UA84726C2 - Производные простагландинов, способ их получения, фармацевтическая композиция (варианты) и способ лечения глаукомы или гипертензии глаза - Google Patents

Производные простагландинов, способ их получения, фармацевтическая композиция (варианты) и способ лечения глаукомы или гипертензии глаза

Info

Publication number
UA84726C2
UA84726C2 UAA200607454A UAA200607454A UA84726C2 UA 84726 C2 UA84726 C2 UA 84726C2 UA A200607454 A UAA200607454 A UA A200607454A UA A200607454 A UAA200607454 A UA A200607454A UA 84726 C2 UA84726 C2 UA 84726C2
Authority
UA
Ukraine
Prior art keywords
glaucoma
treatment
variants
preparation
pharmaceutical composition
Prior art date
Application number
UAA200607454A
Other languages
English (en)
Ukrainian (uk)
Inventor
Энниио Онджини
Франческа Бенедини
Валерио Кироли
Сольдато Пьеро Дель
Original Assignee
Никокс С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34778199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA84726(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Никокс С.А. filed Critical Никокс С.А.
Publication of UA84726C2 publication Critical patent/UA84726C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

В заявке описаны нитропроизводные простагландинов, которые имеют повышенную фармакологическую активность и улучшенную переносимость. Они могут использоваться для лечения глаукомы и гипертензии глаза.
UAA200607454A 2004-01-05 2004-12-27 Производные простагландинов, способ их получения, фармацевтическая композиция (варианты) и способ лечения глаукомы или гипертензии глаза UA84726C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04100001 2004-01-05

Publications (1)

Publication Number Publication Date
UA84726C2 true UA84726C2 (ru) 2008-11-25

Family

ID=34778199

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200607454A UA84726C2 (ru) 2004-01-05 2004-12-27 Производные простагландинов, способ их получения, фармацевтическая композиция (варианты) и способ лечения глаукомы или гипертензии глаза

Country Status (40)

Country Link
US (5) US7273946B2 (ru)
EP (3) EP3002277B1 (ru)
JP (1) JP3984283B2 (ru)
KR (2) KR100854838B1 (ru)
CN (1) CN100469765C (ru)
AP (1) AP2006003638A0 (ru)
AR (2) AR047081A1 (ru)
AU (1) AU2004313688B2 (ru)
BR (1) BRPI0418245B8 (ru)
CA (1) CA2551409C (ru)
CR (2) CR8498A (ru)
CY (1) CY1117417T1 (ru)
DK (1) DK1704141T3 (ru)
EA (1) EA010595B1 (ru)
EC (1) ECSP066684A (ru)
ES (2) ES2767136T3 (ru)
GE (1) GEP20094780B (ru)
GT (1) GT200500293A (ru)
HK (1) HK1096084A1 (ru)
HR (1) HRP20160500T1 (ru)
HU (1) HUE027357T2 (ru)
IL (1) IL176416A (ru)
MA (1) MA28284A1 (ru)
ME (1) ME02433B (ru)
MX (1) MXPA06007678A (ru)
MY (1) MY147181A (ru)
NO (2) NO337217B1 (ru)
NZ (1) NZ548271A (ru)
OA (1) OA13356A (ru)
PA (1) PA8620901A1 (ru)
PE (1) PE20051052A1 (ru)
PL (1) PL1704141T3 (ru)
RS (1) RS54717B1 (ru)
SI (1) SI1704141T1 (ru)
TN (1) TNSN06210A1 (ru)
TW (1) TWI337994B (ru)
UA (1) UA84726C2 (ru)
UY (1) UY28709A1 (ru)
WO (1) WO2005068421A1 (ru)
ZA (1) ZA200605354B (ru)

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US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
WO2008071421A1 (en) * 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
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KR20220107078A (ko) 2007-06-04 2022-08-01 테크필즈 인크 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도
WO2009035565A1 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
US7517912B1 (en) * 2007-10-31 2009-04-14 Meta Cosmetics, Llc Prostaglandin analog compositions and methods to treat epithelial-related conditions
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
CN111808011B (zh) 2008-12-04 2024-02-27 泰飞尔生物医药(苏州)有限公司 高穿透性组合物及其应用
US8637558B2 (en) 2008-12-30 2014-01-28 Industry-Academic Cooperation Foundation, Chosun University Thiazolidinedione derivative and use thereof
US9162969B2 (en) 2009-09-15 2015-10-20 Dsm Ip Assets B.V. Nitrooxyesters, their preparation and use
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
ES2727203T3 (es) 2011-08-29 2019-10-14 Mati Therapeutics Inc Administración por liberación sostenida de agentes activos para tratar glaucoma e hipertensión ocular
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
WO2013164671A1 (en) 2012-05-03 2013-11-07 Qlt Inc. Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
US9446015B2 (en) * 2012-10-23 2016-09-20 Nicox Science Ireland Quinone based nitric oxide donating compounds for ophthalmic use
EP2986288B1 (en) * 2013-04-18 2017-04-12 Nicox Science Ireland Quinone based nitric oxide donating compounds for ophthalmic use
JP2017502089A (ja) 2014-01-10 2017-01-19 マニスティー パートナーズ エルエルシーＭａｎｉｓｔｅｅ Ｐａｒｔｎｅｒｓ Ｌｌｃ 偏頭痛の処置
MX2017004809A (es) * 2014-10-15 2017-07-26 Novartis Ag Conjugados y derivados de prostaglandina para tratar el glaucoma y la hipertension ocular.
WO2016155906A1 (en) * 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
WO2016156104A1 (en) 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
CN108366984A (zh) 2015-09-22 2018-08-03 灰色视觉公司 用于治疗眼部病症的化合物和组合物
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
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KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
CN109988089B (zh) * 2018-05-29 2022-04-26 上海凡秦医药科技有限公司 一种前列腺素化合物、制备方法及其用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
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CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
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Also Published As

Publication number Publication date
IL176416A (en) 2013-05-30
HK1096084A1 (en) 2007-05-25
EP1704141A1 (en) 2006-09-27
ME02433B (me) 2016-09-20
EA010595B1 (ru) 2008-10-30
KR20060113753A (ko) 2006-11-02
CR8498A (es) 2006-11-15
NO337217B1 (no) 2016-02-15
US20090030076A1 (en) 2009-01-29
US8058467B2 (en) 2011-11-15
MXPA06007678A (es) 2006-09-01
ES2767136T3 (es) 2020-06-16
TW200526567A (en) 2005-08-16
US20110136904A1 (en) 2011-06-09
US20080058392A1 (en) 2008-03-06
TWI337994B (en) 2011-03-01
US7449469B2 (en) 2008-11-11
JP2007518716A (ja) 2007-07-12
PE20051052A1 (es) 2005-12-17
PA8620901A1 (es) 2005-08-30
EP1704141B1 (en) 2016-02-24
DK1704141T3 (en) 2016-05-02
SI1704141T1 (sl) 2016-04-29
CA2551409C (en) 2011-02-22
WO2005068421A8 (en) 2006-02-09
HUE027357T2 (en) 2016-09-28
CA2551409A1 (en) 2005-07-28
NO339685B1 (no) 2017-01-23
US20050272743A1 (en) 2005-12-08
US20100130507A1 (en) 2010-05-27
NO20151341A1 (no) 2006-09-07
AR047081A1 (es) 2006-01-04
PL1704141T3 (pl) 2016-08-31
MY147181A (en) 2012-11-14
UY28709A1 (es) 2005-08-31
AP2006003638A0 (en) 2006-06-30
EA200601099A1 (ru) 2006-10-27
TNSN06210A1 (fr) 2007-12-03
OA13356A (en) 2007-04-13
KR20080007415A (ko) 2008-01-18
NO20063567L (no) 2006-09-07
AU2004313688B2 (en) 2010-08-05
KR100854838B1 (ko) 2008-08-29
CN1906159A (zh) 2007-01-31
IL176416A0 (en) 2006-10-05
BRPI0418245B8 (pt) 2021-05-25
US7273946B2 (en) 2007-09-25
JP3984283B2 (ja) 2007-10-03
AR098931A2 (es) 2016-06-22
EP3002277B1 (en) 2019-11-06
ES2566800T3 (es) 2016-04-15
KR100850133B1 (ko) 2008-08-04
US7629345B2 (en) 2009-12-08
CR20110131A (es) 2011-03-30
BRPI0418245B1 (pt) 2017-05-30
CY1117417T1 (el) 2017-04-26
EP3643702A1 (en) 2020-04-29
NZ548271A (en) 2010-01-29
CN100469765C (zh) 2009-03-18
BRPI0418245A (pt) 2007-04-17
US7910767B2 (en) 2011-03-22
GT200500293A (es) 2007-07-06
HRP20160500T1 (hr) 2016-06-03
WO2005068421A1 (en) 2005-07-28
ECSP066684A (es) 2006-10-25
GEP20094780B (en) 2009-09-25
RS54717B1 (en) 2016-08-31
ZA200605354B (en) 2009-09-30
EP3002277A1 (en) 2016-04-06
MA28284A1 (fr) 2006-11-01
AU2004313688A1 (en) 2005-07-28

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