ATE231883T1 - Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren - Google Patents

Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren

Info

Publication number
ATE231883T1
ATE231883T1 AT97926356T AT97926356T ATE231883T1 AT E231883 T1 ATE231883 T1 AT E231883T1 AT 97926356 T AT97926356 T AT 97926356T AT 97926356 T AT97926356 T AT 97926356T AT E231883 T1 ATE231883 T1 AT E231883T1
Authority
AT
Austria
Prior art keywords
amino acid
acid derivatives
thrombin inhibitors
novel amino
novel
Prior art date
Application number
AT97926356T
Other languages
English (en)
Inventor
David Gustafsson
Jan-Erik Nystroem
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE231883T1 publication Critical patent/ATE231883T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
AT97926356T 1996-06-07 1997-06-05 Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren ATE231883T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9602263A SE9602263D0 (sv) 1996-06-07 1996-06-07 New amino acid derivatives
PCT/SE1997/000989 WO1997046577A1 (en) 1996-06-07 1997-06-05 New amino acid derivatives and their use as thrombin inhibitors

Publications (1)

Publication Number Publication Date
ATE231883T1 true ATE231883T1 (de) 2003-02-15

Family

ID=20402928

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97926356T ATE231883T1 (de) 1996-06-07 1997-06-05 Neuartige aminosäurederivate und deren verwendung als thrombininhibitoren

Country Status (26)

Country Link
US (2) US6255301B1 (de)
EP (1) EP0910573B1 (de)
JP (1) JP4237824B2 (de)
CN (1) CN1129604C (de)
AR (1) AR008046A1 (de)
AT (1) ATE231883T1 (de)
AU (1) AU723420B2 (de)
BR (1) BR9709560A (de)
CA (1) CA2255625A1 (de)
CZ (1) CZ398698A3 (de)
DE (1) DE69718791T2 (de)
DK (1) DK0910573T3 (de)
EE (1) EE9800425A (de)
ES (1) ES2191840T3 (de)
HU (1) HUP0002404A3 (de)
ID (1) ID17016A (de)
IL (2) IL127325A0 (de)
IS (1) IS4906A (de)
NO (1) NO317135B1 (de)
NZ (1) NZ332964A (de)
PL (1) PL330482A1 (de)
SE (1) SE9602263D0 (de)
SK (1) SK165398A3 (de)
TR (1) TR199802536T2 (de)
WO (1) WO1997046577A1 (de)
ZA (1) ZA974542B (de)

Families Citing this family (25)

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SA96170106A (ar) * 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados
SE9704543D0 (sv) 1997-12-05 1997-12-05 Astra Ab New compounds
EP1073449A4 (de) 1998-04-24 2003-01-02 Dimensional Pharm Inc Amidinohydrazone von aminosäuren, alkoxyguanidine und aminoguanidine als proteaseinhibitoren
SE9804313D0 (sv) 1998-12-14 1998-12-14 Astra Ab New compounds
NZ512714A (en) * 1999-01-13 2003-10-31 Astrazeneca Ab Amidinobenzylamine derivatives useful as thrombin inhibitors
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE9902270D0 (sv) * 1999-06-16 1999-06-16 Astra Ab Pharmaceutically active compounds
SE0001803D0 (sv) * 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
BR0113212A (pt) * 2000-08-16 2003-07-08 Astrazeneca Ab Composto, formulação farmacêutica, uso de um composto ou de um seu derivado farmaceuticamente aceitável, métodos de tratamento de uma condição em que a inibição da trombina é requerida, e de uma condição em que a terapia anticoagulante é indicada, e, processo para a preparação de um composto
US6433186B1 (en) * 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
US7129233B2 (en) 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
SE0201661D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab New salts
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030
SI2242759T1 (sl) 2008-02-06 2013-01-31 Astrazeneca Ab Spojine
GB0913342D0 (en) 2009-07-31 2009-09-16 Astrazeneca Ab Compounds - 801
KR101181918B1 (ko) * 2010-11-09 2012-09-11 주식회사 세라젬 온열치료기용 상하운동 조절장치
WO2015044951A1 (en) 2013-09-30 2015-04-02 Council Of Scientific & Industrial Research 3,7-diazabicyclo[3.3.1 ]nonane carboxamides as antithrombotic agents
FI3102200T3 (fi) * 2014-02-07 2023-05-31 Exithera Pharmaceuticals Inc Terapeuttisia yhdisteitä ja koostumuksia
CN108530297B (zh) * 2017-03-03 2021-09-24 联化科技股份有限公司 2-氯-3-甲基苯甲酸及其中间体的制备方法

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HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
IL77748A (en) 1985-02-04 1991-11-21 Merrell Dow Pharma Amino acid and peptide derivatives as peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (de) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV Protease-Hemmer
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SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
NZ245039A (en) 1991-11-12 1994-12-22 Lilly Co Eli N-phenylalanyl and n-phenylglycyl derivatives of the dipeptide of l-azetidine-2-carboxylic acid and l-arginine aldehyde; anti-blood clotting compositions
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
CA2131367A1 (en) 1992-03-04 1993-09-16 Sandor Bajusz New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof
TW223629B (de) 1992-03-06 1994-05-11 Hoffmann La Roche
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
US5780631A (en) 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
EP0648780A1 (de) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterozyklische Thrombinhemmer
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
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DE4421052A1 (de) * 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
MX9705970A (es) 1995-02-10 1997-11-29 Basf Ag Inhibidores de trombina.
NZ302649A (en) 1995-02-17 2000-01-28 Basf Ag Dipeptide amidine derivatives, preparation and pharmaceutical compositions thereof
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
CA2216859A1 (en) 1995-04-04 1996-10-10 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
SA96170106A (ar) 1995-07-06 2005-12-03 أسترا أكتيبولاج مشتقات حامض أميني جديدة
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
SE9704543D0 (sv) * 1997-12-05 1997-12-05 Astra Ab New compounds

Also Published As

Publication number Publication date
DE69718791D1 (de) 2003-03-06
DE69718791T2 (de) 2003-10-23
IL127325A0 (en) 1999-09-22
AU3114097A (en) 1998-01-05
TR199802536T2 (xx) 1999-03-22
AR008046A1 (es) 1999-12-09
ID17016A (id) 1997-12-04
ES2191840T3 (es) 2003-09-16
SK165398A3 (en) 1999-08-06
SE9602263D0 (sv) 1996-06-07
EP0910573B1 (de) 2003-01-29
CN1129604C (zh) 2003-12-03
CN1226895A (zh) 1999-08-25
US6255301B1 (en) 2001-07-03
JP4237824B2 (ja) 2009-03-11
JP2000512631A (ja) 2000-09-26
AU723420B2 (en) 2000-08-24
NO985700D0 (no) 1998-12-04
NZ332964A (en) 2000-08-25
CZ398698A3 (cs) 1999-07-14
NO985700L (no) 1999-02-05
IS4906A (is) 1998-11-25
PL330482A1 (en) 1999-05-24
IL127325A (en) 2006-10-31
CA2255625A1 (en) 1997-12-11
WO1997046577A1 (en) 1997-12-11
US20020019371A1 (en) 2002-02-14
EE9800425A (et) 1999-06-15
BR9709560A (pt) 1999-08-10
US6838478B2 (en) 2005-01-04
NO317135B1 (no) 2004-08-23
DK0910573T3 (da) 2003-06-23
ZA974542B (en) 1997-12-08
EP0910573A1 (de) 1999-04-28
HUP0002404A3 (en) 2001-02-28
HUP0002404A2 (hu) 2000-10-28

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