AR008046A1 - Nuevos derivados de aminoacidos, formulacion farmaceutica que los incluye, metodos para la elaboracion de medicamentos y proceso para la preparacion dedichos derivados. - Google Patents
Nuevos derivados de aminoacidos, formulacion farmaceutica que los incluye, metodos para la elaboracion de medicamentos y proceso para la preparacion dedichos derivados.Info
- Publication number
- AR008046A1 AR008046A1 ARP970102484A ARP970102484A AR008046A1 AR 008046 A1 AR008046 A1 AR 008046A1 AR P970102484 A ARP970102484 A AR P970102484A AR P970102484 A ARP970102484 A AR P970102484A AR 008046 A1 AR008046 A1 AR 008046A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently
- phenyl
- preparation
- alkyl
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Compuestos de fórmula (I), donde R1 es H, C(O)R11, SiR12R13R14, o alquilo C1-6 opcionalmente sustituido; R12, R13 y R14 son independientemente H,fenilo o alquilo C1-6; y R11 es independientemente H o alquilo C1-4; R2 y R3 son independientementeH, alquilo C1-4, ciclohexilo o fenilo, Rx es unfragmento de fórmula IIa, IIb o IIc, donde k, l y m son independientemente 0, 1, 2, 3 o 4; R4 y R5 son independientemente H, Si(Me)3, 1- y 2-naftilo,hidrocarbilo policíclico, CHR41R42, o alquilo C1-4 (opcionalmente sustituido), o cicloalquilo C3-8 o fenilo (opcionalmente sustituidos); R41 y R42 sonindependientemente ciclohexilo o fenilo; y R6 y R7 son independientemente H, alquilo C1-4, cicloalquilo C3-8, fenilo, o junto con el carbono al cualestán unidos, forman un anillo de cicloalquilo C3-8; Y es CH2, (CH2)2, CH=CH, (CH2)3, CH2CH=CH o CH=CHCH2, estando los tres últimos opcionalmente sustituidoscon alquilo C1-4, metileno, oxo o hidroxi; n es 0, 1, 2, 3, o 4; y B es un fragmentode fórmulas IVd, IVe, o IVf, donde X1 y X2 son independientementeun enlace simple o CH2; D1 y D2 son independientemente H, OH, ORa, OC(O)Rb, OC(O)ORc, C(O)ORd, C(O)Re y Ra, Rb, Rc, Rd y Re son independientemente fenilo,bencilo, (CH2)2OC(O)CH3, oalquilo C1-6 opcionalmente interrumpido por oxígeno o una sal farmacéuticamente aceptable del mismo. Además, se dan aconocer una formulación farmacéutica que los incluye, métodos para la elaboración de medicamentos y un proceso para la preparación de dichosderivados.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602263A SE9602263D0 (sv) | 1996-06-07 | 1996-06-07 | New amino acid derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR008046A1 true AR008046A1 (es) | 1999-12-09 |
Family
ID=20402928
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102484A AR008046A1 (es) | 1996-06-07 | 1997-06-06 | Nuevos derivados de aminoacidos, formulacion farmaceutica que los incluye, metodos para la elaboracion de medicamentos y proceso para la preparacion dedichos derivados. |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US6255301B1 (es) |
| EP (1) | EP0910573B1 (es) |
| JP (1) | JP4237824B2 (es) |
| CN (1) | CN1129604C (es) |
| AR (1) | AR008046A1 (es) |
| AT (1) | ATE231883T1 (es) |
| AU (1) | AU723420B2 (es) |
| BR (1) | BR9709560A (es) |
| CA (1) | CA2255625A1 (es) |
| CZ (1) | CZ398698A3 (es) |
| DE (1) | DE69718791T2 (es) |
| DK (1) | DK0910573T3 (es) |
| EE (1) | EE9800425A (es) |
| ES (1) | ES2191840T3 (es) |
| HU (1) | HUP0002404A3 (es) |
| ID (1) | ID17016A (es) |
| IL (2) | IL127325A0 (es) |
| IS (1) | IS4906A (es) |
| NO (1) | NO317135B1 (es) |
| NZ (1) | NZ332964A (es) |
| PL (1) | PL330482A1 (es) |
| SE (1) | SE9602263D0 (es) |
| SK (1) | SK165398A3 (es) |
| TR (1) | TR199802536T2 (es) |
| WO (1) | WO1997046577A1 (es) |
| ZA (1) | ZA974542B (es) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SA96170106A (ar) * | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
| AU750561B2 (en) | 1998-04-24 | 2002-07-25 | 3-Dimensional Pharmaceuticals, Inc. | Amino acid amidinohydrazones, alkoxyguanidines and aminoguanidines as protease inhibitors |
| SE9804313D0 (sv) | 1998-12-14 | 1998-12-14 | Astra Ab | New compounds |
| CA2355792A1 (en) * | 1999-01-13 | 2000-07-20 | Astrazeneca Ab | New amidinobenzylamine derivatives and their use as thrombin inhibitors |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| SE9902270D0 (sv) * | 1999-06-16 | 1999-06-16 | Astra Ab | Pharmaceutically active compounds |
| SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| US6433186B1 (en) * | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| EP1311480B1 (en) * | 2000-08-16 | 2008-09-03 | AstraZeneca AB | New amidino derivatives and their use as thrombin inhibitors |
| US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| CN102083839B (zh) | 2008-02-06 | 2014-03-26 | 阿斯利康(瑞典)有限公司 | 化合物 |
| GB0913342D0 (en) | 2009-07-31 | 2009-09-16 | Astrazeneca Ab | Compounds - 801 |
| KR101181918B1 (ko) * | 2010-11-09 | 2012-09-11 | 주식회사 세라젬 | 온열치료기용 상하운동 조절장치 |
| IN2013DE02892A (es) | 2013-09-30 | 2015-04-03 | Council Scient Ind Res | |
| EP3102200B1 (en) * | 2014-02-07 | 2023-04-05 | Exithera Pharmaceuticals Inc. | Therapeutic compounds and compositions |
| CN108530297B (zh) * | 2017-03-03 | 2021-09-24 | 联化科技股份有限公司 | 2-氯-3-甲基苯甲酸及其中间体的制备方法 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| AU600226B2 (en) | 1985-02-04 | 1990-08-09 | Merrell Pharmaceuticals Inc. | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897514B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| TW201303B (es) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| CZ333492A3 (en) | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| CA2131367A1 (en) | 1992-03-04 | 1993-09-16 | Sandor Bajusz | New anticoagulant peptide derivatives and pharmaceutical compositions containing the same as well as a process for the preparation thereof |
| TW223629B (es) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| US5583146A (en) | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| US5780631A (en) | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| US5726159A (en) | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| DE4421052A1 (de) * | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4443390A1 (de) | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
| EA002767B1 (ru) | 1995-02-10 | 2002-08-29 | Басф Акциенгезельшафт | Ингибиторы тромбина |
| MX9706069A (es) * | 1995-02-17 | 1997-10-31 | Basf Ag | Nuevos inhibidores de la trombina. |
| US5914319A (en) | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| EP0820453A4 (en) | 1995-04-04 | 2001-08-29 | Merck & Co Inc | THROMBIN INHIBITORS |
| US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| TW541316B (en) | 1995-12-21 | 2003-07-11 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| JPH1095898A (ja) | 1996-09-25 | 1998-04-14 | Sumitomo Bakelite Co Ltd | 難燃性樹脂組成物およびこれを用いた積層板 |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| SE9704543D0 (sv) * | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
-
1996
- 1996-06-07 SE SE9602263A patent/SE9602263D0/xx unknown
-
1997
- 1997-05-23 ZA ZA9704542A patent/ZA974542B/xx unknown
- 1997-06-03 ID IDP971884A patent/ID17016A/id unknown
- 1997-06-05 US US08/860,871 patent/US6255301B1/en not_active Expired - Fee Related
- 1997-06-05 AU AU31140/97A patent/AU723420B2/en not_active Ceased
- 1997-06-05 IL IL12732597A patent/IL127325A0/xx active IP Right Grant
- 1997-06-05 CZ CZ983986A patent/CZ398698A3/cs unknown
- 1997-06-05 SK SK1653-98A patent/SK165398A3/sk unknown
- 1997-06-05 PL PL97330482A patent/PL330482A1/xx unknown
- 1997-06-05 JP JP50050298A patent/JP4237824B2/ja not_active Expired - Fee Related
- 1997-06-05 DK DK97926356T patent/DK0910573T3/da active
- 1997-06-05 WO PCT/SE1997/000989 patent/WO1997046577A1/en active IP Right Grant
- 1997-06-05 BR BR9709560A patent/BR9709560A/pt active Search and Examination
- 1997-06-05 NZ NZ332964A patent/NZ332964A/xx not_active IP Right Cessation
- 1997-06-05 AT AT97926356T patent/ATE231883T1/de not_active IP Right Cessation
- 1997-06-05 TR TR1998/02536T patent/TR199802536T2/xx unknown
- 1997-06-05 EE EE9800425A patent/EE9800425A/xx unknown
- 1997-06-05 HU HU0002404A patent/HUP0002404A3/hu unknown
- 1997-06-05 CA CA002255625A patent/CA2255625A1/en not_active Abandoned
- 1997-06-05 DE DE69718791T patent/DE69718791T2/de not_active Expired - Fee Related
- 1997-06-05 ES ES97926356T patent/ES2191840T3/es not_active Expired - Lifetime
- 1997-06-05 EP EP97926356A patent/EP0910573B1/en not_active Expired - Lifetime
- 1997-06-05 CN CN97196864A patent/CN1129604C/zh not_active Expired - Fee Related
- 1997-06-06 AR ARP970102484A patent/AR008046A1/es not_active Application Discontinuation
-
1998
- 1998-11-25 IS IS4906A patent/IS4906A/is unknown
- 1998-11-30 IL IL127325A patent/IL127325A/en not_active IP Right Cessation
- 1998-12-04 NO NO19985700A patent/NO317135B1/no not_active IP Right Cessation
-
2001
- 2001-04-30 US US09/844,427 patent/US6838478B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |