ES2178291T3 - Uso de acidos 3-benzoil-aceticos, esteres, o amidas para el tratamiento del glaucoma glc1a. - Google Patents
Uso de acidos 3-benzoil-aceticos, esteres, o amidas para el tratamiento del glaucoma glc1a.Info
- Publication number
- ES2178291T3 ES2178291T3 ES98960732T ES98960732T ES2178291T3 ES 2178291 T3 ES2178291 T3 ES 2178291T3 ES 98960732 T ES98960732 T ES 98960732T ES 98960732 T ES98960732 T ES 98960732T ES 2178291 T3 ES2178291 T3 ES 2178291T3
- Authority
- ES
- Spain
- Prior art keywords
- glaucoma
- treatment
- glcuca
- amidas
- benzoil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Uso de un compuesto de estructura: R=H, alquilo ramificado o no ramificado con 1 a 4 átomos de carbono, CF3 o SR4 Y = OR¿ o NR¿¿R¿ R¿=H excepto cuando Y = OR¿, alquilo ramificado o no ramificado con 1 a 10 átomos de carbono; arilo substituido o no substituido, definiéndose el substituido como X mas adelante; heterociclo substituido o no substituido, definiéndose el substituido como X mas adelante; o -(CH2)nZ(CH2)n1A n = 2-6 n1 = 1-6 Z=nada, O, C=O, OC(=O), C(=O)O, C(=O)NR3, NR3 C(=O), S(O)n2, CHOR3 o NR3 n2 = 0-2 R3=H, alquilo ramificado o no ramificado con 1 a 6 átomos de carbono, arilo substituido o no substituido, definiéndose el substituido como X mas adelante, o heterociclo substituido o no substituido, definiéndose el substituido como X mas adelante. A = H, OH, arilo substituido o no substituido, definiéndose el substituido como X mas adelante, heterociclo substituido o no substituido definiéndose el substituido como X mas adelante, o -(CH2)nOR3 R¿¿ =H, OH o OR¿ X y X¿ independientemente =H, F, Cl, Br, I, OR¿, CN, OH, S(O)n2R4, CF3, R4 o NO2 R4 =alquilo ramificado o no ramificado con 1 a 6 átomos de carbono. m=0-3 m¿=0-5 W=O o H, en la fabricación de un medicamento para el tratamiento de glaucoma GLC1A.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/994,903 US6066671A (en) | 1997-12-19 | 1997-12-19 | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2178291T3 true ES2178291T3 (es) | 2002-12-16 |
Family
ID=25541199
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES98960732T Expired - Lifetime ES2178291T3 (es) | 1997-12-19 | 1998-12-04 | Uso de acidos 3-benzoil-aceticos, esteres, o amidas para el tratamiento del glaucoma glc1a. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US6066671A (es) |
| EP (1) | EP1039895B1 (es) |
| JP (1) | JP2001526218A (es) |
| AT (1) | ATE218336T1 (es) |
| AU (1) | AU746075C (es) |
| BR (1) | BR9813767A (es) |
| CA (1) | CA2313386A1 (es) |
| DE (1) | DE69805846T2 (es) |
| DK (1) | DK1039895T3 (es) |
| ES (1) | ES2178291T3 (es) |
| HK (1) | HK1027748A1 (es) |
| PT (1) | PT1039895E (es) |
| WO (1) | WO1999032104A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7138511B1 (en) | 1997-01-28 | 2006-11-21 | The Regents Of The University Of California | Nucleic acids, kits and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
| US6475724B1 (en) * | 1997-01-28 | 2002-11-05 | The Regents Of The University Of California | Nucleic acids, kits, and methods for the diagnosis, prognosis and treatment of glaucoma and related disorders |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6416777B1 (en) * | 1999-10-21 | 2002-07-09 | Alcon Universal Ltd. | Ophthalmic drug delivery device |
| US7943162B2 (en) | 1999-10-21 | 2011-05-17 | Alcon, Inc. | Drug delivery device |
| ES2231257T3 (es) | 1999-10-21 | 2005-05-16 | Alcon Inc. | Dispositivo para la administracion de farmacos. |
| AR030345A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes relacionados con angiogenesis |
| AR030346A1 (es) * | 2000-08-14 | 2003-08-20 | Alcon Inc | Metodo de tratamiento de desordenes neurodegenerativos de la retina y cabeza de nervio optico |
| PT1409065E (pt) | 2001-07-23 | 2007-03-30 | Alcon Inc | Dispositivo de administração de fármacos oftálmicos |
| MXPA03011610A (es) | 2001-07-23 | 2004-07-01 | Alcon Inc | Dispositivo para la administracion de farmacos oftalmicos. |
| US20040132773A1 (en) * | 2001-08-13 | 2004-07-08 | Gamache Daniel A | Method of treating neurodgenerative disorders of the retina and optic nerve head |
| US20030119000A1 (en) * | 2001-11-05 | 2003-06-26 | Jon Polansky | Methods to screen and treat individuals with glaucoma or the propensity to develop glaucoma |
| AU2003231730A1 (en) * | 2002-05-03 | 2003-11-17 | Alcon, Inc. | Method of treating vascular endothelial growth factor mediated vascular disorders using amfenac or nepafenac |
| US6864282B2 (en) | 2002-08-05 | 2005-03-08 | Allergan, Inc. | 9,11-cycloendoperoxide pro-drugs of prostaglandin analogues for treatment of ocular hypertension and glaucoma |
| US8129431B2 (en) * | 2003-01-21 | 2012-03-06 | Senju Pharmaceutical Co., Ltd. | Aqueous liquid preparation containing 2-amino-3-(4-bromobenzoyl)phenylacetic acid |
| US20030187072A1 (en) * | 2003-02-14 | 2003-10-02 | Kapin Michael A. | Method of treating angiogenesis-related disorders |
| AR043161A1 (es) * | 2003-02-14 | 2005-07-20 | Sucampo Pharmaceuticals Inc | Composicion oftalmica para tratar hipertension ocular y glaucoma |
| AU2004263149B2 (en) * | 2003-08-07 | 2010-08-19 | Allergan, Inc. | Compositions for delivery of therapeutics into the eyes and methods for making and using same |
| ATE442146T1 (de) | 2003-11-07 | 2009-09-15 | Senju Pharma Co | Pharmazeutische zusammensetzung mit prostaglandin |
| ES2314354T3 (es) * | 2004-11-09 | 2009-03-16 | Novagali Pharma S.A. | Emulsion de tipo aceite en agua con baja concentracion de agente cationico y potencial zeta positivo. |
| TWI358290B (en) * | 2004-12-02 | 2012-02-21 | Alcon Inc | Topical nepafenac formulations |
| PL2026651T3 (pl) * | 2006-03-08 | 2013-06-28 | Cortria Corp | Terapia kombinowana za pomocą nieselektywnych inhibitorów COX dla zapobiegania uszkodzeń żołądka związanych z COX |
| US20080153818A1 (en) * | 2006-12-21 | 2008-06-26 | Bingaman David P | Methods for preventing inflammation during surgery |
| US20090105245A1 (en) * | 2006-12-21 | 2009-04-23 | Bingaman David P | Methods for treating macular edema and ocular angiogenesis using an anti-inflammatory agent and a receptor tyrosine kinase inhibitor |
| WO2008080110A1 (en) * | 2006-12-21 | 2008-07-03 | Alcon, Inc. | Methods for treating macular edema and pathologic ocular angiogenesis using a neuroprotective agent and a receptor tyrosine kinase inhibitor |
| US20100292289A1 (en) * | 2007-11-30 | 2010-11-18 | Ampla Pharmaceuticals Inc. | Treatment of metabolic syndrome with novel amides |
| EP2127638A1 (en) | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
| US8227451B2 (en) * | 2008-11-12 | 2012-07-24 | Auspex Pharmaceuticals | Phenylacetic acid inhibitors of cyclooxygenase |
| US20110293549A1 (en) | 2009-02-03 | 2011-12-01 | Athena Cosmetics, Inc. | Composition, method and kit for enhancing hair |
| EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
| EP2389939A1 (en) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
| US9630909B2 (en) | 2013-06-27 | 2017-04-25 | Mylan Laboratories Ltd | Process for the preparation of nepafenac |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA805476B (en) * | 1979-09-26 | 1981-11-25 | Robins Co Inc A H | 2-amino-3-benzoyl-phenylacetamides and cyclic homologues |
| US4683242A (en) * | 1985-10-28 | 1987-07-28 | A. H. Robins Company, Incorporated | Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters |
| US5151444B1 (en) | 1987-09-18 | 1999-07-06 | R Tech Ueno Ltd | Ocular hypotensive agents |
| US5565492A (en) | 1988-07-18 | 1996-10-15 | Alcon Laboratories, Inc. | Prostaglandin combinations in glaucoma therapy |
| ES2317964T5 (es) | 1988-09-06 | 2015-02-20 | Pfizer Health Ab | Derivado de prostaglandina-F2alfa para el tratamiento de glaucoma o hipertensión ocular |
| US5093329A (en) | 1990-03-12 | 1992-03-03 | Allergan, Inc. | Intraocular pressure reducing prostaglandin-like 7-oxabicyclo derivatives |
| US5270049A (en) | 1990-11-09 | 1993-12-14 | Allergan, Inc. | 2-decarboxyl-2-aminoalkyl-prostaglandins as ocular hypotensives |
| US5510383A (en) | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| US5721273A (en) | 1993-12-15 | 1998-02-24 | Alcon Laboratories, Inc. | Use of certain 9-halo-13,14-dihydroprostaglandins to treat glaucoma and ocular hypertension |
| US5627209A (en) | 1993-12-15 | 1997-05-06 | Alcon Laboratories, Inc. | Use of certain 9-haloprostaglandins to treat glaucoma and ocular hypertension |
| US5474985A (en) | 1993-12-22 | 1995-12-12 | The Regents Of The University Of California | Preventing and treating elevated intraocular pressure associated with administered or endogenous steroids using non-steroidal cyclooxygenase inhibitors |
| US5475034A (en) * | 1994-06-06 | 1995-12-12 | Alcon Laboratories, Inc. | Topically administrable compositions containing 3-benzoylphenylacetic acid derivatives for treatment of ophthalmic inflammatory disorders |
| US5807892A (en) | 1994-09-30 | 1998-09-15 | Alcon Laboratories, Inc. | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension |
| US5698733A (en) | 1994-09-30 | 1997-12-16 | Alcon Laboratories, Inc. | Use of 9-deoxy prostaglandin derivatives to treat glaucoma |
| AU3609795A (en) * | 1994-10-10 | 1996-05-02 | Novartis Ag | Ophthalmic and aural compositions containing diclofenac potassium |
| US5606043A (en) * | 1994-11-03 | 1997-02-25 | The Regents Of The University Of California | Methods for the diagnosis of glaucoma |
| US5607966A (en) | 1994-12-23 | 1997-03-04 | Alcon Laboratories, Inc. | Esters and amides of non-steroidal anti-inflammatory carboxylic acids which may be used as anti-oxidants, 5-lipoxygenase inhibitors and non-steroidal anti-inflammatory prodrugs |
| US5925673A (en) | 1994-12-23 | 1999-07-20 | Alcon Laboratories, Inc. | Benzofurans and benzopyrans as cytoprotective agents |
| AU7672096A (en) * | 1995-06-07 | 1998-06-03 | Alcon Laboratories, Inc. | Conformationally rigid aryl- or heteroaryl prostaglandins for use in glaucoma therapy |
| US5674888A (en) * | 1995-06-07 | 1997-10-07 | University Of California | Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division |
| US5599535A (en) | 1995-06-07 | 1997-02-04 | Regents Of The University Of California | Methods for the cyto-protection of the trabecular meshwork |
| US5750564A (en) | 1995-09-12 | 1998-05-12 | Hellberg; Mark | Anti-oxidant esters of non-steroidal anti-inflammatory agents |
| US5866602A (en) | 1995-12-22 | 1999-02-02 | Alcon Laboratories, Inc. | Keto-substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives |
| US5994397A (en) | 1995-12-22 | 1999-11-30 | Alcon Laboratories, Inc. | Substituted tetrahydrofuran analogs of prostaglandins as ocular hypotensives |
| US5814660A (en) | 1995-12-22 | 1998-09-29 | Alcon Laboratories, Inc. | 9-oxa prostaglandin analogs as ocular hypotensives |
| JP2001514628A (ja) * | 1997-03-07 | 2001-09-11 | アルコン ラボラトリーズ，インコーポレイテッド | 緑内障治療に用いるための１３−チアプロスタグランジン |
| US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| SE9803761D0 (sv) | 1998-11-04 | 1998-11-04 | Synphora Ab | Method to avoid increased iridial pigmentation during prostaglandin treatment |
-
1997
- 1997-12-19 US US08/994,903 patent/US6066671A/en not_active Expired - Lifetime
-
1998
- 1998-12-04 PT PT98960732T patent/PT1039895E/pt unknown
- 1998-12-04 BR BR9813767-0A patent/BR9813767A/pt not_active Application Discontinuation
- 1998-12-04 AT AT98960732T patent/ATE218336T1/de not_active IP Right Cessation
- 1998-12-04 DK DK98960732T patent/DK1039895T3/da active
- 1998-12-04 DE DE69805846T patent/DE69805846T2/de not_active Expired - Fee Related
- 1998-12-04 ES ES98960732T patent/ES2178291T3/es not_active Expired - Lifetime
- 1998-12-04 WO PCT/US1998/025744 patent/WO1999032104A1/en active IP Right Grant
- 1998-12-04 AU AU16259/99A patent/AU746075C/en not_active Ceased
- 1998-12-04 CA CA002313386A patent/CA2313386A1/en not_active Abandoned
- 1998-12-04 EP EP98960732A patent/EP1039895B1/en not_active Expired - Lifetime
- 1998-12-04 JP JP2000525095A patent/JP2001526218A/ja active Pending
-
2000
- 2000-05-22 US US09/575,833 patent/US6342524B1/en not_active Expired - Fee Related
- 2000-10-19 HK HK00106632A patent/HK1027748A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2313386A1 (en) | 1999-07-01 |
| PT1039895E (pt) | 2002-10-31 |
| AU746075B2 (en) | 2002-04-11 |
| DK1039895T3 (da) | 2002-09-23 |
| US6066671A (en) | 2000-05-23 |
| HK1027748A1 (en) | 2001-01-23 |
| EP1039895B1 (en) | 2002-06-05 |
| DE69805846T2 (de) | 2003-01-16 |
| EP1039895A1 (en) | 2000-10-04 |
| JP2001526218A (ja) | 2001-12-18 |
| WO1999032104A1 (en) | 1999-07-01 |
| DE69805846D1 (de) | 2002-07-11 |
| AU1625999A (en) | 1999-07-12 |
| AU746075C (en) | 2002-10-17 |
| ATE218336T1 (de) | 2002-06-15 |
| BR9813767A (pt) | 2000-10-03 |
| US6342524B1 (en) | 2002-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2178291T3 (es) | Uso de acidos 3-benzoil-aceticos, esteres, o amidas para el tratamiento del glaucoma glc1a. | |
| ES2193901T1 (es) | Derivados de prostaglandina para el tratamiento de glaucoma o hipertension ocular. | |
| DK0639563T3 (da) | Anvendelse af fluprostenolisopropylester til behandling af glaukom og okulær hypertension | |
| BRPI0418245A (pt) | nitróxi-derivados de prostaglandina | |
| MX9702349A (es) | Usos de derivado de 9-deoxi prostaglandina para tratar glaucoma. | |
| DK0695759T3 (da) | Peptapeptid-methylestere, der inhiberer human cancer | |
| ES2193337T3 (es) | Utilizacion de sales de estroncio para el tratamiento de la artrosis. | |
| BR9811099A (pt) | Inibidores de urocinase | |
| PT831826E (pt) | Composicao farmaceutica que inclui um inibidor de proteinase e um monoglicerideo | |
| AU5186799A (en) | Peptides of il-2 and derivatives thereof and their use as therapeutic agents | |
| DK0869965T3 (da) | Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler | |
| DK0912185T3 (da) | Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler | |
| HRP20030983B1 (en) | Pharmaceutical composition comprising a lipase inhibitor and a sucrose fatty acid ester | |
| DE69430538D1 (de) | 2-azylalkyl-oder arylalenyl-cyclopentanheptan-und heptensäuren, derivate und therapeutische anwendung | |
| ATE281432T1 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
| DE60016181D1 (de) | C-16 ungesätigte fp-selektive prostaglandin analoge | |
| AU687906B2 (en) | Use of certain prostaglandin analogues to treat glaucoma and ocular hypertension | |
| NO983444L (no) | Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5<alfa>-reduktaseinhibitorer | |
| SE9401087D0 (sv) | New prostaglandin derivatives for the treatment of glaucoma or ocular hypertension | |
| ITMI922657A1 (it) | Composizione terapeutica per uso rettale a base di flunisolide e/o dei relativi esteri per il trattamento di disordini intestinali a carattere infiammatorio | |
| ES2167942T3 (es) | Empleo de 2-aminotetralinas 6,7-sustituidas apropiadas para la preparacion de una composicion farmaceutica para el tratamiento terapeutico de patologias inflamatorias y/o autoinmunes. | |
| AR013138A1 (es) | Uso de derivados de azuleno como inhibidores de las metaloproteinas | |
| BR0208146A (pt) | Uso de propentofilina para controlar pressão intra-ocular |