BRPI0418245A - nitróxi-derivados de prostaglandina - Google Patents
nitróxi-derivados de prostaglandinaInfo
- Publication number
- BRPI0418245A BRPI0418245A BRPI0418245-6A BRPI0418245A BRPI0418245A BR PI0418245 A BRPI0418245 A BR PI0418245A BR PI0418245 A BRPI0418245 A BR PI0418245A BR PI0418245 A BRPI0418245 A BR PI0418245A
- Authority
- BR
- Brazil
- Prior art keywords
- nitroxy
- prostaglandin derivatives
- derivatives
- prostaglandin
- glaucoma
- Prior art date
Links
- -1 Nitroxy Prostaglandin Chemical class 0.000 title 1
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Abstract
"NITROXI-DERIVADOS DE PROSTAGLANDINA". São descritos nitróxi-derivados de prostaglandinas tendo atividade farmacológica aumentada e tolerabilidade melhorada. Eles podem ser empregados para o tratamento de glaucoma e de hipertensão ocular.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04100001 | 2004-01-05 | ||
PCT/EP2004/014820 WO2005068421A1 (en) | 2004-01-05 | 2004-12-27 | Prostaglandin nitrooxyderivatives |
Publications (3)
Publication Number | Publication Date |
---|---|
BRPI0418245A true BRPI0418245A (pt) | 2007-04-17 |
BRPI0418245B1 BRPI0418245B1 (pt) | 2017-05-30 |
BRPI0418245B8 BRPI0418245B8 (pt) | 2021-05-25 |
Family
ID=34778199
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0418245A BRPI0418245B8 (pt) | 2004-01-05 | 2004-12-27 | composto derivado de nitróxi de prostaglandina, processo para preparar dito composto, composição farmacêutica compreendendo dito composto e usos destes |
Country Status (40)
Country | Link |
---|---|
US (5) | US7273946B2 (pt) |
EP (3) | EP3002277B1 (pt) |
JP (1) | JP3984283B2 (pt) |
KR (2) | KR100850133B1 (pt) |
CN (1) | CN100469765C (pt) |
AP (1) | AP2006003638A0 (pt) |
AR (2) | AR047081A1 (pt) |
AU (1) | AU2004313688B2 (pt) |
BR (1) | BRPI0418245B8 (pt) |
CA (1) | CA2551409C (pt) |
CR (2) | CR8498A (pt) |
CY (1) | CY1117417T1 (pt) |
DK (1) | DK1704141T3 (pt) |
EA (1) | EA010595B1 (pt) |
EC (1) | ECSP066684A (pt) |
ES (2) | ES2767136T3 (pt) |
GE (1) | GEP20094780B (pt) |
GT (1) | GT200500293A (pt) |
HK (1) | HK1096084A1 (pt) |
HR (1) | HRP20160500T1 (pt) |
HU (1) | HUE027357T2 (pt) |
IL (1) | IL176416A (pt) |
MA (1) | MA28284A1 (pt) |
ME (1) | ME02433B (pt) |
MX (1) | MXPA06007678A (pt) |
MY (1) | MY147181A (pt) |
NO (2) | NO337217B1 (pt) |
NZ (1) | NZ548271A (pt) |
OA (1) | OA13356A (pt) |
PA (1) | PA8620901A1 (pt) |
PE (1) | PE20051052A1 (pt) |
PL (1) | PL1704141T3 (pt) |
RS (1) | RS54717B1 (pt) |
SI (1) | SI1704141T1 (pt) |
TN (1) | TNSN06210A1 (pt) |
TW (1) | TWI337994B (pt) |
UA (1) | UA84726C2 (pt) |
UY (1) | UY28709A1 (pt) |
WO (1) | WO2005068421A1 (pt) |
ZA (1) | ZA200605354B (pt) |
Families Citing this family (39)
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RS54717B1 (en) | 2004-01-05 | 2016-08-31 | Nicox S.A. | PROSTAGLANDIN NITRO OXIDERIVES |
JP2009500315A (ja) * | 2005-06-29 | 2009-01-08 | ファイザー・インク | フルオロプロスタグランジンのニトロ誘導体 |
CA2613748A1 (en) * | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Prostaglandin derivatives |
US8067414B2 (en) * | 2006-03-29 | 2011-11-29 | Nicox S.A. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
DE102006052755A1 (de) * | 2006-11-08 | 2008-05-15 | N-Zyme Biotec Gmbh | Michaelsysteme als Transglutaminaseinhibitoren |
JP2010513262A (ja) | 2006-12-15 | 2010-04-30 | ニコックス エス エイ | カルボニックアンヒドラーゼ阻害剤誘導体 |
WO2008071421A1 (en) * | 2006-12-15 | 2008-06-19 | Nicox S.A. | Nitrate esters of carbonic anhydrase inhibitors |
PL2170826T3 (pl) | 2007-06-04 | 2022-09-05 | Techfields Inc | Proleki nsaia o bardzo wysokim współczynniku przenikania przez skórę i błony oraz ich nowe zastosowania lecznicze |
WO2009035565A1 (en) * | 2007-09-07 | 2009-03-19 | Qlt Plug Delivery, Inc | Prostaglandin analogues for implant devices and methods |
US7649021B2 (en) * | 2007-10-31 | 2010-01-19 | Meta Cosmetics, Llc | Prostaglandin analog compositions to treat epithelial-related conditions |
AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
US7807716B2 (en) * | 2008-09-24 | 2010-10-05 | Oral Delivery Technology Ltd. | Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use |
BRPI0922263B1 (pt) | 2008-12-04 | 2021-08-31 | Chongxi Yu | Composição de alta penetração de um fármaco principal, e seus usos |
WO2010077101A2 (ko) | 2008-12-30 | 2010-07-08 | 조선대학교산학협력단 | 신규한 티아졸리딘디온 유도체 및 그의 용도 |
US9162969B2 (en) | 2009-09-15 | 2015-10-20 | Dsm Ip Assets B.V. | Nitrooxyesters, their preparation and use |
CN101885684B (zh) * | 2010-07-01 | 2013-10-30 | 南京中医药大学 | 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用 |
CA2846384C (en) | 2011-08-29 | 2020-12-15 | Qlt Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
HU231203B1 (hu) * | 2011-12-21 | 2021-10-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás travoprost előállítására |
CN105473130A (zh) | 2012-05-03 | 2016-04-06 | 麦提疗法有限公司 | 治疗开角型青光眼和高眼压症的药物递送系统和方法 |
JP6405312B2 (ja) * | 2012-10-23 | 2018-10-17 | ニコックス サイエンス アイルランド | 眼科用のキノン系一酸化窒素供与化合物 |
ES2624446T3 (es) * | 2013-04-18 | 2017-07-14 | Nicox Science Ireland | Compuestos donantes de óxido nítrico a base de quinona para uso oftalmológico |
EP3091985A4 (en) | 2014-01-10 | 2017-11-29 | Manistee Partners LLC | Treatment of migraines |
WO2016061370A1 (en) * | 2014-10-15 | 2016-04-21 | Novartis Ag | Prostaglandin conjugates and derivatives for treating glaucoma and ocular hypertension |
US10280138B2 (en) | 2015-03-31 | 2019-05-07 | Nicox S.A. | Nitric oxide donating derivatives of fluprostenol |
WO2016156104A1 (en) | 2015-03-31 | 2016-10-06 | Nicox S.A. | Nitric oxide donating derivatives of latanoprost free acid |
EP3088388A1 (en) | 2015-04-30 | 2016-11-02 | NicOx S.A. | Nitric oxide donating derivatives of prostaglandins |
KR20180058758A (ko) | 2015-09-22 | 2018-06-01 | 그레이버그 비젼, 인크. | 안구 장애의 치료를 위한 화합물 및 조성물 |
HU231175B1 (hu) * | 2015-12-04 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával |
KR20190104993A (ko) * | 2016-11-08 | 2019-09-11 | 보오슈 앤드 롬 인코포레이팃드 | 정상 안압 녹내장을 치료하기 위한 산화질소 방출 프로스타글란딘 유도체 |
KR102069205B1 (ko) | 2017-08-09 | 2020-01-22 | 연성정밀화학(주) | 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체 |
RU2718744C2 (ru) | 2018-05-17 | 2020-04-14 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Производные простагландина F2альфа для снижения внутриглазного давления |
CN109988089B (zh) * | 2018-05-29 | 2022-04-26 | 上海凡秦医药科技有限公司 | 一种前列腺素化合物、制备方法及其用途 |
CN108892624B (zh) * | 2018-06-20 | 2020-12-15 | 重庆威鹏药业有限公司 | 沙库巴曲硝基氧衍生物及其制备方法和应用 |
US11332433B2 (en) | 2020-07-24 | 2022-05-17 | Chirogate International Inc. | Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same |
CN113943266A (zh) * | 2021-11-18 | 2022-01-18 | 广州楷石医药有限公司 | 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途 |
CN116444377A (zh) * | 2022-01-07 | 2023-07-18 | 广州楷石医药有限公司 | 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途 |
CA3195291A1 (en) * | 2022-04-13 | 2023-10-13 | Caravel Therapeutics, Inc. | Preservative-free ophthalmic pharmaceutical emulsion and its application |
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US3922293A (en) | 1971-12-30 | 1975-11-25 | Upjohn Co | Prostaglandin F-type 9-monoacylates |
US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
ES2186670T3 (es) | 1988-09-06 | 2003-05-16 | Pharmacia Ab | Derivados de prostaglandina para el tratamiento del glaucoma o la hipertension ocular. |
DE69311361T2 (de) | 1992-10-13 | 1998-01-08 | Alcon Lab Inc | Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten |
US5328933A (en) * | 1992-10-28 | 1994-07-12 | Allergan, Inc. | Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues |
US5625083A (en) | 1995-06-02 | 1997-04-29 | Bezuglov; Vladimir V. | Dinitroglycerol esters of unsaturated fatty acids and prostaglandins |
IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
IT1292377B1 (it) * | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
US6417228B1 (en) | 1998-11-02 | 2002-07-09 | Alcon Manufacturing, Ltd.. | 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
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US20030018079A1 (en) | 2000-11-13 | 2003-01-23 | Richardson Helene | Treatment |
CN1259051C (zh) | 2001-04-19 | 2006-06-14 | 帝化制药株式会社 | 药物及药物试剂盒 |
RS54717B1 (en) * | 2004-01-05 | 2016-08-31 | Nicox S.A. | PROSTAGLANDIN NITRO OXIDERIVES |
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2004
- 2004-12-27 RS RS20160251A patent/RS54717B1/en unknown
- 2004-12-27 NZ NZ548271A patent/NZ548271A/en unknown
- 2004-12-27 EP EP15194684.5A patent/EP3002277B1/en active Active
- 2004-12-27 UA UAA200607454A patent/UA84726C2/ru unknown
- 2004-12-27 KR KR1020067013440A patent/KR100850133B1/ko active IP Right Grant
- 2004-12-27 GE GEAP20049494A patent/GEP20094780B/en unknown
- 2004-12-27 CN CNB2004800398051A patent/CN100469765C/zh active Active
- 2004-12-27 HU HUE04804405A patent/HUE027357T2/en unknown
- 2004-12-27 OA OA1200600221A patent/OA13356A/en unknown
- 2004-12-27 WO PCT/EP2004/014820 patent/WO2005068421A1/en active Application Filing
- 2004-12-27 EA EA200601099A patent/EA010595B1/ru not_active IP Right Cessation
- 2004-12-27 KR KR1020087000325A patent/KR100854838B1/ko active IP Right Grant
- 2004-12-27 CA CA2551409A patent/CA2551409C/en active Active
- 2004-12-27 SI SI200432309T patent/SI1704141T1/sl unknown
- 2004-12-27 JP JP2006546105A patent/JP3984283B2/ja active Active
- 2004-12-27 PL PL04804405T patent/PL1704141T3/pl unknown
- 2004-12-27 ME MEP-2016-79A patent/ME02433B/me unknown
- 2004-12-27 DK DK04804405.1T patent/DK1704141T3/en active
- 2004-12-27 MX MXPA06007678A patent/MXPA06007678A/es active IP Right Grant
- 2004-12-27 AU AU2004313688A patent/AU2004313688B2/en active Active
- 2004-12-27 AP AP2006003638A patent/AP2006003638A0/xx unknown
- 2004-12-27 ES ES15194684T patent/ES2767136T3/es active Active
- 2004-12-27 ES ES04804405.1T patent/ES2566800T3/es active Active
- 2004-12-27 EP EP04804405.1A patent/EP1704141B1/en active Active
- 2004-12-27 EP EP19196238.0A patent/EP3643702A1/en not_active Withdrawn
- 2004-12-27 BR BRPI0418245A patent/BRPI0418245B8/pt active IP Right Grant
- 2004-12-31 TW TW093141786A patent/TWI337994B/zh active
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2005
- 2005-01-03 AR ARP050100012A patent/AR047081A1/es active IP Right Grant
- 2005-01-03 MY MYPI20050009A patent/MY147181A/en unknown
- 2005-01-04 PE PE2005000037A patent/PE20051052A1/es active IP Right Grant
- 2005-01-04 PA PA20058620901A patent/PA8620901A1/es unknown
- 2005-01-04 UY UY28709A patent/UY28709A1/es not_active Application Discontinuation
- 2005-01-05 US US11/029,698 patent/US7273946B2/en active Active
- 2005-10-18 GT GT200500293A patent/GT200500293A/es unknown
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2006
- 2006-06-19 IL IL176416A patent/IL176416A/en active IP Right Grant
- 2006-06-28 ZA ZA200605354A patent/ZA200605354B/xx unknown
- 2006-06-29 EC EC2006006684A patent/ECSP066684A/es unknown
- 2006-06-30 CR CR8498A patent/CR8498A/es unknown
- 2006-07-04 TN TNP2006000210A patent/TNSN06210A1/fr unknown
- 2006-07-05 MA MA29169A patent/MA28284A1/fr unknown
- 2006-08-07 NO NO20063567A patent/NO337217B1/no unknown
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2007
- 2007-03-30 HK HK07103447.6A patent/HK1096084A1/xx unknown
- 2007-08-20 US US11/841,628 patent/US7449469B2/en active Active
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2008
- 2008-09-15 US US12/210,975 patent/US7629345B2/en active Active
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2009
- 2009-11-06 US US12/613,985 patent/US7910767B2/en active Active
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2011
- 2011-02-11 US US13/025,740 patent/US8058467B2/en active Active
- 2011-03-11 CR CR20110131A patent/CR20110131A/es unknown
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2014
- 2014-12-22 AR ARP140104875A patent/AR098931A2/es not_active Application Discontinuation
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2015
- 2015-10-08 NO NO20151341A patent/NO339685B1/no unknown
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2016
- 2016-04-26 CY CY20161100340T patent/CY1117417T1/el unknown
- 2016-05-11 HR HRP20160500TT patent/HRP20160500T1/hr unknown
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Legal Events
Date | Code | Title | Description |
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B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 27/12/2004 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |