PA8620901A1 - Derivados de prostaglandinas - Google Patents

Derivados de prostaglandinas

Info

Publication number
PA8620901A1
PA8620901A1 PA20058620901A PA8620901A PA8620901A1 PA 8620901 A1 PA8620901 A1 PA 8620901A1 PA 20058620901 A PA20058620901 A PA 20058620901A PA 8620901 A PA8620901 A PA 8620901A PA 8620901 A1 PA8620901 A1 PA 8620901A1
Authority
PA
Panama
Prior art keywords
derivatives
prostaglandinas
prostaglandina
glaucoma
nitro
Prior art date
Application number
PA20058620901A
Other languages
English (en)
Inventor
Ennio Ongini
Francesca Benedini
Valerio Chiroli
Soldaro Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34778199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PA8620901(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of PA8620901A1 publication Critical patent/PA8620901A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

DERIVADOS NITRO DE PROSTAGLANDINA DE ACTIVIDAD FARMACOLOGICA MEJORADA Y UNA MAYOR TOLERABILIDAD. PUEDEN EMPLEARSE PARA EL TRATAMIENTO DE GLAUCOMA Y DE LA HIPERTENSION OCULAR.
PA20058620901A 2004-01-05 2005-01-04 Derivados de prostaglandinas PA8620901A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04100001 2004-01-05

Publications (1)

Publication Number Publication Date
PA8620901A1 true PA8620901A1 (es) 2005-08-30

Family

ID=34778199

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20058620901A PA8620901A1 (es) 2004-01-05 2005-01-04 Derivados de prostaglandinas

Country Status (40)

Country Link
US (5) US7273946B2 (es)
EP (3) EP3002277B1 (es)
JP (1) JP3984283B2 (es)
KR (2) KR100854838B1 (es)
CN (1) CN100469765C (es)
AP (1) AP2006003638A0 (es)
AR (2) AR047081A1 (es)
AU (1) AU2004313688B2 (es)
BR (1) BRPI0418245B8 (es)
CA (1) CA2551409C (es)
CR (2) CR8498A (es)
CY (1) CY1117417T1 (es)
DK (1) DK1704141T3 (es)
EA (1) EA010595B1 (es)
EC (1) ECSP066684A (es)
ES (2) ES2767136T3 (es)
GE (1) GEP20094780B (es)
GT (1) GT200500293A (es)
HK (1) HK1096084A1 (es)
HR (1) HRP20160500T1 (es)
HU (1) HUE027357T2 (es)
IL (1) IL176416A (es)
MA (1) MA28284A1 (es)
ME (1) ME02433B (es)
MX (1) MXPA06007678A (es)
MY (1) MY147181A (es)
NO (2) NO337217B1 (es)
NZ (1) NZ548271A (es)
OA (1) OA13356A (es)
PA (1) PA8620901A1 (es)
PE (1) PE20051052A1 (es)
PL (1) PL1704141T3 (es)
RS (1) RS54717B1 (es)
SI (1) SI1704141T1 (es)
TN (1) TNSN06210A1 (es)
TW (1) TWI337994B (es)
UA (1) UA84726C2 (es)
UY (1) UY28709A1 (es)
WO (1) WO2005068421A1 (es)
ZA (1) ZA200605354B (es)

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EP3002277B1 (en) 2004-01-05 2019-11-06 Nicox S.A. Prostaglandin derivatives
CA2613748A1 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
CA2613010A1 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Fluoroprostaglandins nitroderivatives
WO2007126609A1 (en) * 2006-03-29 2007-11-08 Nitromed, Inc. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
US20100063035A1 (en) 2006-12-15 2010-03-11 Nicox S.A. Carbonic anhydrase inhibitors derivatives
WO2008071421A1 (en) * 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
JP2010529101A (ja) 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
WO2009035565A1 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
RU2010121880A (ru) * 2007-10-31 2011-12-10 Памела ЛИПКИН (US) Композиции аналогов простагландина и способы лечения состояний, затрагивающих эпителий
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
MX362949B (es) 2008-12-04 2019-02-27 Yu Chongxi Composiciones de alta penetracion y sus aplicaciones.
WO2010077101A2 (ko) 2008-12-30 2010-07-08 조선대학교산학협력단 신규한 티아졸리딘디온 유도체 및 그의 용도
WO2011032936A1 (en) * 2009-09-15 2011-03-24 Dsm Ip Assets B.V. Nitrooxyesters, their preparation and use
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
EP3290024B1 (en) 2011-08-29 2019-04-17 Mati Therapeutics Inc. Sustained release delivery of active agents to treat glaucoma and ocular hypertension
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
WO2013164671A1 (en) 2012-05-03 2013-11-07 Qlt Inc. Drug delivery system and methods of treating open angle glaucoma and ocular hypertension
ES2841993T3 (es) * 2012-10-23 2021-07-12 Nicox Sa Compuestos donantes de óxido nítrico a base de quinona para uso oftálmico
WO2014170264A1 (en) * 2013-04-18 2014-10-23 Nicox Science Ireland Quinone based nitric oxide donating compounds for ophthalmic use
US9913849B2 (en) 2014-01-10 2018-03-13 Manistee Partners Llc Treatment of migraines
CN112022856A (zh) * 2014-10-15 2020-12-04 爱尔康公司 用于治疗青光眼和眼压过高的前列腺素偶联物和衍生物
WO2016156104A1 (en) 2015-03-31 2016-10-06 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
MX2018003462A (es) 2015-09-22 2018-09-06 Graybug Vision Inc Compuestos y composiciones para el tratamiento de trastornos oculares.
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
BR112019009330A2 (pt) 2016-11-08 2019-07-30 Bausch & Lomb composto
KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
CN109988089B (zh) * 2018-05-29 2022-04-26 上海凡秦医药科技有限公司 一种前列腺素化合物、制备方法及其用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
US11332433B2 (en) 2020-07-24 2022-05-17 Chirogate International Inc. Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
CN116444377A (zh) * 2022-01-07 2023-07-18 广州楷石医药有限公司 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途
CA3195291A1 (en) * 2022-04-13 2023-10-13 Caravel Therapeutics, Inc. Preservative-free ophthalmic pharmaceutical emulsion and its application

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US3922293A (en) 1971-12-30 1975-11-25 Upjohn Co Prostaglandin F-type 9-monoacylates
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
JP2721414B2 (ja) 1988-09-06 1998-03-04 フアーマシア・アンド・アツプジヨン・アー・ベー 縁内障または眼圧亢進の治療のためのプロスタグランジン誘導体
ATE153855T1 (de) 1992-10-13 1997-06-15 Alcon Lab Inc Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292377B1 (it) * 1997-06-19 1999-02-08 Nicox Sa Composizioni farmaceutiche a base di prostaglandine
US6417228B1 (en) 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
WO2000051978A1 (en) 1999-03-01 2000-09-08 Nitromed, Inc. Nitrosated and nitrosylated prostaglandins, compositions and metods of use
AR035541A1 (es) 2000-11-13 2004-06-16 Pharmacia Ab Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio
BR0209063A (pt) 2001-04-19 2004-08-10 Teika Pharmaceutical Co Ltd Medicamentos e kits de uso medicinal
EP3002277B1 (en) 2004-01-05 2019-11-06 Nicox S.A. Prostaglandin derivatives

Also Published As

Publication number Publication date
EP1704141B1 (en) 2016-02-24
TNSN06210A1 (fr) 2007-12-03
BRPI0418245B1 (pt) 2017-05-30
US20110136904A1 (en) 2011-06-09
AU2004313688A1 (en) 2005-07-28
ECSP066684A (es) 2006-10-25
KR100854838B1 (ko) 2008-08-29
WO2005068421A8 (en) 2006-02-09
HRP20160500T1 (hr) 2016-06-03
AU2004313688B2 (en) 2010-08-05
EP3002277A1 (en) 2016-04-06
GEP20094780B (en) 2009-09-25
US20050272743A1 (en) 2005-12-08
JP2007518716A (ja) 2007-07-12
JP3984283B2 (ja) 2007-10-03
US7449469B2 (en) 2008-11-11
HK1096084A1 (en) 2007-05-25
BRPI0418245A (pt) 2007-04-17
US8058467B2 (en) 2011-11-15
US7629345B2 (en) 2009-12-08
MXPA06007678A (es) 2006-09-01
KR100850133B1 (ko) 2008-08-04
NZ548271A (en) 2010-01-29
PE20051052A1 (es) 2005-12-17
AR098931A2 (es) 2016-06-22
WO2005068421A1 (en) 2005-07-28
EA010595B1 (ru) 2008-10-30
ZA200605354B (en) 2009-09-30
US20080058392A1 (en) 2008-03-06
MY147181A (en) 2012-11-14
NO337217B1 (no) 2016-02-15
AP2006003638A0 (en) 2006-06-30
CY1117417T1 (el) 2017-04-26
HUE027357T2 (en) 2016-09-28
IL176416A0 (en) 2006-10-05
GT200500293A (es) 2007-07-06
CR8498A (es) 2006-11-15
US7910767B2 (en) 2011-03-22
CN1906159A (zh) 2007-01-31
NO20063567L (no) 2006-09-07
DK1704141T3 (en) 2016-05-02
EP3643702A1 (en) 2020-04-29
ES2566800T3 (es) 2016-04-15
US20100130507A1 (en) 2010-05-27
TWI337994B (en) 2011-03-01
CR20110131A (es) 2011-03-30
NO20151341A1 (no) 2006-09-07
RS54717B1 (en) 2016-08-31
SI1704141T1 (sl) 2016-04-29
PL1704141T3 (pl) 2016-08-31
IL176416A (en) 2013-05-30
MA28284A1 (fr) 2006-11-01
OA13356A (en) 2007-04-13
KR20060113753A (ko) 2006-11-02
UA84726C2 (ru) 2008-11-25
CN100469765C (zh) 2009-03-18
EP3002277B1 (en) 2019-11-06
UY28709A1 (es) 2005-08-31
ES2767136T3 (es) 2020-06-16
EA200601099A1 (ru) 2006-10-27
US20090030076A1 (en) 2009-01-29
KR20080007415A (ko) 2008-01-18
EP1704141A1 (en) 2006-09-27
CA2551409C (en) 2011-02-22
TW200526567A (en) 2005-08-16
CA2551409A1 (en) 2005-07-28
NO339685B1 (no) 2017-01-23
AR047081A1 (es) 2006-01-04
ME02433B (me) 2016-09-20
BRPI0418245B8 (pt) 2021-05-25
US7273946B2 (en) 2007-09-25

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