ATE237334T1 - Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer - Google Patents

Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer

Info

Publication number
ATE237334T1
ATE237334T1 AT97921224T AT97921224T ATE237334T1 AT E237334 T1 ATE237334 T1 AT E237334T1 AT 97921224 T AT97921224 T AT 97921224T AT 97921224 T AT97921224 T AT 97921224T AT E237334 T1 ATE237334 T1 AT E237334T1
Authority
AT
Austria
Prior art keywords
pharmaceutical compositions
inflammatory
tester
new pharmaceutical
steroid
Prior art date
Application number
AT97921224T
Other languages
English (en)
Inventor
Foe S Tjoeng
Mark G Currie
Mark E Zupec
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE237334T1 publication Critical patent/ATE237334T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97921224T 1996-05-02 1997-04-28 Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer ATE237334T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/642,128 US5985862A (en) 1996-05-02 1996-05-02 Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1997/006374 WO1997040836A1 (en) 1996-05-02 1997-04-28 Novel pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs

Publications (1)

Publication Number Publication Date
ATE237334T1 true ATE237334T1 (de) 2003-05-15

Family

ID=24575322

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97921224T ATE237334T1 (de) 1996-05-02 1997-04-28 Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer

Country Status (11)

Country Link
US (1) US5985862A (de)
EP (1) EP0912185B1 (de)
JP (1) JP2000509388A (de)
AT (1) ATE237334T1 (de)
AU (1) AU2732597A (de)
CA (1) CA2252876A1 (de)
DE (1) DE69720996T2 (de)
DK (1) DK0912185T3 (de)
ES (1) ES2197341T3 (de)
PT (1) PT912185E (de)
WO (1) WO1997040836A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
WO2000049993A2 (en) * 1999-02-24 2000-08-31 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
PT1305329E (pt) 2000-08-05 2007-12-24 Glaxo Group Ltd Éster s-fluorometílico do ácido 6.alfa.,9.alfa.-difluoro- 17.alfa.-(2-furanilcarboxil)oxi-11.beta.-hidroxi-16.alfa.-metil- 3-oxo-androsta-1,4-dieno-17-carbotióico como um agente antiinflamatório
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6858596B2 (en) 2000-08-05 2005-02-22 Smithkline Beecham Corporation Formulation containing anti-inflammatory androstane derivative
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
MY137522A (en) 2001-04-30 2009-02-27 Glaxo Group Ltd Novel anti-inflammatory androstane derivatives.
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
EP1336602A1 (de) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
US20060247216A1 (en) * 2002-10-25 2006-11-02 Haj-Yehia Abdullah I Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US8226987B2 (en) * 2005-02-22 2012-07-24 Zoorob George K Herbal preparation to relieve inflammation and smooth muscle contraction
CA2621117A1 (en) * 2005-09-02 2007-03-08 Nicox S.A. Steroids nitrooxyderivatives
JP5520948B2 (ja) * 2008-07-31 2014-06-11 ニコックス エス エイ ２１位の芳香族リンカーを介して硝酸エステルに結合したグルココルチコイド類および眼科におけるそれらの使用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082573A (en) * 1965-02-12 1967-09-06 Boots Pure Drug Co Ltd Improvements in the preparation of steroid esters
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
HU164115B (de) * 1971-05-07 1973-12-28
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
DE4223800A1 (de) * 1992-07-20 1994-01-27 Cassella Farbwerke Mainkur Ag Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
ES2125342T3 (es) * 1992-07-30 1999-03-01 Cal Int Ltd Esteres y combinaciones de un nitrato organico y de un salicilato.
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
HU218923B (hu) * 1993-10-06 2000-12-28 Nicox S.A. Gyulladásgátló és/vagy fájdalomcsillapító hatású nitrát-észterek, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására

Also Published As

Publication number Publication date
DK0912185T3 (da) 2003-08-04
JP2000509388A (ja) 2000-07-25
US5985862A (en) 1999-11-16
CA2252876A1 (en) 1997-11-06
ES2197341T3 (es) 2004-01-01
WO1997040836A1 (en) 1997-11-06
DE69720996D1 (de) 2003-05-22
AU2732597A (en) 1997-11-19
PT912185E (pt) 2003-08-29
EP0912185B1 (de) 2003-04-16
EP0912185A1 (de) 1999-05-06
DE69720996T2 (de) 2004-02-05

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