) 1998-11-04
ATE224382T1 (de) 2002-10-15
CA2237194A1 (en) 1997-06-05
ZA969490B (en) 1997-06-02
HU223660B1 (hu) 2004-11-29
HK1016601A1 (en) 1999-11-05
DK0874839T3 (da) 2003-01-27
AU704086B2 (en) 1999-04-15
BR9611838A (pt) 1999-03-09
HUP9901990A2 (en) 2000-07-28
CN1203596A (zh) 1998-12-30
HUP9901990A3 (en) 2000-08-28
NZ324118A (en) 1999-02-25

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