DE69720996D1 - Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer - Google Patents

Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer

Info

Publication number
DE69720996D1
DE69720996D1 DE69720996T DE69720996T DE69720996D1 DE 69720996 D1 DE69720996 D1 DE 69720996D1 DE 69720996 T DE69720996 T DE 69720996T DE 69720996 T DE69720996 T DE 69720996T DE 69720996 D1 DE69720996 D1 DE 69720996D1
Authority
DE
Germany
Prior art keywords
pharmaceutical compositions
nitrate ester
new pharmaceutical
steroid
inflammatory inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69720996T
Other languages
English (en)
Other versions
DE69720996T2 (de
Inventor
S Tjoeng
G Currie
E Zupec
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Publication of DE69720996D1 publication Critical patent/DE69720996D1/de
Application granted granted Critical
Publication of DE69720996T2 publication Critical patent/DE69720996T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69720996T 1996-05-02 1997-04-28 Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer Expired - Fee Related DE69720996T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US642128 1996-05-02
US08/642,128 US5985862A (en) 1996-05-02 1996-05-02 Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs
PCT/US1997/006374 WO1997040836A1 (en) 1996-05-02 1997-04-28 Novel pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs

Publications (2)

Publication Number Publication Date
DE69720996D1 true DE69720996D1 (de) 2003-05-22
DE69720996T2 DE69720996T2 (de) 2004-02-05

Family

ID=24575322

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69720996T Expired - Fee Related DE69720996T2 (de) 1996-05-02 1997-04-28 Neue pharmazeutische zusammensetzungen von steroid-nitratester zur verwendung als enzündungshemmer

Country Status (11)

Country Link
US (1) US5985862A (de)
EP (1) EP0912185B1 (de)
JP (1) JP2000509388A (de)
AT (1) ATE237334T1 (de)
AU (1) AU2732597A (de)
CA (1) CA2252876A1 (de)
DE (1) DE69720996T2 (de)
DK (1) DK0912185T3 (de)
ES (1) ES2197341T3 (de)
PT (1) PT912185E (de)
WO (1) WO1997040836A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824669A (en) 1996-03-22 1998-10-20 Nitromed, Inc. Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
IT1285770B1 (it) 1996-10-04 1998-06-18 Nicox Sa Composti corticoidei
AU3703900A (en) * 1999-02-24 2000-09-14 Nitromed, Inc. Nitrosated and nitrosylated steroids for the treatment of cardiovascular diseases and disorders
IT1311922B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
OA12394A (en) 2000-08-05 2004-07-09 Glaxo Group Ltd 6.Alpha-,9.alpha.-difluoro-17.alpha.-'(2-furanylcarboxyl)oxyl-11.beta.-hydroxy-16.alpha.-methyl-3-oxo-androst-1,4,-diene-17-carbothioic acid s-fuoromethyl ester as an anti-inflammatory agent.
GB0019172D0 (en) 2000-08-05 2000-09-27 Glaxo Group Ltd Novel compounds
US6777399B2 (en) 2000-08-05 2004-08-17 Smithkline Beecham Corporation Anti-inflammatory androstane derivative compositions
IT1320176B1 (it) * 2000-12-22 2003-11-26 Nicox Sa Dispersioni solide di principi attivi nitrati.
US6696592B2 (en) 2001-05-22 2004-02-24 Nicox-S.A. Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof
US20040110691A1 (en) * 2001-11-13 2004-06-10 Stamler Jonathan S. Thiol reactive agents as a therapeutic modality
US6627602B2 (en) * 2001-11-13 2003-09-30 Duke University Preventing desensitization of receptors
EP1336602A1 (de) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrat-Prodrugs zur Freisetzung von Stickstoffmonoxid in kontrollierter und selektiver Weise sowie deren Verwendung zur Prävention und Behandlung inflammatorischer, ischämischer und proliferativer Erkrankungen
GB2389530B (en) 2002-06-14 2007-01-10 Cipla Ltd Pharmaceutical compositions
AU2003278565A1 (en) * 2002-10-25 2004-05-13 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
SE0300971D0 (sv) * 2003-04-03 2003-04-03 Aga Ab Nitric oxide in treatment of inflammation
US8226987B2 (en) * 2005-02-22 2012-07-24 Zoorob George K Herbal preparation to relieve inflammation and smooth muscle contraction
NZ566128A (en) * 2005-09-02 2011-03-31 Nicox Sa Nitrooxy derivatives of glucocorticoids
WO2010012567A1 (en) * 2008-07-31 2010-02-04 Nicox S.A. Glucocorticoids attached to nitrate esters via an aromatic linker in position 21 and their use in ophthalmology

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1082573A (en) * 1965-02-12 1967-09-06 Boots Pure Drug Co Ltd Improvements in the preparation of steroid esters
US3639434A (en) * 1967-02-02 1972-02-01 Boots Pure Drug Co Ltd 17-acyloxysteroids and their manufacture
HU164115B (de) * 1971-05-07 1973-12-28
DE2236115A1 (de) * 1972-07-20 1974-02-07 Schering Ag Verfahren zur herstellung von delta hoch 4.9(11).16 -3.20diketosteroiden
DE4223800A1 (de) * 1992-07-20 1994-01-27 Cassella Farbwerke Mainkur Ag Verwendung von 1.2.5-Oxadiazol-2-oxiden zur Behandlung erektiler Dysfunktionen
JPH07509484A (ja) * 1992-07-30 1995-10-19 シーエーエル・インターナショナル・リミテッド 有機硝酸塩とサリチル酸塩とのエステル及び混合物
IT1256450B (it) * 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
ATE168986T1 (de) * 1993-10-06 1998-08-15 Nicox Sa Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung

Also Published As

Publication number Publication date
US5985862A (en) 1999-11-16
EP0912185A1 (de) 1999-05-06
WO1997040836A1 (en) 1997-11-06
EP0912185B1 (de) 2003-04-16
ES2197341T3 (es) 2004-01-01
AU2732597A (en) 1997-11-19
PT912185E (pt) 2003-08-29
DE69720996T2 (de) 2004-02-05
DK0912185T3 (da) 2003-08-04
CA2252876A1 (en) 1997-11-06
JP2000509388A (ja) 2000-07-25
ATE237334T1 (de) 2003-05-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee