EE9900006A - Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena - Google Patents
Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritenaInfo
- Publication number
- EE9900006A EE9900006A EEP199900006A EE9900006A EE9900006A EE 9900006 A EE9900006 A EE 9900006A EE P199900006 A EEP199900006 A EE P199900006A EE 9900006 A EE9900006 A EE 9900006A EE 9900006 A EE9900006 A EE 9900006A
- Authority
- EE
- Estonia
- Prior art keywords
- thrombin inhibitors
- amidine derivatives
- novel amidine
- novel
- derivatives
- Prior art date
Links
- 229940122388 Thrombin inhibitor Drugs 0.000 title 1
- 150000001409 amidines Chemical class 0.000 title 1
- 239000003868 thrombin inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/71—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/63—Esters of sulfonic acids
- C07C309/72—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/73—Esters of sulfonic acids having sulfur atoms of esterified sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/84—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/53—Organo-phosphine oxides; Organo-phosphine thioxides
- C07F9/5304—Acyclic saturated phosphine oxides or thioxides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9602646A SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Pharmaceutically-useful compounds |
| PCT/SE1997/001150 WO1998001422A1 (en) | 1996-07-04 | 1997-06-26 | New amidino derivatives and their use as thrombin inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| EE9900006A true EE9900006A (et) | 1999-06-15 |
Family
ID=20403276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EEP199900006A EE9900006A (et) | 1996-07-04 | 1997-06-26 | Uued amidinoderivaadid ja nende kasutamine trombiini inhibiitoritena |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6221898B1 (et) |
| EP (1) | EP0917528B1 (et) |
| JP (1) | JP2000515505A (et) |
| KR (1) | KR20000022437A (et) |
| CN (1) | CN1228765A (et) |
| AR (1) | AR007614A1 (et) |
| AT (1) | ATE224365T1 (et) |
| BR (1) | BR9710142A (et) |
| CA (1) | CA2260190A1 (et) |
| CZ (1) | CZ1299A3 (et) |
| DE (1) | DE69715635T2 (et) |
| EE (1) | EE9900006A (et) |
| HU (1) | HUP9902410A3 (et) |
| ID (1) | ID19479A (et) |
| IL (1) | IL127885A0 (et) |
| IS (1) | IS4930A (et) |
| NO (1) | NO986180L (et) |
| NZ (1) | NZ333394A (et) |
| PL (1) | PL331047A1 (et) |
| SE (1) | SE9602646D0 (et) |
| SK (1) | SK172098A3 (et) |
| TR (1) | TR199802767T2 (et) |
| WO (1) | WO1998001422A1 (et) |
| ZA (1) | ZA975591B (et) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
| SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | Astra Ab | New compounds |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| DE60039533D1 (de) * | 1999-12-23 | 2008-08-28 | Ampac Fine Chemicals Llc | Verbessertes verfahren zur herstellung von 2s,3s-n-isobutyl-n-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamid hydrochlorid und anderen derivaten von 2-hydroxy-1,3-diamin |
| US6548706B2 (en) | 1999-12-23 | 2003-04-15 | Aerojet Fine Chemicals Llc | Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| MXPA03002975A (es) * | 2000-10-04 | 2004-02-12 | Kissei Pharmaceutical | Derivados de 5-amidino-2-hidroxibencenslfonamida, composiciones farmaceuticas que contienen los mismos e intermediarios para su preparacion. |
| US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| US7067539B2 (en) | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
| AR034517A1 (es) * | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| EP1312602A1 (en) * | 2001-11-15 | 2003-05-21 | Eisai Co., Ltd. | Amidino derivatives, and anticoagulants and thrombosis therapeutic agents containing them |
| JP4209659B2 (ja) | 2001-11-15 | 2009-01-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | アミジノ誘導体並びにそれを用いた抗血液凝固剤および血栓症治療剤 |
| BR0215182A (pt) * | 2001-12-20 | 2004-10-19 | Bristol Myers Squibb Co | Derivados de (alfa)- (n-sulfonamido) acetamida como inibidores de (beta)-amilóide |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| US20050026168A1 (en) * | 2002-12-13 | 2005-02-03 | Genesis Group Inc. | Method for the detection of risk factors associated with myocardial infarction |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| US7524354B2 (en) * | 2005-07-07 | 2009-04-28 | Research Foundation Of State University Of New York | Controlled synthesis of highly monodispersed gold nanoparticles |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
| JP5304785B2 (ja) * | 2008-06-23 | 2013-10-02 | アステラス製薬株式会社 | スルホンアミド化合物又はその塩 |
| GB0815782D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815781D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| GB0815784D0 (en) | 2008-08-29 | 2008-10-08 | Xention Ltd | Novel potassium channel blockers |
| BR112013015260B1 (pt) | 2010-12-16 | 2020-03-24 | Allergan, Inc. | Derivados de enxofre como moduladores de receptor de quimiocina, composição compreendendo o mesmo e seu uso |
| CN102358753B (zh) * | 2011-10-14 | 2013-06-05 | 山西大学 | 一种胰蛋白酶抑制剂活性片段衍生物及其制备方法和应用 |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| ZA86746B (en) | 1985-02-04 | 1986-09-24 | Merrell Dow Pharma | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| TW201303B (et) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| CZ333492A3 (en) | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| US5264457A (en) | 1992-02-14 | 1993-11-23 | G. D. Searle & Co. | Phenyl amidines sulfonamides useful as platelet aggregation inhibitors |
| DK0629212T3 (da) | 1992-03-04 | 1998-05-25 | Gyogyszerkutato Intezet | Antikoagulerende peptidderivater og farmaceutiske præparater indeholdende disse samt fremgangsmåde til fremstilling deraf. |
| TW223629B (et) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| US5583146A (en) | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| TW257757B (et) | 1993-03-03 | 1995-09-21 | Boehringer Mannheim Gmbh | |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| US5780631A (en) | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| AU1025795A (en) | 1994-01-27 | 1995-08-03 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| US5726159A (en) | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4430757A1 (de) | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue 4-Aminopyridazine, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| DE4430755A1 (de) | 1994-08-30 | 1996-03-07 | Boehringer Mannheim Gmbh | Neue Phosphanoxide, Verfahren zu ihrer Herstellung sowie diese Verbindungen enthaltende Arzneimittel |
| EP0798295B1 (en) * | 1994-12-02 | 2003-02-26 | Yamanouchi Pharmaceutical Co. Ltd. | Novel amidinonaphthyl derivative or salt thereof |
| KR100388185B1 (ko) | 1995-02-17 | 2003-11-28 | 애보트 게엠베하 운트 콤파니 카게 | 트롬빈 억제제로서의 신규 디펩티드 아미딘 |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| IL118007A0 (en) * | 1995-05-24 | 1996-08-04 | Du Pont Merck Pharma | Isoxazoline compounds pharmaceutical compositions containing them and their use |
| SA96170106A (ar) | 1995-07-06 | 2005-12-03 | أسترا أكتيبولاج | مشتقات حامض أميني جديدة |
| US5792769A (en) | 1995-09-29 | 1998-08-11 | 3-Dimensional Pharmaceuticals, Inc. | Guanidino protease inhibitors |
| IL123802A0 (en) | 1995-09-29 | 1998-10-30 | 3-Dimensional Pharma Inc | Guanidino protease inhibitors |
| AR005245A1 (es) | 1995-12-21 | 1999-04-28 | Astrazeneca Ab | Prodrogas de inhibidores de trombina, una formulación farmaceutica que las comprende, el uso de dichas prodrogas para la manufactura de un medicamento y un procedimiento para su preparacion |
| KR19990076817A (ko) | 1995-12-29 | 1999-10-15 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 아미디노 프로테아제 억제제 |
| WO1997047299A1 (en) | 1996-06-12 | 1997-12-18 | 3-Dimensional Pharmaceuticals, Inc. | Amidino and guanidino heterocyclic protease inhibitors |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| US6285302B1 (en) | 1998-12-28 | 2001-09-04 | Texas Instruments Incorporated | Runlength-limited code and method |
-
1996
- 1996-07-04 SE SE9602646A patent/SE9602646D0/xx unknown
-
1997
- 1997-06-23 AR ARP970102753A patent/AR007614A1/es not_active Application Discontinuation
- 1997-06-24 ZA ZA975591A patent/ZA975591B/xx unknown
- 1997-06-26 KR KR1019980710870A patent/KR20000022437A/ko not_active Application Discontinuation
- 1997-06-26 JP JP10505123A patent/JP2000515505A/ja not_active Ceased
- 1997-06-26 EP EP97932085A patent/EP0917528B1/en not_active Expired - Lifetime
- 1997-06-26 SK SK1720-98A patent/SK172098A3/sk unknown
- 1997-06-26 BR BR9710142A patent/BR9710142A/pt unknown
- 1997-06-26 WO PCT/SE1997/001150 patent/WO1998001422A1/en not_active Application Discontinuation
- 1997-06-26 PL PL97331047A patent/PL331047A1/xx unknown
- 1997-06-26 US US08/894,833 patent/US6221898B1/en not_active Expired - Fee Related
- 1997-06-26 NZ NZ333394A patent/NZ333394A/xx not_active IP Right Cessation
- 1997-06-26 IL IL12788597A patent/IL127885A0/xx unknown
- 1997-06-26 AT AT97932085T patent/ATE224365T1/de not_active IP Right Cessation
- 1997-06-26 EE EEP199900006A patent/EE9900006A/et unknown
- 1997-06-26 TR TR1998/02767T patent/TR199802767T2/xx unknown
- 1997-06-26 HU HU9902410A patent/HUP9902410A3/hu unknown
- 1997-06-26 CA CA002260190A patent/CA2260190A1/en not_active Abandoned
- 1997-06-26 CZ CZ9912A patent/CZ1299A3/cs unknown
- 1997-06-26 DE DE69715635T patent/DE69715635T2/de not_active Expired - Fee Related
- 1997-06-26 CN CN97197578A patent/CN1228765A/zh active Pending
- 1997-07-02 ID IDP972305A patent/ID19479A/id unknown
-
1998
- 1998-12-21 IS IS4930A patent/IS4930A/is unknown
- 1998-12-29 NO NO986180A patent/NO986180L/no not_active Application Discontinuation
-
2001
- 2001-04-23 US US09/839,609 patent/US7074820B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| NO986180D0 (no) | 1998-12-29 |
| HUP9902410A2 (hu) | 1999-11-29 |
| IS4930A (is) | 1998-12-21 |
| ZA975591B (en) | 1998-12-24 |
| ATE224365T1 (de) | 2002-10-15 |
| CZ1299A3 (cs) | 1999-06-16 |
| CA2260190A1 (en) | 1998-01-15 |
| AR007614A1 (es) | 1999-11-10 |
| DE69715635T2 (de) | 2003-08-07 |
| HUP9902410A3 (en) | 2001-10-29 |
| SK172098A3 (en) | 1999-06-11 |
| ID19479A (id) | 1998-07-16 |
| PL331047A1 (en) | 1999-06-21 |
| DE69715635D1 (de) | 2002-10-24 |
| EP0917528A1 (en) | 1999-05-26 |
| US6221898B1 (en) | 2001-04-24 |
| US7074820B2 (en) | 2006-07-11 |
| NZ333394A (en) | 2000-08-25 |
| CN1228765A (zh) | 1999-09-15 |
| AU3562897A (en) | 1998-02-02 |
| JP2000515505A (ja) | 2000-11-21 |
| SE9602646D0 (sv) | 1996-07-04 |
| NO986180L (no) | 1999-03-04 |
| TR199802767T2 (xx) | 1999-04-21 |
| KR20000022437A (ko) | 2000-04-25 |
| IL127885A0 (en) | 1999-10-28 |
| WO1998001422A1 (en) | 1998-01-15 |
| BR9710142A (pt) | 1999-08-10 |
| AU726236B2 (en) | 2000-11-02 |
| EP0917528B1 (en) | 2002-09-18 |
| US20020040043A1 (en) | 2002-04-04 |
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