NO20063567L - Prostaglandin nitrooksyderivater - Google Patents

Prostaglandin nitrooksyderivater

Info

Publication number
NO20063567L
NO20063567L NO20063567A NO20063567A NO20063567L NO 20063567 L NO20063567 L NO 20063567L NO 20063567 A NO20063567 A NO 20063567A NO 20063567 A NO20063567 A NO 20063567A NO 20063567 L NO20063567 L NO 20063567L
Authority
NO
Norway
Prior art keywords
prostaglandin
nitric oxide
oxide derivatives
improved
derivatives
Prior art date
Application number
NO20063567A
Other languages
English (en)
Other versions
NO337217B1 (no
Inventor
Piero Del Soldato
Ennio Ongini
Francesca Benedini
Valerio Chiroli
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34778199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20063567(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of NO20063567L publication Critical patent/NO20063567L/no
Publication of NO337217B1 publication Critical patent/NO337217B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

Prostaglandinnitroderivater som har forbedret farmakologisk aktivitet og forbedret tolererbarhet er beskrevet. De kan anvendes for behandling av glaukom og okkulær hypertensjon.
NO20063567A 2004-01-05 2006-08-07 Prostaglandinnitrooksyderivater, fremgangsmåte for fremstilling derav, anvendelse derav, samt farmasøytisk sammensetning som innbefatter slike derivater NO337217B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04100001 2004-01-05
PCT/EP2004/014820 WO2005068421A1 (en) 2004-01-05 2004-12-27 Prostaglandin nitrooxyderivatives

Publications (2)

Publication Number Publication Date
NO20063567L true NO20063567L (no) 2006-09-07
NO337217B1 NO337217B1 (no) 2016-02-15

Family

ID=34778199

Family Applications (2)

Application Number Title Priority Date Filing Date
NO20063567A NO337217B1 (no) 2004-01-05 2006-08-07 Prostaglandinnitrooksyderivater, fremgangsmåte for fremstilling derav, anvendelse derav, samt farmasøytisk sammensetning som innbefatter slike derivater
NO20151341A NO339685B1 (no) 2004-01-05 2015-10-08 Prostaglandinnitrooksyderivater, fremgangsmåte for fremstilling derav, anvendelse derav, samt farmasøytisk sammensetning som innbefatter slike derivater

Family Applications After (1)

Application Number Title Priority Date Filing Date
NO20151341A NO339685B1 (no) 2004-01-05 2015-10-08 Prostaglandinnitrooksyderivater, fremgangsmåte for fremstilling derav, anvendelse derav, samt farmasøytisk sammensetning som innbefatter slike derivater

Country Status (40)

Country Link
US (5) US7273946B2 (no)
EP (3) EP3643702A1 (no)
JP (1) JP3984283B2 (no)
KR (2) KR100850133B1 (no)
CN (1) CN100469765C (no)
AP (1) AP2006003638A0 (no)
AR (2) AR047081A1 (no)
AU (1) AU2004313688B2 (no)
BR (1) BRPI0418245B8 (no)
CA (1) CA2551409C (no)
CR (2) CR8498A (no)
CY (1) CY1117417T1 (no)
DK (1) DK1704141T3 (no)
EA (1) EA010595B1 (no)
EC (1) ECSP066684A (no)
ES (2) ES2566800T3 (no)
GE (1) GEP20094780B (no)
GT (1) GT200500293A (no)
HK (1) HK1096084A1 (no)
HR (1) HRP20160500T1 (no)
HU (1) HUE027357T2 (no)
IL (1) IL176416A (no)
MA (1) MA28284A1 (no)
ME (1) ME02433B (no)
MX (1) MXPA06007678A (no)
MY (1) MY147181A (no)
NO (2) NO337217B1 (no)
NZ (1) NZ548271A (no)
OA (1) OA13356A (no)
PA (1) PA8620901A1 (no)
PE (1) PE20051052A1 (no)
PL (1) PL1704141T3 (no)
RS (1) RS54717B1 (no)
SI (1) SI1704141T1 (no)
TN (1) TNSN06210A1 (no)
TW (1) TWI337994B (no)
UA (1) UA84726C2 (no)
UY (1) UY28709A1 (no)
WO (1) WO2005068421A1 (no)
ZA (1) ZA200605354B (no)

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NZ548271A (en) 2004-01-05 2010-01-29 Nicox Sa Prostaglandin nitrooxyderivatives
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CA2647859C (en) * 2006-03-29 2016-01-05 Nitromed, Inc. Nitric oxide enhancing prostaglandin compounds, compositions and methods of use
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
WO2008071421A1 (en) * 2006-12-15 2008-06-19 Nicox S.A. Nitrate esters of carbonic anhydrase inhibitors
CA2671137A1 (en) 2006-12-15 2008-06-26 Nicox S.A. Carbonic anhydrase inhibitors derivatives
CN105820107B (zh) 2007-06-04 2022-09-09 泰飞尔公司 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其新的医药用途
WO2009035565A1 (en) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Prostaglandin analogues for implant devices and methods
CA2704337A1 (en) * 2007-10-31 2009-05-07 Beverly W. Lubit Prostaglandin analog compositions and methods to treat epithelial-related conditions
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
KR20200022525A (ko) 2008-12-04 2020-03-03 충시 위 고투과력을 가진 조성물 및 이의 적용
US8637558B2 (en) 2008-12-30 2014-01-28 Industry-Academic Cooperation Foundation, Chosun University Thiazolidinedione derivative and use thereof
US9162969B2 (en) 2009-09-15 2015-10-20 Dsm Ip Assets B.V. Nitrooxyesters, their preparation and use
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
CN103889401B (zh) 2011-08-29 2017-10-13 Qlt公司 持续释放递送活性剂以治疗青光眼和高眼压
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
CN105473130A (zh) 2012-05-03 2016-04-06 麦提疗法有限公司 治疗开角型青光眼和高眼压症的药物递送系统和方法
EP2911656B1 (en) * 2012-10-23 2020-12-02 Nicox SA Quinone based nitric oxide donating compounds for ophthalmic use
CA2909622C (en) * 2013-04-18 2021-05-18 Nicox Science Ireland Quinone based nitric oxide donating compounds for ophthalmic use
JP2017502089A (ja) 2014-01-10 2017-01-19 マニスティー パートナーズ エルエルシーＭａｎｉｓｔｅｅ Ｐａｒｔｎｅｒｓ Ｌｌｃ 偏頭痛の処置
MX2020012011A (es) * 2014-10-15 2022-04-19 Alcon Inc Conjugados y derivados de prostaglandina para tratar el glaucoma y la hipertension ocular.
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
US10047047B2 (en) 2015-03-31 2018-08-14 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
BR112018005589A2 (pt) 2015-09-22 2018-10-09 Graybug Vision Inc “composto, composição farmaceuticamente aceitável, e, uso de um composto”
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
MX2019005321A (es) 2016-11-08 2019-10-14 Bausch & Lomb Derivados de prostaglandina que liberan oxido nitrico para el tratamiento de glaucoma de tension normal.
KR102069205B1 (ko) 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
RU2718744C2 (ru) 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
CN109988089B (zh) * 2018-05-29 2022-04-26 上海凡秦医药科技有限公司 一种前列腺素化合物、制备方法及其用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
US11332433B2 (en) * 2020-07-24 2022-05-17 Chirogate International Inc. Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
CN116444377A (zh) * 2022-01-07 2023-07-18 广州楷石医药有限公司 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途
CA3195291A1 (en) * 2022-04-13 2023-10-13 Caravel Therapeutics, Inc. Preservative-free ophthalmic pharmaceutical emulsion and its application

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US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
ES2213504T1 (es) 1988-09-06 2004-09-01 Pfizer Health Ab Derivados de prostaglandina para el tratamiento del glaucoma o hipertension ocular.
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Also Published As

Publication number Publication date
KR20080007415A (ko) 2008-01-18
NO339685B1 (no) 2017-01-23
ES2767136T3 (es) 2020-06-16
US20110136904A1 (en) 2011-06-09
US8058467B2 (en) 2011-11-15
AR047081A1 (es) 2006-01-04
ME02433B (me) 2016-09-20
AU2004313688A1 (en) 2005-07-28
PE20051052A1 (es) 2005-12-17
EP3002277B1 (en) 2019-11-06
WO2005068421A8 (en) 2006-02-09
KR100850133B1 (ko) 2008-08-04
CA2551409C (en) 2011-02-22
WO2005068421A1 (en) 2005-07-28
EP3643702A1 (en) 2020-04-29
HRP20160500T1 (hr) 2016-06-03
CR8498A (es) 2006-11-15
EP3002277A1 (en) 2016-04-06
JP3984283B2 (ja) 2007-10-03
RS54717B1 (en) 2016-08-31
AR098931A2 (es) 2016-06-22
GT200500293A (es) 2007-07-06
BRPI0418245B8 (pt) 2021-05-25
AU2004313688B2 (en) 2010-08-05
MXPA06007678A (es) 2006-09-01
PA8620901A1 (es) 2005-08-30
ZA200605354B (en) 2009-09-30
US20080058392A1 (en) 2008-03-06
CY1117417T1 (el) 2017-04-26
CR20110131A (es) 2011-03-30
GEP20094780B (en) 2009-09-25
OA13356A (en) 2007-04-13
PL1704141T3 (pl) 2016-08-31
EP1704141A1 (en) 2006-09-27
US7449469B2 (en) 2008-11-11
NZ548271A (en) 2010-01-29
SI1704141T1 (sl) 2016-04-29
EA200601099A1 (ru) 2006-10-27
MY147181A (en) 2012-11-14
US20090030076A1 (en) 2009-01-29
HK1096084A1 (en) 2007-05-25
ES2566800T3 (es) 2016-04-15
AP2006003638A0 (en) 2006-06-30
KR20060113753A (ko) 2006-11-02
UA84726C2 (ru) 2008-11-25
MA28284A1 (fr) 2006-11-01
BRPI0418245B1 (pt) 2017-05-30
NO20151341A1 (no) 2006-09-07
BRPI0418245A (pt) 2007-04-17
CN100469765C (zh) 2009-03-18
EP1704141B1 (en) 2016-02-24
DK1704141T3 (en) 2016-05-02
TWI337994B (en) 2011-03-01
IL176416A (en) 2013-05-30
JP2007518716A (ja) 2007-07-12
ECSP066684A (es) 2006-10-25
CN1906159A (zh) 2007-01-31
IL176416A0 (en) 2006-10-05
US7629345B2 (en) 2009-12-08
US7910767B2 (en) 2011-03-22
TNSN06210A1 (fr) 2007-12-03
TW200526567A (en) 2005-08-16
CA2551409A1 (en) 2005-07-28
NO337217B1 (no) 2016-02-15
UY28709A1 (es) 2005-08-31
US7273946B2 (en) 2007-09-25
EA010595B1 (ru) 2008-10-30
US20050272743A1 (en) 2005-12-08
HUE027357T2 (en) 2016-09-28
US20100130507A1 (en) 2010-05-27
KR100854838B1 (ko) 2008-08-29

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