ATE224910T1 - Derivate von dolestatin, deren herstellung und verwendung - Google Patents

Derivate von dolestatin, deren herstellung und verwendung

Info

Publication number
ATE224910T1
ATE224910T1 AT96918661T AT96918661T ATE224910T1 AT E224910 T1 ATE224910 T1 AT E224910T1 AT 96918661 T AT96918661 T AT 96918661T AT 96918661 T AT96918661 T AT 96918661T AT E224910 T1 ATE224910 T1 AT E224910T1
Authority
AT
Austria
Prior art keywords
dolestatin
derivatives
preparation
Prior art date
Application number
AT96918661T
Other languages
English (en)
Inventor
Andreas Haupt
Franz Emling
Cynthia A Romerdahl
Original Assignee
Abbott Gmbh & Co Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Gmbh & Co Kg filed Critical Abbott Gmbh & Co Kg
Application granted granted Critical
Publication of ATE224910T1 publication Critical patent/ATE224910T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT96918661T 1995-06-07 1996-06-03 Derivate von dolestatin, deren herstellung und verwendung ATE224910T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/472,453 US5831002A (en) 1992-05-20 1995-06-07 Antitumor peptides
PCT/EP1996/002393 WO1996040752A1 (en) 1995-06-07 1996-06-03 Novel dolastatin derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
ATE224910T1 true ATE224910T1 (de) 2002-10-15

Family

ID=23875567

Family Applications (2)

Application Number Title Priority Date Filing Date
AT96918660T ATE223431T1 (de) 1995-06-07 1996-06-03 Derivate von dolastatin, dreen herstellung un verwendung
AT96918661T ATE224910T1 (de) 1995-06-07 1996-06-03 Derivate von dolestatin, deren herstellung und verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT96918660T ATE223431T1 (de) 1995-06-07 1996-06-03 Derivate von dolastatin, dreen herstellung un verwendung

Country Status (33)

Country Link
US (1) US5831002A (de)
EP (2) EP0871656B1 (de)
JP (2) JP3957751B2 (de)
KR (2) KR100437985B1 (de)
CN (2) CN1182153C (de)
AR (2) AR003427A1 (de)
AT (2) ATE223431T1 (de)
AU (2) AU725170B2 (de)
BG (2) BG102125A (de)
BR (2) BR9609424A (de)
CA (2) CA2219818C (de)
CO (2) CO4700527A1 (de)
CZ (2) CZ293683B6 (de)
DE (2) DE69623992T2 (de)
DK (2) DK0871656T3 (de)
ES (2) ES2188759T3 (de)
HR (2) HRP960257A2 (de)
HU (2) HU228071B1 (de)
IL (2) IL122216A (de)
MX (2) MX9709146A (de)
MY (2) MY119042A (de)
NO (2) NO317670B1 (de)
NZ (2) NZ310443A (de)
PL (2) PL185763B1 (de)
PT (2) PT832104E (de)
RO (2) RO118953B1 (de)
SI (2) SI0832104T1 (de)
SK (1) SK282466B6 (de)
TR (2) TR199701545T1 (de)
TW (2) TW508357B (de)
UA (2) UA46775C2 (de)
WO (2) WO1996040752A1 (de)
ZA (2) ZA964711B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
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US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) * 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
TW474946B (en) * 1995-12-15 2002-02-01 Basf Ag Novel compounds, the preparation and use thereof
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) * 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) * 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
CA2360740A1 (en) 1999-03-02 2000-09-08 Boehringer Ingelheim Pharmaceuticals, Inc. Compounds useful as reversible inhibitors of cathepsin s
US6420364B1 (en) 1999-09-13 2002-07-16 Boehringer Ingelheim Pharmaceuticals, Inc. Compound useful as reversible inhibitors of cysteine proteases
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法
US7018642B2 (en) 2001-04-27 2006-03-28 The Procter & Gamble Company Compounds, compositions, and methods for controlling biofilms
AU2002359792A1 (en) * 2001-12-18 2003-06-30 Proteologics, Inc. Methods and compositions for the inhibition of viral release
WO2003072754A2 (en) * 2002-02-27 2003-09-04 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Conjugates of ligand, linker and cytotoxic agent and related compositions and methods of use
WO2006013552A2 (en) 2004-08-02 2006-02-09 Ramot At Tel Aviv University Ltd. Articles of peptide nanostructures and method of forming the same
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
AU2006283677A1 (en) * 2005-08-19 2007-03-01 Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Topical formulations of histone deacetylase inhibitors and methods of using the same
US10004828B2 (en) * 2005-10-11 2018-06-26 Romat at Tel-Aviv University Ltd. Self-assembled Fmoc-ff hydrogels
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics, Inc. composto de ligação de domìnio bir da iap
JP5452223B2 (ja) * 2006-07-24 2014-03-26 テトラロジック ファーマシューティカルズ コーポレーション Ｉａｐ阻害剤
EP2146719B1 (de) 2007-04-12 2013-08-14 ScinoPharm Taiwan, Ltd. Verfahren zur herstellung von galantamin
UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8283372B2 (en) 2009-07-02 2012-10-09 Tetralogic Pharmaceuticals Corp. 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic
NZ602368A (en) 2010-02-12 2014-10-31 Pharmascience Inc Iap bir domain binding compounds
KR20140003521A (ko) 2010-12-30 2014-01-09 이난타 파마슈티칼스, 인코포레이티드 페난트리딘 매크로사이클릭 ｃ형 간염 세린 프로테아제 억제제
CN103534256B (zh) 2010-12-30 2016-08-10 益安药业 大环丙型肝炎丝氨酸蛋白酶抑制剂
US10201584B1 (en) 2011-05-17 2019-02-12 Abbvie Inc. Compositions and methods for treating HCV
KR20200128601A (ko) * 2011-05-27 2020-11-13 암브룩스, 인코포레이티드 비-천연 아미노산 연결된 돌라스타틴 유도체를 함유하는 조성물, 이를 수반하는 방법, 및 용도
WO2015103490A1 (en) 2014-01-03 2015-07-09 Abbvie, Inc. Solid antiviral dosage forms
CA3230737A1 (en) 2021-09-03 2023-03-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4879278A (en) * 1989-05-16 1989-11-07 Arizona Board Of Regents Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
DK0934950T3 (da) * 1991-08-09 2002-07-29 Teikoku Hormone Mfg Co Ltd Tetrapeptidderivat
UA45304C2 (uk) * 1992-05-20 2002-04-15 Басф Аг Похідні пептиду або їх солі, фармацевтична композиція
US5530097A (en) * 1994-08-01 1996-06-25 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory peptide amides
US5504191A (en) * 1994-08-01 1996-04-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide methyl esters

Also Published As

Publication number Publication date
JP4221062B2 (ja) 2009-02-12
DE69623472T2 (de) 2003-08-21
BG102125A (en) 1998-09-30
CN1187198A (zh) 1998-07-08
DK0832104T3 (da) 2003-01-06
NO318384B1 (no) 2005-03-14
PL185762B1 (pl) 2003-07-31
DK0871656T3 (da) 2003-01-27
SK165397A3 (en) 1998-10-07
SK282466B6 (sk) 2002-02-05
ZA964711B (en) 1997-12-08
JPH11504653A (ja) 1999-04-27
UA46775C2 (uk) 2002-06-17
KR19990022583A (ko) 1999-03-25
JPH11504652A (ja) 1999-04-27
AU6124196A (en) 1996-12-30
CA2219818C (en) 2008-05-20
CA2219818A1 (en) 1996-12-19
CA2219819C (en) 2008-05-20
AU6124296A (en) 1996-12-30
DE69623472D1 (de) 2002-10-10
AU725164B2 (en) 2000-10-05
BG102152A (en) 1998-09-30
MX9709147A (es) 1998-03-31
CN1182153C (zh) 2004-12-29
EP0832104B1 (de) 2002-09-04
KR100437985B1 (ko) 2004-09-18
IL122215A0 (en) 1998-04-05
MX9709146A (es) 1998-03-31
HRP960257A2 (en) 1998-02-28
DE69623992T2 (de) 2003-05-22
ES2188759T3 (es) 2003-07-01
BR9609424A (pt) 2000-03-28
CO4700527A1 (es) 1998-12-29
AU725170B2 (en) 2000-10-05
SI0871656T1 (en) 2003-08-31
RO118953B1 (ro) 2004-01-30
US5831002A (en) 1998-11-03
ES2186783T3 (es) 2003-05-16
CZ293682B6 (cs) 2004-07-14
EP0871656A1 (de) 1998-10-21
EP0871656B1 (de) 2002-09-25
CZ376597A3 (cs) 1998-06-17
TR199701544T1 (xx) 1998-03-21
KR19990022582A (ko) 1999-03-25
HUP9801817A3 (en) 1999-06-28
PT832104E (pt) 2002-12-31
SI0832104T1 (en) 2003-08-31
HU228073B1 (hu) 2012-09-28
NO975711D0 (no) 1997-12-05
NO975710D0 (no) 1997-12-05
HU228071B1 (hu) 2012-09-28
HUP9801817A2 (hu) 1998-11-30
CN1182154C (zh) 2004-12-29
PL323723A1 (en) 1998-04-14
NO317670B1 (no) 2004-11-29
AR003136A1 (es) 1998-07-08
UA46776C2 (uk) 2002-06-17
BR9609423A (pt) 1999-06-29
CZ376397A3 (cs) 1998-06-17
IL122216A0 (en) 1998-04-05
PL185763B1 (pl) 2003-07-31
NO975710L (no) 1998-02-02
KR100437986B1 (ko) 2004-09-18
PL323726A1 (en) 1998-04-14
MY119042A (en) 2005-03-31
TW424096B (en) 2001-03-01
PT871656E (pt) 2002-12-31
EP0832104A1 (de) 1998-04-01
CA2219819A1 (en) 1996-12-19
ZA964710B (en) 1997-12-08
NO975711L (no) 1998-01-30
CO4700526A1 (es) 1998-12-29
CZ293683B6 (cs) 2004-07-14
CN1187199A (zh) 1998-07-08
IL122216A (en) 2002-02-10
NZ310443A (en) 1999-10-28
WO1996040751A1 (en) 1996-12-19
ATE223431T1 (de) 2002-09-15
AR003427A1 (es) 1998-08-05
MY124487A (en) 2006-06-30
TR199701545T1 (xx) 1998-04-21
HRP960277A2 (en) 1997-10-31
HUP9801910A3 (en) 1999-06-28
RO119783B1 (ro) 2005-03-30
DE69623992D1 (de) 2002-10-31
NZ310444A (en) 1999-11-29
HUP9801910A2 (hu) 1999-01-28
WO1996040752A1 (en) 1996-12-19
JP3957751B2 (ja) 2007-08-15
TW508357B (en) 2002-11-01
IL122215A (en) 2001-08-26

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