AP902A - Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants - Google Patents

Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants Download PDF

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Publication number
AP902A
AP902A APAP/P/1998/001245A AP9801245A AP902A AP 902 A AP902 A AP 902A AP 9801245 A AP9801245 A AP 9801245A AP 902 A AP902 A AP 902A
Authority
AP
ARIPO
Prior art keywords
hiv
methyl
compound
reaction mixture
recited
Prior art date
Application number
APAP/P/1998/001245A
Other languages
English (en)
Other versions
AP9801245A0 (en
Inventor
Walter Gerhard Brouwer
Ewa Maria Osika
Benjamin James Pierce
Original Assignee
Uniroyal Chem Co Inc
Uniroyal Chemical Co /Uniroyal Chemical Cie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Chem Co Inc, Uniroyal Chemical Co /Uniroyal Chemical Cie filed Critical Uniroyal Chem Co Inc
Publication of AP9801245A0 publication Critical patent/AP9801245A0/xx
Application granted granted Critical
Publication of AP902A publication Critical patent/AP902A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
APAP/P/1998/001245A 1995-11-30 1996-11-15 Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants AP902A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/565,493 US5696151A (en) 1995-11-30 1995-11-30 Compounds useful for the inhibition of the replication of HIV-1 and HIV-1 mutants
PCT/US1996/018394 WO1997019940A1 (en) 1995-11-30 1996-11-15 Furan- and thiophenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of hiv-1 and hiv-1 mutants

Publications (2)

Publication Number Publication Date
AP9801245A0 AP9801245A0 (en) 1998-06-30
AP902A true AP902A (en) 2000-11-23

Family

ID=24258853

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1998/001245A AP902A (en) 1995-11-30 1996-11-15 Furan and thiophenenecarbothioamide derivatives, their preparation and their use as inhibitors of the replication of HIV-1 and HIV-1 mutants

Country Status (21)

Country Link
US (1) US5696151A (es)
EP (1) EP0874839B1 (es)
JP (1) JP3027771B2 (es)
KR (1) KR100505841B1 (es)
CN (1) CN1098847C (es)
AP (1) AP902A (es)
AT (1) ATE224382T1 (es)
AU (1) AU704086B2 (es)
BR (1) BR9611838A (es)
CA (1) CA2237194C (es)
DE (1) DE69623819T2 (es)
DK (1) DK0874839T3 (es)
ES (1) ES2183986T3 (es)
HK (1) HK1016601A1 (es)
HU (1) HU223660B1 (es)
NZ (1) NZ324118A (es)
OA (1) OA10864A (es)
PT (1) PT874839E (es)
TW (1) TW448169B (es)
WO (1) WO1997019940A1 (es)
ZA (1) ZA969490B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6143780A (en) * 1999-09-17 2000-11-07 Uniroyal Chemical Company, Inc. N-arylmethylthioanilide compounds useful for the inhibition of the replication of HIV
US6017947A (en) * 1999-09-17 2000-01-25 Brouwer; Walter Gerhard Heterocyclic carbodithioperoxyimidic compounds useful for the inhibition of the replication of HIV
US6498254B1 (en) * 2001-10-29 2002-12-24 Uniroyal Chemical Company, Inc. Antiretroviral compounds and compositions
US7064139B2 (en) * 2001-10-29 2006-06-20 Uniroyal Chemical Company, Inc. Method for treating retroviral infections
DE102008015032A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte Pyrazolamide und ihre Verwendung
DE102008015033A1 (de) 2008-03-17 2009-09-24 Aicuris Gmbh & Co. Kg Substituierte (Pyrazolyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062863A1 (de) 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte (Thiophenyl-carbonyl)imidazolidinone und ihre Verwendung
DE102008062878A1 (de) * 2008-12-17 2010-06-24 Aicuris Gmbh & Co. Kg Substituierte Furancarboxamide und ihre Verwendung
CN101987842A (zh) * 2009-07-31 2011-03-23 上海开拓者医药发展有限公司 一种2-甲基噻吩衍生物的制备方法
CN106715401A (zh) 2014-07-24 2017-05-24 拜耳作物科学股份公司 杀真菌的吡唑衍生物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005761A1 (en) * 1989-10-16 1991-05-02 Uniroyal Chemical Ltd./Uniroyal Chemical Ltee Treatment of hiv infections and compounds useful therein

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5968910A (en) * 1994-11-30 1999-10-19 Jan M. R. Balzarini Compositions containing two or three inhibitors of different HIV reverse transcriptases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991005761A1 (en) * 1989-10-16 1991-05-02 Uniroyal Chemical Ltd./Uniroyal Chemical Ltee Treatment of hiv infections and compounds useful therein

Also Published As

Publication number Publication date
JP3027771B2 (ja) 2000-04-04
EP0874839B1 (en) 2002-09-18
OA10864A (en) 2003-02-18
KR100505841B1 (ko) 2005-12-14
DE69623819D1 (de) 2002-10-24
TW448169B (en) 2001-08-01
PT874839E (pt) 2003-02-28
KR19990071682A (ko) 1999-09-27
CA2237194C (en) 2006-06-13
ES2183986T3 (es) 2003-04-01
DE69623819T2 (de) 2003-05-28
WO1997019940A1 (en) 1997-06-05
JPH11504657A (ja) 1999-04-27
US5696151A (en) 1997-12-09
AU1119997A (en) 1997-06-19
AP9801245A0 (en) 1998-06-30
CN1098847C (zh) 2003-01-15
EP0874839A1 (en) 1998-11-04
ATE224382T1 (de) 2002-10-15
CA2237194A1 (en) 1997-06-05
ZA969490B (en) 1997-06-02
HU223660B1 (hu) 2004-11-29
HK1016601A1 (en) 1999-11-05
DK0874839T3 (da) 2003-01-27
AU704086B2 (en) 1999-04-15
BR9611838A (pt) 1999-03-09
HUP9901990A2 (en) 2000-07-28
CN1203596A (zh) 1998-12-30
HUP9901990A3 (en) 2000-08-28
NZ324118A (en) 1999-02-25

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