AR035541A1 - Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio - Google Patents

Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio

Info

Publication number
AR035541A1
AR035541A1 ARP010105259A ARP010105259A AR035541A1 AR 035541 A1 AR035541 A1 AR 035541A1 AR P010105259 A ARP010105259 A AR P010105259A AR P010105259 A ARP010105259 A AR P010105259A AR 035541 A1 AR035541 A1 AR 035541A1
Authority
AR
Argentina
Prior art keywords
iop
combination
pio
intraocular pressure
need
Prior art date
Application number
ARP010105259A
Other languages
English (en)
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22937766&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR035541(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Publication of AR035541A1 publication Critical patent/AR035541A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Glass Compositions (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

Abstract

Método de tratamiento para pacientes que sufren de glaucoma severo y para el tratamiento de individuos que necesitan una gran reducción de la presión intraocular (PIO) que comprende la administración simultánea de una combinación de agentes redustores de la PIO en el ojo. Uso de dos o varios agentes combinados junto con la capacidad para reducir la presión intraocular en una terapia con una mayor eficacia para tratar glaucoma avanzado en pacientes que padecen de deterioros detectables de la visión, cuando dichos agentes se administran simultáneamente. El uso combinado también presenta ventajas para el tratamiento de individuos que necesitan una gran reducción de la PIO, tal como los que están expuestos a factores de riesgo que los vuelve susceptibles a deterioros visuales. Preferentemente, se usa una combinación de reductores de la PIO que tiene diferentes acciones fisiológicas. Una combinación adecuada sería un agente que incremente el flujo del humor acuoso y un agente reductor de la formación de humor acuoso. Son de particular utilidad las prostaglandinas o los derivados de prostglandinas que tienen capacidad para reducir la PIO en combinación con uno o varios agentesreductores de la PIO que tengan otra acción fisiológica. Dichas prostglandinas se pueden seleccionar entre análogos y derivados de prostaglandina F2a (PGF2a). Son de especial utilidad aquellos derivados PGF2a que tienen un sustituyente con forma de anillo en el extremo terminal de la cadena omega de la estructura de prostaglandina F2a, tal como 13,14-dihidro-17-fenil-18,19,20-trinor-prostglandina-F2a-isopropiléster (latanoprost), 16-(meta-triflurometil)-fenoxi-17,18,19,20-tetranor-prostglandina-F2a-isopropiléster (travaprost) y compuesto similares. También es de utilidad el análogo del metabolito PGF2a, unoprostona de isopropilo.
ARP010105259A 2000-11-13 2001-11-09 Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio AR035541A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24812300P 2000-11-13 2000-11-13

Publications (1)

Publication Number Publication Date
AR035541A1 true AR035541A1 (es) 2004-06-16

Family

ID=22937766

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP010105259A AR035541A1 (es) 2000-11-13 2001-11-09 Un metodo de tratamiento para pacientes que sufren de glaucoma severo o necesitan una reduccion de la presion intraocular (pio) y el uso de una combinacion de agentes reductores de la pio

Country Status (17)

Country Link
US (1) US20030018079A1 (es)
EP (1) EP1333837A1 (es)
JP (1) JP2004513148A (es)
KR (1) KR20030068150A (es)
CN (1) CN1233324C (es)
AR (1) AR035541A1 (es)
AU (1) AU2002215277A1 (es)
BR (1) BR0115208A (es)
CA (1) CA2426049A1 (es)
EA (1) EA200300560A1 (es)
HU (1) HUP0400548A3 (es)
MX (1) MXPA03004183A (es)
NO (1) NO20032122L (es)
NZ (1) NZ525817A (es)
PL (1) PL362855A1 (es)
WO (1) WO2002038158A1 (es)
ZA (1) ZA200303771B (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI298257B (en) 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
WO2003078662A1 (en) * 2002-03-13 2003-09-25 Genomic Health Gene expression profiling in biopsied tumor tissues
WO2003079997A2 (en) * 2002-03-21 2003-10-02 Cayman Chemical Company Prostaglandin f2 alpha analogs in combinaiotn with antimicrobials for treating glaucoma
US20050245509A1 (en) 2002-08-29 2005-11-03 Santen Pharmacecutical Co., Ltd. Remedy for glaucoma comprising rho kinase inhibitor and prostaglandins
US7074827B2 (en) * 2002-10-24 2006-07-11 Sucampo Ag (Usa) Inc. Method for treating ocular hypertension and glaucoma
CA2506464C (en) 2002-11-18 2012-07-31 Santen Pharmaceutical Co., Ltd. Therapeutic agent for glaucoma comprising rho kinase inhibitor and .beta.-blocker
AU2004269910A1 (en) * 2003-09-05 2005-03-17 Novartis Ag Compositions comprising benzo (G) quinoline derivatives and prostaglandin derivatives
EP1704141B1 (en) 2004-01-05 2016-02-24 Nicox S.A. Prostaglandin nitrooxyderivatives
EP1759702B1 (en) * 2004-05-26 2009-01-07 Arturo Jimenez Bayardo Method of preparing a latanoprost ophthalmic solution and solution thus produced
GB0501192D0 (en) * 2005-01-20 2005-03-02 Resolution Chemicals Ltd Stable prostaglandin-containing compositions
EP1902731B1 (en) 2005-06-21 2013-04-10 Kowa Company, Ltd. Preventive or remedy for glaucoma
EP1905452B1 (en) 2005-07-12 2013-06-19 Kowa Company, Ltd. Agent for prevention or treatment of glaucoma
ITRM20080182A1 (it) * 2008-04-07 2009-10-08 Medivis S R L Preparato oftalmico a base di dorzolamide e latanoprost per il trattamento topico del glaucoma.
WO2010119305A1 (en) * 2009-04-14 2010-10-21 Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi Using of quaternary ammonium compounds in dissolving of latanoprost
CN102085175B (zh) * 2009-12-02 2013-01-30 沈阳兴齐眼药股份有限公司 一种眼用凝胶剂及其制备方法
FR2961694B1 (fr) * 2010-06-29 2013-01-25 Thea Lab Systeme de delivrance polymerique d'une solution non visqueuse a base de prostaglandine sans conservateur
US9061034B2 (en) 2010-07-29 2015-06-23 Allergan, Inc. Preservative free bimatoprost and timolol solutions
WO2012100347A1 (en) * 2011-01-24 2012-08-02 Inceptum Research & Therapeutics, Inc. Compositions comprising a prostaglandin for treating neuropsychiatric conditions
TW202239413A (zh) 2011-02-04 2022-10-16 日商興和股份有限公司 眼科用製劑
CN102389433A (zh) * 2011-11-04 2012-03-28 兆科药业(香港)有限公司 一种药物组合物及其复方制剂
TWI788484B (zh) 2017-12-21 2023-01-01 日商參天製藥股份有限公司 賽佩普斯特（Ｓｅｐｅｔａｐｒｏｓｔ）及Ｒｈｏ激酶抑制劑之組合醫藥
KR20200103041A (ko) 2017-12-21 2020-09-01 산텐 세이야꾸 가부시키가이샤 오미데네팍의 조합

Also Published As

Publication number Publication date
HUP0400548A3 (en) 2007-05-29
KR20030068150A (ko) 2003-08-19
BR0115208A (pt) 2003-10-07
CN1473046A (zh) 2004-02-04
NZ525817A (en) 2005-03-24
WO2002038158A1 (en) 2002-05-16
ZA200303771B (en) 2004-05-17
NO20032122L (no) 2003-07-01
WO2002038158A8 (en) 2003-01-30
EA200300560A1 (ru) 2003-10-30
AU2002215277A1 (en) 2002-05-21
MXPA03004183A (es) 2004-12-02
JP2004513148A (ja) 2004-04-30
NO20032122D0 (no) 2003-05-12
CN1233324C (zh) 2005-12-28
EP1333837A1 (en) 2003-08-13
HUP0400548A2 (hu) 2004-06-28
PL362855A1 (en) 2004-11-02
CA2426049A1 (en) 2002-05-16
US20030018079A1 (en) 2003-01-23

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