DK0912185T3 - Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler - Google Patents

Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler

Info

Publication number
DK0912185T3
DK0912185T3 DK97921224T DK97921224T DK0912185T3 DK 0912185 T3 DK0912185 T3 DK 0912185T3 DK 97921224 T DK97921224 T DK 97921224T DK 97921224 T DK97921224 T DK 97921224T DK 0912185 T3 DK0912185 T3 DK 0912185T3
Authority
DK
Denmark
Prior art keywords
pharmaceutical compositions
compositions containing
nitrate ester
inflammatory drugs
ester derivatives
Prior art date
Application number
DK97921224T
Other languages
English (en)
Inventor
Foe S Tjoeng
Mark G Currie
Mark E Zupec
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of DK0912185T3 publication Critical patent/DK0912185T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK97921224T 1996-05-02 1997-04-28 Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler DK0912185T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/642,128 US5985862A (en) 1996-05-02 1996-05-02 Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1997/006374 WO1997040836A1 (en) 1996-05-02 1997-04-28 Novel pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs

Publications (1)

Publication Number Publication Date
DK0912185T3 true DK0912185T3 (da) 2003-08-04

Family

ID=24575322

Family Applications (1)

Application Number Title Priority Date Filing Date
DK97921224T DK0912185T3 (da) 1996-05-02 1997-04-28 Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler

Country Status (11)

Country Link
US (1) US5985862A (da)
EP (1) EP0912185B1 (da)
JP (1) JP2000509388A (da)
AT (1) ATE237334T1 (da)
AU (1) AU2732597A (da)
CA (1) CA2252876A1 (da)
DE (1) DE69720996T2 (da)
DK (1) DK0912185T3 (da)
ES (1) ES2197341T3 (da)
PT (1) PT912185E (da)
WO (1) WO1997040836A1 (da)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) * 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
AU3703900A (en) * 1999-02-24 2000-09-14 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
EP1305329B2 (en) 2000-08-05 2015-03-18 Glaxo Group Limited 6.alpha.,9.alpha.-difluoro-17.alpha.-(2-furanylcarboxyl)oxy-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4-diene-17-carbothioic acid s-fluoromethyl ester as an anti-inflammatory agent
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
EP1562975A2 (en) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US8226987B2 (en) * 2005-02-22 2012-07-24 Zoorob George K Herbal preparation to relieve inflammation and smooth muscle contraction
NZ566128A (en) * 2005-09-02 2011-03-31 Nicox Sa Nitrooxy derivatives of glucocorticoids
PT2318427E (pt) * 2008-07-31 2014-01-22 Nicox Sa Glucocorticóides ligados a ésteres de nitrato através de um grupo de ligação aromático na posição 21 e sua utilização em oftalmologia

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082574A (en) * 1965-02-12 1967-09-06 Boots Pure Drug Co Ltd Steroid esters
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
HU164115B (da) * 1971-05-07 1973-12-28
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
DE4223800A1 (de) * 1992-07-20 1994-01-27 Cassella Farbwerke Mainkur Ag Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
DE69321596T2 (de) * 1992-07-30 1999-04-22 Cal International Ltd Ester und kombinationen von einem organischen nitrat und einem salicyclat
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
WO1995009831A1 (en) * 1993-10-06 1995-04-13 Nicox S.A. Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation

Also Published As

Publication number Publication date
DE69720996T2 (de) 2004-02-05
CA2252876A1 (en) 1997-11-06
JP2000509388A (ja) 2000-07-25
US5985862A (en) 1999-11-16
PT912185E (pt) 2003-08-29
ATE237334T1 (de) 2003-05-15
EP0912185A1 (en) 1999-05-06
DE69720996D1 (de) 2003-05-22
EP0912185B1 (en) 2003-04-16
ES2197341T3 (es) 2004-01-01
WO1997040836A1 (en) 1997-11-06
AU2732597A (en) 1997-11-19

Similar Documents

Publication Publication Date Title
DK0912185T3 (da) Nye farmaceutiske sammensætninger indeholdende steroidnitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler
DK0873351T3 (da) Steroidnitrit/nitratesterderivater anvendelige som antiinflammatoriske lægemidler
BR9406979A (pt) Composto,composicão farmaceutica para tratar uma doenca inflamatória suscetivel de tratamento com um agente anti- inflamatório nao esteroidal processos para tratar uma doenca inflamatória e para preparar um composto sal famacéuticamente aceitável uso de um composto composicão farmaceutica anti-inflamatória nao esteroidal
CA2273240A1 (en) Compositions and methods for treating or preventing inflammatory diseases
WO1999062510A3 (en) Compositions comprising anti-microtubule agents for treating or preventing inflammatory diseases
ECSP941104A (es) Derivados de 2,6 diaminopurina, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
BR0112160A (pt) Agentes antiinflamatórios seletivos para glicocorticóides
WO1998056771A3 (en) Piperazine derivatives and their use as anti-inflammatory agents
DK0900233T3 (da) Steroid-nitrit- og -nitratesterderivater, der kan anvendes som antiinflammatoriske lægemidler
DE69904804D1 (de) Glucocorticoid selektive entzündungshemmende mittel
DE69710065D1 (de) Androsten-derivate
DK0929565T3 (da) Nitratestere af corticoidforbindelser og farmaceutiske anvendelser deraf
DK0869965T3 (da) Steroidnitritesterderivater anvendelige som antiinflammatoriske lægemidler
DE69919179D1 (de) Substituierte gamma-phenyl-delta-lactone und deren analoge, und ihre verwendungen
ES2221950T3 (es) Dihidrobenzofurano y compuestos relacionados utiles como agentes anti-inflamatorios.
PT1492773E (pt) Compostos de 4-(heterociclilo)-benzenossulfoximinapara o tratamento da inflamação
IE43693L (en) Androstane derivatives
MX9301157A (es) Derivados de bencimidazolona, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
IS6130A (is) Bólgueyðandi meðhöndlun fyrir bólgu tengt smit
ES2089286T3 (es) Nuevas 2-amino-5-ciano-1,4-dihidropiridinas, procedimiento para su preparacion y su uso en medicamentos.
DE69407057T2 (de) 1,3.5 (10) - estratriene derivate mit oraler wirkung
IT1256061B (it) Composizione terapeutica per uso rettale a base di flunisolide e/o deirelativi esteri per il trattamento di disordini intestinali a carattere infiammatorio
NO20001846L (no) Nye farmasøytisk aktive forbindelser, deres fremstilling og anvendelse som ECE-inhibitorer
ITMI911930A1 (it) Composizioni farmaceutiche di stereoisomeri di ossiracetam e loro impiego terapeutico.