AR098931A2 - Compuestos derivados de prostaglandinas - Google Patents
Compuestos derivados de prostaglandinasInfo
- Publication number
- AR098931A2 AR098931A2 ARP140104875A ARP140104875A AR098931A2 AR 098931 A2 AR098931 A2 AR 098931A2 AR P140104875 A ARP140104875 A AR P140104875A AR P140104875 A ARP140104875 A AR P140104875A AR 098931 A2 AR098931 A2 AR 098931A2
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- ono2
- compound
- integer
- group
- Prior art date
Links
- 239000002361 compost Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 229910004679 ONO2 Inorganic materials 0.000 abstract 4
- 150000003180 prostaglandins Chemical class 0.000 abstract 3
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 2
- 206010018307 Glaucoma and ocular hypertension Diseases 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 150000002828 nitro derivatives Chemical class 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/04—Nitro compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
Derivados nitro de prostaglandinas de actividad farmacológica mejorada y una mayor tolerabilidad. Pueden emplearse para el tratamiento del glaucoma y de la hipertensión ocular. Reivindicación 1: Un compuesto derivado de prostaglandina de fórmula general (1): R-X-Y-ONO₂ (1) donde: R es el residuo de prostaglandina de fórmula (2) donde el símbolo ⁻ ⁻ ⁻ ⁻ ⁻ representa un enlace simple ; L es un resto de fórmula (3); X es -O-; Y es un radical bivalente que tiene el siguiente significado: a) alquileno C₁₋₂₀ de cadena lineal o ramificada, que está opcionalmente sustituido con uno o más sustituyentes seleccionados del grupo formado por: átomos de halógeno, hidroxi, -ONO₂ o T, donde T es -OC(O)(alquil C₁₋₁₀)-ONO₂ u -O(alquil C₁₋₁₀)-ONO₂; b) un compuesto de fórmula (4) donde n es un número entero entre 0 y 20, y n¹ es 1; c) un compuesto de fórmula (5) donde: Y¹ es -CH=CH-(CH₂)ₙ₂-; Z es (CH)ₙ₁-; n² es un número entero entre 0 y 2; n¹ es un número entero entre 1 y 20; R² es CH₃; y X¹ es -COO-; caracterizado porque dicho compuesto se selecciona del grupo formado por los compuestos del grupo de fórmulas (6).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04100001 | 2004-01-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR098931A2 true AR098931A2 (es) | 2016-06-22 |
Family
ID=34778199
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100012A AR047081A1 (es) | 2004-01-05 | 2005-01-03 | Derivados de prostaglandinas, metodos para su preparacion, composiciones farmaceuticas que las contienen y su uso en el tratamiento del glaucoma y de la hipertension ocular. |
| ARP140104875A AR098931A2 (es) | 2004-01-05 | 2014-12-22 | Compuestos derivados de prostaglandinas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050100012A AR047081A1 (es) | 2004-01-05 | 2005-01-03 | Derivados de prostaglandinas, metodos para su preparacion, composiciones farmaceuticas que las contienen y su uso en el tratamiento del glaucoma y de la hipertension ocular. |
Country Status (40)
| Country | Link |
|---|---|
| US (5) | US7273946B2 (es) |
| EP (3) | EP3002277B1 (es) |
| JP (1) | JP3984283B2 (es) |
| KR (2) | KR100854838B1 (es) |
| CN (1) | CN100469765C (es) |
| AP (1) | AP2006003638A0 (es) |
| AR (2) | AR047081A1 (es) |
| AU (1) | AU2004313688B2 (es) |
| BR (1) | BRPI0418245B8 (es) |
| CA (1) | CA2551409C (es) |
| CR (2) | CR8498A (es) |
| CY (1) | CY1117417T1 (es) |
| DK (1) | DK1704141T3 (es) |
| EA (1) | EA010595B1 (es) |
| EC (1) | ECSP066684A (es) |
| ES (2) | ES2767136T3 (es) |
| GE (1) | GEP20094780B (es) |
| GT (1) | GT200500293A (es) |
| HK (1) | HK1096084A1 (es) |
| HR (1) | HRP20160500T1 (es) |
| HU (1) | HUE027357T2 (es) |
| IL (1) | IL176416A (es) |
| MA (1) | MA28284A1 (es) |
| ME (1) | ME02433B (es) |
| MX (1) | MXPA06007678A (es) |
| MY (1) | MY147181A (es) |
| NO (2) | NO337217B1 (es) |
| NZ (1) | NZ548271A (es) |
| OA (1) | OA13356A (es) |
| PA (1) | PA8620901A1 (es) |
| PE (1) | PE20051052A1 (es) |
| PL (1) | PL1704141T3 (es) |
| RS (1) | RS54717B1 (es) |
| SI (1) | SI1704141T1 (es) |
| TN (1) | TNSN06210A1 (es) |
| TW (1) | TWI337994B (es) |
| UA (1) | UA84726C2 (es) |
| UY (1) | UY28709A1 (es) |
| WO (1) | WO2005068421A1 (es) |
| ZA (1) | ZA200605354B (es) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ME02433B (me) | 2004-01-05 | 2016-09-20 | Nicox Sa | Nitrooksiderivati prostaglandina |
| JP2009500315A (ja) * | 2005-06-29 | 2009-01-08 | ファイザー・インク | フルオロプロスタグランジンのニトロ誘導体 |
| CA2613748A1 (en) * | 2005-06-29 | 2007-01-04 | Pfizer Inc. | Prostaglandin derivatives |
| EP2007705A4 (en) * | 2006-03-29 | 2011-09-07 | Nicox Sa | NITROGEN MONOXIDE REINFORCING PROSTAGLANDIN COMPOUNDS, COMPOSITION AND APPLICATION PROCESS |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| DE102006052755A1 (de) * | 2006-11-08 | 2008-05-15 | N-Zyme Biotec Gmbh | Michaelsysteme als Transglutaminaseinhibitoren |
| JP2010513262A (ja) | 2006-12-15 | 2010-04-30 | ニコックス エス エイ | カルボニックアンヒドラーゼ阻害剤誘導体 |
| WO2008071421A1 (en) * | 2006-12-15 | 2008-06-19 | Nicox S.A. | Nitrate esters of carbonic anhydrase inhibitors |
| KR101853971B1 (ko) | 2007-06-04 | 2018-05-02 | 테크필즈 인크 | 매우 높은 피부 및 막 침투율을 가지는 비스테로이드성 소염제(ｎｓａｉａ) 약물전구체 및 이들의 새로운 의약적 용도 |
| WO2009035565A1 (en) * | 2007-09-07 | 2009-03-19 | Qlt Plug Delivery, Inc | Prostaglandin analogues for implant devices and methods |
| US7632868B2 (en) * | 2007-10-31 | 2009-12-15 | Meta Cosmetics, Llc | Prostaglandin analog compositions to treat epithelial-related conditions |
| AR076731A1 (es) * | 2008-05-09 | 2011-07-06 | Pfizer | Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas |
| US7807716B2 (en) * | 2008-09-24 | 2010-10-05 | Oral Delivery Technology Ltd. | Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use |
| BRPI0922263B1 (pt) | 2008-12-04 | 2021-08-31 | Chongxi Yu | Composição de alta penetração de um fármaco principal, e seus usos |
| US8637558B2 (en) | 2008-12-30 | 2014-01-28 | Industry-Academic Cooperation Foundation, Chosun University | Thiazolidinedione derivative and use thereof |
| CN102498088A (zh) * | 2009-09-15 | 2012-06-13 | 帝斯曼知识产权资产管理有限公司 | 硝基氧基酯及其制备和用途 |
| CN101885684B (zh) * | 2010-07-01 | 2013-10-30 | 南京中医药大学 | 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用 |
| EP3290024B1 (en) | 2011-08-29 | 2019-04-17 | Mati Therapeutics Inc. | Sustained release delivery of active agents to treat glaucoma and ocular hypertension |
| HU231203B1 (hu) * | 2011-12-21 | 2021-10-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Új eljárás travoprost előállítására |
| JP6213560B2 (ja) | 2012-05-03 | 2017-10-18 | マティ セラピューティクス，インク． | 薬剤送達システムならびに開放隅角緑内障および高眼圧症を治療する方法 |
| CN104994845B (zh) * | 2012-10-23 | 2017-11-17 | 尼科斯科学爱尔兰公司 | 用于眼科应用的醌基一氧化氮供体化合物 |
| ES2624446T3 (es) * | 2013-04-18 | 2017-07-14 | Nicox Science Ireland | Compuestos donantes de óxido nítrico a base de quinona para uso oftalmológico |
| US9913849B2 (en) | 2014-01-10 | 2018-03-13 | Manistee Partners Llc | Treatment of migraines |
| CN107106573A (zh) * | 2014-10-15 | 2017-08-29 | 诺华股份有限公司 | 用于治疗青光眼和眼压过高的前列腺素偶联物和衍生物 |
| US10047047B2 (en) | 2015-03-31 | 2018-08-14 | Nicox S.A. | Nitric oxide donating derivatives of latanoprost free acid |
| WO2016155906A1 (en) * | 2015-03-31 | 2016-10-06 | Nicox S.A. | Nitric oxide donating derivatives of fluprostenol |
| EP3088388A1 (en) | 2015-04-30 | 2016-11-02 | NicOx S.A. | Nitric oxide donating derivatives of prostaglandins |
| CA2999766A1 (en) | 2015-09-22 | 2017-03-30 | Graybug Vision, Inc. | Compounds and compositions for the treatment of ocular disorders |
| HU231175B1 (hu) * | 2015-12-04 | 2021-06-28 | CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. | Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával |
| CA3043000A1 (en) | 2016-11-08 | 2018-05-17 | Bausch & Lomb Incorporated | Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma |
| KR102069205B1 (ko) | 2017-08-09 | 2020-01-22 | 연성정밀화학(주) | 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체 |
| RU2718744C2 (ru) | 2018-05-17 | 2020-04-14 | Общество с ограниченной ответственностью "Гурус БиоФарм" | Производные простагландина F2альфа для снижения внутриглазного давления |
| CN109988089B (zh) * | 2018-05-29 | 2022-04-26 | 上海凡秦医药科技有限公司 | 一种前列腺素化合物、制备方法及其用途 |
| CN108892624B (zh) * | 2018-06-20 | 2020-12-15 | 重庆威鹏药业有限公司 | 沙库巴曲硝基氧衍生物及其制备方法和应用 |
| US11332433B2 (en) * | 2020-07-24 | 2022-05-17 | Chirogate International Inc. | Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same |
| CN113943266A (zh) * | 2021-11-18 | 2022-01-18 | 广州楷石医药有限公司 | 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途 |
| CN116444377A (zh) * | 2022-01-07 | 2023-07-18 | 广州楷石医药有限公司 | 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途 |
| CA3195291A1 (en) * | 2022-04-13 | 2023-10-13 | Caravel Therapeutics, Inc. | Preservative-free ophthalmic pharmaceutical emulsion and its application |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3922293A (en) | 1971-12-30 | 1975-11-25 | Upjohn Co | Prostaglandin F-type 9-monoacylates |
| US4952581A (en) | 1987-04-03 | 1990-08-28 | The Trustees Of Columbia University In The City Of New York | Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure |
| EP0569046B1 (en) | 1988-09-06 | 2002-11-13 | Pharmacia Aktiebolag | Prostaglandin derivatives for the treatment of glaucoma or ocular hypertension |
| AU674038B2 (en) | 1992-10-13 | 1996-12-05 | Alcon Laboratories, Inc. | Combinations of prostaglandins and clonidine derivatives for the treatment of glaucoma |
| US5328933A (en) * | 1992-10-28 | 1994-07-12 | Allergan, Inc. | Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues |
| US5625083A (en) * | 1995-06-02 | 1997-04-29 | Bezuglov; Vladimir V. | Dinitroglycerol esters of unsaturated fatty acids and prostaglandins |
| IT1295694B1 (it) | 1996-11-14 | 1999-05-27 | Nicox Sa | Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica |
| IT1292377B1 (it) * | 1997-06-19 | 1999-02-08 | Nicox Sa | Composizioni farmaceutiche a base di prostaglandine |
| US6417228B1 (en) | 1998-11-02 | 2002-07-09 | Alcon Manufacturing, Ltd.. | 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension |
| AU3713600A (en) | 1999-03-01 | 2000-09-21 | Nitromed, Inc. | Nitrosated and nitrosylated prostaglandins, compositions and metods of use |
| AR035541A1 (es) | 2000-11-13 | 2004-06-16 | Pharmacia Ab | Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio |
| US7816399B2 (en) * | 2001-04-19 | 2010-10-19 | Teika Pharmaceutical Co., Ltd. | Medicines and medicinal kits |
| ME02433B (me) * | 2004-01-05 | 2016-09-20 | Nicox Sa | Nitrooksiderivati prostaglandina |
-
2004
- 2004-12-27 ME MEP-2016-79A patent/ME02433B/me unknown
- 2004-12-27 AP AP2006003638A patent/AP2006003638A0/xx unknown
- 2004-12-27 DK DK04804405.1T patent/DK1704141T3/en active
- 2004-12-27 EP EP15194684.5A patent/EP3002277B1/en active Active
- 2004-12-27 WO PCT/EP2004/014820 patent/WO2005068421A1/en active Application Filing
- 2004-12-27 KR KR1020087000325A patent/KR100854838B1/ko active IP Right Grant
- 2004-12-27 SI SI200432309T patent/SI1704141T1/sl unknown
- 2004-12-27 BR BRPI0418245A patent/BRPI0418245B8/pt active IP Right Grant
- 2004-12-27 EP EP19196238.0A patent/EP3643702A1/en not_active Withdrawn
- 2004-12-27 CN CNB2004800398051A patent/CN100469765C/zh active Active
- 2004-12-27 EP EP04804405.1A patent/EP1704141B1/en active Active
- 2004-12-27 CA CA2551409A patent/CA2551409C/en active Active
- 2004-12-27 JP JP2006546105A patent/JP3984283B2/ja active Active
- 2004-12-27 EA EA200601099A patent/EA010595B1/ru not_active IP Right Cessation
- 2004-12-27 OA OA1200600221A patent/OA13356A/en unknown
- 2004-12-27 AU AU2004313688A patent/AU2004313688B2/en active Active
- 2004-12-27 RS RS20160251A patent/RS54717B1/en unknown
- 2004-12-27 NZ NZ548271A patent/NZ548271A/en unknown
- 2004-12-27 ES ES15194684T patent/ES2767136T3/es active Active
- 2004-12-27 ES ES04804405.1T patent/ES2566800T3/es active Active
- 2004-12-27 HU HUE04804405A patent/HUE027357T2/en unknown
- 2004-12-27 UA UAA200607454A patent/UA84726C2/ru unknown
- 2004-12-27 GE GEAP20049494A patent/GEP20094780B/en unknown
- 2004-12-27 PL PL04804405T patent/PL1704141T3/pl unknown
- 2004-12-27 KR KR1020067013440A patent/KR100850133B1/ko active IP Right Grant
- 2004-12-27 MX MXPA06007678A patent/MXPA06007678A/es active IP Right Grant
- 2004-12-31 TW TW093141786A patent/TWI337994B/zh active
-
2005
- 2005-01-03 AR ARP050100012A patent/AR047081A1/es active IP Right Grant
- 2005-01-03 MY MYPI20050009A patent/MY147181A/en unknown
- 2005-01-04 PA PA20058620901A patent/PA8620901A1/es unknown
- 2005-01-04 UY UY28709A patent/UY28709A1/es not_active Application Discontinuation
- 2005-01-04 PE PE2005000037A patent/PE20051052A1/es active IP Right Grant
- 2005-01-05 US US11/029,698 patent/US7273946B2/en active Active
- 2005-10-18 GT GT200500293A patent/GT200500293A/es unknown
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2006
- 2006-06-19 IL IL176416A patent/IL176416A/en active IP Right Grant
- 2006-06-28 ZA ZA200605354A patent/ZA200605354B/xx unknown
- 2006-06-29 EC EC2006006684A patent/ECSP066684A/es unknown
- 2006-06-30 CR CR8498A patent/CR8498A/es unknown
- 2006-07-04 TN TNP2006000210A patent/TNSN06210A1/fr unknown
- 2006-07-05 MA MA29169A patent/MA28284A1/fr unknown
- 2006-08-07 NO NO20063567A patent/NO337217B1/no unknown
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2007
- 2007-03-30 HK HK07103447.6A patent/HK1096084A1/xx unknown
- 2007-08-20 US US11/841,628 patent/US7449469B2/en active Active
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2008
- 2008-09-15 US US12/210,975 patent/US7629345B2/en active Active
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2009
- 2009-11-06 US US12/613,985 patent/US7910767B2/en active Active
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2011
- 2011-02-11 US US13/025,740 patent/US8058467B2/en active Active
- 2011-03-11 CR CR20110131A patent/CR20110131A/es unknown
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2014
- 2014-12-22 AR ARP140104875A patent/AR098931A2/es not_active Application Discontinuation
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2015
- 2015-10-08 NO NO20151341A patent/NO339685B1/no unknown
-
2016
- 2016-04-26 CY CY20161100340T patent/CY1117417T1/el unknown
- 2016-05-11 HR HRP20160500TT patent/HRP20160500T1/hr unknown
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