DE69731664D1 - Thrombininhibitoren - Google Patents

Thrombininhibitoren

Info

Publication number
DE69731664D1
DE69731664D1 DE69731664T DE69731664T DE69731664D1 DE 69731664 D1 DE69731664 D1 DE 69731664D1 DE 69731664 T DE69731664 T DE 69731664T DE 69731664 T DE69731664 T DE 69731664T DE 69731664 D1 DE69731664 D1 DE 69731664D1
Authority
DE
Germany
Prior art keywords
thrombin inhibitors
thrombin
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69731664T
Other languages
English (en)
Inventor
Boeckel Adriaan Van
Egbert Adang
Albertus Peters
Bernardus Rewinkel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Akzo Nobel NV
Original Assignee
Akzo Nobel NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV
Application granted granted Critical
Publication of DE69731664D1 publication Critical patent/DE69731664D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69731664T 1996-08-23 1997-08-19 Thrombininhibitoren Expired - Lifetime DE69731664D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96202336 1996-08-23
PCT/EP1997/004579 WO1998007308A2 (en) 1996-08-23 1997-08-19 Thrombin inhibitors

Publications (1)

Publication Number Publication Date
DE69731664D1 true DE69731664D1 (de) 2004-12-23

Family

ID=8224306

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69731664T Expired - Lifetime DE69731664D1 (de) 1996-08-23 1997-08-19 Thrombininhibitoren

Country Status (10)

Country Link
EP (1) EP0956293B1 (de)
AR (1) AR009302A1 (de)
AT (1) ATE282629T1 (de)
AU (1) AU4618197A (de)
DE (1) DE69731664D1 (de)
ID (1) ID18075A (de)
IL (1) IL121474A0 (de)
TW (1) TW515803B (de)
WO (1) WO1998007308A2 (de)
ZA (1) ZA977209B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877156A (en) * 1997-04-24 1999-03-02 Akzo Nobel, N.V. Thrombin inhibitors
EP0884325A1 (de) * 1997-04-24 1998-12-16 Akzo Nobel N.V. Inhibitoren des Thrombins, die einen peptid-Heterocyclus aufweisen
GB0507577D0 (en) 2005-04-14 2005-05-18 Novartis Ag Organic compounds
WO2007140117A1 (en) 2006-05-23 2007-12-06 Irm Llc Compounds and compositions as channel activating protease inhibitors
EP2027143A2 (de) 2006-05-23 2009-02-25 Irm Llc Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer
US8293915B2 (en) 2007-02-09 2012-10-23 Irm Llc Compounds and compositions as channel activating protease inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5672582A (en) * 1993-04-30 1997-09-30 Merck & Co., Inc. Thrombin inhibitors
SE9301916D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
ZA951617B (en) * 1994-03-04 1997-02-27 Lilly Co Eli Antithrombotic agents.
JPH10513151A (ja) * 1994-12-22 1998-12-15 バイオケム ファーマ インコーポレイテッド トロンビン阻害剤としての複素環式ケトアルギニンペプチド
US5827860A (en) * 1995-06-07 1998-10-27 Ortho Pharmaceutical Corporation Peptidyl heterocycles useful in the treatment of thrombin related disorders
IL119466A (en) * 1995-11-03 2001-08-26 Akzo Nobel Nv Thrombin inhibitors, their preparation and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IL121474A0 (en) 1998-02-08
WO1998007308A3 (en) 2000-08-24
AR009302A1 (es) 2000-04-12
EP0956293A1 (de) 1999-11-17
ZA977209B (en) 1998-02-20
EP0956293B1 (de) 2004-11-17
WO1998007308A2 (en) 1998-02-26
AU4618197A (en) 1998-03-06
ID18075A (id) 1998-02-26
TW515803B (en) 2003-01-01
ATE282629T1 (de) 2004-12-15

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Legal Events

Date Code Title Description
8332 No legal effect for de