MA28284A1 - Nitro-oxydérivés de prostaglandines - Google Patents

Nitro-oxydérivés de prostaglandines

Info

Publication number
MA28284A1
MA28284A1 MA29169A MA29169A MA28284A1 MA 28284 A1 MA28284 A1 MA 28284A1 MA 29169 A MA29169 A MA 29169A MA 29169 A MA29169 A MA 29169A MA 28284 A1 MA28284 A1 MA 28284A1
Authority
MA
Morocco
Prior art keywords
prostaglandins
nitro
oxidized
oxyderivated
nicox
Prior art date
Application number
MA29169A
Other languages
English (en)
Inventor
Ennio Ongini
Francesca Benedini
Valerio Chiroli
Soldato Piero Del
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34778199&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA28284(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of MA28284A1 publication Critical patent/MA28284A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/04—Nitro compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)

Abstract

DEPOSANT Société dite : NICOX, S.A. REVENDICATION DE PRIORITES EP 5 Janvier 2004 04100001.9 Voir en annexe le titre de l'invention et le texte de l'abrégé Nitro-oxydérivés de prostaglandines Des nitro-oxyderivés de prostaglandines ayant une activité pharmacologique améliorée et une capacité de tolérance accrue sont décrits. Ils peuvent être utilisés pour le traitement du glaucome et de l'hypertension oculaire.
MA29169A 2004-01-05 2006-07-05 Nitro-oxydérivés de prostaglandines MA28284A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04100001 2004-01-05

Publications (1)

Publication Number Publication Date
MA28284A1 true MA28284A1 (fr) 2006-11-01

Family

ID=34778199

Family Applications (1)

Application Number Title Priority Date Filing Date
MA29169A MA28284A1 (fr) 2004-01-05 2006-07-05 Nitro-oxydérivés de prostaglandines

Country Status (40)

Country Link
US (5) US7273946B2 (fr)
EP (3) EP3002277B1 (fr)
JP (1) JP3984283B2 (fr)
KR (2) KR100854838B1 (fr)
CN (1) CN100469765C (fr)
AP (1) AP2006003638A0 (fr)
AR (2) AR047081A1 (fr)
AU (1) AU2004313688B2 (fr)
BR (1) BRPI0418245B8 (fr)
CA (1) CA2551409C (fr)
CR (2) CR8498A (fr)
CY (1) CY1117417T1 (fr)
DK (1) DK1704141T3 (fr)
EA (1) EA010595B1 (fr)
EC (1) ECSP066684A (fr)
ES (2) ES2767136T3 (fr)
GE (1) GEP20094780B (fr)
GT (1) GT200500293A (fr)
HK (1) HK1096084A1 (fr)
HR (1) HRP20160500T1 (fr)
HU (1) HUE027357T2 (fr)
IL (1) IL176416A (fr)
MA (1) MA28284A1 (fr)
ME (1) ME02433B (fr)
MX (1) MXPA06007678A (fr)
MY (1) MY147181A (fr)
NO (2) NO337217B1 (fr)
NZ (1) NZ548271A (fr)
OA (1) OA13356A (fr)
PA (1) PA8620901A1 (fr)
PE (1) PE20051052A1 (fr)
PL (1) PL1704141T3 (fr)
RS (1) RS54717B1 (fr)
SI (1) SI1704141T1 (fr)
TN (1) TNSN06210A1 (fr)
TW (1) TWI337994B (fr)
UA (1) UA84726C2 (fr)
UY (1) UY28709A1 (fr)
WO (1) WO2005068421A1 (fr)
ZA (1) ZA200605354B (fr)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3002277B1 (fr) 2004-01-05 2019-11-06 Nicox S.A. Dérivés de prostaglandine
CA2613748A1 (fr) * 2005-06-29 2007-01-04 Pfizer Inc. Derives de prostaglandine
CA2613010A1 (fr) * 2005-06-29 2007-01-04 Pfizer Inc. Derives nitres de fluoroprostaglandines
WO2007126609A1 (fr) * 2006-03-29 2007-11-08 Nitromed, Inc. Prostaglandines amplificatrices d'oxyde nitrique, compositions et méthodes d'utilisation
US20090238763A1 (en) 2006-07-09 2009-09-24 Chongxi Yu High penetration compositions and uses thereof
US20090221703A1 (en) 2006-07-09 2009-09-03 Chongxi Yu High penetration composition and uses thereof
DE102006052755A1 (de) * 2006-11-08 2008-05-15 N-Zyme Biotec Gmbh Michaelsysteme als Transglutaminaseinhibitoren
US20100063035A1 (en) 2006-12-15 2010-03-11 Nicox S.A. Carbonic anhydrase inhibitors derivatives
WO2008071421A1 (fr) * 2006-12-15 2008-06-19 Nicox S.A. Esters de l'acide nitrique des inhibiteurs d'anhydrase carbonique
JP2010529101A (ja) 2007-06-04 2010-08-26 テックフィールズ インコーポレイテッド 非常に速い皮膚及び膜浸透速度を有するｎｓａｉａプロドラッグ及びその新規医薬使用
WO2009035565A1 (fr) * 2007-09-07 2009-03-19 Qlt Plug Delivery, Inc Analogues de prostaglandines pour des dispositifs d'implant et procédés
RU2010121880A (ru) * 2007-10-31 2011-12-10 Памела ЛИПКИН (US) Композиции аналогов простагландина и способы лечения состояний, затрагивающих эпителий
AR076731A1 (es) * 2008-05-09 2011-07-06 Pfizer Prostamidas donadoras de oxido nitrico, uso de los mismos y composiciones farmaceuticas
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
MX362949B (es) 2008-12-04 2019-02-27 Yu Chongxi Composiciones de alta penetracion y sus aplicaciones.
WO2010077101A2 (fr) 2008-12-30 2010-07-08 조선대학교산학협력단 Nouveau dérivé de thiazolidinedione et ses applications
WO2011032936A1 (fr) * 2009-09-15 2011-03-24 Dsm Ip Assets B.V. Nitroxyesters, leur préparation et leur utilisation
CN101885684B (zh) * 2010-07-01 2013-10-30 南京中医药大学 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用
EP3290024B1 (fr) 2011-08-29 2019-04-17 Mati Therapeutics Inc. Administration à libération prolongée d'agents actifs pour traiter le glaucome et l'hypertension oculaire
HU231203B1 (hu) * 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
WO2013164671A1 (fr) 2012-05-03 2013-11-07 Qlt Inc. Système d'administration de médicament et procédés de traitement d'un glaucome à angle ouvert et de l'hypertension oculaire
ES2841993T3 (es) * 2012-10-23 2021-07-12 Nicox Sa Compuestos donantes de óxido nítrico a base de quinona para uso oftálmico
WO2014170264A1 (fr) * 2013-04-18 2014-10-23 Nicox Science Ireland Composés donneurs d'oxyde nitrique à base de quinone à usage ophtalmique
US9913849B2 (en) 2014-01-10 2018-03-13 Manistee Partners Llc Treatment of migraines
CN112022856A (zh) * 2014-10-15 2020-12-04 爱尔康公司 用于治疗青光眼和眼压过高的前列腺素偶联物和衍生物
WO2016156104A1 (fr) 2015-03-31 2016-10-06 Nicox S.A. Dérivés d'acide libre latanoprost donneurs d'oxygène
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
EP3088388A1 (fr) 2015-04-30 2016-11-02 NicOx S.A. Dérivés de prostaglandines donneurs d'oxyde nitrique
MX2018003462A (es) 2015-09-22 2018-09-06 Graybug Vision Inc Compuestos y composiciones para el tratamiento de trastornos oculares.
HU231175B1 (hu) * 2015-12-04 2021-06-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Tetszőleges, előre meghatározott minőségű Latanoprostene bunod előállítása gravitációs kromatográfiával
BR112019009330A2 (pt) 2016-11-08 2019-07-30 Bausch & Lomb composto
KR102069205B1 (ko) * 2017-08-09 2020-01-22 연성정밀화학(주) 라타노프로스틴 부노드의 제조 방법 및 그를 위한 중간체
RU2718744C2 (ru) * 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
CN109988089B (zh) * 2018-05-29 2022-04-26 上海凡秦医药科技有限公司 一种前列腺素化合物、制备方法及其用途
CN108892624B (zh) * 2018-06-20 2020-12-15 重庆威鹏药业有限公司 沙库巴曲硝基氧衍生物及其制备方法和应用
US11332433B2 (en) 2020-07-24 2022-05-17 Chirogate International Inc. Process for the preparation of latanoprostene bunod and intermediate thereof and compositions comprising the same
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
CN116444377A (zh) * 2022-01-07 2023-07-18 广州楷石医药有限公司 一种氧化氮供体型曲前列尼尔类衍生物及其药物组合物和用途
CA3195291A1 (fr) * 2022-04-13 2023-10-13 Caravel Therapeutics, Inc. Emulsion pharmaceutique ophtalmique sans preservatif et application connexe

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3922293A (en) 1971-12-30 1975-11-25 Upjohn Co Prostaglandin F-type 9-monoacylates
US4952581A (en) 1987-04-03 1990-08-28 The Trustees Of Columbia University In The City Of New York Use of a prostaglandin in combination with an adrenergic blocking agent for reduction of intraocular pressure
JP2721414B2 (ja) 1988-09-06 1998-03-04 フアーマシア・アンド・アツプジヨン・アー・ベー 縁内障または眼圧亢進の治療のためのプロスタグランジン誘導体
ATE153855T1 (de) 1992-10-13 1997-06-15 Alcon Lab Inc Zusammensetzungen zur behandlung von glaukoma die prostaglandine und clonidinderivate enthalten
US5328933A (en) * 1992-10-28 1994-07-12 Allergan, Inc. Cyclopentane heptenylnitro and heptanylnitro-2-aliphatic or aryl aliphatic derivatives and homologues
US5625083A (en) 1995-06-02 1997-04-29 Bezuglov; Vladimir V. Dinitroglycerol esters of unsaturated fatty acids and prostaglandins
IT1295694B1 (it) 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
IT1292377B1 (it) * 1997-06-19 1999-02-08 Nicox Sa Composizioni farmaceutiche a base di prostaglandine
US6417228B1 (en) 1998-11-02 2002-07-09 Alcon Manufacturing, Ltd.. 13-Aza prostaglandins for the treatment of glaucoma and ocular hypertension
WO2000051978A1 (fr) 1999-03-01 2000-09-08 Nitromed, Inc. Prostaglandines nitrosees et nitrosylees, compositions et methodes d'utilisation
AR035541A1 (es) 2000-11-13 2004-06-16 Pharmacia Ab Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio
BR0209063A (pt) 2001-04-19 2004-08-10 Teika Pharmaceutical Co Ltd Medicamentos e kits de uso medicinal
EP3002277B1 (fr) 2004-01-05 2019-11-06 Nicox S.A. Dérivés de prostaglandine

Also Published As

Publication number Publication date
EP1704141B1 (fr) 2016-02-24
TNSN06210A1 (fr) 2007-12-03
BRPI0418245B1 (pt) 2017-05-30
US20110136904A1 (en) 2011-06-09
AU2004313688A1 (en) 2005-07-28
ECSP066684A (es) 2006-10-25
KR100854838B1 (ko) 2008-08-29
WO2005068421A8 (fr) 2006-02-09
HRP20160500T1 (hr) 2016-06-03
AU2004313688B2 (en) 2010-08-05
EP3002277A1 (fr) 2016-04-06
GEP20094780B (en) 2009-09-25
US20050272743A1 (en) 2005-12-08
JP2007518716A (ja) 2007-07-12
JP3984283B2 (ja) 2007-10-03
US7449469B2 (en) 2008-11-11
HK1096084A1 (en) 2007-05-25
BRPI0418245A (pt) 2007-04-17
US8058467B2 (en) 2011-11-15
US7629345B2 (en) 2009-12-08
MXPA06007678A (es) 2006-09-01
KR100850133B1 (ko) 2008-08-04
NZ548271A (en) 2010-01-29
PE20051052A1 (es) 2005-12-17
AR098931A2 (es) 2016-06-22
WO2005068421A1 (fr) 2005-07-28
EA010595B1 (ru) 2008-10-30
ZA200605354B (en) 2009-09-30
US20080058392A1 (en) 2008-03-06
MY147181A (en) 2012-11-14
NO337217B1 (no) 2016-02-15
AP2006003638A0 (en) 2006-06-30
CY1117417T1 (el) 2017-04-26
HUE027357T2 (en) 2016-09-28
IL176416A0 (en) 2006-10-05
GT200500293A (es) 2007-07-06
CR8498A (es) 2006-11-15
US7910767B2 (en) 2011-03-22
CN1906159A (zh) 2007-01-31
NO20063567L (no) 2006-09-07
DK1704141T3 (en) 2016-05-02
EP3643702A1 (fr) 2020-04-29
ES2566800T3 (es) 2016-04-15
US20100130507A1 (en) 2010-05-27
TWI337994B (en) 2011-03-01
CR20110131A (es) 2011-03-30
NO20151341A1 (no) 2006-09-07
RS54717B1 (en) 2016-08-31
SI1704141T1 (sl) 2016-04-29
PL1704141T3 (pl) 2016-08-31
IL176416A (en) 2013-05-30
OA13356A (en) 2007-04-13
KR20060113753A (ko) 2006-11-02
UA84726C2 (ru) 2008-11-25
CN100469765C (zh) 2009-03-18
EP3002277B1 (fr) 2019-11-06
UY28709A1 (es) 2005-08-31
ES2767136T3 (es) 2020-06-16
EA200601099A1 (ru) 2006-10-27
US20090030076A1 (en) 2009-01-29
KR20080007415A (ko) 2008-01-18
PA8620901A1 (es) 2005-08-30
EP1704141A1 (fr) 2006-09-27
CA2551409C (fr) 2011-02-22
TW200526567A (en) 2005-08-16
CA2551409A1 (fr) 2005-07-28
NO339685B1 (no) 2017-01-23
AR047081A1 (es) 2006-01-04
ME02433B (fr) 2016-09-20
BRPI0418245B8 (pt) 2021-05-25
US7273946B2 (en) 2007-09-25

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