ATE211135T1 - Aminocyclohexylester und ihre anwendung - Google Patents
Aminocyclohexylester und ihre anwendungInfo
- Publication number
- ATE211135T1 ATE211135T1 AT94926755T AT94926755T ATE211135T1 AT E211135 T1 ATE211135 T1 AT E211135T1 AT 94926755 T AT94926755 T AT 94926755T AT 94926755 T AT94926755 T AT 94926755T AT E211135 T1 ATE211135 T1 AT E211135T1
- Authority
- AT
- Austria
- Prior art keywords
- application
- compounds
- aminocyclohexyl ester
- compositions
- present
- Prior art date
Links
- -1 AMINOCYCLOHEXYL Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 102000004310 Ion Channels Human genes 0.000 abstract 1
- 206010003119 arrhythmia Diseases 0.000 abstract 1
- 230000006793 arrhythmia Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 150000007970 thio esters Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/24—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/30—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/20—Acenaphthenes; Hydrogenated acenaphthenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12657593A | 1993-09-24 | 1993-09-24 | |
| PCT/CA1994/000513 WO1995008544A1 (en) | 1993-09-24 | 1994-09-23 | Aminocyclohexylesters and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE211135T1 true ATE211135T1 (de) | 2002-01-15 |
Family
ID=22425575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94926755T ATE211135T1 (de) | 1993-09-24 | 1994-09-23 | Aminocyclohexylester und ihre anwendung |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US5637583A (de) |
| EP (1) | EP0720605B1 (de) |
| AT (1) | ATE211135T1 (de) |
| AU (1) | AU7650294A (de) |
| CA (1) | CA2172513C (de) |
| DE (1) | DE69429524T2 (de) |
| ES (1) | ES2170102T3 (de) |
| WO (1) | WO1995008544A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6399618B1 (en) * | 1997-07-09 | 2002-06-04 | Cardiome Pharma Corp | Compositions and methods for modulating sexual activity |
| RO121028B1 (ro) * | 1998-04-01 | 2006-11-30 | Nortran Pharmaceuticals Inc. | Compuşi aminociclohexil eteri şi utilizările acestora |
| US6150285A (en) | 1998-06-17 | 2000-11-21 | Advanced Micro Devices, Inc. | Method for simultaneous deposition and sputtering of TEOS |
| AU4981199A (en) * | 1998-07-08 | 2000-02-01 | Gregory N. Beatch | Compositions and methods for modulating sexual activity |
| AU1738900A (en) * | 1998-11-19 | 2000-06-05 | Nortran Pharmaceuticals Inc. | Serotonin ligands as pro-erectile compounds |
| US6979685B1 (en) * | 1999-02-12 | 2005-12-27 | Cardiome Pharma Corp. | Cycloalkyl amine compounds and uses thereof |
| US7507545B2 (en) | 1999-03-31 | 2009-03-24 | Cardiome Pharma Corp. | Ion channel modulating activity method |
| US7524879B2 (en) | 2000-10-06 | 2009-04-28 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| US7057053B2 (en) | 2000-10-06 | 2006-06-06 | Cardiome Pharma Corp. | Ion channel modulating compounds and uses thereof |
| WO2003026611A2 (en) * | 2001-09-26 | 2003-04-03 | Baxter International Inc. | Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal |
| US7112340B2 (en) * | 2001-10-19 | 2006-09-26 | Baxter International Inc. | Compositions of and method for preparing stable particles in a frozen aqueous matrix |
| DE10213051B4 (de) * | 2002-03-23 | 2013-03-07 | Grünenthal GmbH | Substituierte 4-Aminocyclohexanole |
| US20030220344A1 (en) * | 2002-04-04 | 2003-11-27 | Luiz Belardinelli | Method of treating arrhythmias |
| US20050227974A9 (en) * | 2002-08-01 | 2005-10-13 | Euro-Celtique S.A. | Aminoalkyl-substituted aryl compounds and their use as sodium channel blockers |
| HK1079703A1 (zh) * | 2002-10-11 | 2006-04-13 | 巴克斯特国际公司 | 通过静脉施用卤化挥发性麻醉药保护心脏和保护神经的方法 |
| ATE529401T1 (de) | 2003-05-02 | 2011-11-15 | Cardiome Pharma Corp | Aminocyclohexylether-verbindungen und deren verwendung |
| US20090041841A1 (en) * | 2003-05-02 | 2009-02-12 | Cardiome Pharma Corp. | Controlled release tablet formulations for the prevention of arrhythmias |
| US7345086B2 (en) | 2003-05-02 | 2008-03-18 | Cardiome Pharma Corp. | Uses of ion channel modulating compounds |
| WO2005018635A2 (en) * | 2003-08-07 | 2005-03-03 | Cardiome Pharma Corp. | Ion channel modulating activity i |
| US7345087B2 (en) | 2003-10-31 | 2008-03-18 | Cardiome Pharma Corp. | Aminocyclohexyl ether compounds and uses thereof |
| EP1729814A2 (de) * | 2004-04-01 | 2006-12-13 | Cardiome Pharma Corp. | Pegylierte ionenkanalmodulatoren |
| WO2005113011A2 (en) | 2004-04-01 | 2005-12-01 | Cardiome Pharma Corp. | Prodrugs of ion channel modulating compounds and uses thereof |
| WO2005097869A1 (en) * | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Polymers comprising ion channel modulating compounds and uses thereof |
| US8058304B2 (en) | 2004-04-01 | 2011-11-15 | Cardiome Pharma Corp. | Merged ion channel modulating compounds and uses thereof |
| MX2007005496A (es) | 2004-11-08 | 2007-07-09 | Cardiome Pharma Corp | Nuevo regimen de dosificacion para compuestos moduladores de canal de iones, para el tratamiento de fibrilacion auricular aguda en un humano. |
| US7216794B2 (en) * | 2005-06-09 | 2007-05-15 | Texas Instruments Incorporated | Bond capillary design for ribbon wire bonding |
| WO2006138202A2 (en) * | 2005-06-14 | 2006-12-28 | Baxter International Inc. | Pharmaceutical formulations for minimizing drug-drug interactions |
| BRPI0618661A2 (pt) * | 2005-11-15 | 2011-09-06 | Baxter Int | composições de inibidores de lipoxigenase |
| WO2008080047A2 (en) * | 2006-12-23 | 2008-07-03 | Baxter International Inc. | Magnetic separation of fine particles from compositions |
| US8722736B2 (en) * | 2007-05-22 | 2014-05-13 | Baxter International Inc. | Multi-dose concentrate esmolol with benzyl alcohol |
| US8426467B2 (en) * | 2007-05-22 | 2013-04-23 | Baxter International Inc. | Colored esmolol concentrate |
| US20080293814A1 (en) * | 2007-05-22 | 2008-11-27 | Deepak Tiwari | Concentrate esmolol |
| WO2010132696A1 (en) * | 2009-05-14 | 2010-11-18 | Gilead Palo Alto, Inc. | Ranolazine for the treatment of cns disorders |
| EP2605772B1 (de) | 2010-08-16 | 2016-06-22 | Cardiome International AG | Verfahren zur herstellung von aminocyclohexyl-etherverbindungen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2954380A (en) * | 1958-11-26 | 1960-09-27 | Us Vitamin Pharm Corp | Piperazinocyclohexyl esters |
| FR1389414A (fr) * | 1962-12-27 | 1965-02-19 | Lab Farmaceutici A Malizia S P | Nouveaux esters de cyclohexanol substitué et leur procédé de préparation |
| JPS5219637A (en) * | 1975-08-04 | 1977-02-15 | Toyama Chem Co Ltd | Preparation of novel biscarboxylic acid esters |
| US4438130A (en) * | 1981-11-12 | 1984-03-20 | The Upjohn Company | Analgesic 1-oxa-, aza- and thia-spirocyclic compounds |
| DK139684A (da) * | 1983-04-11 | 1984-10-12 | Janssen Pharmaceutica Nv | N-aryl-alpha-amino-carboxamider |
| US4656182A (en) * | 1983-12-06 | 1987-04-07 | Warner-Lambert Company | Substituted trans-1,2-diaminocyclohexyl amide compounds |
| WO1986007257A2 (en) * | 1985-06-07 | 1986-12-18 | The Upjohn Company | Antiarrhythmic use for aminocycloalkylamides |
| US4737493A (en) * | 1985-07-01 | 1988-04-12 | Warner-Lambert Company | 7-((substituted)amino)-8-((substituted)carbonyl)-methylamino)-1-oxaspiro(4,5)decanes as analgesic agents |
| US4855316A (en) * | 1988-02-18 | 1989-08-08 | Warner-Lambert Company | 1,2-diamino-4,5-dimethoxycyclohexyl amide analgesic compounds |
| FR2689893A1 (fr) * | 1992-04-09 | 1993-10-15 | Rhone Poulenc Rorer Sa | Dérivés de diphényl-1,1 hydroxy-3 (sila)cyclopentane, leur préparation et les médicaments les contenant. |
-
1994
- 1994-09-23 DE DE69429524T patent/DE69429524T2/de not_active Expired - Lifetime
- 1994-09-23 ES ES94926755T patent/ES2170102T3/es not_active Expired - Lifetime
- 1994-09-23 WO PCT/CA1994/000513 patent/WO1995008544A1/en not_active Ceased
- 1994-09-23 AU AU76502/94A patent/AU7650294A/en not_active Abandoned
- 1994-09-23 EP EP94926755A patent/EP0720605B1/de not_active Expired - Lifetime
- 1994-09-23 AT AT94926755T patent/ATE211135T1/de not_active IP Right Cessation
- 1994-09-23 CA CA002172513A patent/CA2172513C/en not_active Expired - Fee Related
- 1994-09-27 US US08/313,691 patent/US5637583A/en not_active Expired - Lifetime
-
1997
- 1997-02-27 US US08/807,728 patent/US5885984A/en not_active Expired - Lifetime
-
1999
- 1999-03-17 US US09/271,087 patent/US6174879B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5637583A (en) | 1997-06-10 |
| DE69429524T2 (de) | 2002-08-08 |
| CA2172513A1 (en) | 1995-03-30 |
| WO1995008544A1 (en) | 1995-03-30 |
| EP0720605B1 (de) | 2001-12-19 |
| AU7650294A (en) | 1995-04-10 |
| DE69429524D1 (de) | 2002-01-31 |
| US5885984A (en) | 1999-03-23 |
| US6174879B1 (en) | 2001-01-16 |
| EP0720605A1 (de) | 1996-07-10 |
| ES2170102T3 (es) | 2002-08-01 |
| CA2172513C (en) | 2008-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |