ATE229034T1 - 3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen - Google Patents
3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasenInfo
- Publication number
- ATE229034T1 ATE229034T1 AT97935308T AT97935308T ATE229034T1 AT E229034 T1 ATE229034 T1 AT E229034T1 AT 97935308 T AT97935308 T AT 97935308T AT 97935308 T AT97935308 T AT 97935308T AT E229034 T1 ATE229034 T1 AT E229034T1
- Authority
- AT
- Austria
- Prior art keywords
- mercaptoacetylamino
- oxo
- inhibitors
- substituted
- matrix metalloproteinases
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US71929196A | 1996-09-19 | 1996-09-19 | |
PCT/US1997/013738 WO1998012211A1 (en) | 1996-09-19 | 1997-08-04 | 3-mercaptoacetylamino-1,5-substituted-2-oxo-azepan derivatives useful as inhibitors of matrix metalloproteinase |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE229034T1 true ATE229034T1 (de) | 2002-12-15 |
Family
ID=24889504
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT97935308T ATE229034T1 (de) | 1996-09-19 | 1997-08-04 | 3-mercaptoacetylamino-1,5-substituierte-2-oxo- azepan derivate und deren verwendung als inhibitoren von matrix-metalloproteinasen |
Country Status (21)
Country | Link |
---|---|
EP (1) | EP0928291B1 (de) |
JP (1) | JP3962091B2 (de) |
KR (1) | KR100545460B1 (de) |
CN (1) | CN1150205C (de) |
AR (1) | AR009363A1 (de) |
AT (1) | ATE229034T1 (de) |
AU (1) | AU718055B2 (de) |
BR (1) | BR9713207A (de) |
CA (1) | CA2266759C (de) |
DE (1) | DE69717647T2 (de) |
DK (1) | DK0928291T3 (de) |
ES (1) | ES2184126T3 (de) |
HK (1) | HK1020741A1 (de) |
HU (1) | HUP9904165A3 (de) |
IL (2) | IL129035A0 (de) |
NO (1) | NO991316L (de) |
NZ (1) | NZ334490A (de) |
PT (1) | PT928291E (de) |
TW (1) | TW445262B (de) |
WO (1) | WO1998012211A1 (de) |
ZA (1) | ZA978307B (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1817700A (en) * | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Inc. | 1-carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of mmp-12 |
US6486193B2 (en) | 1998-12-31 | 2002-11-26 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metalloproteinases |
US6770640B1 (en) | 1998-12-31 | 2004-08-03 | Aventis Pharmaceuticals Inc. | 1-Carboxymethyl-2-oxo-azepan derivatives useful as selective inhibitors of MMP-12 |
AU1926500A (en) * | 1998-12-31 | 2000-07-24 | Aventis Pharmaceuticals Inc. | 3-substituted pyrrolidines useful as inhibitors of matrix metallo-proteinases |
CA2360305A1 (en) | 1999-02-09 | 2000-08-17 | Bristol-Myers Squibb Company | Lactam inhibitors of fxa and method |
US6344450B1 (en) | 1999-02-09 | 2002-02-05 | Bristol-Myers Squibb Company | Lactam compounds and their use as inhibitors of serine proteases and method |
JP2003513972A (ja) | 1999-11-10 | 2003-04-15 | スミスクライン・ビーチャム・コーポレイション | プロテアーゼ阻害剤 |
AU1474801A (en) | 1999-11-10 | 2001-06-06 | Smithkline Beecham Corporation | Protease inhibitors |
WO2001034599A1 (en) | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
US7141607B1 (en) | 2000-03-10 | 2006-11-28 | Insite Vision Incorporated | Methods and compositions for treating and inhibiting retinal neovascularization |
SK13632002A3 (sk) | 2000-03-21 | 2003-02-04 | Smithkline Beecham Corporation | C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty |
US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
US7704521B2 (en) | 2007-04-11 | 2010-04-27 | Zinpro Corporation | Rumen protected essential amino acids |
US20080255234A1 (en) * | 2007-04-11 | 2008-10-16 | Zinpro Corporation | Rumen protected lysine |
WO2018220032A1 (en) | 2017-05-31 | 2018-12-06 | B.R.A.I.N. Biotechnology Research And Information Network Ag | Optimization of the expression of serine proteases in host cells |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988006890A1 (en) * | 1987-03-17 | 1988-09-22 | Research Corporation Technologies, Inc. | Synthetic inhibitors of mammalian collagenase |
JPH07304746A (ja) * | 1994-05-11 | 1995-11-21 | Kanebo Ltd | 新規ベンゾアゼピンカルボン酸誘導体 |
MX9702487A (es) * | 1994-10-05 | 1998-04-30 | Darwin Discovery Ltd | Compuestos peptidilo y su uso terapeutico como inhibidores de las metaloproteasas. |
US5672598A (en) * | 1995-03-21 | 1997-09-30 | The Procter & Gamble Company | Lactam-containing hydroxamic acids |
-
1997
- 1997-08-04 CA CA002266759A patent/CA2266759C/en not_active Expired - Fee Related
- 1997-08-04 BR BR9713207-1A patent/BR9713207A/pt not_active IP Right Cessation
- 1997-08-04 JP JP51465898A patent/JP3962091B2/ja not_active Expired - Fee Related
- 1997-08-04 DK DK97935308T patent/DK0928291T3/da active
- 1997-08-04 EP EP97935308A patent/EP0928291B1/de not_active Expired - Lifetime
- 1997-08-04 NZ NZ334490A patent/NZ334490A/xx not_active IP Right Cessation
- 1997-08-04 DE DE69717647T patent/DE69717647T2/de not_active Expired - Lifetime
- 1997-08-04 IL IL12903597A patent/IL129035A0/xx active IP Right Grant
- 1997-08-04 AT AT97935308T patent/ATE229034T1/de active
- 1997-08-04 CN CNB971990247A patent/CN1150205C/zh not_active Expired - Fee Related
- 1997-08-04 KR KR1019997002336A patent/KR100545460B1/ko not_active IP Right Cessation
- 1997-08-04 PT PT97935308T patent/PT928291E/pt unknown
- 1997-08-04 AU AU38278/97A patent/AU718055B2/en not_active Ceased
- 1997-08-04 ES ES97935308T patent/ES2184126T3/es not_active Expired - Lifetime
- 1997-08-04 WO PCT/US1997/013738 patent/WO1998012211A1/en active IP Right Grant
- 1997-08-04 HU HU9904165A patent/HUP9904165A3/hu unknown
- 1997-09-13 TW TW086113339A patent/TW445262B/zh not_active IP Right Cessation
- 1997-09-15 ZA ZA9708307A patent/ZA978307B/xx unknown
- 1997-09-17 AR ARP970104242A patent/AR009363A1/es active IP Right Grant
-
1999
- 1999-03-17 IL IL129035A patent/IL129035A/en not_active IP Right Cessation
- 1999-03-18 NO NO991316A patent/NO991316L/no not_active Application Discontinuation
- 1999-12-21 HK HK99105993A patent/HK1020741A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0928291A1 (de) | 1999-07-14 |
HK1020741A1 (en) | 2000-05-19 |
EP0928291B1 (de) | 2002-12-04 |
AU718055B2 (en) | 2000-04-06 |
NO991316D0 (no) | 1999-03-18 |
WO1998012211A1 (en) | 1998-03-26 |
HUP9904165A2 (hu) | 2000-03-28 |
NZ334490A (en) | 2000-08-25 |
NO991316L (no) | 1999-05-18 |
ES2184126T3 (es) | 2003-04-01 |
IL129035A0 (en) | 2000-02-17 |
HUP9904165A3 (en) | 2002-01-28 |
DE69717647T2 (de) | 2003-09-25 |
KR100545460B1 (ko) | 2006-01-24 |
JP2001501926A (ja) | 2001-02-13 |
CA2266759A1 (en) | 1998-03-26 |
JP3962091B2 (ja) | 2007-08-22 |
IL129035A (en) | 2006-12-10 |
ZA978307B (en) | 1998-03-19 |
AU3827897A (en) | 1998-04-14 |
CN1150205C (zh) | 2004-05-19 |
BR9713207A (pt) | 2000-04-04 |
DE69717647D1 (de) | 2003-01-16 |
PT928291E (pt) | 2003-03-31 |
CA2266759C (en) | 2004-10-26 |
CN1234039A (zh) | 1999-11-03 |
AR009363A1 (es) | 2000-04-12 |
DK0928291T3 (da) | 2003-03-17 |
TW445262B (en) | 2001-07-11 |
KR20000036246A (ko) | 2000-06-26 |
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